CN116173098A - Heatstroke-preventing mosquito-repellent woody cooling oil and preparation method and use method thereof - Google Patents
Heatstroke-preventing mosquito-repellent woody cooling oil and preparation method and use method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a preparation method of heatstroke-preventing mosquito-repellent woody cooling oil, which comprises the following steps: concentrating and purifying the plant medicinal materials, separating cellulose by using a degumming agent, and filtering to obtain cellulose dry pulp; embedding detumescence drugs by adopting a high polymer material to obtain slow-release microspheres; mixing cellulose dry pulp and slow-release microspheres in an organic solvent, heating and stirring to enable the cellulose to be attached to the surfaces of the microspheres, and obtaining a cellulose coated microsphere solution; the invention can play a role in detumescence and removing blood stasis on damaged wounds and the periphery thereof, can provide a local overhead structure on the surfaces of the wounds, and can ensure the ventilation effect after covering by matching with the crosslinked pores of cellulose, reduce the bacterial proliferation or proliferation phenomenon, and slowly release the drug through the microsphere slow release drug to keep the blood concentration stable.
Description
Technical Field
The invention relates to the field of medicine preparation or composite material, in particular to heatstroke prevention mosquito-repellent woody cooling oil and a preparation method and a use method thereof.
Background
The essential balm has effects of dispelling pathogenic wind, relieving pain, relieving inflammation and itching, and can be used for treating wind cold, wind heat heatstroke, mosquito sting, burn, scald, and motion sickness. It is applied topically on temple, glabrous, yintang acupoint or nostril, insect bite, burn and scald, local injury, skin injury with ulcer, etc.
The mosquito bites are frequently happened in summer, especially infants and infants, the skin is tender, once the mosquito bites, a big red bag is formed, the mosquito bites are itchy and red, a plurality of ointment for treating the mosquito bites exist in life, such as calamine lotion, cooling oil, floral water, essential balm and the like, and the ointment can quickly eliminate the mosquito bites.
Insect dermatitis is also called papular urticaria, and is a common skin disease of children in summer and autumn. Many insects causing dermatitis are commonly mosquitoes, bed bugs, fleas, mites, biting midges (small black worms) and the like, and other caterpillars, such as the poisonous burrs of the mulberry caterpillars and the spiny caterpillars, can cause diseases when entering the skin. Among them, mites are the most common, but mites are very small and are everywhere in nature, and they can not only directly bite the skin to cause insect dermatitis, but also cause skin inflammation through the feces, saliva and the like. Insect dermatitis manifests itself as pimples, wheal, edematous erythema, blisters, papules, ecchymosis, etc. at the site of the bite. The middle part is visible with the sucking points scattered in distribution or groups. Can occur in various parts of the body and is accompanied by varying degrees of itching and stinging. Among them, itching of skin is the most common.
When the mosquito bites, the essential balm is directly smeared at the bitten position, on one hand, the essential balm volatilizes fast, the effect is not durable, on the other hand, the essential balm with high concentration directly stimulates the skin, the allergy and the swelling are easy to be serious, and no essential balm product which can be slowly released and can avoid the aggravation of the swelling by the assistance of physical stimulation exists.
Disclosure of Invention
The invention overcomes the defects of the prior art and provides a preparation method of heatstroke-preventing mosquito-repellent woody cooling oil.
In order to achieve the above purpose, the invention adopts the following technical scheme: a preparation method of heatstroke-preventing mosquito-repellent woody essential balm is characterized by comprising the following steps: the method comprises the following steps: s1: concentrating and purifying herba Menthae stem and leaf to obtain oleum Menthae Dementholatum and Mentha arvensis extract, and separating cellulose with degumming agent; s2: pouring dry cellulose into a cracking agent solution, stirring and filtering, adding broken cellulose into a hardening agent solution, and filtering to obtain hardened cellulose; s3: preparing cooling paste from the mint paste, and mixing the cooling paste with the hardened cellulose to obtain mixed cooling paste; s4: mixing the cooling paste to prepare microsphere preparation; and mixing with diethyl ether solution, and storing to obtain the final product.
In a preferred embodiment of the present invention, peppermint oil, camphor oil and clove oil may be mixed in the preparation process of the cooling paste in step S3.
In a preferred embodiment of the present invention, in step S4, a multiple emulsion solvent evaporation method is used to prepare the microsphere preparation.
In a preferred embodiment of the present invention, the preparation process of the microsphere preparation comprises the following steps: firstly, preparing a mixed cooling paste into a solution, adding the prepared solution into a dichloromethane solution of PLGA, stirring in an ice bath, pouring into a methylcellulose solution and an isopropanol solution, and stirring until the solvent is completely volatilized; stopping stirring, centrifuging, washing with deionized water, vacuum drying to obtain microsphere, and dissolving microsphere in solution to obtain microsphere preparation.
In a preferred embodiment of the invention, the mass ratio of the hardened cellulose to the cooling paste in the mixed cooling paste is 1:12-18.
In a preferred embodiment of the present invention, the hardener solution in step S2 is a methylcellulose solution of polyamide epichlorohydrin resin.
The invention also provides a heatstroke-preventing mosquito-repellent woody cooling oil, which is characterized in that: the cooling ointment comprises cooling ointment microspheres and diethyl ether solution for placing the cooling ointment microspheres, wherein the outer shell of the cooling ointment microspheres is coated with a high polymer material, cooling ointment medicines and mixed hardened cellulose are arranged in the cooling ointment microspheres, and the cooling ointment microspheres are dispersed and suspended in a solution.
In a preferred embodiment of the present invention, the mass-to-volume ratio of the cooling paste microspheres in the solution is 1:2-5.
The invention also provides a using method of the heatstroke prevention mosquito-repellent woody cooling oil, which is characterized in that the cooling oil is smeared at a mosquito bite position, the liquid-absorbent fabric is covered and pressed until pain and itching disappear or weaken, the liquid-absorbent fabric is soaked with sterile normal saline, and the moisture-absorbent fabric is peeled off after drying and solidification, so that the residual hardened cellulose is removed.
The invention solves the defects existing in the background technology, and has the following beneficial effects:
(1) The microspheres prepared by coating the hard cellulose and the cooling paste with the polymer material not only can play a role in relieving itching at the biting position by using the cooling property, but also can play a role in relieving itching by physical stimulation through the hard cellulose, and the hard cellulose can also be used for guiding tissue fluid, so that the biting position is restored quickly.
(2) According to the invention, the mint stems and leaves are used for extracting cellulose, so that the hard cellulose not only has the effect of relieving itching by physical stimulation, but also can provide a cooling and itching relieving effect, and the cooling and itching relieving effect can be further deeply maintained based on the contact of the hard cellulose and skin, and the hard cellulose is matched with the cooling oil medicine slowly released by the microspheres, so that the long-acting stable itching relieving effect is provided.
(3) The polymer material microsphere can slowly release medicines, is broken after gradual dehydration, plays a role in covering a target area, and avoids invasion of external bacteria.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required to be used in the embodiments or the description of the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments described in the present invention, and other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art;
FIG. 1 is a flow chart of a preparation method of a preferred embodiment of the present invention.
Detailed Description
Reference to "an embodiment," "one embodiment," or "other embodiments" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least some embodiments, but not necessarily all embodiments, in connection with the accompanying drawings in which embodiments of the invention are described clearly and fully below. If the specification states that a substance "may", "perhaps" or "can" be included, that substance or characteristic need not be included. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The preparation method of the heatstroke-preventing mosquito-repellent woody cooling oil shown in figure 1 comprises the following steps: s1: concentrating and purifying herba Menthae stem and leaf to obtain oleum Menthae Dementholatum and Mentha arvensis extract, and separating cellulose with degumming agent; it should be noted that, the plant degumming method of the present invention can also adopt the following methods:
degumming by a water method: the hydrophilicity of colloid such as phospholipid is utilized, hot water is added into oil under stirring, so that the phospholipid absorbs water to expand and coagulate, the expanded oil can absorb other colloid in the oil, the solubility of colloid in the oil is reduced, and the colloid is separated from the oil through natural sedimentation.
The acid method is to heat the crude oil to 80-90 ℃, then to fully mix with 0.05-0.20% phosphoric acid or citric acid solution, to stay for 5-20 min, then to add 1-5% water, to mix vigorously, and to re-separate. Furthermore, the extended dry degumming process is characterized in that the oil treated by a simple acid method is cooled to 30 ℃ and then directly enters a decoloring section, and colloid in the oil and the pigment substances are removed by utilizing the adsorption effect of an adsorbent and are suitable for low-content phosphatide (less than 200 mg/kg).
Alkali degumming, in which peptized impurities are hydrolyzed under the alkali condition, and then neutralization, condensation, adsorption and the like are carried out to remove the peptized impurities.
S2: pouring dry cellulose into a cracking agent solution, stirring and filtering, adding broken cellulose into a methyl cellulose solution of polyamide epichlorohydrin resin, and filtering to obtain hardened cellulose;
s3: the mentha extract is used for preparing cooling paste, and materials such as camphor, eucalyptus oil, clove oil, cinnamon oil, camphor oil and the like can be added, and hardened cellulose is added to obtain mixed cooling paste, wherein the mass ratio of the hardened cellulose to the cooling paste is 1:12-18;
s4: the microsphere preparation is prepared by mixing the cooling paste, preferably by adopting a multiple emulsion solvent volatilization method: firstly, preparing a mixed cooling paste into a solution, adding the prepared solution into a dichloromethane solution of PLGA, stirring in an ice bath, pouring into a methylcellulose solution and an isopropanol solution, and stirring until the solvent is completely volatilized; stopping stirring, performing centrifugal separation, washing with deionized water, and vacuum drying to obtain microspheres, and dissolving the microspheres in a solution to obtain a microsphere preparation; mixing the microsphere preparation with diethyl ether solution, and preserving to obtain the objective woody essential balm.
The invention also provides a heatstroke preventing mosquito repellent woody cooling oil, which comprises cooling cream microspheres and diethyl ether solution for placing the cooling cream microspheres, wherein the outer shell of the cooling cream microspheres is coated with a high polymer material, cooling cream medicines and mixed hardened cellulose are arranged in the cooling cream microspheres, the cooling cream microspheres are dispersed and suspended in the solution, and the mass volume ratio of the cooling cream microspheres in the solution is 1:2-5.
The woody cooling oil adopts the mint stems and leaves to extract cellulose, so that the hard cellulose not only can play a role in relieving itching by physical stimulation, but also can provide cooling and itching relieving effects, and the cooling and itching relieving effects can be further deeply maintained based on the contact of the hard cellulose and the skin, and the hard cellulose is matched with cooling oil medicine slowly released by the microspheres, so that a long-acting stable itching relieving effect is provided.
The invention also provides a using method of the heatstroke-preventing mosquito-repellent woody cooling oil, which comprises the following steps: the essential balm is smeared on the mosquito bite position, the liquid-absorbing fabric is covered and then pressed until pain and itching disappear or weaken, the liquid-absorbing fabric is soaked with sterile normal saline, and the moisture-absorbing fabric is peeled off after drying and solidification, so that the residual hardened cellulose is removed.
In the use process, the polymer material microspheres can slowly release medicines, are broken after gradual dehydration, play a role in covering a target area and prevent external bacteria from invading and infecting.
In conclusion, the microspheres prepared by coating the hard cellulose and the cooling paste with the polymer material not only can play a role in relieving itching at the biting position by using the cooling property, but also can play a role in relieving itching by physical stimulation through the hard cellulose, and the hard cellulose can also be used for guiding tissue fluid, so that the biting position recovery is quickened.
Example 1
Extracting herba Menthae stem and leaf by distillation, heating herba Menthae in a distillation container to volatilize oleum Menthae Dementholatum, collecting, extracting with water and oil to obtain oleum Menthae Dementholatum and Mentholum, and separating cellulose with degumming agent;
pouring dry cellulose into a cracking agent solution, stirring and filtering, adding broken cellulose into a methyl cellulose solution of polyamide epichlorohydrin resin, and filtering to obtain hardened cellulose;
the mentha extract is used for preparing a cooling paste, and materials such as camphor, eucalyptus oil, clove oil, cinnamon oil, camphor oil and the like can be added, and hardened cellulose is added to obtain a mixed cooling paste, wherein the mass ratio of the hardened cellulose to the cooling paste is 1:12;
the microsphere preparation is prepared by adopting a multiple emulsion solvent volatilization method: firstly, preparing a mixed cooling paste into a solution, adding the prepared solution into a dichloromethane solution of PLGA, stirring in an ice bath, pouring into a methylcellulose solution and an isopropanol solution, and stirring until the solvent is completely volatilized; stopping stirring, performing centrifugal separation, washing with deionized water, and vacuum drying to obtain microspheres, and dissolving the microspheres in a solution to obtain a microsphere preparation; mixing the microsphere preparation with diethyl ether solution, and preserving to obtain the objective woody essential balm.
Comparative example one
This comparative example examines the cellulose filling rate inside the microspheres by changing the mass ratio of the hardened cellulose.
Extracting herba Menthae stem and leaf by distillation, heating herba Menthae in a distillation container to volatilize oleum Menthae Dementholatum, collecting, extracting with water and oil to obtain oleum Menthae Dementholatum and Mentholum, and separating cellulose with degumming agent;
pouring dry cellulose into a cracking agent solution, stirring and filtering, adding broken cellulose into a methyl cellulose solution of polyamide epichlorohydrin resin, and filtering to obtain hardened cellulose;
the mentha extract is used for preparing a cooling paste, and materials such as camphor, eucalyptus oil, clove oil, cinnamon oil, camphor oil and the like can be added, and hardened cellulose is added to obtain a mixed cooling paste, wherein the mass ratio of the hardened cellulose to the cooling paste is 1:18;
the microsphere preparation is prepared by adopting a multiple emulsion solvent volatilization method: firstly, preparing a mixed cooling paste into a solution, adding the prepared solution into a dichloromethane solution of PLGA, stirring in an ice bath, pouring into a methylcellulose solution and an isopropanol solution, and stirring until the solvent is completely volatilized; stopping stirring, performing centrifugal separation, washing with deionized water, and vacuum drying to obtain microspheres, and dissolving the microspheres in a solution to obtain a microsphere preparation; mixing the microsphere preparation with diethyl ether solution, and preserving to obtain the objective woody essential balm.
Comparative example two
This comparative example replaces gelatin with PLGA to examine the particle size of the microspheres and their distribution.
Extracting herba Menthae stem and leaf by distillation, heating herba Menthae in a distillation container to volatilize oleum Menthae Dementholatum, collecting, extracting with water and oil to obtain oleum Menthae Dementholatum and Mentholum, and separating cellulose with degumming agent;
pouring dry cellulose into a cracking agent solution, stirring and filtering, adding broken cellulose into a methyl cellulose solution of polyamide epichlorohydrin resin, and filtering to obtain hardened cellulose;
the mentha extract is used for preparing a cooling paste, and materials such as camphor, eucalyptus oil, clove oil, cinnamon oil, camphor oil and the like can be added, and hardened cellulose is added to obtain a mixed cooling paste, wherein the mass ratio of the hardened cellulose to the cooling paste is 1:12;
the microsphere preparation is prepared by adopting a multiple emulsion solvent volatilization method: firstly, preparing a mixed cooling paste into a solution, adding the prepared solution into a gelatin water solution, stirring in an ice bath, pouring into a methyl cellulose solution and an isopropanol solution, and stirring until the solvent is completely volatilized; stopping stirring, performing centrifugal separation, washing with deionized water, and vacuum drying to obtain microspheres, and dissolving the microspheres in a solution to obtain a microsphere preparation; mixing the microsphere preparation with diethyl ether solution, and preserving to obtain the objective woody essential balm.
Comparative example three
In this comparative example, a proper amount of glycerin was added to gelatin, and the toughness of the microsphere shell was examined in sequence.
This comparative example replaces gelatin with PLGA to examine the particle size of the microspheres and their distribution.
Extracting herba Menthae stem and leaf by distillation, heating herba Menthae in a distillation container to volatilize oleum Menthae Dementholatum, collecting, extracting with water and oil to obtain oleum Menthae Dementholatum and Mentholum, and separating cellulose with degumming agent;
pouring dry cellulose into a cracking agent solution, stirring and filtering, adding broken cellulose into a methyl cellulose solution of polyamide epichlorohydrin resin, and filtering to obtain hardened cellulose;
the mentha extract is used for preparing a cooling paste, and materials such as camphor, eucalyptus oil, clove oil, cinnamon oil, camphor oil and the like can be added, and hardened cellulose is added to obtain a mixed cooling paste, wherein the mass ratio of the hardened cellulose to the cooling paste is 1:12;
the microsphere preparation is prepared by adopting a multiple emulsion solvent volatilization method: firstly, preparing a mixed cooling paste into a solution, adding the prepared solution into a gelatin water solution, stirring in an ice bath, pouring into a methyl cellulose solution and an isopropanol solution, and stirring until the solvent is completely volatilized; stopping stirring, performing centrifugal separation, washing with deionized water, and vacuum drying to obtain microspheres, and dissolving the microspheres in a solution to obtain a microsphere preparation; mixing the microsphere preparation with diethyl ether solution, and preserving to obtain the objective woody essential balm.
Characterizing the microsphere, and observing the surface morphology of the microsphere by using a scanning electron microscope; the particle size and distribution of the microspheres were measured using a laser particle sizer.
Example 1, comparative examples 1-3 all had a small burst effect at the early stage, and were the result of rapid drug release from the microsphere surface. The release rate of the microsphere prepared in the first 2 weeks is relatively faster in the embodiment 1, the release rate is gradually slow to be similar to that of the comparative example after 2 weeks, the accumulated release rate after one month is more than 80 percent, which is higher than 72 percent of that of the comparative example 1, 75 percent of that of the comparative example 2 and 62 percent of that of the comparative example 3, and the microsphere prepared in the embodiment one can realize the requirement of long-term slow release of components and has good slow release effect.
The above-described preferred embodiments according to the present invention are intended to suggest that, from the above description, various changes and modifications can be made by the person skilled in the art without departing from the scope of the technical idea of the present invention. The technical scope of the present invention is not limited to the description, but must be determined according to the scope of claims.
Claims (10)
1. A preparation method of heatstroke-preventing mosquito-repellent woody essential balm is characterized by comprising the following steps: the method comprises the following steps:
s1: concentrating and purifying herba Menthae stem and leaf to obtain oleum Menthae Dementholatum and Mentha arvensis extract, and separating cellulose with degumming agent;
s2: pouring dry cellulose into a cracking agent solution, stirring and filtering, adding broken cellulose into a hardening agent solution, and filtering to obtain hardened cellulose;
s3: preparing cooling paste from the mint paste, and mixing the cooling paste with the hardened cellulose to obtain mixed cooling paste;
s4: mixing the cooling paste to prepare microsphere preparation; and mixing with diethyl ether solution, and storing to obtain the final product.
2. The method for preparing the heatstroke-preventing mosquito-repellent woody essential balm according to claim 1, which is characterized in that: in the preparation process of the cooling paste in the step S3, peppermint oil, camphor oil and clove oil can be mixed.
3. The method for preparing the heatstroke-preventing mosquito-repellent woody essential balm according to claim 1, which is characterized in that: in the step S4, a multiple emulsion solvent volatilization method is adopted to prepare the microsphere preparation.
4. The method for preparing the heatstroke preventing mosquito repellent woody cooling oil according to claim 3, which is characterized in that: the preparation process of the microsphere preparation comprises the following steps:
firstly, preparing a mixed cooling paste into a solution, adding the prepared solution into a dichloromethane solution of PLGA, stirring in an ice bath, pouring into a methylcellulose solution and an isopropanol solution, and stirring until the solvent is completely volatilized; stopping stirring, centrifuging, washing with deionized water, vacuum drying to obtain microsphere, and dissolving microsphere in solution to obtain microsphere preparation.
5. The method for preparing the heatstroke-preventing mosquito-repellent woody essential balm according to claim 1, which is characterized in that: in the step S3, the mass ratio of the hardened cellulose to the cooling paste in the mixed cooling paste is 1:12-18.
6. The method for preparing the heatstroke-preventing mosquito-repellent woody essential balm according to claim 1, which is characterized in that: the hardener solution in the step S2 is methyl cellulose solution of polyamide epichlorohydrin resin.
7. The heatstroke-preventing mosquito-repellent woody cooling oil produced by the preparation method of claim 1, which is characterized in that: the cooling ointment comprises cooling ointment microspheres and diethyl ether solution for placing the cooling ointment microspheres, wherein the outer shell of the cooling ointment microspheres is coated with a high polymer material, cooling ointment medicines and mixed hardened cellulose are arranged in the cooling ointment microspheres, and the cooling ointment microspheres are dispersed and suspended in a solution.
8. The heatstroke preventing mosquito repellent woody essential balm according to claim 7, wherein: the mass volume ratio of the cooling ointment microspheres in the solution is 1:2-5.
9. The method of claim 7, wherein the essential balm is applied to the mosquito bite site and covered with a liquid absorbing fabric and then pressed.
10. The method for using the heatstroke preventing mosquito repellent woody cooling oil according to claim 9, which is characterized in that: covering until pain and itching disappear or weaken, soaking the liquid-absorbing fabric with sterile physiological saline, drying and solidifying, and then stripping the moisture-absorbing fabric, thereby removing residual hardened cellulose.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424105A (en) * | 2002-12-31 | 2003-06-18 | 北京东方凯恩医药科技有限公司 | Medicinal spray |
| CN101653422A (en) * | 2008-08-20 | 2010-02-24 | 山东绿叶制药有限公司 | Risperidone slow-release microsphere, preparation method and application thereof |
| CN105616211A (en) * | 2014-10-28 | 2016-06-01 | 赖婷婷 | Floral water |
| CN106474070A (en) * | 2015-08-26 | 2017-03-08 | 四川科伦药物研究院有限公司 | A kind of overcome lag phase, the microsphere of constant release hydrophobic drug and preparation method |
| CN109511688A (en) * | 2018-11-22 | 2019-03-26 | 河南农业大学 | A kind of woody Anti-mosquito disinsectization compound essential oil and preparation method thereof |
| CN111663193A (en) * | 2020-05-26 | 2020-09-15 | 潍坊欣龙生物材料有限公司 | Method for improving strength of cellulose fiber and cellulose fiber prepared by method |
-
2022
- 2022-12-31 CN CN202211740657.2A patent/CN116173098A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1424105A (en) * | 2002-12-31 | 2003-06-18 | 北京东方凯恩医药科技有限公司 | Medicinal spray |
| CN101653422A (en) * | 2008-08-20 | 2010-02-24 | 山东绿叶制药有限公司 | Risperidone slow-release microsphere, preparation method and application thereof |
| CN105616211A (en) * | 2014-10-28 | 2016-06-01 | 赖婷婷 | Floral water |
| CN106474070A (en) * | 2015-08-26 | 2017-03-08 | 四川科伦药物研究院有限公司 | A kind of overcome lag phase, the microsphere of constant release hydrophobic drug and preparation method |
| CN109511688A (en) * | 2018-11-22 | 2019-03-26 | 河南农业大学 | A kind of woody Anti-mosquito disinsectization compound essential oil and preparation method thereof |
| CN111663193A (en) * | 2020-05-26 | 2020-09-15 | 潍坊欣龙生物材料有限公司 | Method for improving strength of cellulose fiber and cellulose fiber prepared by method |
Non-Patent Citations (2)
| Title |
|---|
| 张素风;等: "聚酰胺环氧氯丙烷增强聚丙烯腈纤维纸的研究", 中国造纸, vol. 37, no. 04, pages 174 - 29 * |
| 谭红香;等: "以PHBV-PLGA为载体的硫酸庆大霉素缓释微球", 功能高分子学报, vol. 22, no. 01, pages 12 - 16 * |
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