CN116113440A - Actrii-alk4拮抗剂和治疗心力衰竭的方法 - Google Patents

Actrii-alk4拮抗剂和治疗心力衰竭的方法 Download PDF

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Publication number
CN116113440A
CN116113440A CN202180056305.2A CN202180056305A CN116113440A CN 116113440 A CN116113440 A CN 116113440A CN 202180056305 A CN202180056305 A CN 202180056305A CN 116113440 A CN116113440 A CN 116113440A
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amino acid
seq
acid sequence
domain
polypeptide comprises
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CN202180056305.2A
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Chinese (zh)
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R·N·V·S·苏拉加尼
J·李
P·安德烈
R·库马尔
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • C07K14/475—Growth factors; Growth regulators
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CN202180056305.2A 2020-06-17 2021-06-16 Actrii-alk4拮抗剂和治疗心力衰竭的方法 Pending CN116113440A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063040400P 2020-06-17 2020-06-17
US63/040,400 2020-06-17
US202163159003P 2021-03-10 2021-03-10
US63/159,003 2021-03-10
PCT/US2021/037557 WO2021257655A1 (en) 2020-06-17 2021-06-16 Actrii-alk4 antagonists and methods of treating heart failure

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CN116113440A true CN116113440A (zh) 2023-05-12

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CN202180056305.2A Pending CN116113440A (zh) 2020-06-17 2021-06-16 Actrii-alk4拮抗剂和治疗心力衰竭的方法

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US (1) US20240252628A1 (https=)
EP (1) EP4168036A4 (https=)
JP (1) JP2023534127A (https=)
KR (1) KR20230025432A (https=)
CN (1) CN116113440A (https=)
AU (1) AU2021293908A1 (https=)
BR (1) BR112022025473A2 (https=)
CA (1) CA3182523A1 (https=)
MX (1) MX2022016243A (https=)
WO (1) WO2021257655A1 (https=)

Cited By (1)

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CN118671353A (zh) * 2024-05-30 2024-09-20 中国人民解放军总医院第一医学中心 用于ais诊断的生物标志物及其应用

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KR102877920B1 (ko) 2015-11-16 2025-10-30 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 티틴-기반 근증 및 다른 티틴성병증의 치료를 위한 물질 및 방법
AR114350A1 (es) 2018-01-31 2020-08-26 Res Institute At Nationwide Children’S Hospital Terapia genética para la distrofia muscular de cinturas del tipo 2c
KR20210028162A (ko) 2018-06-29 2021-03-11 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 지대근 이영양증 2a형을 치료하기 위한 재조합 아데노 연관 바이러스 생성물 및 방법
AU2020229340A1 (en) 2019-02-26 2021-09-16 Research Institute At Nationwide Children's Hospital Adeno-associated virus vector delivery of B-sarcoglycan and the treatment of muscular dystrophy
RS65421B1 (sr) 2019-08-21 2024-05-31 Res Inst Nationwide Childrens Hospital Isporuka adeno-asociranog virusnog vektora alfa-sarkoglikana i lečenje mišićne distrofije
WO2022192411A1 (en) * 2021-03-10 2022-09-15 Acceleron Pharma Inc. Actrii-alk4 antagonists and methods of treating heart failure
JP2024511315A (ja) * 2021-03-10 2024-03-13 アクセルロン ファーマ インコーポレイテッド Ａｃｔｒｉｉ－ａｌｋ４アンタゴニスト及び心不全の治療方法
EP4219726A1 (en) * 2021-10-15 2023-08-02 Research Institute at Nationwide Children's Hospital Self-complementary adeno-associated virus vector and its use in treatment of muscular dystrophy

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CN107849114A (zh) * 2015-04-06 2018-03-27 阿塞勒隆制药公司 单臂i型和ii型受体融合蛋白和其用途
CN110678195A (zh) * 2016-10-05 2020-01-10 阿塞勒隆制药公司 ALK4:ActRIIB异多聚体及其用途

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CN107849114A (zh) * 2015-04-06 2018-03-27 阿塞勒隆制药公司 单臂i型和ii型受体融合蛋白和其用途
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Publication number Priority date Publication date Assignee Title
CN118671353A (zh) * 2024-05-30 2024-09-20 中国人民解放军总医院第一医学中心 用于ais诊断的生物标志物及其应用

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WO2021257655A1 (en) 2021-12-23
EP4168036A4 (en) 2024-07-17
CA3182523A1 (en) 2021-12-23
MX2022016243A (es) 2023-03-08
US20240252628A1 (en) 2024-08-01
AU2021293908A1 (en) 2023-01-19
JP2023534127A (ja) 2023-08-08
EP4168036A1 (en) 2023-04-26
BR112022025473A2 (pt) 2023-03-07
KR20230025432A (ko) 2023-02-21

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