CN116036117A - 与三价糖缀合物连接的核酸 - Google Patents

与三价糖缀合物连接的核酸 Download PDF

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CN116036117A
CN116036117A CN202211456959.7A CN202211456959A CN116036117A CN 116036117 A CN116036117 A CN 116036117A CN 202211456959 A CN202211456959 A CN 202211456959A CN 116036117 A CN116036117 A CN 116036117A
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modified
alkylene
nucleotides
group
strand
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Chinese (zh)
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克里斯蒂安·弗劳恩多夫
马克·卡梅伦
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Silence Therapeutics GmbH
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Silence Therapeutics GmbH
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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CN202211456959.7A 2016-04-05 2017-04-05 与三价糖缀合物连接的核酸 Pending CN116036117A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP16163939.8 2016-04-05
EP16163939.8A EP3228326A1 (en) 2016-04-05 2016-04-05 Nucleic acid linked to a trivalent glycoconjugate
CN201780035060.9A CN109562188B (zh) 2016-04-05 2017-04-05 与三价糖缀合物连接的核酸
PCT/EP2017/058112 WO2017174657A1 (en) 2016-04-05 2017-04-05 Nucleic acid linked to a trivalent glycoconjugate

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CN201780035060.9A Division CN109562188B (zh) 2016-04-05 2017-04-05 与三价糖缀合物连接的核酸

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CN116036117A true CN116036117A (zh) 2023-05-02

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CN202211456959.7A Pending CN116036117A (zh) 2016-04-05 2017-04-05 与三价糖缀合物连接的核酸
CN201780035060.9A Active CN109562188B (zh) 2016-04-05 2017-04-05 与三价糖缀合物连接的核酸

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EP (3) EP3228326A1 (https=)
JP (1) JP7120925B2 (https=)
CN (2) CN116036117A (https=)
AU (1) AU2017245687B2 (https=)
CA (1) CA3019981A1 (https=)
DK (1) DK3439703T3 (https=)
ES (1) ES2805026T3 (https=)
HU (1) HUE049931T2 (https=)
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WO (1) WO2017174657A1 (https=)

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KR20240051221A (ko) 2021-09-02 2024-04-19 사일런스 테라퓨틱스 게엠베하 세포에서 보체 인자 b (cfb)의 발현을 억제하기 위한 핵산
JP2024541559A (ja) * 2021-11-29 2024-11-08 シャンハイ アルゴ バイオファーマシューティカル カンパニー，リミテッド Ｂ型肝炎ウイルス（ｈｂｖ）タンパク質の発現を阻害するための組成物および方法
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CA3019981A1 (en) 2017-10-12
US20210079397A1 (en) 2021-03-18
JP7120925B2 (ja) 2022-08-17
EP3744350A1 (en) 2020-12-02
US10913945B2 (en) 2021-02-09
ES2805026T3 (es) 2021-02-10
EP3439703A1 (en) 2019-02-13
WO2017174657A1 (en) 2017-10-12
AU2017245687B2 (en) 2023-03-09
CN109562188A (zh) 2019-04-02
JP2019510793A (ja) 2019-04-18
AU2017245687A1 (en) 2018-10-25
EP3439703B1 (en) 2020-04-29
EP3228326A1 (en) 2017-10-11
CN109562188B (zh) 2022-12-06
PL3439703T3 (pl) 2020-10-19
US11912993B2 (en) 2024-02-27
US20190119676A1 (en) 2019-04-25
HUE049931T2 (hu) 2020-11-30

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