CN116096741B - 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法 - Google Patents

用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法 Download PDF

Info

Publication number
CN116096741B
CN116096741B CN202180056036.XA CN202180056036A CN116096741B CN 116096741 B CN116096741 B CN 116096741B CN 202180056036 A CN202180056036 A CN 202180056036A CN 116096741 B CN116096741 B CN 116096741B
Authority
CN
China
Prior art keywords
amino acid
feline
polypeptide
wild
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202180056036.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN116096741A (zh
Inventor
W·布朗迪克
B·谢瓦利埃
J·霍恩
M·纳塔拉扬
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Invitex
Original Assignee
Invitex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invitex filed Critical Invitex
Priority to CN202411349658.3A priority Critical patent/CN119899259A/zh
Publication of CN116096741A publication Critical patent/CN116096741A/zh
Application granted granted Critical
Publication of CN116096741B publication Critical patent/CN116096741B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202180056036.XA 2020-07-10 2021-06-23 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法 Active CN116096741B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411349658.3A CN119899259A (zh) 2020-07-10 2021-06-23 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063050535P 2020-07-10 2020-07-10
US63/050,535 2020-07-10
US202163143720P 2021-01-29 2021-01-29
US63/143,720 2021-01-29
PCT/US2021/038714 WO2022010652A1 (en) 2020-07-10 2021-06-23 Compositions for increasing half-life of a therapeutic agent in felines and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202411349658.3A Division CN119899259A (zh) 2020-07-10 2021-06-23 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法

Publications (2)

Publication Number Publication Date
CN116096741A CN116096741A (zh) 2023-05-09
CN116096741B true CN116096741B (zh) 2024-10-18

Family

ID=77043030

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202180056036.XA Active CN116096741B (zh) 2020-07-10 2021-06-23 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法
CN202411349658.3A Pending CN119899259A (zh) 2020-07-10 2021-06-23 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202411349658.3A Pending CN119899259A (zh) 2020-07-10 2021-06-23 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法

Country Status (11)

Country Link
US (4) US11498953B2 (enExample)
EP (1) EP4178977A1 (enExample)
JP (2) JP7881538B2 (enExample)
KR (1) KR20230038522A (enExample)
CN (2) CN116096741B (enExample)
AU (1) AU2021306179A1 (enExample)
BR (1) BR112022027028A2 (enExample)
CA (1) CA3188448A1 (enExample)
MX (1) MX2023000500A (enExample)
TW (1) TW202216749A (enExample)
WO (1) WO2022010652A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10093731B2 (en) 2017-02-24 2018-10-09 Kindred Biosciences, Inc. Anti-IL31 antibodies for veterinary use
AU2018318440A1 (en) 2017-08-15 2020-02-13 Kindred Biosciences, Inc. IgG Fc variants for veterinary use
CN120005022A (zh) 2019-01-03 2025-05-16 因外泰克斯公司 用于增加治疗剂在犬中的半衰期的组合物及使用方法
JP7671275B2 (ja) 2019-08-29 2025-05-01 エランコ・ユーエス・インコーポレイテッド 動物用の抗ｉｌ３１抗体
JP7832123B2 (ja) 2020-05-11 2026-03-17 インベテックス インコーポレイテッド 治療薬のイヌにおける半減期を増加させるための組成物及びその使用方法
EP4166574A4 (en) * 2020-06-10 2025-01-15 Bica Therapeutics Inc. FUSION PROTEIN WITH ERYTHROPOIETIN POLYPEPTIDE
CN116096741B (zh) 2020-07-10 2024-10-18 因外泰克斯公司 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法
EP4255933A4 (en) * 2020-12-07 2025-07-23 Invetx Inc COMPOSITIONS FOR INCREASING THE HALF-LIFE OF A THERAPEUTIC AGENT IN LIVESTOCK ANIMALS AND METHODS OF USE
US20240400708A1 (en) * 2020-12-18 2024-12-05 Zoetis Services Llc Mutations in feline antibody constant regions
AU2023415535A1 (en) 2022-12-27 2025-07-10 Invetx, Inc. Polypeptides with altered binding to neonatal fc receptor (fcrn) and methods of use
CN121002059A (zh) 2023-01-20 2025-11-21 因外泰克斯公司 用于伴侣动物的双特异性结合剂
IL322604A (en) * 2023-02-08 2025-10-01 Levicept Ltd Fusion protein
EP4669757A1 (en) 2024-03-21 2025-12-31 Akston Biosciences Corporation PD-L1 ANALOGUE FUSION PROTEINS FOR ANTIGEN-SPECIFIC IMMUNOTHERAPY AND METHODS OF USE
CN121779581B (zh) * 2026-03-09 2026-06-16 华中农业大学 长效猫粒细胞巨噬细胞集落刺激因子重组蛋白、及其cho细胞表达方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101001873A (zh) * 2004-08-04 2007-07-18 应用分子进化公司 Fc区变体
CN101098890A (zh) * 2004-11-12 2008-01-02 赞科股份有限公司 对FcRn的结合被改变的Fc变体

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US5683888A (en) 1989-07-22 1997-11-04 University Of Wales College Of Medicine Modified bioluminescent proteins and their use
US5292658A (en) 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
DK0575319T3 (da) 1991-03-11 2000-07-10 Univ Georgia Res Found Kloning og ekspression af Renilla-luciferase
CA2169298A1 (en) 1993-09-10 1995-03-16 Martin Chalfie Uses of green fluorescent protein
WO1995021191A1 (en) 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
US5777079A (en) 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
US5874304A (en) 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
US5804387A (en) 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US5876995A (en) 1996-02-06 1999-03-02 Bryan; Bruce Bioluminescent novelty items
US5925558A (en) 1996-07-16 1999-07-20 The Regents Of The University Of California Assays for protein kinases using fluorescent protein substrates
US5976796A (en) 1996-10-04 1999-11-02 Loma Linda University Construction and expression of renilla luciferase and green fluorescent protein fusion genes
ATE290205T1 (de) 1996-12-12 2005-03-15 Prolume Ltd Vorrichtung und verfahren zum nachweis und identifizieren von infektiösen wirkstoffen
AU765703B2 (en) 1998-03-27 2003-09-25 Bruce J. Bryan Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
US7658921B2 (en) 2000-12-12 2010-02-09 Medimmune, Llc Molecules with extended half-lives, compositions and uses thereof
WO2005047327A2 (en) 2003-11-12 2005-05-26 Biogen Idec Ma Inc. NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
CA2577133A1 (en) 2004-08-19 2006-03-23 Genentech, Inc. Polypeptide variants with altered effector function
US8546543B2 (en) * 2004-11-12 2013-10-01 Xencor, Inc. Fc variants that extend antibody half-life
US8802820B2 (en) * 2004-11-12 2014-08-12 Xencor, Inc. Fc variants with altered binding to FcRn
WO2010110838A2 (en) 2009-03-25 2010-09-30 Vet Therapeutics Inc. Antibody constant domain regions and uses thereof
WO2010117448A2 (en) 2009-04-05 2010-10-14 Provenance Biopharmaceuticals Corp. Chimeric immunocytokines and methods of use thereof
AU2012252152B2 (en) 2011-05-06 2016-07-07 Zoetis Services Llc Anti-nerve growth factor antibodies and methods of preparing and using the same
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
US20130129727A1 (en) 2011-11-17 2013-05-23 Nanjingjinsirui Science & Technology Biology Corporation Methods and systems for increasing protein stability
US20140294812A1 (en) * 2013-03-15 2014-10-02 Xencor, Inc. Fc variants that improve fcrn binding and/or increase antibody half-life
WO2016044676A2 (en) * 2014-09-18 2016-03-24 AskGene Pharma, Inc. Novel feline erythropoietin receptor agonists
US11596699B2 (en) 2016-04-29 2023-03-07 CureVac SE RNA encoding an antibody
EP3481413A4 (en) 2016-07-08 2020-01-08 Askgene Pharma, Inc. FUSION PROTEIN WITH LEPTIN AND METHOD FOR THE PRODUCTION AND USE THEREOF
EP3526246A1 (en) * 2016-10-17 2019-08-21 Vetoquinol SA Modified antibody constant region
US10093731B2 (en) 2017-02-24 2018-10-09 Kindred Biosciences, Inc. Anti-IL31 antibodies for veterinary use
AU2018318440A1 (en) 2017-08-15 2020-02-13 Kindred Biosciences, Inc. IgG Fc variants for veterinary use
BR112020017701A2 (pt) 2018-03-12 2020-12-29 Zoetis Services Llc Anticorpos anti-ngf e métodos dos mesmos
JP7449234B2 (ja) 2018-03-16 2024-03-13 ゾエティス・サービシーズ・エルエルシー 獣医学使用のためのインターロイキン３１モノクローナル抗体
JP2022500037A (ja) 2018-09-14 2022-01-04 キンドレッド バイオサイエンシズ インコーポレイテッド 獣医学的使用のための抗ｉｌ４受容体抗体
EP3866842A4 (en) 2018-10-18 2022-07-13 Kindred Biosciences, Inc. FC VARIANTS WITH MODIFIED BINDING TO THE NEONATAL FC RECEPTOR (FCRN) FOR VETERINARY USE
WO2020116560A1 (ja) * 2018-12-05 2020-06-11 株式会社バイカ・セラピュティクス 抗体のＦｃ領域改変体
WO2020139984A1 (en) 2018-12-27 2020-07-02 Kindred Biosciences, Inc. Igg fc variants for veterinary use
CN120005022A (zh) * 2019-01-03 2025-05-16 因外泰克斯公司 用于增加治疗剂在犬中的半衰期的组合物及使用方法
CN115135669B (zh) 2020-02-19 2026-05-19 硕腾服务有限责任公司 修饰的Fc区
IL297287A (en) 2020-04-17 2022-12-01 Zoetis Services Llc Canine antibody variants
EP4136109A1 (en) 2020-04-17 2023-02-22 Zoetis Services LLC Feline antibody variants
JP7832123B2 (ja) 2020-05-11 2026-03-17 インベテックス インコーポレイテッド 治療薬のイヌにおける半減期を増加させるための組成物及びその使用方法
US20220119513A1 (en) 2020-06-08 2022-04-21 Zoetis Services Llc Anti-tgfb antibodies and therapeutic uses thereof
CN116096741B (zh) 2020-07-10 2024-10-18 因外泰克斯公司 用于延长治疗剂在猫科动物中的半衰期的组合物和使用方法
KR20230104157A (ko) 2020-10-07 2023-07-07 조에티스 서비시즈 엘엘씨 항-ngf 항체 및 그의 사용 방법
TW202607038A (zh) 2020-10-19 2026-02-16 美商碩騰服務公司 犬及貓抑瘤素Ｍ受體β之抗體及其用途
US20240400708A1 (en) 2020-12-18 2024-12-05 Zoetis Services Llc Mutations in feline antibody constant regions
US20250011410A1 (en) 2021-11-23 2025-01-09 Invetx, Inc. Anti-ngf antibodies and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101001873A (zh) * 2004-08-04 2007-07-18 应用分子进化公司 Fc区变体
CN101098890A (zh) * 2004-11-12 2008-01-02 赞科股份有限公司 对FcRn的结合被改变的Fc变体

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"In Vitro functional characterization of feline IgGs";Catherine J. Strietzel 等;《Veterinary Immunology and Immunopathology》;图4 *

Also Published As

Publication number Publication date
US20230090405A1 (en) 2023-03-23
JP2023534636A (ja) 2023-08-10
MX2023000500A (es) 2023-04-12
CN116096741A (zh) 2023-05-09
US11739135B2 (en) 2023-08-29
WO2022010652A1 (en) 2022-01-13
KR20230038522A (ko) 2023-03-20
BR112022027028A2 (pt) 2023-03-07
US20220259282A1 (en) 2022-08-18
US20220009994A1 (en) 2022-01-13
US12344650B2 (en) 2025-07-01
AU2021306179A1 (en) 2023-03-02
CA3188448A1 (en) 2022-01-13
CN119899259A (zh) 2025-04-29
US20250304650A1 (en) 2025-10-02
JP7881538B2 (ja) 2026-06-29
US11498953B2 (en) 2022-11-15
JP2026126235A (ja) 2026-08-04
EP4178977A1 (en) 2023-05-17
TW202216749A (zh) 2022-05-01

Similar Documents

Publication Publication Date Title
US20230279118A1 (en) Compositions for increasing half-life of a therapeutic agent in canines and methods of use
US11739135B2 (en) Compositions for increasing half-life of a therapeutic agent in felines and methods of use
CN115867572B (zh) 用于增加治疗剂在犬中的半衰期的组合物和使用方法
US20250197478A1 (en) Compositions for increasing half-life of a therapeutic agent in livestock animals and methods of use
KR20250130357A (ko) 신생아 fc 수용체 (fcrn)에 대한 결합이 변경된 폴리펩타이드 및 사용 방법
KR20250137204A (ko) 신생아 fc 수용체(fcrn)에 대한 결합이 변경된 폴리펩타이드 및 사용 방법
RU2828219C2 (ru) Композиции для увеличения периода полужизни терапевтического средства у собак и способы применения
HK40085105A (en) Compositions for increasing half-life of a therapeutic agent in felines and methods of use
HK40128509A (en) Compositions for increasing half-life of a therapeutic agent in canines and methods of use
HK40085105B (en) Compositions for increasing half-life of a therapeutic agent in felines and methods of use
HK40127007A (en) Compositions for increasing half-life of a therapeutic agent in canines and methods of use
HK40102570A (en) Compositions for increasing half-life of a therapeutic agent in livestock animals and methods of use
HK40063007B (en) Compositions for increasing half-life of a therapeutic agent in canines and methods of use

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40085105

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant