CN105561000A - Quick hemostasis patch for nursing in emergency department - Google Patents
Quick hemostasis patch for nursing in emergency department Download PDFInfo
- Publication number
- CN105561000A CN105561000A CN201610060070.5A CN201610060070A CN105561000A CN 105561000 A CN105561000 A CN 105561000A CN 201610060070 A CN201610060070 A CN 201610060070A CN 105561000 A CN105561000 A CN 105561000A
- Authority
- CN
- China
- Prior art keywords
- parts
- extract
- powder
- emergency department
- rhizoma imperatae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a quick hemostasis patch for nursing in the emergency department. The quick hemostasis patch consists of a backing layer, a medicine-carrying adhesive layer and an anti-sticking layer, wherein the medicine-carrying adhesive layer is prepared from, by weight, 0.01-0.5 part of vitamin K1, 0.01-0.5 part of p-carboxybenzylamine, 0.01-0.5 part of adrenobazonum, 10-25 parts of carboxymethyl chitosan, 10-20 parts of a honeysuckle extract, 10-20 parts of a rhizoma imperatae extract, 10-20 parts of a cattail pollen extract, 10-30 parts of hydroxypropyl methyl cellulose, 10-20 parts of a pressure sensitive adhesive, 5-15 parts of glycerin and 20-50 parts of deionized water. The made patch has a bacteriostatic effect, can also achieve the effects of quickly stopping bleeding and promoting wound healing and can be widely used in clinical treatment.
Description
Technical field
The present invention relates to a kind of patch, belong to field of pharmaceutical preparations, in particular to a kind of emergency department nursing quick-acting haemostatic powder patch.
Background technology
Patch refers to the auxiliary genus material outside for article major ingredient, and a critical function of modern wound patch, is the critical function that replacing damaged skin, and acts on to wound healing and skin lesion healing always.It can be resisted mechanical factor (as foul, collision, inflammation etc.), resist pollution and chemical stimulation; Prevent two degree of infection; Prevent dry and body fluid loss (electrolyte loss); Prevent heat from losing; Initiatively affect wound healing process by debridement, create the microenvironment promoting wound healing.But existing patch in use, haemostatic effect is poor, and slow down speed of wound healing, easily causes superinfection simultaneously.
Pollen Typhae, Chinese medicine name.For the dry pollen of Typhaceae plant Typha angustifolia Herba Typhae TyphaangustifoliaL., typha orientalis TyphaorientalisPresl or congener.There is hemostasis, blood stasis dispelling, treating stranguria effect." herbal classic ": trusted subordinate's frigiopyrexia of bladder, diuresis, hemostasis, repercussive blood.Clothes of a specified duration are made light of one's life by commiting suicide physical strength profiting, and prolong life angle.
Rhizoma Imperatae, Chinese medicine name.For the dry rhizome of grass Herba Imperatae ImperatacylindricaBeauv.var.major (Nees) C.E.Hubb..There is cooling blood for hemostasis, clearing away heat and promoting diuresis effect." herbal classic ": impairment caused by overstrain weakness with emaciation, invigorating the spleen and replenishing QI, except blood stasis, blood close cold and heat, diuresis.
Flos Lonicerae has another name called Radix Ophiopogonis (formal name used at school: Lonicerajaponica)." Flos Lonicerae " one comes from Compendium of Material Medica, owing to opening as white at the beginning of Flos Lonicerae, after transfer yellow to, hence obtain one's name Flos Lonicerae.Medical material Flos Lonicerae is Caprifoliaceae woodbine Radix Ophiopogonis and congener dry flower or is with the flower just opened.Flos Lonicerae is described as the good medicine of heat-clearing and toxic substances removing from ancient times.Its property sweet cold fragrance, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.Flos Lonicerae can dispelling wind-heat, also kind removing summer-heat blood poison, for various febrile disease, as fever of the body, dermexanthesis, sends out the diseases such as speckle, pyretic toxicity carbuncle sore, laryngopharynx swelling and pain, equal Be very effective.Modern study proves, Flos Lonicerae contains the pharmacological component such as chlorogenic acid, luteolin glycosides, have stronger restraint to the various pathogens such as Hemolytic streptococcus, staphylococcus aureus and upper respiratory tract infection Causative virus etc., in addition also can enhancing immunity, antiearly pregnancy, hepatoprotective, antitumor, antiinflammatory, antipyretic, hemostasis (blood coagulation), suppress intestinal absorption cholesterol etc.
Summary of the invention
The invention provides a kind of emergency department nursing quick-acting haemostatic powder patch, adopt the multiple medicine with styptic activity compatible, rapidly, lasting medicine, and can promote wound healing, can be widely used in clinical treatment in hemostasis.
Concrete, quick-acting haemostatic powder patch is used in the nursing of a kind of emergency department of the present invention, be made up of backing layer, medicine carrying adhesive layer and adherent layer, medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.01-0.5 part, para-amino-methyl-benzoic acid 0.01-0.5 part, carbazochrome salicylate 0.01-0.5 part, carboxymethyl chitosan 10-25 part, Flos Lonicerae extract 10-20 part, Rhizoma Imperatae extract 10-20 part, Pollen Tyjphae extract 10-20 part, hydroxypropyl emthylcellulose 10-30 part, pressure sensitive adhesive 10-20 part, glycerol 5-15 part, deionized water 20-50 part.
In the embodiment that the present invention one is concrete, in described a kind of emergency department nursing quick-acting haemostatic powder patch, the weight proportion of vitamin K1, para-amino-methyl-benzoic acid, carbazochrome salicylate is 2:1:2.
In the embodiment that the present invention one is concrete, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.5 part, para-amino-methyl-benzoic acid 0.25 part, carbazochrome salicylate 0.5 part, carboxymethyl chitosan 20 parts, Flos Lonicerae extract 15 parts, Rhizoma Imperatae extract 15 parts, Pollen Tyjphae extract 15 parts, hydroxypropyl emthylcellulose 20 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts.
In the embodiment that the present invention one is concrete, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.2 part, para-amino-methyl-benzoic acid 0.1 part, carbazochrome salicylate 0.2 part, carboxymethyl chitosan 10 parts, Flos Lonicerae extract 12 parts, Rhizoma Imperatae extract 12 parts, Pollen Tyjphae extract 12 parts, hydroxypropyl emthylcellulose 25 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts.
In the embodiment that the present invention one is concrete, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.3 part, para-amino-methyl-benzoic acid 0.15 part, carbazochrome salicylate 0.3 part, carboxymethyl chitosan 25 parts, Flos Lonicerae extract 20 parts, Rhizoma Imperatae extract 20 parts, Pollen Tyjphae extract 20 parts, hydroxypropyl emthylcellulose 30 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts.
In the embodiment that the present invention one is concrete, the weight proportion of Flos Lonicerae extract, Rhizoma Imperatae extract, Pollen Tyjphae extract is 1:1:1.
In the embodiment that the present invention one is concrete, the preparation method of described Flos Lonicerae extract comprises the steps: deionized water Chinese medicine honeysuckle being added 5-10 times amount, reflux, extract, 3 times under 50-70 DEG C of condition, each 1-3 hour, filtering residue is for subsequent use, merging filtrate, crushed after being dried, get dry extract powder 1; Add the alcoholic solution of 5-10 times amount 50-70% in filtering residue, be transferred in Microwave Extraction Apparatus, under 500-800W condition, extraction 10-30min, filter, obtain extracting solution, crushed after being dried, get dry extract powder 2, merges dried cream powder 1 and dried cream powder 2, to obtain final product.
In the embodiment that the present invention one is concrete, the preparation method of described Rhizoma Imperatae extract comprises: alcoholic solution Rhizoma Imperatae medicinal material coarse powder being added the 50-70% of 5-10 times amount, reflux, extract, 3 times under 50-70 DEG C of condition, each 1-3 hour, filtering residue is for subsequent use, merging filtrate, crushed after being dried, get dry extract powder 1; Add in filtering residue in 5-10 times amount deionized water, be transferred in Microwave Extraction Apparatus, under 500-800W condition, extraction 10-30min, filter, obtain extracting solution, crushed after being dried, get dry extract powder 2, merges dried cream powder 1 and dried cream powder 2, to obtain final product.
In the embodiment that the present invention one is concrete, the preparation method of described Pollen Tyjphae extract comprises: alcoholic solution Pollen Typhae being added the 60-80% of 5-10 times amount, reflux, extract, 3 times under 50-70 DEG C of condition, each 1-3 hour, merging filtrate, dry, pulverizing gets dry extract powder, to obtain final product
In the present invention, Flos Lonicerae extract, Rhizoma Imperatae extract and Pollen Tyjphae extract all can adopt commercially available prod.
The preparation method of patch of the present invention can adopt the preparation method of this area routine, such as the vitamin K1 of recipe quantity, para-amino-methyl-benzoic acid, carbazochrome salicylate, carboxymethyl chitosan, Flos Lonicerae extract, Rhizoma Imperatae extract, Pollen Tyjphae extract, hydroxypropyl emthylcellulose, pressure sensitive adhesive, glycerol and deionized water are mixed, adopt homogenizer homogenous disperse 30-60min, be applied on back lining materials, heating, drying, then cover upper adherent layer, size cutting on demand, sterilization, packaging.
Detailed description of the invention
Embodiment 1:
Quick-acting haemostatic powder patch is used in the nursing of a kind of emergency department, and be made up of backing layer, medicine carrying adhesive layer and adherent layer, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.5 part, para-amino-methyl-benzoic acid 0.25 part, carbazochrome salicylate 0.5 part, carboxymethyl chitosan 20 parts, Flos Lonicerae extract 15 parts, Rhizoma Imperatae extract 15 parts, Pollen Tyjphae extract 15 parts, hydroxypropyl emthylcellulose 20 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts;
The vitamin K1 of recipe quantity, para-amino-methyl-benzoic acid, carbazochrome salicylate, carboxymethyl chitosan, Flos Lonicerae extract, Rhizoma Imperatae extract, Pollen Tyjphae extract, hydroxypropyl emthylcellulose, pressure sensitive adhesive, glycerol and deionized water are mixed, adopt homogenizer homogenous disperse 40min, be applied on back lining materials, heating, drying, cover upper adherent layer again, size cutting on demand, sterilization, packaging; Wherein said Flos Lonicerae extract, Rhizoma Imperatae extract, Pollen Tyjphae extract adopt commercially available prod.
Embodiment 2:
Quick-acting haemostatic powder patch is used in the nursing of a kind of emergency department, and be made up of backing layer, medicine carrying adhesive layer and adherent layer, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.2 part, para-amino-methyl-benzoic acid 0.1 part, carbazochrome salicylate 0.2 part, carboxymethyl chitosan 10 parts, Flos Lonicerae extract 12 parts, Rhizoma Imperatae extract 12 parts, Pollen Tyjphae extract 12 parts, hydroxypropyl emthylcellulose 25 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts;
The preparation method of wherein said Flos Lonicerae extract comprises the steps: deionized water Chinese medicine honeysuckle being added 10 times amount, reflux, extract, 3 times under 60 DEG C of conditions, and each 2 hours, filtering residue was for subsequent use, merging filtrate, crushed after being dried, and get dry extract powder 1; Add the alcoholic solution of 10 times amount 60% in filtering residue, be transferred in Microwave Extraction Apparatus, under 600W condition, extraction 20min, filter, obtain extracting solution, crushed after being dried, get dry extract powder 2, merges dried cream powder 1 and dried cream powder 2, to obtain final product;
The preparation method of wherein said Rhizoma Imperatae extract comprises: alcoholic solution Rhizoma Imperatae medicinal material coarse powder being added 70% of 10 times amount, reflux, extract, 3 times under 60 DEG C of conditions, and each 2 hours, filtering residue was for subsequent use, merging filtrate, crushed after being dried, and get dry extract powder 1; Add in filtering residue in 6 times amount deionized waters, be transferred in Microwave Extraction Apparatus, under 600W condition, extraction 20min, filter, obtain extracting solution, crushed after being dried, get dry extract powder 2, merges dried cream powder 1 and dried cream powder 2, to obtain final product;
The preparation method of wherein said Pollen Tyjphae extract comprises: alcoholic solution Pollen Typhae being added 70% of 8 times amount, reflux, extract, 3 times under 60 DEG C of conditions, and each 2 hours, merging filtrate, dry, pulverize the powder that gets dry extract, and to obtain final product;
The vitamin K1 of recipe quantity, para-amino-methyl-benzoic acid, carbazochrome salicylate, carboxymethyl chitosan, Flos Lonicerae extract, Rhizoma Imperatae extract, Pollen Tyjphae extract, hydroxypropyl emthylcellulose, pressure sensitive adhesive, glycerol and deionized water are mixed, adopt homogenizer homogenous disperse 60min, be applied on back lining materials, heating, drying, cover upper adherent layer again, size cutting on demand, sterilization, packaging.
Embodiment 3:
Quick-acting haemostatic powder patch is used in the nursing of a kind of emergency department, and be made up of backing layer, medicine carrying adhesive layer and adherent layer, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.3 part, para-amino-methyl-benzoic acid 0.15 part, carbazochrome salicylate 0.3 part, carboxymethyl chitosan 25 parts, Flos Lonicerae extract 20 parts, Rhizoma Imperatae extract 20 parts, Pollen Tyjphae extract 20 parts, hydroxypropyl emthylcellulose 30 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts; Wherein said Flos Lonicerae extract, Rhizoma Imperatae extract, Pollen Tyjphae extract adopt commercially available prod;
The vitamin K1 of recipe quantity, para-amino-methyl-benzoic acid, carbazochrome salicylate, carboxymethyl chitosan, Flos Lonicerae extract, Rhizoma Imperatae extract, Pollen Tyjphae extract, hydroxypropyl emthylcellulose, pressure sensitive adhesive, glycerol and deionized water are mixed, adopt homogenizer homogenous disperse 30min, be applied on back lining materials, heating, drying, cover upper adherent layer again, size cutting on demand, sterilization, packaging.
Comparative example 1:
Quick-acting haemostatic powder patch is used in the nursing of a kind of emergency department, be made up of backing layer, medicine carrying adhesive layer and adherent layer, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.5 part, para-amino-methyl-benzoic acid 0.25 part, carbazochrome salicylate 0.5 part, carboxymethyl chitosan 20 parts, Flos Lonicerae extract 15 parts, Pollen Tyjphae extract 30 parts, hydroxypropyl emthylcellulose 20 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts;
Preparation method is with embodiment 1.
Comparative example 2:
Quick-acting haemostatic powder patch is used in the nursing of a kind of emergency department, be made up of backing layer, medicine carrying adhesive layer and adherent layer, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.5 part, para-amino-methyl-benzoic acid 0.25 part, carbazochrome salicylate 0.5 part, carboxymethyl chitosan 20 parts, Flos Lonicerae extract 15 parts, Rhizoma Imperatae extract 30 parts, hydroxypropyl emthylcellulose 20 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts;
Preparation method is with embodiment 1.
Comparative example 3:
Quick-acting haemostatic powder patch is used in the nursing of a kind of emergency department, be made up of backing layer, medicine carrying adhesive layer and adherent layer, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.5 part, carbazochrome salicylate 0.75 part, carboxymethyl chitosan 20 parts, Flos Lonicerae extract 15 parts, Rhizoma Imperatae extract 15 parts, Pollen Tyjphae extract 15 parts, hydroxypropyl emthylcellulose 20 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts;
Preparation method is with embodiment 1.
Comparative example 4:
Quick-acting haemostatic powder patch is used in the nursing of a kind of emergency department, be made up of backing layer, medicine carrying adhesive layer and adherent layer, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.75 part, para-amino-methyl-benzoic acid 0.25 part, carboxymethyl chitosan 20 parts, Flos Lonicerae extract 15 parts, Rhizoma Imperatae extract 15 parts, Pollen Tyjphae extract 15 parts, hydroxypropyl emthylcellulose 20 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts;
Preparation method is with embodiment 1.
Embodiment 4: the haemostatic effect of mice docking experiment
Employing Kun Ming mice is laboratory animal, 80, body weight 30-35g.Be divided into 8 groups: blank group, positive controls, embodiment 1 group, embodiment 2 groups, comparative example 1 group, comparative example 2 groups, comparative example 3 groups, comparative example 4 groups, often organize 10, mice is fixed in mouse fixing device, with alcohol swab sterilization mousetail end, cut with sharp shears and cut off at Mouse Tail-tip 1cm place, have blood flow to go out.Each experimental group carries out lower column processing: (1) blank group otch exposes; (2) positive controls closely sticks the Wound plaster of yannan Baiyao of 1cm × 1cm in docking place; (3) all the other are respectively rented and closely stick hemostatic plaster prepared by the above embodiment 1-2 of 1cm × 1cm and comparative example 1-4 in docking place.Observe mice docking place bleeding in experiment, every 10s filter paper sucks wound oozing of blood, until stopped bleeding, and record bleeding stopping period.
The haemostatic effect of table 1 hemostatic plaster of the present invention
Data in table 1 show, hemostatic plaster of the present invention can stop blooding rapidly, and in the present invention, each component is worked in coordination with mutually, jointly plays anastalsis, Rhizoma Imperatae extract, Pollen Tyjphae extract, para-amino-methyl-benzoic acid or the carbazochrome salicylate omitted wherein can cause haemostatic effect to decline; And the data of table 1 also show, adopt ad hoc approach to extract Flos Lonicerae, Rhizoma Imperatae and Pollen Typhae effect and be better than employing commercial goods.
Embodiment 5 wound healing is tested
Laboratory animal adopt male Wistar rat 60, about body weight 200g, is divided into 7 groups: blank group, positive controls, embodiment 2 groups, comparative example 1 group, comparative example 2 groups, comparative example 3 groups, comparative example 4 groups, often organize 10.Rat back 8% sodium sulfide loss of thick fluid hair, anaesthetizes after 24h, then scalds with 80 DEG C of water-baths and within 15 seconds, causes the dark II degree skin scald of rat back 10%, give 5mL normal saline after wound through abdominal cavity.Blank group is by hospital gauze flap coverage, and positive controls adopts YUNNAN BAIYAO flap coverage, and all the other respectively organize the hemostatic plaster flap coverage respectively by embodiment 2 and comparative example 1-4 gained.Respectively determine after wound that time point surveys Wound healing rate: first traced on onionskin by wound surface, then as template, be cut into onesize by homogeneous hard paper, then weigh in the balance heavily, indirectly represent wound surface size with hard paper weight.Be calculated as follows Wound healing rate: Wound healing rate (%)=(original wound surface area-do not heal wound surface area)/original wound surface area.
Table 2 hemostatic plaster of the present invention is on the impact of Wound healing rate
The data of table 2 show, patch of the present invention can promote wound healing.
Claims (9)
1. a quick-acting haemostatic powder patch is used in emergency department's nursing, and be made up of backing layer, medicine carrying adhesive layer and adherent layer, medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.01-0.5 part, para-amino-methyl-benzoic acid 0.01-0.5 part, carbazochrome salicylate 0.01-0.5 part, carboxymethyl chitosan 10-25 part, Flos Lonicerae extract 10-20 part, Rhizoma Imperatae extract 10-20 part, Pollen Tyjphae extract 10-20 part, hydroxypropyl emthylcellulose 10-30 part, pressure sensitive adhesive 10-20 part, glycerol 5-15 part, deionized water 20-50 part.
2. a kind of emergency department according to claim 1 nursing quick-acting haemostatic powder patch, the weight proportion of vitamin K1, para-amino-methyl-benzoic acid, carbazochrome salicylate is 2:1:2.
3. a kind of emergency department nursing quick-acting haemostatic powder patch described in claim 1-2, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.5 part, para-amino-methyl-benzoic acid 0.25 part, carbazochrome salicylate 0.5 part, carboxymethyl chitosan 20 parts, Flos Lonicerae extract 15 parts, Rhizoma Imperatae extract 15 parts, Pollen Tyjphae extract 15 parts, hydroxypropyl emthylcellulose 20 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts.
4. a kind of emergency department nursing quick-acting haemostatic powder patch described in claim 1-2, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.2 part, para-amino-methyl-benzoic acid 0.1 part, carbazochrome salicylate 0.2 part, carboxymethyl chitosan 10 parts, Flos Lonicerae extract 12 parts, Rhizoma Imperatae extract 12 parts, Pollen Tyjphae extract 12 parts, hydroxypropyl emthylcellulose 25 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts.
5. a kind of emergency department nursing quick-acting haemostatic powder patch described in claim 1-2, described medicine carrying adhesive layer is made up of the raw material of following weight portion: vitamin K1 0.3 part, para-amino-methyl-benzoic acid 0.15 part, carbazochrome salicylate 0.3 part, carboxymethyl chitosan 25 parts, Flos Lonicerae extract 20 parts, Rhizoma Imperatae extract 20 parts, Pollen Tyjphae extract 20 parts, hydroxypropyl emthylcellulose 30 parts, pressure sensitive adhesive 15 parts, glycerol 10 parts, deionized water 30 parts.
6. a kind of emergency department according to claim 1 nursing quick-acting haemostatic powder patch, wherein the weight proportion of Flos Lonicerae extract, Rhizoma Imperatae extract, Pollen Tyjphae extract is 1:1:1.
7. a kind of emergency department nursing quick-acting haemostatic powder patch described in claim 1-6, the preparation method of wherein said Flos Lonicerae extract comprises the steps: deionized water Chinese medicine honeysuckle being added 5-10 times amount, reflux, extract, 3 times under 50-70 DEG C of condition, each 1-3 hour, filtering residue is for subsequent use, merging filtrate, crushed after being dried, get dry extract powder 1; Add the alcoholic solution of 5-10 times amount 50-70% in filtering residue, be transferred in Microwave Extraction Apparatus, under 500-800W condition, extraction 10-30min, filter, obtain extracting solution, crushed after being dried, get dry extract powder 2, merges dried cream powder 1 and dried cream powder 2, to obtain final product.
8. a kind of emergency department nursing quick-acting haemostatic powder patch described in claim 1-6, the preparation method of wherein said Rhizoma Imperatae extract comprises: alcoholic solution Rhizoma Imperatae medicinal material coarse powder being added the 50-70% of 5-10 times amount, reflux, extract, 3 times under 50-70 DEG C of condition, each 1-3 hour, filtering residue is for subsequent use, merging filtrate, crushed after being dried, get dry extract powder 1; Add in filtering residue in 5-10 times amount deionized water, be transferred in Microwave Extraction Apparatus, under 500-800W condition, extraction 10-30min, filter, obtain extracting solution, crushed after being dried, get dry extract powder 2, merges dried cream powder 1 and dried cream powder 2, to obtain final product.
9. a kind of emergency department according to claim 1 nursing quick-acting haemostatic powder patch, the preparation method of wherein said Pollen Tyjphae extract comprises: alcoholic solution Pollen Typhae being added the 60-80% of 5-10 times amount, reflux, extract, 3 times under 50-70 DEG C of condition, each 1-3 hour, merging filtrate, dry, pulverize the powder that gets dry extract, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610060070.5A CN105561000B (en) | 2016-01-29 | 2016-01-29 | A kind of emergency department's nursing quick-acting haemostatic powder patch |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610060070.5A CN105561000B (en) | 2016-01-29 | 2016-01-29 | A kind of emergency department's nursing quick-acting haemostatic powder patch |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105561000A true CN105561000A (en) | 2016-05-11 |
| CN105561000B CN105561000B (en) | 2019-04-26 |
Family
ID=55872009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610060070.5A Expired - Fee Related CN105561000B (en) | 2016-01-29 | 2016-01-29 | A kind of emergency department's nursing quick-acting haemostatic powder patch |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105561000B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266717A (en) * | 2016-09-24 | 2017-01-04 | 徐静 | A kind of emergency department nursing efficient quick-acting haemostatic powder patch and preparation method thereof |
| CN109908275A (en) * | 2019-03-11 | 2019-06-21 | 泗水县人民医院 | A kind of emergency department's nursing efficient quick-acting haemostatic powder patch and preparation method thereof |
| CN110269891A (en) * | 2019-08-01 | 2019-09-24 | 河南科技大学第一附属医院 | A kind of emergency department's nursing quick-acting haemostatic powder patch and preparation method thereof |
| CN111513796A (en) * | 2020-04-30 | 2020-08-11 | 常州市第一人民医院 | Automatic radial artery haemostat of decompression |
| CN112245410A (en) * | 2020-09-23 | 2021-01-22 | 徐州融创新材料技术研究院有限公司 | Hemostatic tablet and production method thereof |
| CN115738371A (en) * | 2022-12-05 | 2023-03-07 | 山东柳新堂健康产业有限公司 | Subcritical double-solvent extraction method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1435263A (en) * | 2003-03-05 | 2003-08-13 | 成都拓泰医药科技开发有限公司 | Hematostatic gel |
| CN101584721A (en) * | 2009-07-06 | 2009-11-25 | 江苏泰灵生物科技有限公司 | Chinese traditional medicine antibiotic hemostatic plaster |
| CN103356827A (en) * | 2013-07-26 | 2013-10-23 | 重庆金老虎科技开发有限公司 | Cattail pollen adhesive bandage and preparation method thereof |
-
2016
- 2016-01-29 CN CN201610060070.5A patent/CN105561000B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1435263A (en) * | 2003-03-05 | 2003-08-13 | 成都拓泰医药科技开发有限公司 | Hematostatic gel |
| CN101584721A (en) * | 2009-07-06 | 2009-11-25 | 江苏泰灵生物科技有限公司 | Chinese traditional medicine antibiotic hemostatic plaster |
| CN103356827A (en) * | 2013-07-26 | 2013-10-23 | 重庆金老虎科技开发有限公司 | Cattail pollen adhesive bandage and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 崔福德等: "《药剂学》", 31 January 2006, 中国医药科技出版社 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106266717A (en) * | 2016-09-24 | 2017-01-04 | 徐静 | A kind of emergency department nursing efficient quick-acting haemostatic powder patch and preparation method thereof |
| CN109908275A (en) * | 2019-03-11 | 2019-06-21 | 泗水县人民医院 | A kind of emergency department's nursing efficient quick-acting haemostatic powder patch and preparation method thereof |
| CN110269891A (en) * | 2019-08-01 | 2019-09-24 | 河南科技大学第一附属医院 | A kind of emergency department's nursing quick-acting haemostatic powder patch and preparation method thereof |
| CN111513796A (en) * | 2020-04-30 | 2020-08-11 | 常州市第一人民医院 | Automatic radial artery haemostat of decompression |
| CN112245410A (en) * | 2020-09-23 | 2021-01-22 | 徐州融创新材料技术研究院有限公司 | Hemostatic tablet and production method thereof |
| CN115738371A (en) * | 2022-12-05 | 2023-03-07 | 山东柳新堂健康产业有限公司 | Subcritical double-solvent extraction method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105561000B (en) | 2019-04-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105561000A (en) | Quick hemostasis patch for nursing in emergency department | |
| CN103721131A (en) | Traditional Chinese medicinal suppository for treating female chronic pelvic inflammation and preparation method thereof | |
| US10478463B2 (en) | External-use medicament for cleaning and care of the ovaries, vagina, and vulva | |
| CN105012533A (en) | Traditional Chinese medicine preparation for treating hemorrhoids | |
| CN102755573A (en) | External use traditional Chinese medicine for treating onychomycosis | |
| CN104547585B (en) | The external medicine composition and preparation for the treatment of swelling and pain, edge of a knife wound and exanthemv | |
| CN105943666B (en) | Composition for nursing sensitive skin of infant and preparation method thereof | |
| CN102772712A (en) | Traditional Chinese medicine composition for treating heat-toxicity, flourishing and blood stasis type diabetic foot | |
| CN104906465A (en) | Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof | |
| CN103721138B (en) | A kind of traditional Chinese medicine for external application and its preparation method treating rosacea | |
| CN100438896C (en) | External use muscle relaxing preparation for treating traumatic injury and rheumatism stagnation pain and its preparing method | |
| CN109432245A (en) | It is a kind of to have effects that the Chinese medicine composition of putrefaction-removing granulation-promoting, preparation and application | |
| CN105343399B (en) | A Chinese medicinal composition and ointment for treating skin injury, and preparation method thereof | |
| CN103599379B (en) | Traditional Chinese medicine for treatment of liver and kidney deficient type chronic osteomyelitis and its preparation method | |
| CN103341044B (en) | Itching-relieving compound preparation and preparation method thereof | |
| CN106421824A (en) | Biological coupling slices of ultrasonic therapy instrument and preparation method thereof | |
| CN107308305B (en) | Preparation for treating infantile eczema, dermatitis and infantile eczema | |
| CN104352910A (en) | Traditional Chinese medicine external suppository for treating women morbid leucorrhea and preparation method thereof | |
| CN110680856A (en) | Eczema fumigation powder | |
| CN104888137A (en) | Medicinal preparation for treatment of polycystic ovarian syndrome | |
| CN104623112A (en) | Plaster for treating snake-head furuncle | |
| CN108853293B (en) | Compound essential oil for treating hemorrhoids and preparation method and use method thereof | |
| CN105012503A (en) | Ointment for treating scalding and preparing method thereof | |
| CN104547189B (en) | Traditional Chinese medicine composition for treating burns and scalds and preparation thereof | |
| CN105055689A (en) | Traditional Chinese medicine ointment for treating scalds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190426 Termination date: 20220129 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |