CN116138454A - Fructus lycii medicinal and edible dual-purpose composition with constipation relieving effect and preparation method and application thereof - Google Patents

Fructus lycii medicinal and edible dual-purpose composition with constipation relieving effect and preparation method and application thereof Download PDF

Info

Publication number
CN116138454A
CN116138454A CN202111398087.9A CN202111398087A CN116138454A CN 116138454 A CN116138454 A CN 116138454A CN 202111398087 A CN202111398087 A CN 202111398087A CN 116138454 A CN116138454 A CN 116138454A
Authority
CN
China
Prior art keywords
parts
constipation
composition
weight
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202111398087.9A
Other languages
Chinese (zh)
Other versions
CN116138454B (en
Inventor
郭盛
段然
鲁学军
段金廒
钱大玮
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ningxia Medlar Innovation Center Co ltd
Original Assignee
Ningxia Medlar Innovation Center Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ningxia Medlar Innovation Center Co ltd filed Critical Ningxia Medlar Innovation Center Co ltd
Priority to CN202111398087.9A priority Critical patent/CN116138454B/en
Publication of CN116138454A publication Critical patent/CN116138454A/en
Application granted granted Critical
Publication of CN116138454B publication Critical patent/CN116138454B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G3/366—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing microorganisms, enzymes
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention discloses a composition with constipation prevention effect and a preparation method thereof, wherein the composition is prepared from 1 to 5 parts of medlar, 2 to 10 parts of red bean, 2 to 10 parts of poria cocos, 3 to 8 parts of chicory, 3 to 8 parts of konjak powder, 3 to 8 parts of sweet almond, 1 to 5 parts of fructus cannabis, 1 to 5 parts of cowberry fruit, 1 to 5 parts of radish seed, 1 to 5 parts of black sesame, 0.01 to 0.1 part of taurine, 0.2 to 2 parts of bifidobacterium adolescentis and 0.2 to 2 parts of lactobacillus plantarum. The wolfberry fruit medicine and food dual-purpose composition is prepared through a large number of test screening and optimizing, and is prepared by adopting natural traditional medicine and food dual-purpose plants and functional factors with multiple medicine and food dual-purpose health care effects and preparing an extract with the health care effects through a modern preparation process. Experimental results show that the composition provided by the invention can effectively shorten the first defecation time of constipation model animals and increase the defecation quantity and weight of the constipation model animals, and the composition provided by the invention has the health care function of preventing constipation and can be used for long-term administration of middle-aged and elderly constipation people.

Description

Fructus lycii medicinal and edible dual-purpose composition with constipation relieving effect and preparation method and application thereof
Technical Field
The invention relates to a natural composition, in particular to a medicinal and edible composition with constipation relieving effect, and a preparation method and application thereof.
Background
Constipation is a common symptom in clinic, mainly referring to the reduction of defecation times, the reduction of fecal quantity, dry and hard feces, etc. When the above symptoms are present in combination with 2 or more, symptomatic constipation can be diagnosed. Constipation is usually dominated by a reduction in the frequency of bowel movements, typically 1 time per 2-3 days or longer (or <3 times per week). As China enters the aging society, the incidence rate of senile constipation continues to rise.
The long-term constipation has great harm to human bodies, is easy to induce or aggravate colorectal diseases such as hemorrhoids, fistulae, anal fissures and the like, and causes cardiovascular and cerebrovascular diseases such as cardiovascular and cerebrovascular accidents, hypertension vascular rupture and cerebral hemorrhage and the like; the feces accumulate in the intestinal tract for a prolonged period of time, and can generate a large amount of toxic substances such as benzene, amine, etc., which are reabsorbed by human body to affect the memory and reaction capacity of human body, thereby causing depression and anxiety emotion and inducing mental or psychological factor diseases. Studies have shown that the incidence of intestinal tumors is 4 times higher than normal in patients with long-term constipation.
The modern medicine considers that the reasons for constipation are too little cellulose, insufficient drinking water, small activity, endocrine and metabolic diseases, mental factors and mental diseases, constipation caused by partial medicines and the like. In modern medicine, bulk drugs such as magnesium sulfate, stimulant laxatives such as guide tablets, lubricating laxatives such as liquid paraffin, and osmotic laxatives such as lactulose are mainly used for treating constipation. However, most of the above drugs are symptomatic treatment, and the drugs cannot radically clear the etiology, and have the defects of easy recurrence, inapplicability to long-term use and the like. The traditional Chinese medicine considers that constipation is a clinical manifestation of yin-yang qi-blood-body fluid, viscera functions, diet emotional disorder and six-barrenness invasion of human body, the etiology and pathogenesis can be summarized according to the two aspects of 'excess secret and deficiency secret', and senile constipation is mainly due to deficiency secret, and the treatment is mainly carried out by tonifying qi-blood semen, and has better curative effect.
Therefore, based on the theory of traditional Chinese medicine, the health-care food and medicine with the effects of relaxing bowel and relieving constipation are developed by taking the medicinal and edible products as main raw materials, and have good market prospect.
Disclosure of Invention
The invention aims to: the invention aims to provide a composition which has the effects of relaxing bowel and relieving constipation, and has high safety and no adverse reaction. It is a further object of the present invention to provide a process for the preparation and use of the above composition.
The technical scheme is as follows: in order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a composition with the effects of relaxing bowel and relieving constipation is prepared from the following raw materials in parts by weight: 1 to 5 parts of medlar, 2 to 10 parts of red bean, 2 to 10 parts of tuckahoe, 3 to 8 parts of chicory, 3 to 8 parts of konjaku flour, 3 to 8 parts of sweet almond, 1 to 5 parts of hemp seed, 1 to 5 parts of cowberry fruit, 1 to 5 parts of radish seed, 1 to 5 parts of black sesame, 0.01 to 0.1 part of taurine, 0.2 to 2 parts of bifidobacterium adolescentis and 0.2 to 2 parts of lactobacillus plantarum.
As a preferred scheme, the composition with the effects of relaxing bowel and preventing constipation is prepared from the following raw materials in parts by weight: 3 to 5 parts of medlar, 7 to 9 parts of red bean, 7 to 9 parts of tuckahoe, 4 to 6 parts of chicory, 4 to 6 parts of konjaku flour, 4 to 6 parts of sweet almond, 2 to 4 parts of hemp seed, 2 to 4 parts of cowberry fruit, 1 to 3 parts of radish seed, 2 to 4 parts of black sesame, 0.02 to 0.06 part of taurine, 0.4 to 0.8 part of bifidobacterium adolescentis and 0.4 to 0.8 part of lactobacillus plantarum.
As a more preferable scheme, the composition with the effects of relaxing bowel and preventing constipation is characterized by being prepared from the following raw materials in parts by weight: 4 parts of medlar, 8 parts of red bean, 8 parts of poria cocos, 6 parts of chicory, 6 parts of konjaku flour, 6 parts of sweet almond, 3 parts of fructus cannabis, 4 parts of cowberry fruit, 2 parts of radish seed, 4 parts of black sesame, 0.05 part of taurine, 0.5 part of bifidobacterium adolescentis and 0.5 part of lactobacillus plantarum.
The preparation method of the composition with the effects of relaxing bowel and preventing constipation comprises the following steps:
(1) Uniformly mixing medlar, red bean, tuckahoe, sweet almond, cowberry fruit and radish seed according to parts by weight, adding 8-16 times of water, heating and extracting for 1-3 times, each time for 1-2 hours, filtering, combining the extracting solutions, vacuum concentrating, and drying or spray drying to obtain plant compound extracts such as medlar and the like;
(2) Mixing chicory, black sesame and fructus cannabis according to parts by weight, freezing and crushing at low temperature, sieving with a 60-100 mesh sieve, and uniformly mixing with konjaku flour according to parts by weight to obtain plant composite powder such as konjaku;
(3) And (3) uniformly mixing taurine, bifidobacterium adolescentis and lactobacillus plantarum with the plant composite extract obtained in the step (1) and the plant composite powder obtained in the step (2) according to parts by weight to obtain the composition with constipation preventing effect.
Preferably, the preparation method of the composition with constipation preventing effect comprises the steps of (1) decocting, refluxing or continuously refluxing, wherein the extraction temperature is 95-100 ℃; the vacuum concentration conditions are as follows: the vacuum degree is less than or equal to 50Pa, and the concentration temperature is less than or equal to 50 ℃; the spray drying conditions are as follows: the drying temperature is less than or equal to 60 ℃.
As a preferable scheme, the preparation method of the composition with constipation prevention effect comprises the following steps of freezing and crushing at the temperature of-5 ℃ to-10 ℃ in the step (2), wherein the crushing fineness is 80 meshes.
According to the physicochemical properties of the wolfberry fruit, the red bean, the tuckahoe, the sweet almond, the cowberry fruit, the radish seed, the chicory, the black sesame, the hemp seed and the konjak powder, a large number of experiments are adopted to screen and extract the process and the preparation process, wherein the chicory, the black sesame and the hemp seed adopt a freezing and crushing process, the adverse effects of high-temperature crushing on polysaccharide and unsaturated fatty acid rich in the plant raw materials can be avoided, the defect that the polysaccharide and the unsaturated fatty acid are difficult to crush is eliminated, and the crushing efficiency and the crushing quality are improved. The water decoction extraction processes of the medlar and the like all adopt optimized process parameters, and have the advantages of high extraction efficiency, no damage to active ingredients in plants, low dissolution rate of impurity ingredients and the like. The vacuum low-temperature process is adopted for concentration and drying, so that the active ingredients of the active ingredients can be ensured not to be destroyed.
The composition with constipation preventing effect is applied to constipation prevention, and the plant composition and the food acceptable carrier are prepared into solid granular beverage, tabletting candy, concentrated paste and other food which are convenient to eat.
When the composition with constipation preventing effect is prepared into solid granular beverage, the plant composition is uniformly mixed with natural plant components such as chicory, black sesame, hemp seed, konjak and the like and natural plant components such as lutein and the like and a diluent, and the mixture is prepared into the solid granular beverage by a wet granulator or a dry granulator.
When the composition with constipation prevention function is prepared into a tableting candy, the plant composition is uniformly mixed with composite powder of chicory, black sesame, fructus cannabis, konjak and the like, natural plant components of lutein and the like, lactose or corn starch, and the mixture is prepared into granules, and then the granules are pressed into the tableting candy by a tablet press.
When the composition with constipation preventing effect is prepared into concentrated paste, the plant composition extract is concentrated to proper concentration, and the concentrated paste is prepared by uniformly mixing the plant composition extract, composite powder of chicory, black sesame, fructus cannabis, konjak and the like, and natural plant components of taurine, bifidobacterium adolescentis, lactobacillus plantarum and the like, and filling the paste into a machine.
The plant composition provided by the invention can be prepared according to a conventional method of food when being prepared into other food formulations.
A large number of experimental researches show that the composition provided by the invention can effectively shorten the first defecation time of constipation model animals and obviously increase the defecation times and weight, and has the health care function of preventing constipation, and can be applied to preparation of medicines or health care foods for preventing constipation.
The beneficial effects are that: the composition with constipation prevention effect is prepared by taking Chinese medicinal and edible dual-purpose traditional Chinese medicines such as medlar, red bean, tuckahoe, chicory, konjaku flour, almond, fructus cannabis, cowberry fruit, radish seed, black sesame and the like as main raw materials, compounding probiotics such as taurine, bifidobacterium adolescentis, lactobacillus plantarum and the like according to the health preserving and health care theory of traditional Chinese medicine and the research results of modern pharmacology through a large number of experiments, and screening the optimal proportion composition of medlar, red bean, tuckahoe, chicory, konjaku flour, almond, fructus cannabis, cowberry fruit, radish seed and black sesame through a large number of experiments.
The composition provided by the invention has the effects of tonifying liver and kidney, replenishing vital essence and improving eyesight by recording in Chinese medicine books, and can be used for moistening intestine and drying to relieve constipation while tonifying senile liver and kidney deficiency, and is supplemented with poria cocos and red bean with the effects of promoting diuresis and removing dampness and strengthening spleen, and radish seed and chicory with the effects of promoting digestion and removing distention, so that the composition plays a role in preventing deficiency secret caused by liver and kidney and qi, blood and body fluid of elderly patients. In addition, probiotics such as bifidobacterium adolescentis, lactobacillus plantarum and the like and konjaku flour prebiotics are added into the composition, so that constipation symptoms are further improved from the aspect of adjusting the intestinal flora structure. The natural traditional medicine and food dual-purpose plant extract with multiple health care effects and the probiotics are combined, and the effects of preventing constipation are achieved through cooperation of a plurality of action links such as enhancing immunity, regulating intestinal endothelial microcirculation, promoting intestinal peristalsis, supplementing prebiotics, supplementing probiotics and the like.
The invention screens the proportion of each component through a large number of experiments, and is scientific and reasonable; the whole preparation process has high automation degree and high preparation efficiency, can well retain the active ingredients in the raw materials, has the advantage of homology of medicine and food, has no toxic or side effect, and is suitable for long-term administration of people suffering from constipation.
Detailed Description
The present invention is further illustrated below with reference to specific examples, which are to be construed as merely illustrative of the invention and not limiting of its scope, as various equivalents thereof will suggest themselves to those skilled in the art upon reading the present invention, as defined in the appended claims.
Example 1
1. A composition with constipation prevention effect is prepared from the following raw materials in parts by weight:
4 parts of medlar, 8 parts of red bean, 8 parts of poria cocos, 6 parts of sweet almond, 6 parts of konjaku flour, 4 parts of cowberry fruit, 2 parts of radish seed, 6 parts of chicory, 3 parts of fructus cannabis, 4 parts of black sesame, 0.05 part of taurine, 0.5 part of bifidobacterium adolescentis and 0.5 part of lactobacillus plantarum.
2. A preparation method of a composition with constipation preventing effect comprises the following steps:
(1) Mixing fructus Lycii 4 parts, semen Phaseoli 8 parts, poria 8 parts, semen Armeniacae amarum 6 parts, cowberry fruit 4 parts, and Raphani semen 2 parts, adding 10 times of water, decocting for 2 times each for 1.5 hr, filtering, and mixing extractive solutions; vacuum concentrating under vacuum degree less than or equal to 50Pa and concentration temperature less than or equal to 50deg.C to obtain mixed concentrated solution;
(2) Spray drying the mixed concentrated solution obtained in the step (1) at the drying temperature of less than or equal to 60 ℃ to obtain plant composite extract powder such as medlar;
(3) Mixing 6 parts of chicory, 3 parts of fructus cannabis and 4 parts of black sesame, freezing and crushing at the temperature of minus 8 ℃, sieving with a 80-mesh sieve, and uniformly mixing with 6 parts of konjak powder to obtain plant composite powder such as konjak;
(4) Mixing taurine 0.05 parts, bifidobacterium adolescentis 0.5 parts and lactobacillus plantarum 0.5 parts with the plant composite extract powder obtained in the step (2) and the plant composite powder obtained in the step (3) uniformly to obtain the composition with constipation preventing effect.
Example 2
1. A composition with constipation prevention effect is prepared from the following raw materials in parts by weight:
5 parts of medlar, 9 parts of red bean, 7 parts of tuckahoe, 6 parts of sweet almond, 2 parts of cowberry fruit, 3 parts of radish seed, 4 parts of chicory, 4 parts of hemp seed, 2 parts of black sesame, 8 parts of konjak powder, 0.06 part of taurine, 0.8 part of bifidobacterium adolescentis and 0.8 part of lactobacillus plantarum.
2. A preparation method of a composition with constipation preventing effect comprises the following steps:
(1) 5 parts of medlar, 9 parts of red bean, 7 parts of tuckahoe, 6 parts of sweet almond, 2 parts of cowberry fruit and 3 parts of radish seed, mixing, adding 8 times of water, heating, decocting and extracting for 3 times each time for 1 hour, filtering, and combining the extracting solutions; vacuum concentrating under vacuum degree less than or equal to 50Pa and concentrating temperature less than or equal to 50deg.C to obtain mixed concentrated solution.
(2) Taking the mixed concentrated solution obtained in the step (1), drying and crushing at the drying temperature of less than or equal to 60 ℃ to obtain plant composite extract powder such as medlar and the like;
(3) Mixing 4 parts of chicory, 4 parts of fructus cannabis and 2 parts of black sesame, freezing and crushing at the temperature of minus 10 ℃, sieving with a 60-mesh sieve, and uniformly mixing with 6 parts of konjak powder to obtain plant composite powder such as konjak;
(4) Mixing taurine 0.06 parts, bifidobacterium adolescentis 0.8 parts and lactobacillus plantarum 0.8 parts with the plant composite extract powder obtained in the step (2) and the plant composite powder obtained in the step (3) uniformly to obtain the composition with constipation preventing effect.
Example 3
1. A composition with constipation prevention effect is prepared from the following raw materials in parts by weight:
2 parts of medlar, 10 parts of red bean, 10 parts of poria cocos, 3 parts of sweet almond, 2 parts of cowberry fruit, 1 part of radish seed, 8 parts of chicory, 5 parts of fructus cannabis, 5 parts of black sesame, 8 parts of konjak powder, 0.02 part of taurine, 0.2 part of bifidobacterium adolescentis and 0.2 part of lactobacillus plantarum.
2. A preparation method of a composition with constipation preventing effect comprises the following steps:
(1) Mixing fructus Lycii 2 parts, semen Phaseoli 10 parts, poria 10 parts, semen Armeniacae amarum 3 parts, cowberry fruit 2 parts, raphani semen 1 part, adding 12 times of water, heating and extracting for 1 time each for 2 hr, filtering, and mixing extractive solutions; vacuum concentrating under vacuum degree less than or equal to 50Pa and concentration temperature less than or equal to 50deg.C to obtain mixed concentrated solution;
(2) Spray drying the mixed concentrated solution obtained in the step (1) at the drying temperature of less than or equal to 60 ℃ to obtain plant composite extract powder such as medlar;
(3) Mixing 8 parts of chicory, 5 parts of fructus cannabis and 5 parts of black sesame, freezing and crushing at the temperature of minus 6 ℃, sieving with a 100-mesh sieve, and uniformly mixing with 8 parts of konjak powder to obtain plant composite powder such as konjak;
(4) Mixing taurine 0.02 parts, bifidobacterium adolescentis 0.2 parts and Lactobacillus plantarum 0.2 parts with the plant composite extract powder obtained in step (2) and the plant composite powder obtained in step (3) uniformly to obtain the composition with constipation preventing effect.
Example 4A method for preparing a concentrated paste of a composition having constipation preventing effect comprises the steps of:
(1) Dissolving the composition obtained in example 1 in appropriate amount of water, adding Mel, heating, and mixing to obtain concentrated extract;
(2) Taking the prepared concentrated paste liquid obtained in the step (1), and filling the concentrated paste liquid into glass bottles by a paste filling machine, wherein each bottle contains 250g or 500g; filling into aluminum plastic strip bags, wherein each bag is 10g or 20g.
Example 5 a method for preparing a solid particulate beverage composition having constipation preventing effect comprising the steps of:
(1) Taking the composition obtained in the example 2, adding soluble starch and spice, uniformly mixing, and granulating by a dry granulating machine;
(2) And (5) taking the particles obtained in the step (1), and subpackaging the particles in aluminum-plastic composite bags by using a particle packaging machine.
Example 6 a method for preparing a pressed candy of a composition having constipation preventing effect comprising the steps of:
(1) Taking the composition obtained in the example 1, adding lactose, compressible starch and appropriate amount of essence and spice, and mixing uniformly; making into granule by wet granulating machine, oven drying at below 60deg.C, and grading;
(2) And (3) taking the granules obtained in the step (1), placing the granules into a mixer, adding a tabletting lubricant, mixing for 15 minutes, and pressing the granules into tabletting candies by using the tablet press.
EXAMPLE 7 Constipation prevention function evaluation
1. Instrument and reagent
1. Test agent
The compositions prepared in example 1, example 2 and example 3 were dissolved in water to prepare the desired concentrations.
2. Instrument and reagent
Instrument and equipment: analytical balance (Mettler Toledo), ophthalmic forceps, syringe, activated carbon powder, gum arabic, compound diphenoxylate (vincristine red pharmaceutical company).
Preparing ink: accurately weighing 100g of gum arabic, adding 800mL of water, boiling until the solution is transparent, weighing 50g of active carbon powder, adding into the solution, boiling for three times, cooling the solution, adding water to 1000mL, keeping the volume at 4 ℃ in a refrigerator, and shaking uniformly before use.
Preparing a compound diphenoxylate suspension: taking 10 compound diphenoxylate tablets (each tablet contains 2.5mg of compound diphenoxylate), grinding with a mortar, adding distilled water, suspending, and fixing volume to 100mL to prepare 0.025% compound diphenoxylate suspension. Is prepared before use.
3. Test animal
Animal origin: ICR male mice, 40, 18-22g, were purchased from Shanghai Laek laboratory animal Co., ltd (license number: SCXK (Shanghai) 2017-0005). The conventional feeding temperature is kept at (22+/-2) DEG C, the relative humidity is kept at (60+/-2)%, and the illumination period is 12 hours.
Feeding environment: SPF grade, temperature is kept at (22+ -2) deg.C, relative humidity is kept at (60+ -2)%, and illumination period is 12h.
2. Experimental method
1. Animal grouping treatment and dose setting
Animals were randomly divided into 5 groups (blank, model, and example 1, example 2, example 3) based on body weight after 3 days of adaptive feeding. The recommended dose is calculated according to the recommended dose (10 g/d) for human oral administration, and 5 times the recommended dose for human is taken as the administration dose. After the test drugs are prepared, the mice are irrigated with the normal saline with the same volume as the BW volume, and the blank control group and the model control group are irrigated with the normal saline with the same volume once a day. After 8 days of continuous gastric lavage administration, the compound diphenoxylate is used for molding, and the bowel relaxing function indexes such as the first defecation time, the defecation grain number, the fecal weight and the like are measured.
2. Experimental principle and experimental procedure for bowel relaxing function
(1) Experimental principle of bowel relaxing function
The compound diphenoxylate of the stomach-infused drug is used for establishing a constipation model of the mice, and measuring the defecation time, the defecation grain number and the defecation weight of the mice in 5 or 6 hours for first grain defecation to reflect the defecation condition of the model mice.
(2) Experimental procedure
And (3) establishing a model: after 7d of administration of the test sample, each group of mice fasted without water for 16h. The model control group and each example administration group were respectively given the compound diphenoxylate (10 mg/kgBW) by gavage, and the blank control group was given the same volume of physiological saline by gavage.
The index measuring method comprises the following steps: after animals were given the compound diphenoxylate for 0.5h, mice in the blank control group and the model control group were lavaged with ink, and the administration group was lavaged with ink containing the test drug. Animals were kept in single cages and fed with normal drinking water.
Starting from the stomach-filling ink, the black stool discharge time of the first grains of each animal, the number of black stool discharge grains in 5 hours and the weight are recorded.
3. Data analysis and result determination
1. Influence on body weight
The initial body weight of the animals and the body weight measurement results after the end of the experiment are shown in Table 1. As can be seen from Table 1, the animals in each group had a good weight gain during the test period and were able to feed water normally. No significant differences in body weight were seen between the animals of each group, indicating that the compositions provided by the present invention had no significant effect on the body weight of the animals tested.
TABLE 1 influence of test samples on mouse body weight
Figure BDA0003365333040000071
Grouping (mg/kgBW) Weight before experiment (g) Post-experiment weight (g)
Model control group 25.25±1.98 28.33±3.11
Blank control group 24.99±0.93 29.06±0.97
Example 1 administration group 25.11±1.68 29.56±1.38
Example 2 administration group 24.85±0.98 28.64±2.31
Example 3 administration group 25.21±1.31 29.03±1.54
2. Influence on first bowel movement time
The results of the first bowel movement time measurements for each group of animals are shown in Table 2. As can be seen from table 2, the first grain of the mice in the model group had significantly longer bowel movement time than the blank group within 5h, indicating successful model replication. The mice of the administration groups of the example 1, the example 2 and the example 3 have the first time to discharge the black stool shorter than the model group, wherein the differences of the administration groups of the example 1 and the example 2 are significant compared with the model group. The above results demonstrate that the composition provided by the invention can shorten the first black stool discharge time of mice.
TABLE 2 influence of sample on first time to discharge of black urine in mice
Figure BDA0003365333040000072
Figure BDA0003365333040000073
Figure BDA0003365333040000081
Note that: in comparison with the blank group, ## p is less than 0.01; in comparison with the set of models, * P＜0.05， ** P＜0.01
3. influence on the number of black excrement particles discharged within 5 hours
The results of the analysis of the number of black bowel movements discharged within 5 hours of each group of animals are shown in Table 2. Table 2 shows that the number of black bowel movements in 5h of mice in the model group is significantly less than that in the blank group, indicating successful model replication. The number of the black discharge particles in 5h of the mice in the administration groups of the example 1, the example 2 and the example 3 is higher than that of the mice in the model group, wherein the differences between the administration groups of the example 1 and the example 2 and the model group are significant, which indicates that the composition provided by the invention can increase the number of the black discharge particles of the mice in the constipation model.
4. Influence on total weight of black stool discharged within 5 hours
The total weight analysis results of the black bowel movement in 5h of each group of animals are shown in table 2. Table 2 shows that the total weight of the black bowel movement in 5h of the model mice is significantly lower than that of the blank group, indicating successful replication of the constipation model. The mice in the administration groups of example 1 and example 2 have significantly longer first-time defecation time than the model group, and have significant differences, which indicates that the composition provided by the invention can increase the total weight of the defecation of the constipation model mice.
5. Result determination
From the experimental results, the composition provided by the invention can obviously shorten the first defecation time of a constipation model mouse and increase the number of black bowel movement particles and the total weight of black bowel movement in 5 hours of the model mouse. Based on the experimental results, the composition provided by the invention has the function of relaxing the bowels and protecting health based on animal experiments according to the rules of the function experiments related to relaxing the bowels of the health food functional evaluation program and the inspection method.
The composition provided by the invention can obviously shorten the first black stool discharge time of a constipation animal model and increase the quantity and weight of black stools, and has the function of relaxing the bowels and protecting health, and can be used for preventing constipation. Compared with the existing medicines and health-care foods, the composition adopts natural traditional medicine and food homologous raw materials with multiple health-care effects, is safer and has no adverse reaction.
The foregoing is merely a preferred embodiment of the present invention and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present invention, which are intended to be comprehended within the scope of the present invention.

Claims (8)

1. The composition with the constipation prevention effect is characterized by being prepared from the following raw materials in parts by weight:
1 to 5 parts of medlar, 2 to 10 parts of red bean, 2 to 10 parts of tuckahoe, 3 to 8 parts of chicory, 3 to 8 parts of konjaku flour, 3 to 8 parts of sweet almond, 1 to 5 parts of hemp seed, 1 to 5 parts of cowberry fruit, 1 to 5 parts of radish seed, 1 to 5 parts of black sesame, 0.01 to 0.1 part of taurine, 0.2 to 2 parts of bifidobacterium adolescentis and 0.2 to 2 parts of lactobacillus plantarum.
2. The composition with constipation prevention effect according to claim 1, which is characterized by being prepared from the following raw materials in parts by weight: 3 to 5 parts of medlar, 7 to 9 parts of red bean, 7 to 9 parts of tuckahoe, 4 to 6 parts of chicory, 4 to 6 parts of konjaku flour, 4 to 6 parts of sweet almond, 2 to 4 parts of hemp seed, 2 to 4 parts of cowberry fruit, 1 to 3 parts of radish seed, 2 to 4 parts of black sesame, 0.02 to 0.06 part of taurine, 0.4 to 0.8 part of bifidobacterium adolescentis and 0.4 to 0.8 part of lactobacillus plantarum.
3. The composition with constipation prevention effect according to claim 2, which is characterized by being prepared from the following raw materials in parts by weight: 4 parts of medlar, 8 parts of red bean, 8 parts of poria cocos, 6 parts of chicory, 6 parts of konjaku flour, 6 parts of sweet almond, 3 parts of fructus cannabis, 4 parts of cowberry fruit, 2 parts of radish seed, 4 parts of black sesame, 0.05 part of taurine, 0.5 part of bifidobacterium adolescentis and 0.5 part of lactobacillus plantarum.
4. A method for preparing the composition having constipation-preventing effect as claimed in any one of claims 1 to 3, comprising the steps of:
(1) Uniformly mixing medlar, red bean, tuckahoe, sweet almond, cowberry fruit and radish seed according to parts by weight, adding 8-16 times of water, heating and extracting for 1-3 times, each time for 1-2 hours, filtering, combining the extracting solutions, concentrating in vacuum, and drying or spray drying to obtain a plant composite extract;
(2) Mixing chicory, black sesame and fructus cannabis according to parts by weight, freezing and crushing at low temperature, sieving with a 60-100 mesh sieve, and uniformly mixing with konjak powder according to parts by weight to obtain plant composite powder;
(3) And (3) uniformly mixing taurine, bifidobacterium adolescentis and lactobacillus plantarum with the plant composite extract obtained in the step (1) and the plant composite powder obtained in the step (2) according to parts by weight to obtain the composition with constipation preventing effect.
5. The method for preparing a constipation-preventing composition according to claim 4, wherein the extraction method in step (1) is decoction, reflux or continuous reflux extraction; the extraction temperature is 95-100deg.C; the vacuum concentration conditions are as follows: the vacuum degree is less than or equal to 50Pa, and the concentration temperature is less than or equal to 50 ℃; the spray drying conditions are as follows: the drying temperature is less than or equal to 60 ℃.
6. The method for producing a constipation-preventing composition according to claim 4, wherein the low-temperature freeze-pulverization condition in the step (2) is-5 ℃ to-10 ℃ and the pulverization fineness is 80 mesh.
7. Use of the composition having constipation-preventing effect as claimed in any one of claims 1 to 3 for preparing a health food or medicine having constipation-preventing effect.
8. The use according to claim 7, wherein the extract of the composition and the food and pharmaceutically acceptable carrier are formulated as a concentrated paste, syrup, solid drink, health food or medicament for tableting candy.
CN202111398087.9A 2021-11-19 2021-11-19 Fructus lycii medicinal and edible dual-purpose composition with constipation relieving effect and preparation method and application thereof Active CN116138454B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111398087.9A CN116138454B (en) 2021-11-19 2021-11-19 Fructus lycii medicinal and edible dual-purpose composition with constipation relieving effect and preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111398087.9A CN116138454B (en) 2021-11-19 2021-11-19 Fructus lycii medicinal and edible dual-purpose composition with constipation relieving effect and preparation method and application thereof

Publications (2)

Publication Number Publication Date
CN116138454A true CN116138454A (en) 2023-05-23
CN116138454B CN116138454B (en) 2024-04-16

Family

ID=86339525

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202111398087.9A Active CN116138454B (en) 2021-11-19 2021-11-19 Fructus lycii medicinal and edible dual-purpose composition with constipation relieving effect and preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN116138454B (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107875255A (en) * 2017-11-21 2018-04-06 符卓韬 A kind of composition for relaxing bowel, losing weight
CN107997132A (en) * 2017-11-16 2018-05-08 湖州每天果健康科技有限公司 A kind of fruits and vegetables cereal foods with function of relaxing bowel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107997132A (en) * 2017-11-16 2018-05-08 湖州每天果健康科技有限公司 A kind of fruits and vegetables cereal foods with function of relaxing bowel
CN107875255A (en) * 2017-11-21 2018-04-06 符卓韬 A kind of composition for relaxing bowel, losing weight

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
祝培勤;李辉;: "五仁润肠丸治疗习惯性便秘30例", 中国民间疗法, no. 04, 28 April 2009 (2009-04-28), pages 28 *

Also Published As

Publication number Publication date
CN116138454B (en) 2024-04-16

Similar Documents

Publication Publication Date Title
CN105079309B (en) Composition for relaxing bowel
CN111195314A (en) Traditional Chinese medicine composition for nourishing stomach and promoting digestion and preparation method thereof
WO2023109573A1 (en) Traditional chinese medicine composition for treating hashimoto&#39;s thyroiditis, and preparation method therefor
CN104435299B (en) A kind of Chinese medicine composition for improving the health care of sleep and preparation method thereof
CN106362020B (en) A kind of pine pollen composition and preparation method thereof with improvement defecating feces excretion
CN109999091A (en) A kind of preparation method and its usage of herbal paste, herbal paste
CN109078132B (en) Composition with blood sugar reducing function or auxiliary blood sugar reducing function and preparation method and application thereof
CN108785412B (en) Composition with function of improving sleep and preparation method thereof
CN101049440B (en) Preparation of Chinese traditional medicine in use for diabetes, and preparation method
CN116138454B (en) Fructus lycii medicinal and edible dual-purpose composition with constipation relieving effect and preparation method and application thereof
CN110269915B (en) Weight-losing and lipid-lowering composition and preparation method thereof
CN111317775A (en) Application of preparation for removing food retention and relieving cough for children in preparation of medicine for treating fever and preparation method thereof
CN107569612A (en) A kind of medicine for improving sleep and preparation method thereof
CN104435666B (en) Chinese medicine composition with functions of loosening bowel relieving constipation and its preparation method and application
CN111298021A (en) Traditional Chinese medicine composition for treating functional constipation
CN114306424B (en) Traditional Chinese medicine composition for treating obesity and preparation method and application thereof
CN113952419B (en) Pharmaceutical composition for chronic renal failure and preparation method and application thereof
CN109999088A (en) A kind of compound preparation and its application with effect of relaxing bowel
CN108936632A (en) A kind of krill fat capsule and preparation method thereof
CN109925356A (en) A kind of Chinese medicine composition, preparation and application thereof
CN113068829A (en) Health food for invigorating spleen, promoting digestion and improving immunity, and preparation method and application thereof
WO2021063016A1 (en) Composition with hypolipidemic function, preparation method therefor and application thereof
CN104757549B (en) One kind relaxes bowel composition
TW202010509A (en) Bowel relaxing composition and preparation method and application thereof
CN114259540B (en) Traditional Chinese medicine composition for treating diabetes with syndrome of deficiency of both qi and yin and preparation method and application thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant