CN116106574A

CN116106574A - Sample detection device and control method thereof

Info

Publication number: CN116106574A
Application number: CN202310388062.3A
Authority: CN
Inventors: 周宇森
Original assignee: Shenzhen Dymind Biotechnology Co Ltd
Current assignee: Shenzhen Dymind Biotechnology Co Ltd
Priority date: 2023-04-12
Filing date: 2023-04-12
Publication date: 2023-05-12
Anticipated expiration: 2043-04-12
Also published as: CN116106574B

Abstract

The application discloses a sample detection device and a control method thereof. The sample detection device includes: the device comprises a conveying destination unit, a sharing pipeline, a plurality of branch pipelines and a plurality of liquid supply units, wherein the conveying destination unit is connected with the outflow end of the sharing pipeline; each liquid supply unit is connected to the sharing pipeline through a corresponding branch pipeline respectively, and the liquid supply units are used for conveying the liquid in the liquid supply units to the conveying destination units through the corresponding branch pipelines and the sharing pipeline in sequence; the branch pipelines corresponding to the liquid supply units are sequentially connected to the shared pipeline from the inflow end to the outflow end of the shared pipeline according to the sequence from low to high of the concentration of the specific liquid flowing through the branch pipelines; wherein the specific liquid is the highest concentration of one or more reagents carried in each liquid supply unit. Through the mode, the pipeline cleaning device can clean the shared pipeline by the way when the pipeline is used for conveying liquid, and improves the convenience of pipeline cleaning.

Description

Sample detection device and control method thereof

Technical Field

The present disclosure relates to the field of sample detection, and in particular, to a sample detection device and a control method thereof.

Background

Joint inspection is a development trend of the in vitro diagnosis industry. The detection of a plurality of indexes is completed through one instrument and one tube of blood, the cost is lower, the detection speed is faster, the operation is simpler and more convenient, the care of patients is better, and the device is favored in clinic. Therefore, there are more and more joint inspection devices on the market at present.

After a large number of IVD joint inspection devices appear, the IVD joint inspection devices are simply integrated in a mode of not being 1+1=2 of different inspection items, one of innovations is that a large number of components are reused, the cost of the devices is reduced, and the operation efficiency of the devices is improved.

In the existing IVD joint inspection equipment, because devices are shared, a structure that a plurality of branch pipes are respectively connected with the same main pipe often occurs, but if the design is not good, a plurality of problems are often brought.

Disclosure of Invention

The application mainly provides a sample detection device and a control method thereof, which solve the problems that a main pipeline is easy to be polluted and inconvenient to clean in the prior art.

To solve the above technical problem, a first aspect of the present application provides a sample detection device, including: a transport destination unit, a shared line, a plurality of branch lines, and a plurality of liquid supply units; the conveying destination unit is connected with the outflow end of the sharing pipeline; each liquid supply unit is connected to the sharing pipeline through the corresponding branch pipeline, and the liquid supply unit is used for conveying the liquid in the liquid supply unit to the conveying destination unit through the corresponding branch pipeline and the sharing pipeline in sequence; the branch pipelines corresponding to the liquid supply units are sequentially connected with the shared pipeline from the inflow end to the outflow end of the shared pipeline in the sequence of low-to-high concentration of specific liquid flowing through the branch pipelines; wherein the specific liquid is one of the one or more reagents carried in each of the liquid supply units with the highest concentration.

To solve the above technical problem, a second aspect of the present application provides a control method of a sample detection device, which is applied to the sample detection device provided in the first aspect, wherein the shared pipeline includes a first shared pipeline, the plurality of branch pipelines includes a plurality of first branch pipelines, the sample detection device includes a plurality of two-way valves, each of the two-way valves is correspondingly connected in series to one of the first branch pipelines, and is used for switching a conducting state and a blocking state of the first branch pipeline, and the control method includes: and controlling one of the two-way valves to be selectively communicated so that the first shared pipeline is communicated with one of the sample reaction tanks.

The beneficial effects of this application are: unlike the prior art, the sample detection device comprises a conveying destination unit, a shared pipeline, a plurality of branch pipelines and a plurality of liquid supply units; the conveying destination unit is connected with the outflow end of the sharing pipeline; each liquid supply unit is connected to the sharing pipeline through a corresponding branch pipeline respectively, and the liquid supply units are used for conveying the liquid in the liquid supply units to the conveying destination units through the corresponding branch pipelines and the sharing pipeline in sequence; the branch pipelines corresponding to the liquid supply units are sequentially connected to the shared pipeline from the inflow end to the outflow end of the shared pipeline according to the sequence from low to high of the concentration of the specific liquid flowing through the branch pipelines; wherein the specific liquid is the highest concentration of one or more reagents carried in each liquid supply unit. According to the scheme, the branch pipelines corresponding to the liquid supply units are sequentially connected to the shared pipelines from the inflow end to the outflow end of the shared pipelines according to the sequence from low to high of the concentration of the specific liquid flowing through the branch pipelines, when the specific liquid with higher concentration is conveyed to the conveying destination unit, the shared pipelines polluted by the specific liquid with higher concentration are shorter, when the liquid supply unit close to the outflow end of the shared pipelines conveys the liquid to the conveying destination unit, the shared pipeline sections polluted by the specific liquid with higher concentration are cleaned or diluted by the liquid with lower concentration, and the shared pipelines can be cleaned in the normal liquid conveying process, so that the cleanability of the device is greatly improved, and the shared pipelines are more convenient to clean.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic diagram of an embodiment of a sample detection device according to the present application;

FIG. 2 is a schematic view of another embodiment of a sample testing device according to the present application;

FIG. 3 is a schematic view of a sample testing device according to another embodiment of the present application;

FIG. 4 is a schematic block diagram illustrating one embodiment of a control method of a sample detection apparatus of the present application;

FIG. 5 is a block diagram schematically illustrating the structure of a further embodiment of the sample testing device of the present application;

fig. 6 is a block diagram illustrating the structure of an embodiment of a computer-readable storage medium of the present application.

Detailed Description

The following description of the technical solutions in the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings in the embodiments of the present application, and it is apparent that the described embodiments are only some embodiments of the present application, not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.

The terms "first," "second," and the like in this application are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present application, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise. Furthermore, the terms "comprise" and "have," as well as any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, system, article, or apparatus that comprises a list of steps or elements is not limited to only those listed steps or elements but may include other steps or elements not listed or inherent to such process, method, article, or apparatus.

Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment may be included in at least one embodiment of the present application. The appearances of such phrases in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. Those of skill in the art will explicitly and implicitly understand that the embodiments described herein may be combined with other embodiments.

Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a sample detection device of the present application. The sample detection device 10 of the present embodiment includes: a transport destination unit 11, a plurality of liquid supply units 12, a shared line T13, and a plurality of branch lines T14.

Wherein, the conveying destination unit 11 is connected with the outflow end of the sharing pipeline T13; each liquid supply unit 12 is connected to the shared line T13 through a corresponding branch line T14, and the liquid supply unit 12 is configured to sequentially convey the liquid in the liquid supply unit 12 to the conveyance destination unit 11 through the corresponding branch line T14 and the shared line T13; the branch pipes T14 corresponding to the liquid supply units 12 are connected to the shared pipe T13 in the order from the low concentration to the high concentration of the specific liquid flowing through the branch pipes T14 from the inflow end to the outflow end of the shared pipe T13; wherein the specific liquid is the highest concentration of one or more reagents carried in each liquid supply unit 12. The concentration may be a mass concentration, that is, if the specific liquid is a fluorescent dye reagent, the mass concentration refers to the amount of the organic chemical substance that plays a role in fluorescent dyeing in a unit mass of the reagent, and in the reagent, the solvent is generally an organic alcohol, and the solute is an organic chemical substance that plays a role in fluorescent dyeing.

As shown in fig. 1, the right end of the shared line T13 is an inflow end, and the left end is an outflow end.

The direction from the inflow end to the outflow end of the shared line T13 is the flow direction of the liquid in the shared line T13, and the flow direction of the liquid in the shared line T13 is constantly from the inflow end to the outflow end during the operation of the sample detection device 10.

The specific liquid flowing through the branch line T14 may be the liquid flowing out of the branch line or the raw reagent liquid used for the liquid carried by the branch line.

Alternatively, if the concentration difference of the specific liquid corresponding to the plurality of liquid supply units 12 is smaller than the set difference threshold, the branch lines T14 corresponding to the plurality of liquid supply units 12 are connected to the shared line T13 in a disordered arrangement. It will be appreciated that if the difference in the concentrations of the specific liquids corresponding to the two liquid supply units 12 is small, the difference in the contamination and cleaning effects on the shared line T13 therebetween is not large, and the concentrations of the specific liquids corresponding to the two liquid supply units are considered to be approximately equal, and may be arranged at will without being arranged according to the difference in the concentrations of the specific liquids, the remaining liquid supply units 12 may still be arranged according to the difference in the concentrations of the specific liquids, and the two liquid supply units 12 may be arranged as a whole in the plurality of liquid supply units 12 or according to the difference in the concentrations of the specific liquids, but may be arranged at random between the two liquid supply units 12.

Compared with the prior art, in the embodiment, according to the concentration of the specific liquid in the liquid flowing through the branch pipeline T14 from low to high, the direction from the inflow end to the outflow end of the shared pipeline T13 is sequentially connected to the shared pipeline T13, when the specific liquid with higher concentration is conveyed to the conveying destination unit 11, the shared pipeline T13 polluted by the specific liquid with higher concentration is shorter, when the liquid supply unit 12 near the outflow end of the shared pipeline T13 conveys the liquid to the conveying destination unit 11, the shared pipeline T13 polluted by the specific liquid with higher concentration is shorter, the relatively short connecting site on the shared pipeline T13 effectively reduces the residual quantity of the liquid flowing in the shared pipeline T13, and the cleaning efficiency and the cleaning effect are effectively improved due to the reduction of the residual quantity of the liquid; because the connection points of the branch pipelines T14 and the shared pipeline T13 of the specific liquid with higher concentration are relatively close to the conveying destination unit 11, no matter the cleaning liquid flows in from the inflow end of the shared pipeline T13 or starts to flow in from the connection points of the branch pipelines T14 and the shared pipeline T13 on the shared pipeline T13, the auxiliary cleaning can be carried out on the shared pipeline T13 by the pollution caused when the branch pipelines T14 close to the outflow end of the shared pipeline T13 are provided with the liquid, the auxiliary cleaning can be carried out on the shared pipeline T13, the cleanability of the device is improved, the cross pollution is avoided, and the adverse effect on the sample detection result caused by the pipeline pollution is reduced.

In one embodiment, referring to fig. 2, the transport destination unit 11 includes a sample detection unit 111, the shared line T13 includes a first shared line T131, the branch lines T14 include a plurality of first branch lines T141, and the liquid supply unit 12 includes a sample reaction unit 121. The sample reaction unit 121 includes a sample reaction cell X1, where the sample reaction cell X1 is configured to receive a sample and at least two reagents and react to form a sample solution; the sample detection unit 111 is connected to the outflow end of the first shared pipeline T131; each sample reaction tank X1 is connected to the first shared pipeline T131 through a corresponding first branch pipeline T141, and the sample reaction tanks X1 are used for conveying sample liquid in the sample reaction tanks to the sample detection unit 111 through the corresponding first branch pipeline T141 and the first shared pipeline T131 in sequence so as to realize sample detection; one end of the first branch line T141 corresponding to each sample reaction tank X1 is connected to the first shared line T131 in order from low to high in specific liquid concentration flowing through the first branch line T141, from the inflow end to the outflow end of the first shared line T131. Wherein the specific liquid is the reagent with the highest concentration in at least two reagents received by each sample reaction cell X1.

It can be appreciated that the sample reaction tank X1 is configured to receive a sample stock solution (i.e., a sample solution that is not processed by the reaction tank) and a reagent, where the reagent may include a dye solution, a hemolysis agent, or a diluent, so as to perform dye solution, hemolysis, and/or dilution processing on the sample stock solution with the reagent to obtain a sample solution to be detected, where the sample solution to be detected is sequentially conveyed to the sample detection unit through a first branch pipeline T141 and a shared pipeline connected to the sample reaction tank X1 for detection. The specific liquid is the reagent with the highest concentration in the dye solution, the hemolysis agent, the diluent and other reagents to be used in the sample reaction tank X1.

Optionally, on the basis of the above-mentioned scheme, if the concentration differences of the specific liquids corresponding to the plurality of sample reaction units 121 are smaller than the set difference threshold, the first branch lines T141 corresponding to the plurality of sample reaction units 121 are connected to the first shared line T131 in a disordered arrangement. It can be understood that, if the concentration differences of the specific liquids corresponding to the sample reaction units 121 are small, the difference between the pollution and the cleaning effect on the first shared line T131 is not large, and the concentrations of the specific liquids corresponding to the two sample reaction units are considered to be approximately equal, so that the sample reaction units can be arranged randomly without being arranged according to the concentration differences of the specific liquids, the rest of the sample reaction units 121 are still arranged according to the concentration differences of the specific liquids, and the two sample reaction units 121 are arranged as a whole in all the sample reaction units 121 or according to the concentration differences of the specific liquids, but the two sample reaction units 121 can be arranged randomly.

Compared with the prior art, in this embodiment, the plurality of sample reaction tanks X1 are sequentially connected to the first sharing pipeline T131 from the inflow end to the outflow end of the first sharing pipeline T131 in the order of the concentration from low to high according to the highest concentration reagent used by the sample reaction tanks X1, when the higher concentration specific liquid is contained in the sample reaction tanks to convey the liquid to the sample detection unit 111, the first sharing pipeline T131 contaminated by the higher concentration specific liquid is shorter, when the sample reaction unit 121 near the outflow end of the first sharing pipeline T131 conveys the liquid to the sample detection unit 111, the first sharing pipeline T131 contaminated by the higher concentration specific liquid is shorter, the relatively short connection sites on the first sharing pipeline T131 effectively reduce the residual quantity of the liquid flowing in the first sharing pipeline T131, and effectively improve the cleaning efficiency and the cleaning effect due to the reduction of the residual quantity of the liquid; because the connection point between the first branch pipeline T141 of the specific liquid with higher concentration and the first shared pipeline T131 is relatively close to the sample detection unit 111, no matter the cleaning liquid flows in from the inflow end of the first shared pipeline T131 or starts to flow in the cleaning liquid at the connection point of each first branch pipeline T141 and the first shared pipeline T131 on the first shared pipeline T131, the cleaning liquid can be assisted to clean the first shared pipeline T131 in a cleaning-assisted way, thereby improving the cleanability of the pipeline, avoiding cross contamination and reducing the adverse effect on the sample detection result caused by the pipeline contamination.

Taking specific liquid as fluorescent dye reagent for example, the sample detection device comprises RET and PLT-F shared channel, WNR channel, WDF channel and WPC channel, and the concentrations of RET and PLT-F, WNR, WDF, WPC fluorescent dye reagent can be 0.03%, 0.003%, 0.005%, 0.002% and 0.004% respectively. It is evident that the RET dye liquor is much more concentrated than the other dye liquor, so RET and PLT-F common channels are arranged closest to the outflow end of the shared line T13, WNR channels are arranged second closest to the outflow end of the shared line T13, WPC channels are arranged third closest to the outflow end of the shared line T13, and WDF is arranged last, i.e. closest to the inflow end of the shared line T13.

However, when the concentration of the WNR, WPC, WDF dye liquor is relatively close and the difference is not large, that is, the concentration difference of the specific liquid corresponding to the plurality of liquid supply units 12 is smaller than the set difference threshold, the plurality of liquid supply units 12 may be arranged at will without being arranged according to the concentration difference of the specific liquid. I.e. RET and PLT-F common channels must be arranged closest to the outflow end of the shared line T13, while the order between the WNR channel, WDF channel, WPC channel may not be entirely according to the concentration differences of the specific liquids.

Here, the set difference threshold of the concentration difference between the two specific liquids may be less than 3 times, and may be regarded as the concentration being approximately equal, that is, the concentration difference between the WNR dye solution and the WDF dye solution may be regarded as the concentration being approximately equal between the WNR dye solution and the WDF dye solution because 0.002% by 3> 0.005%.

Here, the set difference threshold of the concentration difference between the two specific liquids may be set to be equal to or less than 0.005%, that is, the concentration difference between the WNR dye solution and the WDF dye solution may be set to be equal to or less than 0.005% -0.002% <0.005%, so that the concentrations of the WNR dye solution and the WDF dye solution may be set to be equal to or less than each other.

In another embodiment, the sharing pipeline T13 includes a second sharing pipeline T132, the plurality of branch pipelines includes a plurality of second branch pipelines T142, the plurality of liquid supply units 12 includes a plurality of reagent supply units 122, the delivery destination unit 11 includes a sample reaction tank X1, the sample reaction tank X1 and the corresponding plurality of reagent supply units 122 are respectively connected through a corresponding second branch pipeline T142, and the sample reaction tank X1 is configured to receive a sample and at least two reagents and react to form a sample liquid; the sample reaction cell X1 is connected to the outflow end of the corresponding second shared line T132.

Each reagent supply unit 122 is connected to a corresponding second shared pipeline T132 through a corresponding second branch pipeline T142, and the reagent supply units 122 are configured to sequentially convey different reagents in the reagent supply units 122 to the sample reaction tank X1 through the corresponding second branch pipeline T142 and the second shared pipeline T132, where one end of the second branch pipeline T142 corresponding to each reagent supply unit 122 is sequentially connected to the second shared pipeline T132 from the inflow end to the outflow end of the second shared pipeline T132 in the order of the specific liquid concentration flowing through the second branch pipeline T142 from low to high.

Wherein, the specific liquid is the reagent that each reagent supplying unit 122 delivers to the corresponding second branch line T142.

Optionally, on the basis of the above-mentioned scheme, if the concentration difference of the specific liquids corresponding to the two reagent supply units is smaller than the set difference threshold, the second branch pipelines corresponding to the two reagent supply units are connected to the second shared pipeline in a disordered arrangement. It will be appreciated that if the difference in concentration of the specific liquid corresponding to the reagent supplying unit 122 is small, the difference in contamination and cleaning effect for the second shared line T132 therebetween is not large, and the concentrations of the specific liquid corresponding to the two are considered to be approximately equal, and may be arranged at will, without being arranged according to the difference in concentration of the specific liquid, the remaining reagent supplying units 122 are still arranged according to the difference in concentration of the specific liquid, and the reagent supplying units 122 as a whole are arranged in all the reagent supplying units 122 or according to the difference in concentration of the specific liquid, but may be arranged at random between the two reagent supplying units 122.

Taking specific liquid as fluorescent dye reagent as an example, the target unit for conveying is a sample reaction tank with RET and PLT-F shared channels. The RET and PLT-F share the same channel because the two channels are different in fluorescent dye liquor and reagent dye liquor, but the diluent or hemolytic agent can be shared, so that the required devices can be saved, and the whole volume can be reduced. The concentrations of the RET fluorescent dye reagent and the PLT-F are respectively 0.03% and 0.003%, the second branch pipeline T142 corresponding to the reagent supply unit of the RET fluorescent dye reagent is connected to an access point close to the outflow end of the second shared pipeline T132 on the second shared pipeline T132, and the second branch pipeline T142 corresponding to the reagent supply unit 122 of the PLT-F fluorescent dye reagent is connected to an access point close to the inflow end of the second shared pipeline T132 on the second shared pipeline T132, namely, the access point of the second branch pipeline T142 corresponding to the reagent supply unit of the RET fluorescent dye reagent on the second shared pipeline T132 is closer to the shared sample reaction pool X1.

For example, referring to fig. 3 in combination, when the sample reaction tank X1 is a WPC channel reaction tank, the reagent supply unit 122 may include a WPC dye solution supply unit and a WPC diluent supply unit, wherein a second branch line T142 corresponding to the WPC dye solution supply unit is connected to an access point near an outflow end of the second sharing line T132 on the second sharing line T132, and the WPC diluent supply unit is connected to an access point near an inflow end of the second sharing line T132 on the second sharing line T132.

When the sample reaction tank X1 is a WNR channel reaction tank, the reagent supply unit 122 may include a WNR dye solution supply unit and a WNR hemolytic agent supply unit, wherein a second branch pipeline T142 corresponding to the WNR dye solution supply unit is connected to an access point near an outflow end of the second sharing pipeline T132 on the second sharing pipeline T132, and a WNR hemolytic agent supply unit is connected to an access point near an inflow end of the second sharing pipeline T132 on the second sharing pipeline T132.

When the sample reaction tank X1 is a WDF channel reaction tank, the reagent supply unit 122 may include a WDF dye solution supply unit and a WDF hemolytic agent supply unit, where a second branch line T142 corresponding to the WDF dye solution supply unit is connected to an access point near an outflow end of the second shared line T132 on the second shared line T132, and the WDF hemolytic agent supply unit is connected to an access point near an inflow end of the second shared line T132 on the second shared line T132.

When the sample reaction tank X1 is a common channel reaction tank for RET and PLT-F, the reagent supply unit 122 may include a PLT-F dye solution supply unit 123, a RET dye solution supply unit 124, a RET hemolytic agent supply unit 125, and the like, wherein a second branch line T142 corresponding to the RET dye solution supply unit 124 is connected to an access point near an outflow end of the second shared line T132 on the second shared line T132, the RET hemolytic agent supply unit 125 is connected to an access point near an inflow end of the second shared line T132 on the second shared line T132, and the PLT-F dye solution supply unit 123 is connected to an access point between the RET dye solution supply unit 124 and a second branch line T142 corresponding to the RET hemolytic agent supply unit 125 on the second shared line T132.

The above-described sample reaction cell types and the arrangement of the reagent supply units 122 corresponding to each sample reaction cell X1 in the liquid conveying direction of the second shared line T132 are merely exemplary descriptions, and the number of the sample reaction units 121 may be increased or decreased according to actual demands, or the arrangement order of any one or more of the above-described sample reaction units 121 and the corresponding types of the reagent supply units 122 may be replaced. And will not be described in detail here.

Compared with the prior art, the embodiment connects the plurality of reagent supply units 122 to the second shared line T132 in sequence from the inflow end to the outflow end of the second shared line T132 according to the order of the concentration of the reagents supplied by the reagent supply units from low to high, when the reagent containing higher concentration is supplied to the sample reaction tank X1, the second shared line T132 contaminated by the reagent containing higher concentration is shorter, and when the reagent supply unit 122 near the outflow end of the second shared line T132 is supplied to the sample reaction tank X1, the reagent containing higher concentration contaminates the second shared line T132 shorter, the relatively short connection point on the second shared line T132 effectively reduces the residual amount of the liquid flowing in the second shared line T132, and effectively improves the cleaning efficiency and the cleaning effect due to the reduced residual amount of the reagent; because the connection point of the second branch pipeline T142 of the higher concentration reagent and the second shared pipeline T132 is relatively close to the sample reaction tank X1, no matter the cleaning liquid flows in from the inflow end of the second shared pipeline T132 or starts to flow in the cleaning liquid at the connection point of each second branch pipeline T142 and the second shared pipeline T132 on the second shared pipeline T132, the second shared pipeline T132 can be assisted with the pollution brought by the auxiliary cleaning when the second branch pipeline T142 close to the outflow end of the second shared pipeline T132 provides the liquid, the cleaning performance of the pipeline is improved, the cross contamination is avoided, and the circulation of the sample preparation channel is ensured.

For example, the first branch line T141 corresponding to each sample reaction unit 121 is connected to the first shared line T131 in the order of the RET and PLT-F shared channel sample reaction cell, WNR channel sample reaction cell, WDF channel sample reaction cell, WPC channel sample reaction cell from the outflow end to the inflow end of the first shared line T131. It will be appreciated that, among the RET and PLT-F shared channel sample reaction cells, WNR channel sample reaction cells, WDF channel sample reaction cells, and WPC channel sample reaction cells, the specific liquid having the highest concentration corresponding to each sample reaction cell tends to decrease in sequence, each sample reaction unit 121 is sequentially connected to the first shared channel T131 from the inflow end to the outflow end of the first shared channel T131 in the order of the concentration of the reagent adopted by each sample reaction unit 121 from low to high, and when the reagent supply unit 122 near the inflow end of the first shared channel T131 supplies the reagent having the lower concentration to the sample reaction cell X1, the channel polluted by the reagent having the higher concentration near the outflow end of the first shared channel T131 is cleaned by the way, so that the cleanability of the channel is improved and the circulation of the sample preparation channel is ensured. In yet another embodiment, the concentrations of the specific liquids required by the WNR channel reaction tank and the WDF channel reaction tank respectively, namely WNR dye liquid and WDF dye liquid, are smaller than the set difference threshold, and the concentrations of the two dye liquids are considered to be approximately equal, when other sample reaction tanks are sequentially arranged and connected on the first pipeline, if WNR channels and WDF channels are simultaneously arranged in the device, the connection sequence of the first branch pipeline T141 corresponding to the two channels on the first shared pipeline T131 can be arranged in an unordered manner, the sequence of the WNR and the WDF can be also according to the sequence of the WDF and the WNR, the whole formed by the WNR and the WDF is still arranged in the sequence of the concentrations in the arrangement of all sample reaction tanks, but the two can be arranged in an unlimited sequence.

Optionally, when the common channel of RET and PLT-F is included in the sample detection device, the access point of the first branch line T141 corresponding to the common channel of RET and PLT-F in the other sample reaction units 121 is the closest one of all the sample reaction units 121 to the outflow end of the first shared line T131. Because the concentration of the reagent used in the RET and PLT-F shared channel is high, the branch pipeline is connected to the first shared pipeline T131 through the access point nearest to the outflow end of the first shared pipeline T131, when the channel provides the sample liquid to the sample detection unit 111, the first shared pipeline T131 flowing through is short, so that the pipeline polluted by the first shared pipeline T131 is short, and the difficulty of pipeline cleaning is reduced.

Alternatively, a sample detection device may include two or more of RET and PLT-F shared channels, WNR channels, WDF channels, WPC channels, and each first branch line T141 is still connected to the first shared line T131 in the above order. For example, when only the RET and PLT-F shared channels and the WPC channels are included, the first branch lines T141 corresponding to the RET and PLT-F shared channels and the WPC channels are connected to the first shared line T131 in this order.

In the sample detection device 10 shown in fig. 3, the sample reaction units 121 connected to the first shared line T131 in the direction from the outflow end to the inflow end of the first shared line T131 are a RET and PLT-F shared channel reaction unit, a WNR channel reaction unit, and a WDF channel reaction unit in this order. It should be understood that in other embodiments, other channel-type reaction units may be further included, for example, the WDF channel reaction unit may be replaced by a WPC channel reaction unit, either one or both reaction units may be omitted, or other access points may be disposed at positions adjacent to the access point of the first shared line T131 on the first branch line T141 corresponding to the WDF channel reaction unit to access the WPC channel reaction unit, and in addition, the number of each channel reaction unit may not be limited to one, and multiple access points adjacent to the first shared line T131 may access multiple channel reaction units of the same type. In this manner, as long as the order of the connection on the first shared line T131 follows the order of "the concentration of the specific liquid flowing through the first branch line T141 is from low to high", the connection is sequentially made to the first shared line T131 from the inflow end to the outflow end of the first shared line T131", and the order of" the concentration difference of the specific liquid is less than the set difference threshold value ", the corresponding first branch line T141 is connected to the first shared line T131 in a disordered arrangement, which is considered to be within the scope of the present application.

Optionally, the first branch line T141 includes a first two-way valve (71, 72, 73), a first sub-line and a second sub-line (not identified in the first and second sub-line diagrams), and the first sub-line communicates with the second sub-line through the first two-way valve (71, 72, 73) to form the first branch line T141. The first sub-pipeline is one of the first sub-pipeline and the second sub-pipeline, which is closer to the first shared pipeline T131.

Optionally, the length of the first sub-pipeline is not greater than a preset first length threshold, and the length of the second sub-pipeline is not greater than a preset second length threshold. The first sub-pipeline may cause cross contamination when the sample is prepared and transported for measurement in different samples, so that the length of the first sub-pipeline is properly reduced, and the pipeline to be cleaned is correspondingly reduced, thereby reducing the cleaning difficulty and cost. The first length threshold preset here may be set to 4cm and the second length threshold may be set to 2.5cm.

Optionally, the length of the first sub-pipeline is not smaller than a preset third length threshold, and the length of the second sub-pipeline is not smaller than the third length threshold. The problem that the ports such as the pipeline, the valve and the reaction tank interface are difficult to connect due to the fact that the pipeline is too short is avoided, and the use cost and the manufacturing difficulty of the sample detection device 10 are reduced. The third length threshold and the fourth length threshold preset here are 1cm.

Optionally, referring to fig. 2, the first shared pipeline T131 includes a plurality of second sub-pipelines T133 and a plurality of three-way connectors 134, the plurality of second sub-pipelines T133 are sequentially connected first through the plurality of three-way connectors 134 to form the first shared pipeline T131, and the first branch pipeline T141 is connected to the first shared pipeline T131 through the other end of the three-way connector 134.

Optionally, the distance between the access points of the adjacent first branch pipelines T141 on the first shared pipeline T131 is a first distance, the distance between the center points of the adjacent reaction tanks X1 corresponding to the adjacent first branch pipelines T141 is a second distance, and the first distance is smaller than or equal to a first set multiple of the second distance, or the second distance is smaller than or equal to a second set multiple of the first distance.

Specifically, the communication site of each first branch line T141 on the first shared line T131 may be denoted as an access point, at least one set of target access points may exist on the first shared line T131, each set of target access points includes a set of two adjacent access points, and the access points included in different sets of target access points may or may not have overlapping access points, which is not limited herein. Of the two adjacent access points, one access point is denoted as a first access point and the other access point is denoted as a second access point, the tube length of the first shared line T131 between the first access point and the second access point being denoted as a first distance. In the two sample reaction units 121 corresponding to the two adjacent access points one by one, the center point of the reaction cell X1 of one sample reaction unit 121 is denoted as a first center point, and the center point of the reaction cell X1 of the other sample reaction unit 121 is denoted as a second center point, and the distance between the first center point and the second center point is a second distance.

Based on the above manner, under the condition that the first distance is not greater than the second distance which is multiple of the first number, it can be ensured that the pipe length of the first shared pipe T131 between two adjacent access points is not too long, and the two first branch pipes T141, besides producing cross contamination on the shared first shared pipe T131, also produce cross contamination on the first shared pipe T131 between the two access points, so that the length of the first shared pipe T131 between the two access points is properly reduced, and the pipes to be cleaned are correspondingly reduced, thereby reducing the cleaning difficulty and cost of the first shared pipe T131.

And under the condition that the second distance is not more than the first distance of the set multiple, the length of the first shared pipeline T131 between two adjacent access points can be ensured not to be too short, and as the three ports of the three-way joint 134 all have a certain length and pipe diameter, the length of the first shared pipeline T131 between the two access points is properly increased, so that the connection pipe operation between the three-way joint 134 and the sub pipeline T133 is facilitated, and the assembly difficulty of the sample detection device 10 is reduced.

In other embodiments, the sample detection device 10 may include the sample detection unit 111, the first shared line T131, the plurality of first branch lines T141, and the sample reaction unit 121, where the sample reaction unit 121 includes the sample reaction tank X1, the second shared line T132, the plurality of second branch lines T142, and the plurality of reagent supply units 122, and the connection relationships between each line and the sample detection unit 111, the sample reaction unit 121, and the reagent supply units 122 are as shown in the above embodiments and fig. 2, and will not be repeated here. The reagent supply unit 122 of the sample reaction unit 121 of this embodiment is sequentially connected to the second shared line T132 from the inflow end to the outflow end of the second shared line T132 according to the order of the reagent concentrations from low to high, so that the higher concentration residual reagent near the outflow end of the second shared line T132 can be cleaned by the lower concentration reagent during sample preparation; the plurality of reaction tanks X1 are sequentially connected to the first sharing pipeline T131 from the inflow end to the outflow end of the first sharing pipeline T131 according to the order of the specific liquid concentration from low to high, so that when the reaction tank X1 near the inflow end of the first sharing pipeline T131 provides the sample liquid to the sample detection unit 111, the first sharing pipeline T131 near the outflow end of the first sharing pipeline T131 polluted by the specific liquid with higher concentration is cleaned by the way, the cleanability of the first sharing pipeline T131 and the second sharing pipeline T132 in the sample detection process is improved, and the cross contamination of the pipelines in the sample detection process is avoided.

Optionally, referring to fig. 3 in combination, the sample detection device 10 may further include a plurality of first metering pumps DP01, first air-path switching components (61, 62, 63, 64, 65, 66, 67), first liquid-path switching components (81, 82, 83, 84, 85, 86, 87), second two-way valves (91, 92, 93), and a first cleaning liquid supply unit DIL, where the plurality of first metering pumps DP01 and the plurality of reagent supply units 122 are in one-to-one correspondence, and the first cleaning liquid supply unit DIL is connected to an access point of the second shared pipeline T132 closest to the inflow end through a third branch pipeline T143.

The first air path switching assembly (61, 62, 63, 64, 65, 66, 67) is used for selectively connecting one end of the first metering pump DP01 to a positive pressure air source or a negative pressure air source (not shown), the first liquid path switching assembly (81, 82, 83, 84, 85, 86, 87) is used for selectively connecting the other end of the first metering pump DP01 to a corresponding reagent supply unit 122 or a second two-way valve (91, 92, 93), the second two-way valve (91, 92, 93) is used for selectively connecting the first liquid path switching assembly (81, 82, 83, 84, 85, 86, 87) to the third branch pipeline T143, and the first cleaning liquid supply unit DIL is used for conveying cleaning liquid to the second shared pipeline T132 when the second two-way valve (91, 92, 93) is connected to the third branch pipeline T143 so as to clean the second shared pipeline T132.

Optionally, the sample detection device 10 further comprises a second cleaning fluid supply unit FCM for connecting to an access point of the first shared conduit T131 closest to the inflow end. When the second cleaning liquid supply unit FCM needs to clean the pipeline, the second cleaning liquid supply unit FCM enters the pipeline system through the first sharing pipeline T131, and is discharged from the outflow end of the first sharing pipeline T131.

In one embodiment, the sample detection device 10 may further include a suction module 15 and a sample pushing module 16, wherein the suction module 15 is connected to the outflow end of the first shared line T131, and the sample pushing module 16 is connected to the inflow end of the first shared line T131. The suction module 15 is configured to generate a negative pressure to quantitatively draw the sample to be tested of the corresponding sample reaction cell X1 into the first shared line T131 when one of the first two-way valves (71, 72, 73) is opened, and the sample pushing module 16 is configured to generate a positive pressure to push the sample to be tested drawn into the first shared line T131 into the sample detection unit 111 for detection.

The suction module 15 includes a second dosing pump DP02, a second air path switching assembly 151, and a third liquid path switching assembly 152. The second air path switching component 151 is configured to selectively connect one end of the second constant delivery pump DP02 to a positive pressure air source or a negative pressure air source (not shown), and the third liquid path switching component 152 is configured to selectively connect the other end of the second constant delivery pump DP02 to the output end of the first sharing pipeline T131 and the waste liquid tank WC2; the sample propulsion module 16 comprises a syringe. When the sample is to be detected, the second air path switching component 151 is connected to the negative pressure air source to generate negative pressure, and after the sample to be detected in the corresponding sample reaction unit 121 is quantitatively extracted to the first shared pipeline T131, the positive pressure generated by the sample pushing module 16 is used to push the sample to be detected in the first shared pipeline T131 to the sample detection unit 111 for detection.

Optionally, the sample detection device 10 may further comprise a third two-way valve 153, the third two-way valve 153 being for connecting the sample detection unit 111 to the waste liquid pool WC1 for delivering waste liquid generated by the sample detection unit 111 to the waste liquid pool WC1 when switched on.

Optionally, the sample testing device 10 further includes a second liquid path switching component 88 and a fourth branch line T144, the reagent supplying unit 122 includes a hemolytic agent supplying unit 122, the hemolytic agent supplying unit is connected to an access point of the second shared line T132 closest to the inflow end through the fourth branch line T144, the second liquid path switching component 88 is configured to selectively connect the other end of the first liquid path switching component 85 corresponding to the hemolytic agent supplying unit 122 to the sample reaction tank X1 and the fourth branch line T144, and when the other end of the first liquid path switching component 85 is connected to the fourth branch line T144, the hemolytic agent is delivered to the first shared line T131 to wash the first shared line T131.

Optionally, the fourth branch line T144 is connected to the first shared line T131 through a three-way joint.

For example, in this embodiment, the hemolytic agent in the WNR channel is sequentially connected to the access point of the first shared pipeline T131 near the inflow end through the first liquid path switching component 85, the second liquid path switching component 88 and the fourth pipeline T144, and the communication between the first liquid path switching component 85 and the second liquid path switching component 88 can be controlled according to a preset time sequence, so as to convey WNR hemolytic agent to the first shared pipeline T131 for cleaning the pipeline. WNR hemolysis agent has the strongest hemolysis capability in all used reagents, and the first shared pipeline can be cleaned by combining the structure with a corresponding liquid path assembly control method.

Alternatively, at least one sample reaction unit 121 includes a first cleaning liquid supply unit DIL, a hemolysis agent supply unit 125, and at least two dye liquid supply units (123, 124); the at least two dye liquor supply units (123, 124) are used for supplying different dye liquor, each dye liquor supply unit (123, 124) is connected to an access point of the second shared pipeline T132 near the outflow end through a second branch pipeline T142, the hemolytic agent supply unit 125 is connected to an access point of the second shared pipeline T132 near the inflow end through a second branch pipeline T142, and the first cleaning liquid supply unit DIL is connected to the inflow end of the second shared pipeline T132.

For example, the first dye liquor supply unit 123 is used for supplying PLT-F dye liquor, the second dye liquor supply unit 124 is used for supplying RET dye liquor, and the hemolysis agent supply unit 125 is used for supplying RET hemolysis agent.

The first air path switching component 61 may selectively connect one end of a first metering pump DP01 to a positive pressure air source or a negative pressure air source (not shown), the first liquid path switching component 81 selectively connects the other end of the first metering pump DP01 to the second dye liquor supply unit 124 or the corresponding second branch pipeline T142, when the first liquid path switching component 81 connects the other end of the first metering pump DP01 to the second dye liquor supply unit 124, the first metering pump DP01 generates negative pressure to quantitatively suck RET dye liquor, and when the first liquid path switching component 81 connects the other end of the first metering pump DP01 to the corresponding second branch pipeline T142, the first metering pump DP01 generates positive pressure to convey the sucked RET dye liquor to the sample reaction tank X1 sequentially through the second branch pipeline T142 and the second sharing pipeline T132.

The first air path switching component 62 may selectively connect one end of a first metering pump DP01 to a positive pressure air source or a negative pressure air source (not shown), the first liquid path switching component 82 selectively connects the other end of the first metering pump DP01 to the first dye liquor supply unit 123 or the corresponding second branch line T142, when the first liquid path switching component 82 connects the other end of the first metering pump DP01 to the first dye liquor supply unit 123, the first metering pump DP01 generates negative pressure to quantitatively suck PLT-F dye liquor, and when the first liquid path switching component 82 connects the other end of the first metering pump DP01 to the corresponding second branch line T142, the first metering pump DP01 generates positive pressure to convey the sucked PLT-F dye liquor to the sample reaction tank X1 sequentially through the second branch line T142 and the second sharing line T132.

The first air path switching component 63 selectively connects one end of a first metering pump DP01 to a positive pressure air source or a negative pressure air source (not shown), the first liquid path switching component 83 selectively connects the other end of the first metering pump DP01 to the hemolytic agent supply unit 125 or the corresponding second branch line T142, when the first liquid path switching component 83 connects the other end of the first metering pump DP01 to the hemolytic agent supply unit 125, the first metering pump DP01 generates negative pressure to quantitatively suck RET hemolytic agent, and when the first liquid path switching component 83 connects the other end of the first metering pump DP01 to the corresponding second branch line T142, the first metering pump DP01 generates positive pressure to convey the sucked RET hemolytic agent to the sample reaction tank X1 sequentially through the second branch line T142 and the second sharing line T132.

The sample reaction unit 121 of the present embodiment may be used for sharing a channel between a RET sample and a PLT sample, and each component is controlled in a time-sharing manner to prepare different samples at different stages, and each reagent supply unit 122 of the sample reaction unit 121 of the present embodiment is sequentially connected to the second shared line T132 through the second branch line T142 in the order from the outflow end to the inflow end of the second shared line T132 in the order of the RET dye, the PLT-F dye, and the RET hemolytic agent supplied by the reagent supply unit 122. In one embodiment, the PLT-F dye liquor and RET dye liquor remained in the second shared line T132 can be cleaned by supplying RET hemolysis agent, so as to improve cleanability of the second shared line T132.

Optionally, the sample detection device 10 further includes a preheating unit (H1, H2, H3), where the preheating unit (H1, H2, H3) is connected between the second two-way valve (92, 91, 93) and an access point on the second shared pipeline T132 closest to the inflow end of the second shared pipeline T132, and the preheating unit (H1, H2, H3) is used for preheating the liquid flowing through the second two-way valve, so that the flowing reagent quickly reaches the ideal temperature, and sample preparation is accelerated.

The present application further provides a control method of a sample detection device, which can be applied to the sample detection device 10 of any one of the foregoing embodiments, in the sample detection device 10, the shared pipeline T13 includes a first shared pipeline T131, the plurality of branch pipelines T14 includes a plurality of first branch pipelines T141, the sample detection device 10 includes a plurality of first two-way valves (71, 72, 73), and each of the first two-way valves (71, 72, 73) is correspondingly connected in series to one of the first branch pipelines T141, for switching a conducting state and a blocking state of the first branch pipeline T141.

The control method of the present embodiment may include the steps of: one of the first two-way valves (71, 72, 73) is selectively controlled to be communicated so that the first shared pipeline T131 is communicated with one of the sample reaction tanks X1.

In contrast to the prior art, in this embodiment, when the sample to be measured in the sample reaction tank X1 needs to be conveyed to the sample detection unit 111, only the corresponding first two-way valve is opened, so that the sample to be measured is prevented from being diffused to other first branch pipelines T141 and sample reaction tanks X1 through the first shared pipeline T131 to cause pollution of other sample liquids and pipelines when the sample to be measured is conveyed.

Alternatively, the transport destination unit 11 includes a sample detection unit 111, the liquid supply unit 12 includes a sample reaction unit 121, the sample reaction unit 121 includes a sample reaction cell X1, and the sample reaction cell X1 is configured to receive a sample and at least two reagents and react to form a sample liquid; the sample detection device 10 further includes a tee 134, a suction module 15, and a sample pushing module 16, wherein a first port of the tee 134 is connected to the outflow end of the first shared line T131, the suction module 15 is connected to a second port of the tee 134, the sample detection unit 111 is connected to a third port of the tee 134, and the sample pushing module 16 is connected to the inflow end of the first shared line T131.

Referring to fig. 4, fig. 4 is a schematic block flow chart of an embodiment of a control method of the sample detection apparatus of the present application. The control method further comprises the following steps:

step S11: and opening the first two-way valves corresponding to the sample reaction tanks to be detected, and closing the first two-way valves corresponding to the other sample reaction tanks.

Wherein the sample reaction cell to be measured is one of a plurality of sample reaction cells X1.

Step S12: the suction module is controlled to generate negative pressure, liquid in the sample reaction tank to be detected is sucked into the first shared pipeline, the sample pushing module is controlled to generate positive pressure, and the liquid in the first shared pipeline is conveyed into the sample detection unit for detection.

In this step, the suction module 15 is controlled to generate negative pressure to quantitatively extract the sample liquid to be tested, the sample liquid to be tested is sucked into the first shared pipeline T131, and then the sample pushing module generates positive pressure to push the sample liquid to be tested in the first shared pipeline T131 into the sample detection unit 111.

Alternatively, when the suction module 15 is controlled to generate negative pressure, the quantitative sample liquid is fed into the first shared line T131, and the first branch line T141 corresponding to the sample detection unit 111 and the first branch line T141 corresponding to the sample reaction unit 121 adjacent to the sample detection unit 111 are connected.

Step S13: and controlling the sample pushing module to reset after the sample detection unit completes detection.

The sample pushing module 16 resets after the sample detection unit 111 completes the detection, in preparation for subsequent regeneration of the positive pressure pushing liquid.

When the sample detection is needed, the embodiment controls to open the first two-way valve corresponding to the reaction tank where the sample to be detected is located, close the first two-way valves corresponding to other reaction tanks, quantitatively extract the sample to be detected to the sample detection unit 111 by utilizing the positive pressure pushing cooperation of the negative pressure suction of the suction module 15 and the sample pushing module 16, and reduce the cross contamination of the samples of all the reaction tanks.

Optionally, the control method may further include the steps of: and respectively presetting a preset working time sequence corresponding to each sample reaction unit, wherein the preset working time sequence comprises a sample preparation period and a cleaning period.

It will be appreciated that the sample preparation period is for taking a corresponding sample and reagent for preparing a sample to be tested, and the cleaning period enables the cleaning liquid in the first cleaning liquid supply unit DIL for a cleaning operation.

Optionally, the control method may further include the steps of: when one of the sample reaction units 121 is in the cleaning period, in response to the sample reaction unit 121 currently in the sample preparation period having completed sample preparation in the sample preparation period, the first two-way valve corresponding to the sample reaction unit 121 of the plurality of sample reaction units 121 having currently completed sample preparation is controlled to be turned on.

In this embodiment, while one of the sample reaction units 121 is in the cleaning period, the first two-way valve corresponding to the prepared sample reaction unit 121 is opened to convey the sample to be tested to the sample detection unit 111, and meanwhile, different sample reaction units are controlled to perform corresponding cleaning operation or detection operation, so as to improve the matching degree of each sample reaction unit 121 and improve the overall efficiency.

Referring to fig. 5, fig. 5 is a schematic block diagram illustrating a sample detection device according to another embodiment of the present application. The sample detection device 200 includes a processor 210 and a memory 220 coupled to each other, where the memory 220 stores a computer program, and the processor 210 is configured to execute the computer program to implement the control method of the sample detection device according to the above embodiments.

For the description of each step of the processing execution, please refer to the description of each step of the control method embodiment of the sample detection device of the present application, and the description is omitted herein.

The memory 220 may be used to store program data and modules, and the processor 210 performs various functional applications and data processing by executing the program data and modules stored in the memory 220. The memory 220 may mainly include a storage program area and a storage data area, wherein the storage program area may store an operating system, application programs required for at least one function, and the like; the storage data area may store data created according to the use of the sample detection device 200, and the like. In addition, memory 220 may include high-speed random access memory, and may also include non-volatile memory, such as at least one magnetic disk storage device, flash memory device, or other volatile solid-state storage device. Accordingly, the memory 220 may also include a memory controller to provide the processor 210 with access to the memory 220.

In the embodiments of the present application, the disclosed method and apparatus may be implemented in other manners. For example, the embodiments of the sample detection device 200 described above are merely illustrative, e.g., the division of the modules or units is merely a logical functional division, and there may be additional divisions in actual implementation, e.g., multiple units or components may be combined or integrated into another system, or some features may be omitted, or not performed. Alternatively, the coupling or direct coupling or communication connection shown or discussed with each other may be an indirect coupling or communication connection via some interfaces, devices or units, which may be in electrical, mechanical or other form.

The units described as separate units may or may not be physically separate, and units shown as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the embodiment.

In addition, each functional unit in each embodiment of the present application may be integrated in one processing unit, or each unit may exist alone physically, or two or more units may be integrated in one unit. The integrated units may be implemented in hardware or in software functional units.

The integrated units, if implemented in the form of software functional units and sold or used as stand-alone products, may be stored in a computer readable storage medium. Based on such understanding, the technical solution of the present application may be embodied essentially or partly contributing to the prior art or in whole or in part in the form of a software product, which is stored in a storage medium.

Any process or method descriptions in flow charts or otherwise described herein may be understood as representing modules, segments, or portions of code which include one or more executable instructions for implementing specific logical functions or steps of the process, and further implementations are included within the scope of the preferred embodiment of the present application in which functions may be executed out of order from that shown or discussed, including substantially concurrently or in reverse order, depending on the functionality involved, as would be understood by those reasonably skilled in the art of the embodiments of the present application.

Referring to fig. 6, fig. 6 is a schematic block diagram illustrating the structure of an embodiment of a computer readable storage medium 300 of the present application, where the computer readable storage medium 300 stores program data 310, and the program data 310 when executed implements the steps of the control method embodiments of the sample detection apparatus as described above.

The computer readable storage medium 300 may be a usb disk, a removable hard disk, a Read-Only Memory (ROM), a random access Memory (RAM, random Access Memory), a magnetic disk, or an optical disk, etc. various media capable of storing program codes.

The foregoing description is only exemplary embodiments of the present application and is not intended to limit the scope of the present application, and all equivalent structures or equivalent processes using the descriptions and the drawings of the present application, or direct or indirect application in other related technical fields are included in the scope of the present application.

Claims

1. A sample testing device, the device comprising: a transport destination unit, a shared line, a plurality of branch lines, and a plurality of liquid supply units;

the conveying destination unit is connected with the outflow end of the sharing pipeline;

each liquid supply unit is connected to the sharing pipeline through the corresponding branch pipeline, and the liquid supply unit is used for conveying the liquid in the liquid supply unit to the conveying destination unit through the corresponding branch pipeline and the sharing pipeline in sequence;

The branch pipelines corresponding to the liquid supply units are sequentially connected with the shared pipeline from the inflow end to the outflow end of the shared pipeline in the sequence of low-to-high concentration of specific liquid flowing through the branch pipelines;

wherein the specific liquid is one of the one or more reagents carried in each of the liquid supply units with the highest concentration.

2. The apparatus of claim 1, wherein the transport destination unit comprises a sample detection unit, the shared line comprises a first shared line, the plurality of branch lines comprises a plurality of first branch lines, the liquid supply unit comprises a sample reaction unit comprising a sample reaction cell for receiving a sample and at least two reagents and reacting to form a sample liquid;

the sample detection unit is connected with the outflow end of the first shared pipeline;

each sample reaction tank is connected to the first shared pipeline through the corresponding first branch pipeline respectively, and the sample reaction tanks are used for conveying sample liquid in the sample reaction tanks to the sample detection unit through the corresponding first branch pipeline and the first shared pipeline in sequence so as to realize sample detection;

One end of the first branch pipeline corresponding to each sample reaction tank is sequentially connected to the first sharing pipeline from the inflow end to the outflow end of the first sharing pipeline according to the sequence from low to high of the concentration of specific liquid flowing through the first branch pipeline, wherein the specific liquid is the reagent with the highest concentration in the at least two reagents received by each reaction tank; or, one end of the first branch pipeline corresponding to each sample reaction tank is sequentially connected to the first shared pipeline from the inflow end to the outflow end of the first shared pipeline according to the sequence from low to high of the specific liquid concentration flowing through the first branch pipeline, wherein if the concentration difference between the specific liquids corresponding to at least two sample reaction tanks in the plurality of sample reaction tanks is smaller than a set difference threshold value, the first branch pipelines corresponding to the at least two sample reaction tanks are connected to the first shared pipeline without limiting the sequence; wherein the specific liquid is the reagent with the highest concentration in the at least two reagents received by each reaction tank;

and/or the number of the groups of groups,

the shared pipeline comprises a second shared pipeline, the plurality of branch pipelines comprise a plurality of second branch pipelines, the plurality of liquid supply units comprise a plurality of reagent supply units, the conveying target unit comprises a sample reaction tank, the sample reaction tank and the corresponding plurality of reagent supply units are respectively connected through a corresponding second branch pipeline, and the sample reaction tank is used for receiving a sample and at least two reagents and reacting to form a sample liquid; the sample reaction tank is connected to the outflow end of the corresponding second sharing pipeline;

Each reagent supply unit is connected to the corresponding second shared pipeline through a corresponding second branch pipeline respectively, and the reagent supply units are used for conveying different reagents in the reagent supply units to the sample reaction tank through the corresponding second branch pipelines and the second shared pipeline in sequence;

one end of the second branch pipeline corresponding to each reagent supply unit is sequentially connected to the second shared pipeline from the inflow end to the outflow end of the second shared pipeline in the sequence of low-to-high specific liquid concentration flowing through the second branch pipeline, wherein the specific liquid is the reagent which is conveyed to the corresponding second branch pipeline by each reagent supply unit; or, one end of the second branch pipeline corresponding to each reagent supply unit is sequentially connected to the second shared pipeline from the inflow end to the outflow end of the second shared pipeline in the sequence from low to high of the specific liquid concentration flowing through the second branch pipeline, and if the concentration difference between the specific liquids corresponding to at least two reagent supply units in the plurality of reagent supply units is smaller than a set difference threshold value, the second branch pipelines corresponding to the at least two reagent supply units are connected to the second shared pipeline in an unlimited sequential order; wherein the specific liquid is the reagent which is conveyed to the corresponding second branch pipeline by each reagent supply unit.

3. The apparatus of claim 2, further comprising a plurality of dosing pumps, a gas path switching assembly, a first liquid path switching assembly, and a two-way valve, a plurality of the dosing pumps being in one-to-one correspondence with a plurality of the reagent supply units, the apparatus further comprising a first cleaning liquid supply unit connected to an access point of the second shared line closest to an inflow end through a third branch line;

the air path switching assembly is used for selectively connecting one end of the quantitative pump to a positive pressure air source or a negative pressure air source;

the first liquid path switching component is used for selectively communicating the other end of the quantitative pump with the corresponding reagent supply unit or the two-way valve;

the two-way valve is used for selectively communicating the first liquid path switching component with a third pipeline, and when the two-way valve is communicated with the third pipeline, the first cleaning liquid supply unit conveys cleaning liquid to the second shared pipeline so as to clean the second shared pipeline;

and/or the device further comprises a second cleaning liquid supply unit for connecting to an access point of the first shared line closest to the inflow end;

And/or the device further comprises a second liquid path switching component and a fourth branch pipeline, the reagent supply unit comprises a hemolytic agent supply unit, the hemolytic agent supply unit is connected to an access point of the second shared pipeline closest to the inflow end through the fourth branch pipeline, the second liquid path switching component is used for selectively connecting the other end of the first liquid path switching component corresponding to the hemolytic agent supply unit to the sample reaction tank and the fourth branch pipeline, and when the other end of the first liquid path switching component is connected to the fourth branch pipeline, the hemolytic agent is conveyed to the first shared pipeline so as to clean the first shared pipeline.

4. The apparatus according to claim 2, wherein at least one of the sample reaction units further comprises a first cleaning liquid supply unit, a hemolysis agent supply unit, and at least two dye liquid supply units; the at least two dye liquor supply units are used for supplying different dye liquor;

the dye liquor supply units are respectively connected with an access point, close to the outflow end, of the second shared pipeline through a second branch pipeline, the hemolytic agent supply unit is connected with an access point, close to the inflow end, of the second shared pipeline through a second branch pipeline, and the first cleaning liquid supply unit is connected with the inflow end of the second shared pipeline.

5. The apparatus of claim 2, wherein a distance between access points of adjacent first branch pipes on the first shared pipe is a first distance, a distance between center points of adjacent reaction tanks corresponding to adjacent first branch pipes is a second distance, and the first distance is less than or equal to a first set multiple of the second distance, or the second distance is less than or equal to a second set multiple of the first distance.

6. The apparatus of claim 2, wherein the first branch line comprises a two-way valve, a first sub-line, and a second sub-line, the first sub-line communicating with the second sub-line through the two-way valve to form the first branch line;

the length of the first sub-pipeline is not greater than a preset first length threshold value, and the length of the second sub-pipeline is not greater than a preset second length threshold value; and/or the length of the first sub-pipeline is not smaller than a preset third length threshold value, and the length of the second sub-pipeline is not smaller than the third length threshold value.

7. A device according to claim 3, further comprising a preheating unit connected between the two-way valve and an access point on the second shared line closest to the inflow end of the second shared line, the preheating unit being adapted to preheat the liquid flowing therethrough.

8. The control method for a sample detection device as claimed in any one of claims 1 to 7, wherein the shared pipeline includes a first shared pipeline, the plurality of branch pipelines includes a plurality of first branch pipelines, the sample detection device includes a plurality of two-way valves, each of the two-way valves is correspondingly connected in series to one of the first branch pipelines, and is used for switching between a conducting state and a blocking state of the first branch pipeline, the control method includes:

and controlling one of the two-way valves to be selectively communicated so that the first shared pipeline is communicated with one of the sample reaction tanks.

9. The control method according to claim 8, wherein the transport destination unit includes a sample detection unit, the liquid supply unit includes a sample reaction unit including a sample reaction cell for receiving a sample and at least two reagents and reacting to form a sample liquid; the sample detection device further comprises a tee joint, a suction module and a sample pushing module, wherein a first interface of the tee joint is connected with the outflow end of the first sharing pipeline, the suction module is connected with a second interface of the tee joint, and the sample detection unit is connected with a third interface of the tee joint;

The sample pushing module is connected to the inflow end of the first sharing pipeline;

the control method further includes:

opening two-way valves corresponding to sample reaction tanks to be detected, and closing two-way valves corresponding to other sample reaction tanks;

controlling the suction module to generate negative pressure, sucking liquid in a sample reaction tank to be detected into the first shared pipeline, controlling the sample pushing module to generate positive pressure, and conveying the liquid in the first shared pipeline into the sample detection unit for detection;

and controlling the sample pushing module to reset after the sample detection unit completes detection.

10. The method of claim 8, wherein the liquid supply unit comprises a sample reaction unit comprising a sample reaction cell for receiving a sample and at least two reagents and reacting to form a sample liquid;

the control method further includes:

respectively presetting a preset working time sequence corresponding to each sample reaction unit, wherein the preset working time sequence comprises a sample preparation period and a cleaning period;

the control method further includes: when one sample reaction unit is in the cleaning period, the two-way valve corresponding to one sample reaction unit which is currently in the sample preparation period is controlled to be conducted in response to the fact that the sample reaction unit which is currently in the sample preparation period finishes the preparation of the sample in the sample preparation period.