CN116113708A - 用于检测肺癌的组合物和方法 - Google Patents

用于检测肺癌的组合物和方法 Download PDF

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Publication number
CN116113708A
CN116113708A CN202180054264.3A CN202180054264A CN116113708A CN 116113708 A CN116113708 A CN 116113708A CN 202180054264 A CN202180054264 A CN 202180054264A CN 116113708 A CN116113708 A CN 116113708A
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polypeptide
biomarker
target
lung cancer
rna
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CN202180054264.3A
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Chinese (zh)
Inventor
J·C·塞德拉克
L·T·博尔托林
D·P·塞勒姆
E·S·温-德恩
D·古森莱特内尔
A·D·库维朗
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Mercy Bioanalytics Inc
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Mercy Bioanalytics Inc
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Publication of CN116113708A publication Critical patent/CN116113708A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5752—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the lungs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
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  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN202180054264.3A 2020-07-08 2021-07-08 用于检测肺癌的组合物和方法 Pending CN116113708A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063049538P 2020-07-08 2020-07-08
US63/049,538 2020-07-08
PCT/US2021/040971 WO2022011197A1 (en) 2020-07-08 2021-07-08 Compositions and methods for detection of lung cancer

Publications (1)

Publication Number Publication Date
CN116113708A true CN116113708A (zh) 2023-05-12

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CN202180054264.3A Pending CN116113708A (zh) 2020-07-08 2021-07-08 用于检测肺癌的组合物和方法

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US (1) US20240011993A1 (enExample)
EP (1) EP4179106A4 (enExample)
JP (1) JP2023533970A (enExample)
KR (1) KR20230044429A (enExample)
CN (1) CN116113708A (enExample)
AU (1) AU2021305652A1 (enExample)
CA (1) CA3188377A1 (enExample)
WO (1) WO2022011197A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116593693A (zh) * 2023-07-11 2023-08-15 四川大学华西医院 一种磁性适配体探针、其制备方法和应用及迁移体富集方法
CN116855605A (zh) * 2023-06-13 2023-10-10 中国医学科学院北京协和医院 Aoc1作为区分卵巢透明细胞癌和高级别浆液性癌的标志物的应用
CN117741153A (zh) * 2023-11-07 2024-03-22 南京联笃生物科技有限公司 一种用于多癌种早期筛查、诊断和/或监测的生物标志物及应用
CN118460477A (zh) * 2024-07-09 2024-08-09 苏州唯思尔康科技有限公司 一种特别适于内载有效货物的外泌体支架蛋白及其应用
CN119798401A (zh) * 2024-12-30 2025-04-11 常州因普迈生物科技有限公司 基于pdzk1ip1蛋白的多肽、抗体及其应用
CN120102887A (zh) * 2025-05-10 2025-06-06 浙江格物致知生物科技有限公司 一种检测肺癌的联检产品及其应用

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* Cited by examiner, † Cited by third party
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US12480940B2 (en) 2018-05-17 2025-11-25 Meso Scale Technologies, Llc. Methods for isolating surface marker displaying agents
CN114875144B (zh) * 2022-04-02 2026-04-17 及智(苏州)医学技术有限公司 用于评估肿瘤ibc疗法的疗效的生物标志物、系统、方法及试剂盒
WO2023212315A2 (en) * 2022-04-29 2023-11-02 Meso Scale Technologies, Llc. Methods for detecting and isolating extracellular vesicles
US20240309453A1 (en) * 2023-03-13 2024-09-19 Northwestern University Diagnosis of acute and chronic lung diseases by quantifying spink1 level
KR102752505B1 (ko) * 2024-04-23 2025-01-16 주식회사 이롬 다중오믹스 기반 폐암 진단용 바이오 마커 패널 및 이를 이용한 폐암 진단방법

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US20160003835A1 (en) * 2012-10-23 2016-01-07 Caris Life Sciences Switzerland Holdings S.A.R.L. Aptamers and uses thereof
EP3268476A1 (en) * 2015-03-09 2018-01-17 Caris Science, Inc. Oligonucleotide probes and uses thereof
US20180312901A1 (en) * 2015-10-21 2018-11-01 Olink Proteomics Ab Method for generating proximity probes
US20190219578A1 (en) * 2018-01-18 2019-07-18 Nanosomix, Inc. Dectection of exosomes and exosomal biomarkers for the diagnosis and prognosis of diseases and disorders
CN110954703A (zh) * 2019-12-27 2020-04-03 杭州迪相实业有限公司 一种同时检测外泌体内蛋白和rna、外泌体膜蛋白的方法

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WO2010056337A2 (en) * 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
EP2542696B1 (en) * 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarkers for theranostics
AU2013361323B2 (en) * 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
GB201511546D0 (en) * 2015-07-01 2015-08-12 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
JP7137474B2 (ja) * 2016-03-15 2022-09-14 メルサナ セラピューティクス，インコーポレイティド ＮａＰｉ２ｂ標的化抗体－薬物コンジュゲート及びその使用方法
JP2019168223A (ja) * 2016-08-12 2019-10-03 公立大学法人和歌山県立医科大学 エクソソームの膜に存在するタンパク質の検出方法
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US20160003835A1 (en) * 2012-10-23 2016-01-07 Caris Life Sciences Switzerland Holdings S.A.R.L. Aptamers and uses thereof
EP3268476A1 (en) * 2015-03-09 2018-01-17 Caris Science, Inc. Oligonucleotide probes and uses thereof
US20180312901A1 (en) * 2015-10-21 2018-11-01 Olink Proteomics Ab Method for generating proximity probes
US20190219578A1 (en) * 2018-01-18 2019-07-18 Nanosomix, Inc. Dectection of exosomes and exosomal biomarkers for the diagnosis and prognosis of diseases and disorders
CN110954703A (zh) * 2019-12-27 2020-04-03 杭州迪相实业有限公司 一种同时检测外泌体内蛋白和rna、外泌体膜蛋白的方法

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GHOLAMREZA TAVOOSIDANA等: "Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer", PNAS, vol. 108, 24 May 2011 (2011-05-24), pages 8809 *
俞鹏翼等: "活化白细胞黏附分子、癌胚抗原相关细胞黏附分子在 非小细胞肺癌组织中的表达及对预后影响", 临床荟萃, vol. 30, 5 August 2015 (2015-08-05), pages 870 - 874 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116855605A (zh) * 2023-06-13 2023-10-10 中国医学科学院北京协和医院 Aoc1作为区分卵巢透明细胞癌和高级别浆液性癌的标志物的应用
CN116593693A (zh) * 2023-07-11 2023-08-15 四川大学华西医院 一种磁性适配体探针、其制备方法和应用及迁移体富集方法
CN116593693B (zh) * 2023-07-11 2023-09-19 四川大学华西医院 一种磁性适配体探针、其制备方法和应用及迁移体富集方法
CN117741153A (zh) * 2023-11-07 2024-03-22 南京联笃生物科技有限公司 一种用于多癌种早期筛查、诊断和/或监测的生物标志物及应用
CN118460477A (zh) * 2024-07-09 2024-08-09 苏州唯思尔康科技有限公司 一种特别适于内载有效货物的外泌体支架蛋白及其应用
CN119798401A (zh) * 2024-12-30 2025-04-11 常州因普迈生物科技有限公司 基于pdzk1ip1蛋白的多肽、抗体及其应用
CN120102887A (zh) * 2025-05-10 2025-06-06 浙江格物致知生物科技有限公司 一种检测肺癌的联检产品及其应用
CN120102887B (zh) * 2025-05-10 2025-07-25 浙江格物致知生物科技有限公司 一种检测肺癌的联检产品及其应用

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AU2021305652A1 (en) 2023-02-23
EP4179106A4 (en) 2024-10-23
JP2023533970A (ja) 2023-08-07
EP4179106A1 (en) 2023-05-17
CA3188377A1 (en) 2022-01-13
WO2022011197A1 (en) 2022-01-13
US20240011993A1 (en) 2024-01-11
KR20230044429A (ko) 2023-04-04

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