CN116113696A - 基因编辑以改善关节功能 - Google Patents

基因编辑以改善关节功能 Download PDF

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Publication number
CN116113696A
CN116113696A CN202180054064.8A CN202180054064A CN116113696A CN 116113696 A CN116113696 A CN 116113696A CN 202180054064 A CN202180054064 A CN 202180054064A CN 116113696 A CN116113696 A CN 116113696A
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gene
exon
guide rna
sequence
seq
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CN202180054064.8A
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Chinese (zh)
Inventor
彼得·J·米利特
伊恩·阿拉斯代尔·拉塞尔
马修·J·艾伦
乔治·根茨
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Ozer Biotherapy Co
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Ozer Biotherapy Co
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14011—Parvoviridae
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Animal Behavior & Ethology (AREA)
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CN202180054064.8A 2020-07-16 2021-07-16 基因编辑以改善关节功能 Pending CN116113696A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063052881P 2020-07-16 2020-07-16
US63/052,881 2020-07-16
US202063055808P 2020-07-23 2020-07-23
US63/055,808 2020-07-23
PCT/US2021/042100 WO2022016121A2 (en) 2020-07-16 2021-07-16 Gene editing to improve joint function

Publications (1)

Publication Number Publication Date
CN116113696A true CN116113696A (zh) 2023-05-12

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CN202180054064.8A Pending CN116113696A (zh) 2020-07-16 2021-07-16 基因编辑以改善关节功能

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US (1) US20230257779A1 (https=)
EP (1) EP4182461A4 (https=)
JP (1) JP2023535351A (https=)
KR (1) KR20230041729A (https=)
CN (1) CN116113696A (https=)
AU (1) AU2021308079A1 (https=)
BR (1) BR112023000738A2 (https=)
CA (1) CA3186119A1 (https=)
IL (1) IL299846A (https=)
MX (1) MX2023000671A (https=)
WO (2) WO2022016100A2 (https=)

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Publication number Priority date Publication date Assignee Title
EP4694913A2 (en) * 2023-04-11 2026-02-18 Orthobio Therapeutics, Inc. Lipid nanoparticles for gene editing systems
WO2025024814A2 (en) * 2023-07-26 2025-01-30 Orthobio Therapeutics, Inc. Transmembrane receptor gene editing
CN117448379A (zh) * 2023-12-22 2024-01-26 上海元戊医学技术有限公司 iPSC来源的IL-10蛋白过表达MSC细胞株的构建方法及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9711040D0 (en) * 1997-05-29 1997-07-23 Duff Gordon W Prediction of inflammatory disease
WO2005077333A2 (en) * 2004-02-10 2005-08-25 University Of Florida Research Foundation, Inc. Gel-based delivery of recombinant adeno-associated virus vectors
US20160279202A1 (en) * 2013-10-31 2016-09-29 Ramot At Tel-Aviv University Ltd. Interleukin-1 (il-1) inhibitors for treating fertility disorders
US20170240901A1 (en) * 2014-02-26 2017-08-24 The University Of Liverpool Nucleic acids, and uses therof
US20170335331A1 (en) * 2014-10-31 2017-11-23 The Trustees Of The University Of Pennsylvania Altering Gene Expression in CART Cells and Uses Thereof
WO2017223107A1 (en) * 2016-06-20 2017-12-28 Unity Biotechnology, Inc. Genome modifying enzyme therapy for diseases modulated by senescent cells
WO2018031950A1 (en) * 2016-08-12 2018-02-15 Caribou Biosciences, Inc. Protein engineering methods

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Publication number Publication date
IL299846A (en) 2023-03-01
WO2022016100A2 (en) 2022-01-20
JP2023535351A (ja) 2023-08-17
US20230257779A1 (en) 2023-08-17
WO2022016100A3 (en) 2022-03-17
MX2023000671A (es) 2023-05-16
BR112023000738A2 (pt) 2023-03-21
AU2021308079A8 (en) 2023-03-16
WO2022016121A3 (en) 2022-03-10
EP4182461A4 (en) 2025-03-19
KR20230041729A (ko) 2023-03-24
WO2022016121A2 (en) 2022-01-20
AU2021308079A1 (en) 2023-03-02
EP4182461A2 (en) 2023-05-24
CA3186119A1 (en) 2022-01-20

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