CN116157135A - 使用基于crispr的碱基编辑器系统抑制谱系特异性抗原的组合物和方法 - Google Patents

使用基于crispr的碱基编辑器系统抑制谱系特异性抗原的组合物和方法 Download PDF

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CN116157135A
CN116157135A CN202180060702.7A CN202180060702A CN116157135A CN 116157135 A CN116157135 A CN 116157135A CN 202180060702 A CN202180060702 A CN 202180060702A CN 116157135 A CN116157135 A CN 116157135A
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cell
cells
hematopoietic stem
genetically engineered
exon
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Chinese (zh)
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S·穆克吉
F·波拉特
A·M·艾力
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Columbia University in the City of New York
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Columbia University in the City of New York
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CN202180060702.7A 2020-06-03 2021-06-03 使用基于crispr的碱基编辑器系统抑制谱系特异性抗原的组合物和方法 Pending CN116157135A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063033966P 2020-06-03 2020-06-03
US202063033970P 2020-06-03 2020-06-03
US63/033,970 2020-06-03
US63/033,966 2020-06-03
US202163183791P 2021-05-04 2021-05-04
US63/183,791 2021-05-04
PCT/US2021/035691 WO2021247856A2 (en) 2020-06-03 2021-06-03 Compositions and methods for inhibition of lineage specific antigens using crispr-based base editor systems

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CN116157135A true CN116157135A (zh) 2023-05-23

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US (1) US20240041923A1 (https=)
EP (1) EP4161535A4 (https=)
JP (1) JP2023528415A (https=)
KR (1) KR20230029632A (https=)
CN (1) CN116157135A (https=)
AU (1) AU2021285907A1 (https=)
CA (1) CA3180738A1 (https=)
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WO (1) WO2021247856A2 (https=)

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Publication number Priority date Publication date Assignee Title
WO2021081244A1 (en) * 2019-10-22 2021-04-29 Fred Hutchinson Cancer Research Center Base editor-mediated cd33 reduction to selectively protect therapeutic cells
CA3232593A1 (en) * 2021-09-14 2023-03-23 Vor Biopharma Inc. Compositions and methods for multiplex base editing in hematopoietic cells
CA3236152A1 (en) * 2021-11-09 2023-05-19 Vor Biopharma Inc. Compositions and methods for erm2 modification
CN120265314A (zh) * 2022-09-28 2025-07-04 瑞泽恩制药公司 抗体抗性修饰受体以增强基于细胞的疗法
CN116850210B (zh) * 2023-01-17 2024-05-31 武汉大学 用于治疗急性髓系白血病的成分和方法
WO2025030010A1 (en) * 2023-08-01 2025-02-06 Vor Biopharma Inc. Compositions comprising genetically engineered hematopoietic stem cells and methods of use thereof

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CN108290939A (zh) * 2015-10-16 2018-07-17 纽约市哥伦比亚大学理事会 用于抑制谱系特异性抗原的组合物和方法
WO2019046285A1 (en) * 2017-08-28 2019-03-07 The Trustees Of Columbia University In The City Of New York CD33 EXON 2 DONOR STEM CELLS FOR USE WITH CD33 TARGETING AGENTS
WO2020047164A1 (en) * 2018-08-28 2020-03-05 Vor Biopharma, Inc Genetically engineered hematopoietic stem cells and uses thereof

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JP2020523365A (ja) * 2017-06-14 2020-08-06 ピーティーシー セラピューティクス，インコーポレーテッド Ｒｎａスプライシングを改変する方法
WO2021081244A1 (en) * 2019-10-22 2021-04-29 Fred Hutchinson Cancer Research Center Base editor-mediated cd33 reduction to selectively protect therapeutic cells

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
CN108290939A (zh) * 2015-10-16 2018-07-17 纽约市哥伦比亚大学理事会 用于抑制谱系特异性抗原的组合物和方法
WO2019046285A1 (en) * 2017-08-28 2019-03-07 The Trustees Of Columbia University In The City Of New York CD33 EXON 2 DONOR STEM CELLS FOR USE WITH CD33 TARGETING AGENTS
WO2020047164A1 (en) * 2018-08-28 2020-03-05 Vor Biopharma, Inc Genetically engineered hematopoietic stem cells and uses thereof

Non-Patent Citations (1)

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FABIANA PERNA ET.AL: "Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML", CANCER CELL, vol. 32, no. 4, 9 October 2017 (2017-10-09), pages 506 - 519, XP085210745, DOI: 10.1016/j.ccell.2017.09.004 *

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EP4161535A4 (en) 2024-07-17
JP2023528415A (ja) 2023-07-04
KR20230029632A (ko) 2023-03-03
WO2021247856A2 (en) 2021-12-09
MX2022015237A (es) 2023-02-09
US20240041923A1 (en) 2024-02-08
CA3180738A1 (en) 2021-12-09
AU2021285907A1 (en) 2023-02-02
EP4161535A2 (en) 2023-04-12
WO2021247856A3 (en) 2022-01-13

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