AU2021285907A1 - Compositions and methods for inhibition of lineage specific antigens using crispr-based base editor systems - Google Patents

Compositions and methods for inhibition of lineage specific antigens using crispr-based base editor systems Download PDF

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AU2021285907A1
AU2021285907A1 AU2021285907A AU2021285907A AU2021285907A1 AU 2021285907 A1 AU2021285907 A1 AU 2021285907A1 AU 2021285907 A AU2021285907 A AU 2021285907A AU 2021285907 A AU2021285907 A AU 2021285907A AU 2021285907 A1 AU2021285907 A1 AU 2021285907A1
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cell
hematopoietic stem
lineage
genetically engineered
grna
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Abdullah Mahmood Ali
Florence Borot
Siddhartha MUKHERJEE
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Columbia University in the City of New York
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Columbia University in the City of New York
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    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0665—Blood-borne mesenchymal stem cells, e.g. from umbilical cord blood
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    • A61K40/41—Vertebrate antigens
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    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4224—Molecules with a "CD" designation not provided for elsewhere
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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AU2021285907A 2020-06-03 2021-06-03 Compositions and methods for inhibition of lineage specific antigens using crispr-based base editor systems Pending AU2021285907A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063033966P 2020-06-03 2020-06-03
US202063033970P 2020-06-03 2020-06-03
US63/033,970 2020-06-03
US63/033,966 2020-06-03
US202163183791P 2021-05-04 2021-05-04
US63/183,791 2021-05-04
PCT/US2021/035691 WO2021247856A2 (en) 2020-06-03 2021-06-03 Compositions and methods for inhibition of lineage specific antigens using crispr-based base editor systems

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AU2021285907A1 true AU2021285907A1 (en) 2023-02-02

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US (1) US20240041923A1 (https=)
EP (1) EP4161535A4 (https=)
JP (1) JP2023528415A (https=)
KR (1) KR20230029632A (https=)
CN (1) CN116157135A (https=)
AU (1) AU2021285907A1 (https=)
CA (1) CA3180738A1 (https=)
MX (1) MX2022015237A (https=)
WO (1) WO2021247856A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021081244A1 (en) * 2019-10-22 2021-04-29 Fred Hutchinson Cancer Research Center Base editor-mediated cd33 reduction to selectively protect therapeutic cells
CA3232593A1 (en) * 2021-09-14 2023-03-23 Vor Biopharma Inc. Compositions and methods for multiplex base editing in hematopoietic cells
CA3236152A1 (en) * 2021-11-09 2023-05-19 Vor Biopharma Inc. Compositions and methods for erm2 modification
CN120265314A (zh) * 2022-09-28 2025-07-04 瑞泽恩制药公司 抗体抗性修饰受体以增强基于细胞的疗法
CN116850210B (zh) * 2023-01-17 2024-05-31 武汉大学 用于治疗急性髓系白血病的成分和方法
WO2025030010A1 (en) * 2023-08-01 2025-02-06 Vor Biopharma Inc. Compositions comprising genetically engineered hematopoietic stem cells and methods of use thereof

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CN108290939B (zh) * 2015-10-16 2023-01-13 纽约市哥伦比亚大学理事会 用于抑制谱系特异性抗原的组合物和方法
JP2020523365A (ja) * 2017-06-14 2020-08-06 ピーティーシー セラピューティクス，インコーポレーテッド Ｒｎａスプライシングを改変する方法
US11718659B2 (en) * 2017-08-28 2023-08-08 The Trustees Of Columbia University In The City Of New York CD33 exon 2 deficient donor stem cells for use with CD33 targeting agents
CA3110837A1 (en) * 2018-08-28 2020-03-05 Vor Biopharma Inc. Genetically engineered hematopoietic stem cells and uses thereof
WO2021081244A1 (en) * 2019-10-22 2021-04-29 Fred Hutchinson Cancer Research Center Base editor-mediated cd33 reduction to selectively protect therapeutic cells

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EP4161535A4 (en) 2024-07-17
JP2023528415A (ja) 2023-07-04
KR20230029632A (ko) 2023-03-03
WO2021247856A2 (en) 2021-12-09
MX2022015237A (es) 2023-02-09
US20240041923A1 (en) 2024-02-08
CN116157135A (zh) 2023-05-23
CA3180738A1 (en) 2021-12-09
EP4161535A2 (en) 2023-04-12
WO2021247856A3 (en) 2022-01-13

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