CN116193985A - 表达重链抗体的转基因动物 - Google Patents
表达重链抗体的转基因动物 Download PDFInfo
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- CN116193985A CN116193985A CN202180060845.8A CN202180060845A CN116193985A CN 116193985 A CN116193985 A CN 116193985A CN 202180060845 A CN202180060845 A CN 202180060845A CN 116193985 A CN116193985 A CN 116193985A
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| PCT/CA2021/050951 WO2022011457A1 (en) | 2020-07-13 | 2021-07-12 | Transgenic animals expressing heavy chain antibodies |
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| US20250361309A1 (en) | 2024-05-24 | 2025-11-27 | Regeneron Pharmaceuticals, Inc. | Tumor-targeted split il12 receptor agonists |
| WO2025255452A2 (en) | 2024-06-07 | 2025-12-11 | Regeneron Pharmaceuticals, Inc. | Antigen-binding molecules that bind to aav particles and uses thereof |
| WO2025255480A1 (en) | 2024-06-07 | 2025-12-11 | Regeneron Pharmaceuticals, Inc. | Tetravalent multispecific binding molecules and methods of use thereof |
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| LT2311874T (lt) * | 2004-07-22 | 2017-11-27 | Erasmus University Medical Center Rotterdam | Rišančiosios molekulės |
| US20090307787A1 (en) * | 2006-01-25 | 2009-12-10 | Franklin Gerardus Grosveld | Generation of heavy-chain only antibodies in transgenic animals |
| SMT201900251T1 (it) * | 2009-12-10 | 2019-07-11 | Regeneron Pharma | Topi che producono anticorpi della catena pesante |
| US9706759B2 (en) * | 2011-12-20 | 2017-07-18 | Regeneron Pharmaceuticals, Inc. | Humanized light chain mice |
| CA3124228C (en) * | 2014-03-21 | 2024-05-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| WO2018144097A1 (en) * | 2016-11-04 | 2018-08-09 | Akeagen Llc | Genetically modified non-human animals and methods for producing heavy chain-only antibodies |
| EP3332637A1 (en) * | 2016-12-09 | 2018-06-13 | Universitätsklinikum Hamburg-Eppendorf | Vhh-containing heavy chain antibody and production thereof |
| WO2019241001A1 (en) * | 2018-06-13 | 2019-12-19 | Crystal Bioscience Inc. | Transgenic chicken with functionally deleted igy ch1 coding sequence |
| WO2022126113A1 (en) * | 2020-12-09 | 2022-06-16 | Trianni, Inc. | Heavy chain-only antibodies |
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| JP2023535345A (ja) | 2023-08-17 |
| EP4179095A4 (en) | 2024-08-21 |
| TW202215950A (zh) | 2022-05-01 |
| CA3171186A1 (en) | 2022-01-20 |
| WO2022011457A1 (en) | 2022-01-20 |
| EP4179095A1 (en) | 2023-05-17 |
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