CN116096889A - 用于抑制angptl3表达的组合物和方法 - Google Patents

用于抑制angptl3表达的组合物和方法 Download PDF

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Publication number
CN116096889A
CN116096889A CN202180036489.6A CN202180036489A CN116096889A CN 116096889 A CN116096889 A CN 116096889A CN 202180036489 A CN202180036489 A CN 202180036489A CN 116096889 A CN116096889 A CN 116096889A
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oligonucleotide
nucleotides
angptl3
length
subject
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Chinese (zh)
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B·D·布朗
H·T·杜德克
U·萨克森
M·艾布拉姆斯
A·图拉诺夫
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Dicerna Pharmaceuticals Inc
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Dicerna Pharmaceuticals Inc
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    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/531—Stem-loop; Hairpin

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202180036489.6A 2020-03-18 2021-03-18 用于抑制angptl3表达的组合物和方法 Pending CN116096889A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062991335P 2020-03-18 2020-03-18
US62/991335 2020-03-18
PCT/US2021/022967 WO2021188795A1 (en) 2020-03-18 2021-03-18 Compositions and methods for inhibiting angptl3 expression

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CN116096889A true CN116096889A (zh) 2023-05-09

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US (1) US20230287425A1 (https=)
EP (1) EP4121536A1 (https=)
JP (3) JP7398007B2 (https=)
KR (1) KR20220156880A (https=)
CN (1) CN116096889A (https=)
AU (2) AU2021236674B2 (https=)
BR (1) BR112022018667A2 (https=)
CA (1) CA3172117A1 (https=)
CL (1) CL2022002521A1 (https=)
IL (1) IL296549A (https=)
MX (1) MX2022011550A (https=)
TW (2) TWI870563B (https=)
WO (1) WO2021188795A1 (https=)

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WO2022079222A1 (en) * 2020-10-16 2022-04-21 Sanofi Novel rna compositions and methods for inhibiting angptl3
JP2024508896A (ja) 2021-03-04 2024-02-28 アルナイラム ファーマシューティカルズ， インコーポレイテッド アンジオポエチン様３（ＡＮＧＰＴＬ３）ｉＲＮＡ組成物およびその使用方法
WO2023092102A1 (en) * 2021-11-19 2023-05-25 Sanegene Bio Usa Inc. Double stranded rna targeting angiopoietin-like 3 (angptl-3) and methods of use thereof
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KR20220156880A (ko) 2022-11-28
CL2022002521A1 (es) 2023-05-19
JP7398007B2 (ja) 2023-12-13
JP2023518409A (ja) 2023-05-01
JP7749645B2 (ja) 2025-10-06
BR112022018667A2 (pt) 2022-11-29
WO2021188795A1 (en) 2021-09-23
IL296549A (en) 2022-11-01
TWI870563B (zh) 2025-01-21
MX2022011550A (es) 2023-01-04
CA3172117A1 (en) 2021-09-23
TW202200163A (zh) 2022-01-01
EP4121536A1 (en) 2023-01-25
AU2025203784A1 (en) 2025-06-19
TW202530410A (zh) 2025-08-01
AU2021236674B2 (en) 2025-03-06
JP2026016378A (ja) 2026-02-03
AU2021236674A1 (en) 2022-10-13
US20230287425A1 (en) 2023-09-14
JP2024041748A (ja) 2024-03-27

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