CN116171277B - Pn6047盐酸盐的多晶型物 - Google Patents

Pn6047盐酸盐的多晶型物

Info

Publication number
CN116171277B
CN116171277B CN202180060408.6A CN202180060408A CN116171277B CN 116171277 B CN116171277 B CN 116171277B CN 202180060408 A CN202180060408 A CN 202180060408A CN 116171277 B CN116171277 B CN 116171277B
Authority
CN
China
Prior art keywords
hcl2
crystalline
salt
hcl salt
pain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202180060408.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN116171277A (zh
Inventor
B·冯·门策
I·斯塔克
H·G·尼尔松
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PharmNovo AB
Original Assignee
PharmNovo AB
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Publication date
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Publication of CN116171277A publication Critical patent/CN116171277A/zh
Application granted granted Critical
Publication of CN116171277B publication Critical patent/CN116171277B/zh
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202180060408.6A 2020-07-17 2021-07-12 Pn6047盐酸盐的多晶型物 Active CN116171277B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE2050910 2020-07-17
SE2050910-5 2020-07-17
PCT/EP2021/069340 WO2022013153A1 (en) 2020-07-17 2021-07-12 Polymorphs of a hydrochloride salt of pn6047

Publications (2)

Publication Number Publication Date
CN116171277A CN116171277A (zh) 2023-05-26
CN116171277B true CN116171277B (zh) 2026-03-06

Family

ID=77168220

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180060408.6A Active CN116171277B (zh) 2020-07-17 2021-07-12 Pn6047盐酸盐的多晶型物

Country Status (7)

Country Link
US (1) US20230174525A1 (https=)
EP (1) EP4182312A1 (https=)
JP (2) JP2023533874A (https=)
CN (1) CN116171277B (https=)
AU (1) AU2021309364A1 (https=)
CA (1) CA3185973A1 (https=)
WO (1) WO2022013153A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1692100A (zh) * 2001-10-03 2005-11-02 阿斯特拉曾尼卡有限公司 4－[哌啶－4－亚基－(3－氨基甲酰苯基)甲基]苯甲酰胺衍生物及其在治疗疼痛、脊椎损伤或胃肠疾病方面的应用
CN107531670A (zh) * 2014-12-19 2018-01-02 菲勒诺沃公司 二芳基亚甲基哌啶衍生物及其作为δ阿片受体激动剂的用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110207745A1 (en) * 2009-11-25 2011-08-25 Astrazeneca Ab Solid forms of 4--n,n-diethylbenzamide, compositions thereof, and uses therewith

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1692100A (zh) * 2001-10-03 2005-11-02 阿斯特拉曾尼卡有限公司 4－[哌啶－4－亚基－(3－氨基甲酰苯基)甲基]苯甲酰胺衍生物及其在治疗疼痛、脊椎损伤或胃肠疾病方面的应用
CN107531670A (zh) * 2014-12-19 2018-01-02 菲勒诺沃公司 二芳基亚甲基哌啶衍生物及其作为δ阿片受体激动剂的用途

Also Published As

Publication number Publication date
JP2023533874A (ja) 2023-08-04
CA3185973A1 (en) 2022-01-20
CN116171277A (zh) 2023-05-26
JP2026016435A (ja) 2026-02-03
EP4182312A1 (en) 2023-05-24
US20230174525A1 (en) 2023-06-08
AU2021309364A8 (en) 2023-03-16
AU2021309364A1 (en) 2023-02-16
WO2022013153A1 (en) 2022-01-20

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