CN116077718A - Collagen functional dressing for promoting healing and repairing and moisturizing skin and preparation method thereof - Google Patents
Collagen functional dressing for promoting healing and repairing and moisturizing skin and preparation method thereof Download PDFInfo
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- CN116077718A CN116077718A CN202211345571.XA CN202211345571A CN116077718A CN 116077718 A CN116077718 A CN 116077718A CN 202211345571 A CN202211345571 A CN 202211345571A CN 116077718 A CN116077718 A CN 116077718A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0033—Collagen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides a collagen functional dressing for promoting healing and repairing, preserving moisture and moistening skin and a preparation method thereof, comprising the steps of taking purified water in a formula, and adding medical type III collagen and sodium propylparaben to obtain a mixture; or taking 60-70% of purified water by weight of the purified water in the formula, adding medical type III collagen and sodium propylparaben, adding a wrapping agent, homogenizing to obtain a mixture, mixing the mixture with the rest purified water, heating and stirring, standing, and cooling to obtain the collagen functional dressing. The collagen functional dressing prepared by adopting the technology of the wrapping agent greatly improves the skin barrier function, can effectively regulate the water-oil balance of the skin, prevents the excessive evaporation of skin moisture, is beneficial to maintaining the skin health, has high component biological activity, and can realize the continuous and stable moisturizing and repairing effects of wound surfaces.
Description
Technical Field
The invention relates to the technical field of collagen dressing, in particular to a collagen functional dressing for promoting healing and repairing, preserving moisture and moistening skin and a preparation method thereof.
Background
Collagen is the most abundant structural protein in animal connective tissue, widely present in skin and cartilage, and accounts for about 85% of extracellular matrix. Plays an important role in the repair, healing and other processes of tissue organs, and collagen forms extracellular matrix by participating in the processes of cell adhesion, proliferation, differentiation and the like. The collagen has good low immunogenicity, biodegradability, biocompatibility and the like, is applied to auxiliary materials for wound healing, and is especially a research hot spot in recent years.
Traditional dressing functions are relatively limited, and the moisturizing effect is basically absent. Currently, more research is directed to moisturizing medical dressings based on polymeric materials, composite materials, and synthetic materials, such as hydrogels, hydrocolloids, and the like. It is a current research hotspot to provide a suitable dressing, i.e. not only with excellent moisture retention, but also with rapid repairability to promote wound healing.
Disclosure of Invention
In view of the above, the invention aims to provide a collagen functional dressing for promoting healing and repairing and moisturizing skin and a preparation method thereof, and the collagen functional dressing has the effects of promoting healing and repairing and moisturizing skin.
The technical scheme of the invention is realized as follows:
a preparation method of a collagen functional dressing for promoting healing and repairing and moisturizing skin comprises the following preparation steps:
step 1: taking 60-70% of purified water by weight in the formula, and adding medical type III collagen and sodium propylparaben to obtain a mixture; or taking 60-70% of purified water by weight in the formula, adding medical type III collagen and sodium propylparaben, adding a wrapping agent, and homogenizing to obtain a mixture;
step 2: mixing the mixture with the rest purified water, heating and stirring, standing, and cooling to obtain the collagen functional dressing
In the further scheme, in the step 2, the heating and stirring are as follows: heating to 50-60deg.C and stirring at 1000-1500 r/min.
In the step 2, the standing time is 30-50min; the temperature is naturally reduced to 25-30 ℃.
The formula comprises the following raw materials in parts by weight: comprises the following raw materials in parts by weight: 12-26 parts of medical type III collagen, 25-65 parts of sodium propylparaben and 80-120 parts of purified water.
The formula comprises the following raw materials in parts by weight: 12-20 parts of medical type III collagen, 45-55 parts of sodium propylparaben and 80-120 parts of purified water.
Further, the formula comprises the following raw materials in parts by weight: 16 parts of medical type III collagen, 50 parts of sodium propylparaben and 100 parts of purified water.
The further proposal is that the coating agent consists of sorbitan palmitate, beta-vegetable oil and zeaxanthin dipalmitate; the additive amount of the wrapping agent in the formula is 3-5 parts.
The wrapping agent prepared from the sorbitan palmitate, the beta-vegetable oil and the zeaxanthin dipalmitate can form a stable wrapping structure, is favorable for protecting active ingredients such as medical type III collagen, sodium propylparaben and the like, can form a lubricating film layer on the wound surface of the wound, improves the transdermal absorbability and wound repair property of the active ingredients, can also provide a certain sealing property, prevents and controls excessive and rapid loss of skin moisture, and plays a role in continuously and effectively maintaining the healthy state of the skin.
In a further scheme, the wrapping agent consists of the following components in percentage by mass of 8:3-4:4-5 sorbitan palmitate, beta-vegetable oil and zeaxanthin dipalmitate.
A collagen functional dressing for promoting healing and repairing and moisturizing skin is prepared by the preparation method of the collagen functional dressing.
Compared with the prior art, the invention has the beneficial effects that:
the medical III-type collagen and sodium propylparaben are adopted, and the sorbitan palmitate, the beta-vegetable oil and the zeaxanthin dipalmitate are selected to form the wrapping agent, so that a certain sealing property can be provided, a synergistic effect can be achieved with other components, the skin barrier function is greatly improved, the water-oil balance of the skin can be effectively regulated, the excessive evaporation of skin moisture is prevented, and the skin health is maintained.
The collagen functional dressing has good healing promoting and repairing effects, and SD rat skin defect model experiments show that the rate of the unoccluded wound surface of the rat is only 1.8% in the 10 th d.
The invention adopts the technology of the wrapping agent to improve the moisturizing skin and healing promoting repair functions of the collagen functional dressing. The wrapping agent prepared from the sorbitan palmitate, the beta-vegetable oil and the zeaxanthin dipalmitate can form a stable wrapping structure, is favorable for protecting active ingredients such as medical type III collagen, sodium propylparaben and the like, can form a lubricating film layer on the wound surface of the wound, improves the transdermal absorbability and wound repair property of the active ingredients, can also provide a certain sealing property, prevents and controls excessive and rapid loss of skin moisture, and plays a role in continuously and effectively maintaining the healthy state of the skin.
Detailed Description
In order to better understand the technical content of the present invention, the following provides specific examples to further illustrate the present invention.
The experimental methods used in the embodiment of the invention are conventional methods unless otherwise specified.
Materials, reagents, and the like used in the examples of the present invention are commercially available unless otherwise specified.
Example 1
A collagen functional dressing for promoting healing and repairing, moisturizing skin comprises the following raw materials: 12 parts of medical type III collagen, 25 parts of sodium propylparaben and 80 parts of purified water;
the preparation method of the collagen functional dressing comprises the following preparation steps:
step 1: according to the weight parts, 60% of purified water in the formula is taken, and medical type III collagen and sodium propylparaben are added to obtain a mixture;
step 2: mixing the mixture with the rest purified water, heating to 50deg.C, stirring at 1000r/min, standing for 30min, and naturally cooling to 25deg.C to obtain the collagen functional dressing.
Example 2
A collagen functional dressing for promoting healing and repairing, moisturizing skin comprises the following raw materials: 26 parts of medical type III collagen, 65 parts of sodium propylparaben and 120 parts of purified water;
the preparation method of the collagen functional dressing comprises the following preparation steps:
step 1: according to the weight parts, 70% of purified water in the formula is taken, and medical type III collagen and sodium propylparaben are added to obtain a mixture;
step 2: mixing the mixture with the rest purified water, heating to 60 ℃ while stirring and mixing at the speed of 1500r/min, standing for 50min after stirring, and naturally cooling to 30 ℃ to obtain the collagen functional dressing.
Example 3
A collagen functional dressing for promoting healing and repairing, moisturizing skin comprises the following raw materials: 20 parts of medical type III collagen, 55 parts of sodium propylparaben and 120 parts of purified water;
the preparation method of the collagen functional dressing comprises the following preparation steps:
step 1: according to the weight parts, 65% of purified water in the formula is taken, and medical type III collagen and sodium propylparaben are added to obtain a mixture;
step 2: mixing the mixture with the rest purified water, heating to 55deg.C, stirring at 1200r/min, standing for 40min, and naturally cooling to 28deg.C to obtain the collagen functional dressing.
Example 4
A collagen functional dressing for promoting healing and repairing, moisturizing skin comprises the following raw materials: 16 parts of medical type III collagen, 50 parts of sodium propylparaben and 100 parts of purified water;
the preparation method of the collagen functional dressing comprises the following preparation steps:
step 1: according to the weight parts, 65% of purified water in the formula is taken, and medical type III collagen and sodium propylparaben are added to obtain a mixture;
step 2: mixing the mixture with the rest purified water, heating to 55deg.C, stirring at 1200r/min, standing for 40min, and naturally cooling to 28deg.C to obtain the collagen functional dressing.
Example 5
A collagen functional dressing for promoting healing and repairing, moisturizing skin comprises the following raw materials: 16 parts of medical type III collagen, 4 parts of a wrapping agent, 50 parts of sodium propylparaben and 100 parts of purified water;
the wrapping agent comprises the following components in percentage by mass: 3:5 sorbitan palmitate, beta-vegetable oil and zeaxanthin dipalmitate;
the preparation method of the collagen functional dressing comprises the following preparation steps:
step 1: according to the weight parts, 65% of purified water in the formula is taken, medical type III collagen and sodium propylparaben are added, a wrapping agent is added, and the mixture is obtained after homogenization;
step 2: mixing the mixture with the rest purified water, heating to 55deg.C, stirring at 1200r/min, standing for 40min, and naturally cooling to 28deg.C to obtain the collagen functional dressing.
Comparative example 1
A collagen functional dressing for promoting healing and repairing, moisturizing skin comprises the following raw materials: 16 parts of medical type III collagen, 4 parts of a wrapping agent, 50 parts of sodium propylparaben and 100 parts of purified water;
the wrapping agent comprises the following components in percentage by mass: 5 sorbitan palmitate and polyglycerol;
the preparation method of the collagen functional dressing comprises the following steps: according to the weight parts, adding medical type III collagen and sodium propylparaben into purified water, adding a wrapping agent, and homogenizing to obtain the collagen functional dressing.
1. Safety test
The collagen functional dressing prepared in the embodiment and the comparative example is respectively subjected to animal skin irritation test, skin sensitization test and in-vitro cytotoxicity test, and the test results show that the prepared collagen functional dressing is safe and nontoxic.
2. Moisturizing skin test
Moisturizing skin experiment was performed using Epikutis 3D skin model, 0.9mL of Epi Growth culture solution was added to 6-well plate wells, 3D epidermis skin model was transferred to 6-well plate wells, and 5% CO was performed at 37℃ 2 The surface of the 3D skin model was washed 15 times with sterile PBS for 24 hours, and a 3D skin model was prepared.
0.3mL of Epi Growth culture solution is added into a hole of a 6-hole plate, the hole is moved into a 3D epidermis skin model, collagen functional dressings obtained in the example and the comparative example are respectively smeared on the surface of the 3D skin model, the smearing amount is 25 mu L, a blank group is not treated, a cover of the 6-hole plate is opened under a sterile condition, the hole is kept stand for 30min, measurement is carried out, and the skin moisture content of the 3D skin model is measured by adopting a skin moisture tester Corneometer CM825 MDD-4, so that the results are shown in the following table 1.
Table 1 measurement results of skin moisture content increase rate of collagen functional dressing to 3D skin model for 30min
| Project | Improvement rate of |
| Example 1 | 64.5％ |
| Example 2 | 67.2％ |
| Example 3 | 66.6％ |
| Example 4 | 70.7％ |
| Example 5 | 83.7％ |
| Comparative example 1 | 51.5％ |
As shown in the table 1, the collagen functional dressing obtained by the invention has good skin moisturizing effect, and the improvement rate of the skin water content is 64.5-83.7%. The medical III-type collagen and sodium propylparaben are adopted, and the sorbitan palmitate, the beta-vegetable oil and the zeaxanthin dipalmitate are selected to form the wrapping agent, so that a certain sealing property can be provided, a synergistic effect can be achieved with other components, the skin barrier function is greatly improved, the water-oil balance of the skin can be effectively regulated, the excessive evaporation of skin moisture is prevented, and the skin health is maintained.
3. Healing promotion and repair experiment
SD rat skin defect model is selected for healing promotion and repair experiments, the average weight of rats is about 180-200g, and adaptive feeding is carried out for 1 week before the experiments. The construction of the SD rat skin defect model is as follows: firstly, removing hair on the back of a rat, cleaning the exposed skin, and then cutting out a wound with the diameter of about 1cm by scissors. Rats were randomly divided into 5 groups of 10 rats each, each group was coated with the collagen functional dressing obtained in examples and comparative examples, respectively, and the control group was treated with clear water. The wound surface area was measured using Image J software, and the unoccluded wound surface rate (%) = (S 1 -S 0 ) X 100, wherein S 0 For preoperative wound area, S 1 Is the wound area on the t-th day after operation.
Taking wound surface tissue on the t th day after operation, drying the wound surface tissue in an incubator until the wound surface tissue is constant in weight, and calculating the water content (%) = (M) of the wound surface 0 -M 1 )/M 0 X 100, wherein M 0 Weight, g, M of wound tissue before drying 1 G is the weight of wound tissue before drying.
Table 2 SD measurement results of the rate of unoccluded wound surface of rat skin defect model and the rate of increase in moisture content of wound surface compared with control
From the above table 2, the collagen functional dressing obtained by the invention has good healing promoting and repairing effects, and the rate of the unclosed wound is 3.7% and 1.8% in 10d, which is obviously better than that of comparative example 1. The medical type III collagen and sodium propylparaben are adopted, meanwhile, the sorbitan palmitate, the beta-vegetable oil and the zeaxanthin dipalmitate are selected to form the wrapping agent, the wrapping agent is scientifically proportioned, the components are mutually cooperated, the healing speed of a wound surface can be accelerated, the moisture content of wound surface tissues is improved, the biological activity of the components is high, and the continuous and stable moistening and repairing effects of the wound surface are realized.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (9)
1. The preparation method of the collagen functional dressing for promoting healing and repairing and moisturizing skin is characterized by comprising the following preparation steps of:
step 1: taking 60-70% of purified water by weight in the formula, and adding medical type III collagen and sodium propylparaben to obtain a mixture; or taking 60-70% of purified water by weight in the formula, adding medical type III collagen and sodium propylparaben, adding a wrapping agent, and homogenizing to obtain a mixture;
step 2: mixing the mixture with the rest purified water, heating and stirring, standing, and cooling to obtain the collagen functional dressing.
2. The method for preparing the collagen functional dressing for promoting healing and repairing, preserving moisture and skin according to claim 1, wherein in the step 2, the heating and stirring are as follows: heating to 50-60deg.C and stirring at 1000-1500 r/min.
3. The method for preparing the collagen functional dressing for promoting healing and repairing and moisturizing skin according to claim 1, wherein in the step 2, the standing time is 30-50min; the temperature is naturally reduced to 25-30 ℃.
4. The preparation method of the collagen functional dressing for promoting healing and repairing and moisturizing skin according to claim 1, which is characterized by comprising the following raw materials in parts by weight: comprises the following raw materials in parts by weight: 12-26 parts of medical type III collagen, 25-65 parts of sodium propylparaben and 80-120 parts of purified water.
5. The preparation method of the collagen functional dressing for promoting healing, repairing, preserving moisture and skin according to claim 4, wherein the formula comprises the following raw materials in parts by weight: 12-20 parts of medical type III collagen, 45-55 parts of sodium propylparaben and 80-120 parts of purified water.
6. The preparation method of the collagen functional dressing for promoting healing, repairing, preserving moisture and skin according to claim 5, wherein the formula comprises the following raw materials in parts by weight: 16 parts of medical type III collagen, 50 parts of sodium propylparaben and 100 parts of purified water.
7. The method for preparing the collagen functional dressing for promoting healing and repairing and moisturizing skin according to claim 1, wherein the wrapping agent consists of sorbitan palmitate, beta-vegetable oil and zeaxanthin dipalmitate; the additive amount of the wrapping agent in the formula is 3-5 parts.
8. The preparation method of the collagen functional dressing for promoting healing, repairing, preserving moisture and skin according to claim 7, wherein the wrapping agent comprises the following components in percentage by mass: 3-4:4-5 sorbitan palmitate, beta-vegetable oil and zeaxanthin dipalmitate.
9. The collagen functional dressing for promoting healing and repairing, preserving moisture and skin prepared by the preparation method of the collagen functional dressing according to any one of claims 1 to 8.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211345571.XA CN116077718A (en) | 2022-10-31 | 2022-10-31 | Collagen functional dressing for promoting healing and repairing and moisturizing skin and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202211345571.XA CN116077718A (en) | 2022-10-31 | 2022-10-31 | Collagen functional dressing for promoting healing and repairing and moisturizing skin and preparation method thereof |
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