CN116196356A - A skin ointment for treating dermatoses - Google Patents

A skin ointment for treating dermatoses Download PDF

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CN116196356A
CN116196356A CN202310265972.2A CN202310265972A CN116196356A CN 116196356 A CN116196356 A CN 116196356A CN 202310265972 A CN202310265972 A CN 202310265972A CN 116196356 A CN116196356 A CN 116196356A
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skin
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ice
cantharis
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李洪
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/648Myriapods, e.g. centipedes or millipedes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234Cnidium (snowparsley)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/59Menispermaceae (Moonseed family), e.g. hyperbaena or coralbead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/758Zanthoxylum, e.g. pricklyash
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention relates to a skin ointment for treating skin diseases, which comprises the following raw materials: centipede, cantharis, scorpion, semen chaenomelis, asarum, realgar, angelica dahurica, root of beancurd, honeycomb, fructus cnidii, croton, mugwort leaf, sulfur, dried body of ice, borneol, ice and pricklyash peel. The skin ointment prepared by the invention is suitable for various skin diseases, such as dermatitis, acne and the like, has a simple use method, is directly smeared on a focus, has a pure traditional Chinese medicine formula, and has no toxic or side effect; has the characteristics of definite curative effect, quick response, high cure rate, no side effect and the like.

Description

A skin ointment for treating dermatoses
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a skin ointment for treating skin diseases.
Background
Dermatological disorders are a generic term for disorders that occur in the skin and skin appendages. The skin is the largest organ of the human body, and various diseases of viscera can be expressed on the skin as well as various kinds of skin diseases. Skin diseases are caused by a plurality of reasons, such as skin diseases caused by infectious factors, such as mycosis, skin bacterial infection and the like, have a certain infectivity, and not only influence the health of the human body, but also cause panic and social discrimination. The ointment for treating the skin diseases can be applied to the skin when the skin diseases are treated, has quick response to western medicines, but treats both symptoms and root causes, has certain side effects, stimulates the skin, causes skin inflammation and repeated infection, increases pain of patients, and has high treatment cost.
Disclosure of Invention
In view of the above background, the present invention provides a skin cream for treating skin diseases.
A skin ointment for treating skin diseases comprises the following raw materials: centipede, cantharis, scorpion, semen chaenomelis, asarum, realgar, angelica dahurica, root of beancurd, honeycomb, fructus cnidii, croton, mugwort leaf, sulfur, dried body of ice, borneol, ice and pricklyash peel.
Preferably, the method comprises the following raw materials: 5 parts of centipede, 6 parts of cantharis, 5 parts of scorpion, 8 parts of semen chaenomelis, 8 parts of asarum, 4 parts of realgar, 4 parts of radix angelicae, 5 parts of bean root, 5 parts of honeycomb, 8 parts of fructus cnidii, 3 parts of croton, 10 parts of mugwort leaf, 5 parts of sulfur, 8 parts of dried body, 8 parts of borneol, 6 parts of ice flakes and 4 parts of pepper.
Preferably, the method comprises the following raw materials: 7 parts of centipede, 5 parts of cantharis, 8 parts of scorpion, 6 parts of semen amomi, 10 parts of asarum, 10 parts of realgar, 10 parts of radix angelicae, 8 parts of bean root, 8 parts of honeycomb, 8 parts of fructus cnidii, 6 parts of croton, 10 parts of mugwort leaf, 6 parts of sulfur, 8 parts of dried body, 5 parts of borneol, 5 parts of ice flakes and 5 parts of pepper.
Preferably, the method comprises the following raw materials: 8 parts of centipede, 8 parts of cantharis, 8 parts of scorpion, 8 parts of semen amomi, 8 parts of asarum, 8 parts of realgar, 8 parts of radix angelicae, 8 parts of bean root, 8 parts of honeycomb, 8 parts of fructus cnidii, 8 parts of croton, 8 parts of mugwort leaf, 8 parts of sulfur, 8 parts of dried body, 8 parts of borneol, 8 parts of ice flakes and 8 parts of pepper.
Preferably, the preparation method comprises the following steps:
(1) Cleaning: cleaning the raw materials and airing;
(2) Grinding: weighing the raw materials in parts by weight, mixing, and grinding into powder;
(3) And (3) blending: mixing the above powders with vegetable oil to obtain paste.
Pharmacological analysis:
centipede): warm nature, toxic, and has effects of calming endogenous wind, relieving spasm, eliminating toxic substances, resolving hard mass, dredging collaterals, and relieving pain. Can be used for treating spasm and convulsion caused by various reasons, such as tetanus, etc.
Cantharis: pungent and hot nature, has strong toxicity, enters liver, stomach and kidney meridians, and has the effects of breaking blood and removing stasis, relieving swelling and pain, counteracting toxic substances and eliminating sores, etc.
Whole worm: namely, scorpio belongs to wind-extinguishing and spasm-stopping herbs. Has effects of calming endogenous wind, relieving spasm, dredging collaterals, relieving pain, removing toxic substances, and resolving hard mass.
Semen Hydnocarpi: pungent in flavor, heat, toxic, entering lung and liver meridians, and has the effects of dispelling wind, removing dampness, killing parasites, relieving itching and the like.
Asarum herb: warm nature, it enters heart, lung and kidney meridians. Has effects in relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, warming lung, and resolving fluid retention.
Realgar: pungent and warm nature, toxicity, liver, stomach and large intestine meridians entered, it has the actions of detoxifying and killing parasites, drying dampness and eliminating phlegm, checking malaria and arresting convulsion.
Radix angelicae: white color, warm nature, pungent taste and slight bitter taste, has the functions of dispelling wind and removing dampness, inducing resuscitation and relieving pain, and relieving swelling and expelling pus, and is widely used for treating common cold headache, eyebrow pain, nasal obstruction, nasosinusitis, toothache, leucorrhea, abscess and other diseases clinically.
Root of beans: pungent and bitter taste, good cold property, and good therapeutic effect on lung and stomach meridians.
Honeycomb: sweet in taste and neutral in nature, enters liver, stomach and kidney meridians; attack and kill parasites, treat scrofula, stubborn tinea and sores and ulcers; dispelling pathogenic wind and relieving pain, and treating toothache and rheumatalgia.
Fructus Cnidii: bitter, pungent and warm in nature, has little toxicity, enters kidney meridian, and can dry dampness, expel wind, kill parasites, relieve itching, warm kidney and strengthen yang.
And (3) a croton: pungent and hot taste, strong toxicity, stomach and large intestine meridian entered, and has the effects of purgation, accumulation removal, water-expelling and detumescence.
Mugwort leaf: has effects in warming channel, stopping bleeding, dispelling cold, relieving pain, regulating menstruation, preventing miscarriage, eliminating dampness, relieving itching, etc., and can be used for treating various diseases such as hemorrhage, abdominal pain due to deficiency-cold, and downward flow of damp-cold.
Sulfur: has the effects of disinfection and sterilization, and also has the effects of tonifying fire, supporting yang and relaxing bowels, has good treatment effect on diseases such as scabies, malignant sores, diarrhea and the like, and also has the effects of insect resistance and insect killing.
And (5) carrying out dry consolidation: has effects in eliminating phlegm, stopping bleeding, relieving diarrhea, removing toxic substances, killing parasite, and inhibiting various bacteria, trichomonas and tubercle bacillus.
Borneol: it has effects of inducing resuscitation, refreshing brain, relieving swelling and pain, and clearing away heat and toxic materials.
Thin ice: has effects in relieving inflammation and itching, relieving pain, refreshing, relieving fever, resisting infection, clearing away heat and toxic materials, improving respiratory symptoms, invigorating spleen, nourishing stomach, promoting digestion, and promoting bile flow.
Pricklyash peel: warm nature and pungent taste, can be used for relieving symptoms such as abdominal pain, preference for pressing, aversion to cold, cold limbs, anorexia, loose stool, etc. caused by deficiency of plain yang-qi and invasion of cold evil, and has effects of warming middle-jiao and dispelling cold.
The beneficial effects of the invention are as follows:
the skin ointment prepared by the invention is suitable for various skin diseases, such as dermatitis, acne and the like, has a simple use method, is directly smeared on a focus, has a pure traditional Chinese medicine formula, and has no toxic or side effect; has the characteristics of definite curative effect, quick response, high cure rate, no side effect and the like.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to examples, but it will be understood by those skilled in the art that the following examples are only for illustrating the present invention and are not to be construed as limiting the scope of the present invention, and specific techniques or conditions are not noted in the examples, according to the techniques or conditions described in the literature in the art or according to the product specification.
Example 1: a skin ointment for treating skin diseases comprises the following raw materials: 5 parts of centipede, 6 parts of cantharis, 5 parts of scorpion, 8 parts of semen chaenomelis, 8 parts of asarum, 4 parts of realgar, 4 parts of radix angelicae, 5 parts of bean root, 5 parts of honeycomb, 8 parts of fructus cnidii, 3 parts of croton, 10 parts of mugwort leaf, 5 parts of sulfur, 8 parts of dried body, 8 parts of borneol, 6 parts of ice flakes and 4 parts of pepper.
Example 2: a skin ointment for treating skin diseases comprises the following raw materials: 7 parts of centipede, 5 parts of cantharis, 8 parts of scorpion, 6 parts of semen amomi, 10 parts of asarum, 10 parts of realgar, 10 parts of radix angelicae, 8 parts of bean root, 8 parts of honeycomb, 8 parts of fructus cnidii, 6 parts of croton, 10 parts of mugwort leaf, 6 parts of sulfur, 8 parts of dried body, 5 parts of borneol, 5 parts of ice flakes and 5 parts of pepper.
Example 3: a skin ointment for treating skin diseases comprises the following raw materials: 8 parts of centipede, 8 parts of cantharis, 8 parts of scorpion, 8 parts of semen amomi, 8 parts of asarum, 8 parts of realgar, 8 parts of radix angelicae, 8 parts of bean root, 8 parts of honeycomb, 8 parts of fructus cnidii, 8 parts of croton, 8 parts of mugwort leaf, 8 parts of sulfur, 8 parts of dried body, 8 parts of borneol, 8 parts of ice flakes and 8 parts of pepper.
The preparation method of the above examples is as follows:
(1) Cleaning: cleaning the raw materials and airing;
(2) Grinding: weighing the raw materials in parts by weight, mixing, and grinding into powder;
(3) And (3) blending: mixing the above powders with vegetable oil to obtain paste.
1. Toxicity test of the inventive drug
This test primarily observes the acute toxic response of animals given the drugs of the invention orally.
The test animals in this test were mice, which were placed in the test environment for 3 days prior to testing, provided normal feed and drinking water during the test, laboratory temperature: 18-22 ℃, relative humidity: 30-50%.
The test process comprises the following steps: the skin ointment prepared by the invention is smeared on the hairless part of the skin of a mouse for 3 times within 1 day, and the poisoning appearance, the weight, the food intake and the death condition of the mouse are observed within 14 days every 4 hours.
Results: mice were normal after oral drenching, no death occurred within 14 days, and after the end of the observation period, mice were sacrificed and examined by dissection without significant abnormalities in the major viscera.
Conclusion: the skin ointment is smeared on the hairless place of the mice for 3 times every day, no death occurs after 14 days, and meanwhile, the main viscera are not obviously abnormal, so the medicine belongs to non-toxic grade.
2. Clinical laboratory cases of the inventive medicament
1. Patient data
The patients with skin diseases from 1 month in 2015 to 9 months before the doctor in 2020 are screened, and 290 cases of patients with dermatitis, skin infection, acne and the like are screened out.
2, efficacy evaluation:
the effect is shown: symptoms are relieved within 1 week, clinical symptoms and signs disappear within 1 month, and relapse is avoided over 1 year;
the method is effective: symptoms are relieved within 1 week of administration, and clinical symptoms and partial signs disappear within 1 month;
invalidation: the symptoms are slightly reduced or not reduced after the administration, and the physical signs are not obviously improved.
3. Patient treatment
For the 290 patients screened above, the medicine of the invention was applied to the lesions.
Treatment course: twice a day, 1 month is a treatment course.
The administration mode is as follows: and (5) external application.
4. Treating a condition
290 patients, 160 men and 130 women, aged 12-70 years, with an average age of 35 years; the disease course is 1 year at the longest and 15 days at the shortest, the medicine is adopted for treatment, and the results of treatment, review and follow-up visit according to the treatment effect standard are as follows: 100 cases of obvious effect, which account for 34.5 percent; 183 cases of effective, 61.3%; the total effective rate is 97.6 percent.
Table 1: statistical table of curative effect
Figure BDA0004132986350000041
The skin ointment prepared by the invention is suitable for various skin diseases, such as dermatitis, acne and the like, has a simple use method, is directly smeared on a focus, has a pure traditional Chinese medicine formula, and has no toxic or side effect; has the characteristics of definite curative effect, quick response, high cure rate, no side effect and the like.
The above description is illustrative of the preferred embodiments of the present invention and is not intended to limit the scope of the present invention, but is to be accorded the full scope of the claims.

Claims (5)

1. A skin ointment for treating skin diseases, which is characterized by comprising the following raw materials: centipede, cantharis, scorpion, semen chaenomelis, asarum, realgar, angelica dahurica, root of beancurd, honeycomb, fructus cnidii, croton, mugwort leaf, sulfur, dried body of ice, borneol, ice and pricklyash peel.
2. A skin ointment for treating skin disorders according to claim 1, comprising the following raw materials: 5 parts of centipede, 6 parts of cantharis, 5 parts of scorpion, 8 parts of semen chaenomelis, 8 parts of asarum, 4 parts of realgar, 4 parts of radix angelicae, 5 parts of bean root, 5 parts of honeycomb, 8 parts of fructus cnidii, 3 parts of croton, 10 parts of mugwort leaf, 5 parts of sulfur, 8 parts of dried body, 8 parts of borneol, 6 parts of ice flakes and 4 parts of pepper.
3. A skin ointment for treating skin disorders according to claim 1, comprising the following raw materials: 7 parts of centipede, 5 parts of cantharis, 8 parts of scorpion, 6 parts of semen amomi, 10 parts of asarum, 10 parts of realgar, 10 parts of radix angelicae, 8 parts of bean root, 8 parts of honeycomb, 8 parts of fructus cnidii, 6 parts of croton, 10 parts of mugwort leaf, 6 parts of sulfur, 8 parts of dried body, 5 parts of borneol, 5 parts of ice flakes and 5 parts of pepper.
4. A skin ointment for treating skin disorders according to claim 1, comprising the following raw materials: 8 parts of centipede, 8 parts of cantharis, 8 parts of scorpion, 8 parts of semen amomi, 8 parts of asarum, 8 parts of realgar, 8 parts of radix angelicae, 8 parts of bean root, 8 parts of honeycomb, 8 parts of fructus cnidii, 8 parts of croton, 8 parts of mugwort leaf, 8 parts of sulfur, 8 parts of dried body, 8 parts of borneol, 8 parts of ice flakes and 8 parts of pepper.
5. A skin ointment for treating skin diseases according to claim 1, wherein the preparation method comprises the steps of:
(1) Cleaning: cleaning the raw materials and airing;
(2) Grinding: weighing the raw materials in parts by weight, mixing, and grinding into powder;
(3) And (3) blending: mixing the above powders with vegetable oil to obtain paste.
CN202310265972.2A 2023-03-20 2023-03-20 A skin ointment for treating dermatoses Withdrawn CN116196356A (en)

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Application publication date: 20230602