CN116138260A - Sterilization composition containing penoxsulam and benzyl picoxystrobin - Google Patents
Sterilization composition containing penoxsulam and benzyl picoxystrobin Download PDFInfo
- Publication number
- CN116138260A CN116138260A CN202110831857.8A CN202110831857A CN116138260A CN 116138260 A CN116138260 A CN 116138260A CN 202110831857 A CN202110831857 A CN 202110831857A CN 116138260 A CN116138260 A CN 116138260A
- Authority
- CN
- China
- Prior art keywords
- benzyl
- picoxystrobin
- penoxsulam
- agent
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005818 Picoxystrobin Substances 0.000 title claims abstract description 59
- -1 benzyl picoxystrobin Chemical compound 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 239000005592 Penoxsulam Substances 0.000 title claims abstract description 24
- SYJGKVOENHZYMQ-UHFFFAOYSA-N Penoxsulam Chemical compound N1=C2C(OC)=CN=C(OC)N2N=C1NS(=O)(=O)C1=C(OCC(F)F)C=CC=C1C(F)(F)F SYJGKVOENHZYMQ-UHFFFAOYSA-N 0.000 title claims abstract description 24
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 10
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 8
- 201000010099 disease Diseases 0.000 claims abstract description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 30
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 28
- 239000004480 active ingredient Substances 0.000 claims abstract description 23
- 239000003795 chemical substances by application Substances 0.000 claims description 23
- 235000007164 Oryza sativa Nutrition 0.000 claims description 20
- 235000009566 rice Nutrition 0.000 claims description 20
- 239000000375 suspending agent Substances 0.000 claims description 16
- 240000008067 Cucumis sativus Species 0.000 claims description 12
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims description 12
- 241000196324 Embryophyta Species 0.000 claims description 8
- 239000004562 water dispersible granule Substances 0.000 claims description 8
- 239000004563 wettable powder Substances 0.000 claims description 7
- 239000002270 dispersing agent Substances 0.000 claims description 6
- 239000000080 wetting agent Substances 0.000 claims description 6
- 235000013339 cereals Nutrition 0.000 claims description 5
- 239000003381 stabilizer Substances 0.000 claims description 5
- 235000013311 vegetables Nutrition 0.000 claims description 5
- 230000000149 penetrating effect Effects 0.000 claims description 4
- 239000002518 antifoaming agent Substances 0.000 claims description 3
- 230000000855 fungicidal effect Effects 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 2
- 239000000945 filler Substances 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 1
- 239000003090 pesticide formulation Substances 0.000 claims 1
- 239000000575 pesticide Substances 0.000 abstract description 11
- 230000002829 reductive effect Effects 0.000 abstract description 6
- 206010059866 Drug resistance Diseases 0.000 abstract description 4
- 239000012752 auxiliary agent Substances 0.000 abstract description 4
- 238000013329 compounding Methods 0.000 abstract description 3
- 230000003111 delayed effect Effects 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 29
- WKBPZYKAUNRMKP-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)pentyl]1,2,4-triazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1C(CCC)CN1C=NC=N1 WKBPZYKAUNRMKP-UHFFFAOYSA-N 0.000 description 22
- 239000005813 Penconazole Substances 0.000 description 22
- 230000000694 effects Effects 0.000 description 20
- 238000002360 preparation method Methods 0.000 description 19
- 241000209094 Oryza Species 0.000 description 18
- GOFJDXZZHFNFLV-UHFFFAOYSA-N 5-fluoro-1,3-dimethyl-N-[2-(4-methylpentan-2-yl)phenyl]pyrazole-4-carboxamide Chemical compound CC(C)CC(C)C1=CC=CC=C1NC(=O)C1=C(F)N(C)N=C1C GOFJDXZZHFNFLV-UHFFFAOYSA-N 0.000 description 14
- 239000005815 Penflufen Substances 0.000 description 14
- 239000003814 drug Substances 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 230000001988 toxicity Effects 0.000 description 8
- 231100000419 toxicity Toxicity 0.000 description 8
- 210000004027 cell Anatomy 0.000 description 7
- 229940079593 drug Drugs 0.000 description 5
- 210000005069 ears Anatomy 0.000 description 5
- 239000001963 growth medium Substances 0.000 description 5
- 239000003899 bactericide agent Substances 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 230000002195 synergetic effect Effects 0.000 description 4
- 239000005740 Boscalid Substances 0.000 description 3
- 241000219112 Cucumis Species 0.000 description 3
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 229940118790 boscalid Drugs 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 241000123650 Botrytis cinerea Species 0.000 description 2
- 241001330975 Magnaporthe oryzae Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 206010035148 Plague Diseases 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
- 229940122840 Succinic dehydrogenase inhibitor Drugs 0.000 description 2
- 241000607479 Yersinia pestis Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 2
- 235000021186 dishes Nutrition 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- LRMHFDNWKCSEQU-UHFFFAOYSA-N ethoxyethane;phenol Chemical compound CCOCC.OC1=CC=CC=C1 LRMHFDNWKCSEQU-UHFFFAOYSA-N 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000000417 fungicide Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- IBSNKSODLGJUMQ-SDNWHVSQSA-N picoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC(C(F)(F)F)=N1 IBSNKSODLGJUMQ-SDNWHVSQSA-N 0.000 description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 229920005606 polypropylene copolymer Polymers 0.000 description 2
- CRFYLQMIDWBKRT-LPYMAVHISA-N pyribencarb Chemical compound C1=C(Cl)C(CNC(=O)OC)=CC(C(\C)=N\OCC=2N=C(C)C=CC=2)=C1 CRFYLQMIDWBKRT-LPYMAVHISA-N 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 229940083037 simethicone Drugs 0.000 description 2
- 239000002002 slurry Substances 0.000 description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 235000002245 Penicillium camembertii Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000012271 agricultural production Methods 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- PUJDIJCNWFYVJX-UHFFFAOYSA-N benzyl carbamate Chemical group NC(=O)OCC1=CC=CC=C1 PUJDIJCNWFYVJX-UHFFFAOYSA-N 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
- GTCAXTIRRLKXRU-UHFFFAOYSA-N carbamic acid methyl ester Natural products COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000011229 interlayer Substances 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000010902 jet-milling Methods 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 210000001589 microsome Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000027756 respiratory electron transport chain Effects 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
- 239000004016 soil organic matter Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention belongs to the technical field of pesticide compounding, and particularly relates to a sterilization composition containing penoxsulam and benzyl picoxystrobin and application thereof, wherein active ingredients of the sterilization composition comprise penoxsulam and benzyl picoxystrobin, and the mass ratio of the active ingredients of penoxsulam to benzyl picoxystrobin is 50:1-1:50. The bactericidal composition disclosed by the invention comprises an active ingredient and an agriculturally acceptable auxiliary agent. When the bactericidal composition is used for preventing and treating plant diseases, the dosage can be reduced, the bactericidal effect is good, the bactericidal spectrum is enlarged, and the drug resistance of the diseases is delayed.
Description
Technical Field
The invention belongs to the technical field of pesticide compounding, and particularly relates to a bactericidal composition containing penconazole and benzyl picoxystrobin and application thereof.
Background
Penflufen (fluididapyr) has the chemical name: 3- (difluoromethyl) -N- [ (3 RS) -7-fluoro-2, 3-dihydro-1, 3-trimethyl-1H-inden-4-yl]-1-methyl-1H-pyrazole-4-carboxamide, CAS accession no: 1383809-87-7, molecular formula: c (C) 18 H 20 F 3 N 3 O has the following structural formula:
penflufen is a novel pyrazole amide fungicide commonly developed by Isagro and Fumei company of America, is a succinic dehydrogenase inhibitor (SDHI) fungicide, has interlayer conduction and top conduction effects on plant leaves, and provides protective sterilization effects.
The chemical name of benzyl picoxystrobin (pyribencarb) is: { 2-chloro-5- [ (E) -1- (6-methyl-2-pyridylmethoxyimino) ethyl]Benzyl } methyl carbamate, CAS accession number: 799247-52-2 with molecular formula of C 18 H 20 ClN 3 O 3 The structural formula is as follows:
the benzyl picoxystrobin is a novel bactericide with a benzyl carbamate structure, and the bactericide plays roles in preventing pathogenic spores from germinating and preventing infection of hosts after the spores germinate by destroying an electron transfer system of microsomes in pathogenic bacteria cells.
The rice blast is one of important diseases of rice, can cause great yield reduction, 40% -50% yield reduction when serious, and even no granule harvest. The rice areas of the world occur uniformly. The disease occurs in various places, wherein the occurrence of leaf and node is more, and the occurrence of the disease can cause yield reduction in different degrees, especially the occurrence of neck plague or node plague is early and heavy, and white ears can cause absolute production.
The gray mold of cucumber is caused by the infection of fungus Botrytis cinerea, which initially generates water stain-like disease spots on pedicel, gradually grows gray mold layer, causes the flower organ to soften, shrink and rot, gradually expands to young melon, and later generates white mold and gradually turns light gray, which causes the growth of the melon to stop, soften, rot and shrink, and finally decays and falls off. When the leaves are infected, the disease spots are initially water-stained, become light brown disease spots with irregular shapes, the edges are obvious, and a small amount of gray brown mildew layers sometimes grow on the disease spots. Under the high humidity condition, the disease spots are rapidly expanded to form large disease spots with the diameters of 15-20 mm; after the stem is infected, the stem is rotten, the melon vine is broken, and rotten seedling is caused. Gray mold of cucumber is one of the main diseases causing cucumber yield reduction.
The frequent use of bactericides containing a single active ingredient causes the occurrence of drug resistance of most pathogens, so that the application amount of pesticides is higher and higher, and the environmental pollution is caused. The experimental study shows that the penflufen and the benzyl picoxystrobin are mixed, so that the penflufen and the benzyl picoxystrobin have obvious synergistic effect within a certain range, the drug resistance of diseases can be well overcome, the drug effect is improved, the pesticide application amount is reduced, and the economic loss is reduced.
Disclosure of Invention
The invention aims to provide a sterilizing composition which has a synergistic effect and is safe and environment-friendly so as to meet the requirements of agricultural production and achieve the purposes of improving the drug effect, reducing the cost and reducing the pollution, and particularly relates to a sterilizing composition containing active ingredients of penflufen and benzyl picoxystrobin.
It is another object of the present invention to provide the use of the above composition for controlling plant diseases.
In order to overcome the defects of the existing single preparation, the technical scheme of the invention is as follows:
the bactericidal composition containing the penoxsulam and the benzyl picoxystrobin comprises the active ingredients of penoxsulam and benzyl picoxystrobin, wherein the mass ratio of the active ingredients of penoxsulam to benzyl picoxystrobin is 50:1-1:50;
further, the mass ratio of the active ingredients of the penflufen to the benzyl picoxystrobin is 1:50, 20:1, 10:1, 5:1, 2:1, 1:1, 2:1, 5:1, 10:1, 20:1 and 50:1;
further, the mass ratio of the active ingredients of the penoxsulam to the benzyl picoxystrobin is 10:1-1:20;
further, the mass ratio of the active ingredients of the penflufen to the benzyl picoxystrobin is 5:1-1:10;
further, the bactericidal composition comprises 1% -90% of the total mass of the penconazole and the penconazole;
further, the bactericidal composition comprises 10% -80% of the total mass of the penconazole and the penconazole;
further, the bactericidal composition contains an active ingredient and also contains pesticide preparation auxiliary ingredients so as to prepare a dosage form suitable for agricultural use;
further, the bactericidal composition contains one or more of auxiliary components of pesticide preparations selected from a filler, a carrier, a solvent, an emulsifier, a wetting agent, a dispersing agent, a penetrating agent, an adhesive, a stabilizer, a synergist, a defoamer, an antifreezing agent, a preservative and a warning color;
further, the bactericidal composition can be prepared into any formulation suitable for agriculture by a known method;
furthermore, the dosage form of the bactericidal composition is preferably suspending agent, water dispersible granule, wettable powder and the like;
when the bactericidal composition is a suspending agent, the sum of the active ingredients is 5-80%, preferably 20-60%; the auxiliary components comprise 0.1-30% of wetting agent, 0.1-30% of dispersing agent, 0.3-30% of penetrating agent, 0.5-10% of stabilizing agent, 1-10% of antifreezing agent, 1-10% of defoaming agent, 0.5-3% of preservative agent and 100% of deionized water;
when the bactericidal composition is water dispersible granules, the sum of the active ingredients is 10% -90%, preferably 20% -80%; the auxiliary components comprise 0.1-30% of wetting agent, 0.1-10% of dispersing agent, 0.1-15% of disintegrating agent, 0.1-20% of stabilizing agent, 0.1-15% of binder and 100% of carrier;
when the bactericidal composition is wettable powder, the sum of the active ingredients is 1-90%, preferably 10-80%; the auxiliary components comprise 0.1-30% of wetting agent, 0.1-30% of dispersing agent, 0.3-30% of penetrating agent, 0.5-10% of stabilizing agent, 1-10% of defoaming agent and 100% of carrier;
further, the use of the bactericidal composition for controlling plant diseases;
further, the plants are vegetables and grain crops;
further, the vegetable crop is cucumber, and the grain crop is rice;
further, the diseases are gray mold and rice blast.
The bactericidal composition has the advantages that:
1) Compared with a single agent, the compound has obvious synergistic effect, and the control effect is improved;
2) The bactericidal composition consists of two active ingredients with different action mechanisms, and is beneficial to overcoming and delaying the generation of drug resistance of germs;
3) The dosage is reduced by mixing the medicaments, so that the cost is reduced and the pollution to the environment is reduced.
Detailed Description
In order to make the technical problems, technical solutions and advantages to be solved by the embodiments of the present invention more apparent, specific embodiments will be described in detail below, but the present invention is by no means limited to the embodiments listed in the present specification. It should be noted that any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Preparation example
Preparation example 1:40% penflufen-benzyl picoxystrobin suspension agent (1:1)
The weight percentages of the penconazole are 20 percent, the benzyl picoxystrobin is 20 percent, the phenol ether phosphate is 3 percent, the sodium polyacrylate is 1 percent, the alkylphenol ethoxylate is 1 percent, the copolymer of propylene oxide and ethylene oxide is 1.5 percent, the propylene glycol is 4 percent, the xanthan gum is 0.5 percent, the isothiazolinone is 0.5 percent, the simethicone is 0.5 percent, and the deionized water is the balance.
The preparation method comprises the following steps: according to the formula proportion, the active ingredients, the surfactant and other functional auxiliary agents are sequentially placed in a reaction kettle, water is added and mixed uniformly, high-speed shearing and wet sanding are carried out, and finally, the suspending agent is obtained by homogenizing and filtering.
Preparation example 2:30% penflufen-benzyl picoxystrobin suspension agent (1:2)
The weight percentages of the penconazole are 10 percent, the benzyl picoxystrobin is 20 percent, the phenol ether phosphate is 3 percent, the sodium polyacrylate is 1.5 percent, the fatty alcohol polyoxyethylene ether is 0.5 percent, the copolymer of propylene oxide and ethylene oxide is 1 percent, the ethylene glycol is 3 percent, the xanthan gum is 0.8 percent, the isothiazolinone is 0.5 percent, the simethicone is 0.5 percent, and the rest is deionized water.
The preparation method comprises the following steps: the same as in preparation example 1.
Preparation example 3:30% penconazole and benzyl picoxystrobin water dispersible granule (1:5)
According to the weight percentage, 5 percent of penconazole, 25 percent of benzyl picoxystrobin, 3 percent of sodium lignin sulfonate, 2.5 percent of polyoxyethylene formaldehyde condensate, 3 percent of nekal BX, 4 percent of polyvinylpyrrolidone, 1.5 percent of sodium benzoate, 1 percent of cellulose and the balance of diatomite are added.
The preparation method comprises the following steps: metering according to the formula proportion, grinding penconazole, benzyl boscalid, dispersing agent, wetting agent, disintegrating agent and the like in water to obtain the particle size of 180 mu m, adding other auxiliary agents, adjusting the concentration and viscosity to obtain slurry for spraying, and sending the obtained slurry into a drying tower for spray drying to obtain the required water dispersible granule.
Preparation example 4:24% penconazole and benzyl picoxystrobin water dispersible granule (1:2)
According to the weight percentage, 8 percent of penconazole, 16 percent of benzyl picoxystrobin, 3 percent of sodium dodecyl sulfate, 2 percent of calcium dodecyl benzene sulfonate, 2 percent of fatty alcohol polyoxyethylene ether, 3 percent of gelatin, 1 percent of polyethylene glycol, 1.5 percent of sodium alginate and the balance of white carbon black.
The preparation method comprises the following steps: the same as in preparation example 3.
Preparation example 5:14% penflufen-benzyl picoxystrobin wettable powder (1:1)
The weight percentages of the penconazole are 7%, the benzyl picoxystrobin is 7%, the sodium dodecyl sulfate is 2.5%, the calcium lignosulfonate is 3%, the ethylene oxide is 1%, and the diatomite is the balance.
The preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients of the penconazole and the benzyl picoxystrobin are added into a carrier, and a surfactant and other functional auxiliary agents are added into the carrier for mixing, and the wettable powder is prepared by mixing after jet milling.
Indoor Activity test
Example 1: indoor combined virulence effect of penflufen and benzyl picoxystrobin on rice blast
The test is based on: ny/T1156.2-2006 section 2 of pesticide, section 2 of biological assay test criteria in pesticide: test Petri dish method for inhibiting growth of pathogenic fungi, NY/T1156.6-2006, section 6 of laboratory biological assay protocol for pesticides: determination of the combined action of compounding.
Test material: the test pathogen was Pyricularia oryzae (Pyricularia oryzae cav.).
Test agent: 95% of penflufen and 96% of benzyl picoxystrobin are provided by a group development center.
And (3) preparation of a medicament: the crude drug was dissolved in DMF, diluted with 0.1% tween 80 in water, and 5 series of mass concentrations were set according to the drug activity.
Preparation of a culture medium: the AEA culture medium is quantitatively packaged in glass bottles before solidification, and sterilized at high temperature. Under the aseptic operation condition, sequentially adding 1mL of corresponding mother liquor to be tested into 39mL of quantitative sterilization AEA culture medium (the temperature is 50-55 ℃) which is heated and melted by each bottle from low concentration to high concentration by using a micropipette, fully shaking uniformly, and subpackaging into 4 culture dishes with the diameter of 9cm to prepare a medicine-containing flat plate with corresponding concentration. Blank plates were prepared in medium.
The test method comprises the following steps: under aseptic conditions, the patties were cut from the edges of their colonies using a sterilized punch having an inner diameter of 0.5 cm. Transferring the bacterial cake to the center of the culture medium with medicine, placing one bacterial cake in each culture dish with the mycelium surface facing downwards (the mycelium surface is contacted with the culture medium), placing the culture dishes after bacterial inoculation into an SPJ-250B biochemical incubator, culturing for 9d at 28 ℃, measuring the colony diameter, calculating the percentage of inhibiting mycelium growth by each medicine treatment, and calculating EC by linear regression analysis between the numerical value of the inhibition rate and the logarithmic value of the series concentration 50 。
The interaction of the mixed medicines is calculated according to the grand cloud Pei method: CTC is less than or equal to 80 and antagonism, CTC is more than or equal to 120 and synergy, CTC is between 80 and 120 and additive effect.
The calculation mode is as follows:
hypha growth inhibition ratio (%) = [ (control colony growth diameter-agent-treated colony growth diameter)/control colony growth diameter]X 100 actual measurement of the mixtureVirulence index (ATI) = (EC of standard agent 50 EC of the mixture 50 )×100
Theoretical Toxicity Index (TTI) of the mixture=toxicity index of agent a×percentage of agent a in the mixture+toxicity index of agent b×percentage of agent B in the mixture
Co-toxicity coefficient (CTC) = [ actual toxicity index of the mixture (ATI)/theoretical toxicity index of the mixture (TTI) ]100
Test results:
TABLE 1 indoor Combined toxicity of penflufen and benzyl picoxystrobin to Rice blast
As can be seen from Table 1, the toxicity of penconazole and benzyl picoxystrobin to rice blast is high, and the EC50 values are 1.448mg/L and 0.535mg/L respectively. The control effects of the penconazole and the benzyl picoxystrobin mixture with different weight ratios on rice blast are different, and CTC analysis shows that the penconazole and the benzyl picoxystrobin have synergistic effects according to the ratio of 10:1-1:20. When the proportion of the penoxsulam to the benzyl picoxystrobin is 5:1-1:10, the co-toxicity coefficient is greater than 130, and under the condition of in-vitro culture, the penoxsulam and the benzyl picoxystrobin are most obvious in the proportion of 1:2, and the co-toxicity coefficient is 196.338 at most.
Verification of field efficacy
Example 2: the penflufen and the benzyl boscalid are mixed to have the field efficacy on the rice blast.
The test is based on: GB/T17980.19-2000 "pesticide field efficacy test criterion (one)" Bactericide for controlling rice leaf diseases ".
Test object: rice blast germ.
Test crop: rice (Long Nuo 496).
Test site: the soil organic matter content of the paddy field in the Longxi Zhenjin pit of the Linchuan area of Fuzhou, jiangxi province is 2.20%, the pH value is 5.4, the fertility is moderate, and the cultivation conditions of all the communities are tested to be uniform and consistent, and the agricultural practice of local science is met.
Test agent: 14% of penoxsulam and benzyl picoxystrobin wettable powder (1:1), 30% of penoxsulam and benzyl picoxystrobin water dispersible granule (1:5), 30% of penoxsulam and benzyl picoxystrobin suspending agent (1:2), 42% of penoxsulam suspending agent and 20% of benzyl picoxystrobin suspending agent, and setting clear water control.
The test method comprises the following steps: according to the dosage of the test agent (see Table 2), the spray is uniformly sprayed at the initial stage of rice blast, and the area of each cell is 30m 2 The construction stems among the cells are separated according to the arrangement of the random block groups. Each treatment is repeated for 4 times, a five-point sampling method is adopted for each cell, 50 ears are taken for each point, and the total is 250 ears for each cell.
The investigation method comprises the following steps: drug efficacy was investigated at 7d and 14d after drug administration, and the total of 2 times was examined, and the classification was performed according to the following classification method.
The grading method comprises the following steps:
level 0: no disease;
stage 1: less than 5% loss per ear (individual stalk onset);
3 stages: 6-20% of loss per spike (about one third of the disease occurs);
5 stages: 21% -50% of loss per ear (incidence of neck or main axis of ear, half-shrunken grain);
7 stages: loss of 51% -70% per spike (neck disease, mostly shrunken grain);
stage 9: loss of 71-100% per spike (neck disease, white spike);
the calculation formula is as follows:
disease index = Σ100 [ (number of ears at each stage×relative number)/(total number of ears in investigation×9) ] ×100
Control effect (%) = (control spike rate-treatment zone spike rate)/control zone spike rate x 100
The test results are shown in Table 2:
TABLE 2 efficacy of penflufen and benzyl picoxystrobin in controlling rice blast 7d,14 d
The field efficacy shows that (see table 2) the mixed action of the penconazole and the benzyl boscalid shows obviously better antibacterial activity than single dose on rice blast. After the medicine is taken, the control effects of 7d,14% of penflufen-benzyl picoxystrobin wettable powder (1:1), 30% of penflufen-benzyl picoxystrobin water dispersible granule (1:5) and 30% of penflufen-benzyl picoxystrobin suspending agent (1:2) are all more than 80%; after the preparation is applied for 14 days, the control effect of each treatment medicament on rice blast is improved, wherein the control effect of 30% of penconazole and benzyl picoxystrobin suspending agents (1:2) is the best, and the control effect is 87.12%.
Example 3: penflufen and benzyl picoxystrobin mixed pesticide effect on cucumber gray mold in field
The test is based on: the test is based on GB/T17980.28-2000 pesticide field efficacy test criterion (I) for controlling vegetable gray mold.
Test object: botrytis cinerea.
Test crop: cucumber (Xintaimi thorns).
Test site: high Meng Cun cucumber field in Xintai, shandong province. The cultivation conditions of all the test communities are uniform and consistent, and the cultivation conditions are in accordance with the local scientific agricultural practice.
Test agent: 42% of penoxsulam suspending agent, 20% of benzyl picoxystrobin suspending agent, 30% of penoxsulam benzyl picoxystrobin suspending agent (1:2), 40% of penoxsulam benzyl picoxystrobin suspending agent (1:1) and clear water control.
The test method comprises the following steps: test setting according to the set dosage of test agent (see Table 3), cells of test agent, control agent and blank control are arranged in random group, and each cell has an area of 20m 2 Each treatment was repeated 4 times, spraying was performed 1 time at the initial stage of cucumber gray mold, the cardinal number was investigated before spraying, and the number of leaves was investigated 7 days after spraying. Sampling at 5 points in each district, investigating 2 plants in each district, investigating all leaves of each plant of cucumber, and grading and recording each leaf according to the number of lesions.
The grading method comprises the following steps:
grade 0 is no disease spots;
the level 1 is 3 single leaves with lesions;
the level 3 is that 4 to 6 single leaves have disease spots;
the 5-level single-leaf has 7-10 disease spots;
the 7 level is that single leaves have 11 to 20 disease spots and are partially condensed into slices;
the grade 9 is that the single leaf has more than one fourth of the densely occupied leaf area of the disease spots.
The calculation formula is as follows:
disease index = Σ100 [ (number of leaves at each stage×number of relative stages)/(total number of leaves in investigation×9) ] ×100
Control effect (%) = [1- (pre-treatment area dosing index x treatment area post-dosing index)/(post-treatment area dosing index x treatment area pre-dosing index) ]x100
The test results are shown in Table 3:
table 3 field control effects of penflufen and benzyl picoxystrobin in controlling cucumber gray mold
The field efficacy shows (see table 3), the prevention and treatment effects of the penconazole and the benzyl picoxystrobin are higher than that of a single dose under the same environment, the prevention and treatment effects are over 80%, wherein the prevention and treatment effects of 30% of penconazole and benzyl picoxystrobin suspending agent (1:2) are the best after-drug 7d, and the prevention and treatment effects are 84.02%.
In conclusion, through indoor toxicity measurement and field efficacy tests, the bactericidal composition containing the penconazole and the benzyl picoxystrobin has good control effects on rice blast and cucumber gray mold, is safe to target crops, has obvious control effects, can effectively reduce cost and reduce medicament residues.
Claims (10)
1. The bactericidal composition containing the penoxsulam and the benzyl picoxystrobin is characterized by comprising active ingredients of penoxsulam and benzyl picoxystrobin, wherein the mass ratio of the active ingredients of penoxsulam to benzyl picoxystrobin is 50:1-1:50.
2. The bactericidal composition of claim 1, wherein the mass ratio of the active ingredients of the penoxsulam to the benzyl picoxystrobin is 10:1-1:20.
3. The bactericidal composition of claim 1, wherein the mass ratio of the active ingredients of the penoxsulam to the benzyl picoxystrobin is 5:1-1:10.
4. The bactericidal composition according to claim 1, characterized in that the sum of the active ingredients penoxsulam and benzyl picoxystrobin mass is 1% -90%, preferably 10% -80% of the composition.
5. The composition of any one of claims 1 to 4, wherein the composition further comprises an auxiliary ingredient containing a pesticide formulation in addition to the active ingredient, to be formulated into a formulation suitable for agricultural use.
6. The composition of claim 5, wherein the auxiliary component is selected from one or more of a filler, a carrier, a solvent, an emulsifier, a wetting agent, a dispersant, a penetrating agent, an adhesive, a stabilizer, a synergist, an antifoaming agent, an antifreezing agent, a preservative, and a warning color.
7. The sterilization composition according to claim 5, wherein the sterilization composition is preferably in the form of suspending agent, wettable powder or water dispersible granule.
8. Use of the fungicidal composition according to any one of claims 1 to 7 for controlling plant diseases.
9. The use according to claim 8, wherein the plant is a vegetable or food crop; the vegetable crop is cucumber, and the grain crop is rice.
10. The use according to claim 8, wherein the disease is gray mold or rice blast.
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