CN116035920A

CN116035920A - Scrubbing liquid and wet towel with broad-spectrum sterilization and disinfection functions for wiping radionuclide and preparation process and application thereof

Info

Publication number: CN116035920A
Application number: CN202211580114.9A
Authority: CN
Inventors: 王明望
Original assignee: Changsha Chengde Huanyu Technology Co ltd
Current assignee: Changsha Chengde Huanyu Technology Co ltd
Priority date: 2022-12-09
Filing date: 2022-12-09
Publication date: 2023-05-02

Abstract

The invention belongs to the field of nuclear biochemical decontamination and sterilization, and particularly discloses a decontaminating liquid and wet tissue for a erasable radionuclide with broad-spectrum sterilization and disinfection, and a preparation process and application thereof. The decontamination solution contains complexing agent, synergistic complexing agent, disinfectant, synergistic disinfectant, humectant, efficacy substance 1, efficacy substance 2, auxiliary agent, surfactant, plant extract and purified water; the wet tissue is formed by sterilizing and sealing a decontamination solution and non-woven fabrics in a dust-free workshop, wherein the mass ratio of the decontamination solution to the non-woven fabrics is 2-5: the decontaminating liquid has good disinfection effect when the concentration is low, and the decontaminating liquid belongs to a long-acting disinfectant, has stable performance, light resistance, heat resistance, easy storage and low toxicity to people, can realize rapid complexing and adsorption on decontaminating radionuclides, has more than 90% of decontaminating effect when being wiped, can realize various types of sterilizable in terms of sterilization and disinfection, has high sterilization speed and has a duration time of not less than 6 hours after sterilization.

Description

Scrubbing liquid and wet towel with broad-spectrum sterilization and disinfection functions for wiping radionuclide and preparation process and application thereof

Technical Field

The invention belongs to the field of nuclear biochemical decontamination and sterilization, and particularly discloses a decontaminating liquid and wet tissue for a erasable radionuclide with broad-spectrum sterilization and disinfection, and a preparation process and application thereof.

Background

In order to avoid or reduce the attack of nuclear biochemical weapons and secondary nuclear biochemical hazards, other nuclear biochemical hazards, natural disasters and losses caused by sudden disasters, decontamination operations should be performed in different fields, so as to reduce the degree of pollution of nuclear biochemistry. There are two main classes of decontamination solutions for chemical warfare agents: the adsorption type or dissolution type decontamination solution and the chemical degradation type decontamination solution mainly adopt physical, chemical and biological methods aiming at the disinfection of biological warfare agents, wherein the chemical decontamination solution mainly comprises active chlorine, active oxygen, aldehydes, heterocyclic gases, alcohols, phenols, quaternary ammonium salts and other disinfectants; the decontamination liquid for radioactive contamination is mainly a substance capable of removing radioactive contamination directly or in the form of a solution, and comprises two kinds of water-based decontamination liquid and film-forming decontamination liquid; the wet towel is a product of immersing a certain amount of liquid in non-woven fabrics, and when the wet towel is used, a target area is quickly soaked by the liquid through physical mechanical movement, so that a target object is quickly cleaned under the double effects of chemistry and physics, the wet towel is convenient to operate and good in cleaning effect, the wet towel is widely used in daily life because of excellent performance, the wet towel can be further developed, and when the wet towel is applied to nuclear biochemical decontamination, the decontamination effect is further improved, and a special decontamination instrument is not needed for carrying out decontamination operation, so that the decontamination effect is achieved.

Chinese patent CN111345314a is used in a novel coronavirus disinfectant, a disinfectant wet wipe and a disinfection method, the wet wipe is ethanol mainly containing 60% -69.9% by volume concentration, and the carrier is selected from the group consisting of: at least one of non-woven cloth, fabric, wood pulp composite cloth, carpenter paper, and the subsequent series of experiments prove that the disinfection is effective for the surfaces of different objects, but the neutralizer experiment is not described, so that the contact time of the disinfectant and virus cannot be judged, which is possibly longer than 1min, so that each parallel group is not parallel, and the disinfection effect of ethanol is mainly described, the auxiliary effect of other disinfection components is not described, so that the ethanol plays a main disinfection effect, has stimulation on skin mucosa, has short duration after disinfection, has no disinfection effect on spores or fungi such as candida albicans, and has room for innovation;

the disinfectant described in Chinese patent CN112998012A comprises the following components in parts by weight: 100-120 parts of ethanol water solution; 0.06-0.12 part of quaternary ammonium salt bactericide; 0.06-0.15 part of benzalkonium chloride; 2-6 parts of humectant; the volume fraction of ethanol in the ethanol water solution is 45-60%; ethanol is used as a main disinfectant, and is matched with single-chain and double-chain quaternary ammonium salt for sterilization and disinfection, so that the disinfectant is suitable for daily life, but is not used in nuclear biochemical scenes and cannot be applied to emergency treatment in nuclear and radiation accidents, so that innovation space is provided;

chinese patent CN112704646a radionuclide-contaminated skin-used wet tissue and application thereof: the decontaminating liquid comprises the following components in percentage by weight: 0.5 to 10 percent of disodium ethylenediamine tetraacetate, 0.5 to 10 percent of tetradecyl dimethyl amine oxide, 0.5 to 10 percent of sodium laureth sulfate, 0.5 to 10 percent of sodium bicarbonate, 0.1 to 10 percent of sodium alginate, 0.5 to 10 percent of phenoxyethanol and the balance of deionized water. The radioactive decontamination wet tissue comprises a wet tissue body and decontamination liquid infiltrated in the wet tissue body, wherein the wet tissue body is made of dust-free cloth, and the raw materials for preparing the decontamination liquid comprise ultrapure water, fatty alcohol polyoxyethylene ether, isopropanol, 2-carboxyphosphonoacetic acid and diethylene triamine penta sodium pentaacetate. The same description of these two patents uses wet tissues to remove radionuclides, but it only involves the decontamination of radionuclides, and has no aspects related to disinfection and sterilization, and has no aspects related to biological warfare agents in nuclear biochemistry and epidemic prevention, so there is room for innovation.

Disclosure of Invention

In order to solve the problems, the invention discloses a decontaminating liquid and a wet tissue for a erasable radionuclide with broad-spectrum sterilization and disinfection, and a preparation process and application thereof. According to the invention, under the background of various factors such as recent nuclear biochemistry and epidemic prevention of major epidemic diseases at home and abroad, the problems about decontamination of radioactive contamination in nuclear biochemistry and biological warfare agent or epidemic prevention of major epidemic diseases in nuclear biochemistry are solved by a product mode of wet tissues, and the disinfection and sterilization of the nuclear radionuclides while the decontamination of the radioactive radionuclides are realized, and the radioactive nuclides can be independently treated for contamination or disinfection and sterilization.

The technical scheme of the invention is as follows:

a decontaminating liquid for a wiped radionuclide, which has broad-spectrum sterilization and disinfection, and comprises a complexing agent, a synergistic complexing agent, a disinfectant, a synergistic disinfectant, a humectant, an efficacy substance 1, an efficacy substance 2, an auxiliary agent, a surfactant, a plant extract and purified water;

the complexing agent is selected from one or more of disodium ethylenediamine tetraacetate, sodium hexametaphosphate, oxalic acid, tartaric acid and sodium citrate;

the synergistic complexing agent is selected from one or more of sodium penta-diethylenetriamine pentaacetate, sodium calcium disodium pentaacetate, sodium tripolyphosphate, diethanolamine and sodium nitrilotriacetate;

the disinfectant is selected from one or more of polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine phosphate, povidone iodine and dodecyl dimethyl benzyl ammonium chloride;

the synergistic disinfectant is one or more selected from benzalkonium chloride, didecyl dimethyl ammonium bromide and hexamethylenetetramine;

the humectant is one or more selected from glycerol, xylitol, isopropanol, trehalose and polyethylene glycol;

the functional substance 1 is one or two selected from sodium hyaluronate and vitamin A;

the functional substance 2 is one or two selected from sodium alginate and water-soluble chitosan;

the surfactant is selected from one or more of alkyl glycoside, cocamidopropyl betaine, N-acyl sarcosinate and sodium dodecyl sulfate;

the plant extract is selected from one or more of lemon extract, chamomile extract, aloe extract and honeysuckle extract;

the auxiliary agent is selected from one or more of sodium silicate, sodium carbonate, disodium hydrogen phosphate and citric acid.

The design principle of the technical scheme is as follows: in nuclear biochemistry, common radionuclides are mainly actinides and lanthanides, and are characterized by relatively active chemical properties, strong alpha decay and spontaneous fission, multiple periods of different decay numbers, complex decay products such as Th, U, pu, am, ce, pm and the like; therefore, complexing the radionuclide or the radioactive dust particles by using the complexing agent increases the solubility of the radionuclide or the radioactive dust particles in the solution or increases the suspension degree of the radioactive dust particles in the solution, which is beneficial to separating the radionuclide or the radioactive dust particles from the surface of the substrate, such as complexing agent: disodium edetate, sodium hexametaphosphate, pentasodium diethylenetriamine pentaacetate, sodium calcium diethylenetriamine pentaacetate, oxalic acid, tartaric acid, citric acid and the like. Such as efficacy 2: the sodium alginate and the water-soluble chitosan can wrap or adsorb radionuclide or dust particles thereof, prevent the radionuclide or the dust particles from diffusing, and achieve the effect of local enrichment; meanwhile, a surfactant is added into the solution to change the surface tension, so that some larger and heavier particles can be quickly wetted, and further can be easily peeled off, for example, the surfactant: alkyl glycosides, cocamidopropyl betaine, N-acyl sarcosinates, sodium dodecyl sulfate, and the like.

In sterilization and disinfection, common disinfectant types include active chlorine, active oxygen, aldehydes, heterocyclic gases, alcohols, phenols, quaternary ammonium salts and other disinfectants, and the disinfectant types can be selected only from quaternary ammonium salts and other disinfectants because of a complexing system and direct contact with the skin surface, so that the disinfectant is mild and not irritative, and the components in the system are not in conflict, such as: benzalkonium chloride, didecyl dimethyl ammonium chloride, polyhexamethylene biguanide hydrochloride, povidone iodine, and the like.

In wet wipes, it is desirable to impart some functional experience, such as efficacy 1: the sodium hyaluronate and the vitamin A can repair the cuticle of the skin, lead the skin to be smooth and fine, counteract the dry body feeling of the skin caused by a large amount of complexing agents, and play roles in thickening and stabilizing in a formula system; such as moisturizers: glycerol, xylitol, isopropanol, trehalose and polyethylene glycol can obviously preserve moisture and also serve as a buffer of a system, so that the non-woven fabric is tightly connected with molecules on the surface of the non-woven fabric when soaked in a decontamination solution, and the non-woven fabric is peeled off from the surface of a matrix while defoaming due to polyhydroxy when the radionuclide is decontaminated; such as plant extracts: lemon extract, chamomile extract, aloe extract and honeysuckle extract bring corresponding disinfection, restoration, aroma and the like, and can be used in daily life, so that users can be improved in quality after using, the market competitiveness of the product is improved on one hand, and the special scene can be used on the other hand.

Further, the decontaminating liquid for the erasable radionuclide with broad-spectrum sterilization and disinfection comprises the following components in percentage by mass: 2% -10% of complexing agent, 3% -6% of synergistic complexing agent, 0.05% -0.2% of disinfectant, 0.01% -0.3% of synergistic disinfectant, 1% -4% of humectant and 1% of efficacy substance: 0.2% -6%, efficacy 2:0.05 to 1 percent of auxiliary agent 0.2 to 2 percent, surfactant 4 to 8 percent, plant extract 0.05 to 2 percent and the balance of purified water.

Furthermore, the decontaminating liquid for the erasable radionuclide with broad-spectrum sterilization and disinfection is characterized in that the adding ratio of the complexing agent to the synergistic complexing agent is 2:1 or 3:2, at this time, the complex decontamination effect is optimal.

Furthermore, the decontaminating liquid for the erasable radionuclide with broad-spectrum sterilization and disinfection is characterized in that the adding ratio of the disinfectant to the synergistic disinfectant is 5:3 or 1:2, at this time, the sterilizing effect is the best and the sterilizing range is the widest.

Further, the above-mentioned decontaminating liquid for a erasable radionuclide having broad-spectrum sterilization and disinfection, wherein the pH of the decontaminating liquid is in the range of 5.0-8.0. Preferably, the conductivity of the production water at 25 ℃ is not more than 5.1 mu s/cm, and the decontamination liquid contains plant extract, skin care agent and other auxiliary materials, so that the requirements of corresponding raw materials of foods, cosmetics or medical use are met.

Further, the preparation process of the decontaminating liquid for the erasable radionuclide with broad-spectrum sterilization and disinfection comprises the following steps:

s1, adding 40% of purified water in a formula into a stirring tank A, adding complexing agent, synergistic complexing agent, disinfectant, synergistic disinfectant and auxiliary agent in a formula proportion, heating to 60-80 ℃, and stirring 3000-5000rap/min until the materials are completely dissolved, wherein the materials are prepared liquid A;

s2, adding 35% of purified water in a formula into a stirring tank B, heating to 85-95 ℃, adding the functional substance 2 in a formula proportion when the water temperature is higher than 85 ℃, stirring at high speed to completely dissolve 8000-9000rap/min, closing heating, suspending stirring, adding 15% of purified water in the formula, reducing the temperature to 50-65 ℃, adding the functional substance 1 in a formula proportion and a humectant, stirring for 10min by 4000-6000rap/min, adding the surfactant and the plant extract in a formula proportion, and stirring 3000-5000rap/min to completely dissolve, wherein the material is a preparation liquid B;

s3, pumping the preparation liquid A into the preparation liquid B by a pump, and stirring the preparation liquid A at 3000-5000rap/min until the preparation liquid A is completely dissolved, thus obtaining the decontamination liquid. In the process, the process is adopted, the dissolution of various materials is accelerated by using different temperatures and stirring speeds, the surfactant and the humectant are used as the buffer of a system, the precipitation reaction caused by the cationic disinfectant and the organic matters can be avoided, the prepared decontamination solution has certain viscosity when the temperature reaches normal temperature, and the decontamination solution is transparent and has plant fragrance, namely the decontamination solution with a disinfection function; double check inspection should be adopted in the batching process.

The invention also discloses a wet towel which is prepared from the non-woven fabric and the decontamination liquid.

Further, in the wet wipe, the nonwoven fabric is one or more selected from the group consisting of a spunlaced nonwoven fabric, a hot rolled nonwoven fabric, and a spunbond nonwoven fabric. Preferably, the nonwoven fabric should be clean and nontoxic, should not use recycled and waste materials, should not contain a mobilizable fluorescent whitening agent, and has a bacterial colony count of not more than 200CFU/g. If the nonwoven fabric is a spunlaced nonwoven fabric, the mass per unit area M (g/M ² ) At 50-60, the transverse and longitudinal breaking strength (N) should be greater than 14, and the mass per unit area M (g/M ² ) At 60-70, the transverse and longitudinal breaking strength (N) should be greater than 18, and the mass per unit area M (g/M ² ) At 70-80, the transverse and longitudinal breaking strength (N) should be greater than 22, and the allowable mass deviation rate per unit area is + -7 (%). If the nonwoven fabric is a hot-rolled nonwoven fabric, the mass per unit area M (g/M ² ) At 19-21, its transverse breaking strength (N) should be greater than 4, and its longitudinal direction greater than 21; mass per unit area M (g/M) ² ) At 21-23, the transverse breaking strength (N) should be greater than 5 and the longitudinal breaking strength (N) should be greater than 23, and the mass deviation rate per unit area may be allowed to be within + -8 (%). If the nonwoven fabric is a spunbonded nonwoven fabric, the mass per unit area M (g/M ² ) At 25-30, the transverse breaking strength (N) should be greater than 20 and the longitudinal direction greater than 36. Single sheetBit area mass M (g/M) ² ) At 30-35, the transverse breaking strength (N) should be greater than 26, the longitudinal breaking strength is greater than 40, and the mass per unit area M (g/M ² ) At 35-40, the transverse breaking strength (N) should be greater than 30, the longitudinal breaking strength is greater than 45, and the mass per unit area M (g/M ² ) At 40-50, the transverse breaking strength (N) should be greater than 36, and the longitudinal breaking strength (N) should be greater than 50, and the mass deviation rate per unit area can be allowed to be within + -6 (%).

Further, the preparation process of the wet tissue comprises the following steps: sterilizing the non-woven fabrics by using an air shower ultraviolet lamp, cutting out the non-woven fabrics by using automatic cutting equipment, and folding the non-woven fabrics up and down and left and right; the automatic liquid adding equipment is adopted for adding liquid, and the mass ratio of the decontamination liquid to the non-woven fabric is 2-5:1. preferably, an automatic slitting device, an automatic liquid adding device, an online weight weighing device and an online metal detector are adopted in the production process, the production workshop meets the requirements of a hundred thousand-level clean workshop, the working table is cleaned and disinfected regularly, and the colony number of the working table is kept to be not more than 20CFU/cm ² The method comprises the steps of carrying out a first treatment on the surface of the Further, the air shower ultraviolet lamp is sterilized, and then the automatic cutting equipment is adopted to cut out the specified size and fold the device up, down, left and right, for example: 22cm x 20cm; adopting automatic liquid adding equipment to add liquid, adopting online weight weighing equipment to carry out non-stop weighing, eliminating products with quality not up to standard, and ensuring that foreign matters are not contained in the products through an online metal detector; in the process, the unit area quality of the non-woven fabric and the water purification and electrolysis rate are detected. The wet tissues should be monitored for dimensional deviation, pH and package sealability during production. The detection and detection of the items such as the liquid content of the finished sterilized wet tissues, the package tightness, the movable fluorescent whitening agent, the content of active ingredients and the like are carried out.

The invention also discloses application of the wet tissue, which is applied to sterilization and disinfection or decontamination of radionuclides of actinide, lanthanide or transition metal nuclides.

In some embodiments, the disinfecting effect: after the wet tissues have the action time of 0.5min, 1.0min and 1.5min, the killing rate of the wet tissues on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and candida albicans is more than or equal to 99.9 percent (or the killing log value is more than or equal to 3.0), and the natural bacteria can be lower than the detection limit within 6 hours continuously after the sterilization treatment is carried out on the natural bacteria. After the action time of the disinfectant wet tissue extrusion liquid is 0.5min, 1.0min and 1.5min, the killing rate of the disinfectant wet tissue extrusion liquid on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, candida albicans, herpes simplex virus (HSV-1), influenza A virus (H1N 1), adenovirus (AdV 3) and poliomyelitis virus type 1 vaccine strains is more than or equal to 99.9 percent (or the killing logarithmic value is more than or equal to 3.0).

In some embodiments, radionuclide decontaminating effects: has good decontamination effect on actinide, lanthanide and transition metal nuclides, and is singly wiped for 5min to pollute 12H ²³⁵ U、 ²³² Th、 ²³⁹ Pu、 ¹⁴⁴ Ce、 ⁶⁰ Co decontamination effect is more than 80%, and 12H is infected by wiping for 5min ²³⁵ U、 ²³² Th、 ²³⁹ Pu、 ¹⁴⁴ Ce、 ⁶⁰ The Co decontamination effect is more than 90 percent.

Compared with the prior art, the invention has the following beneficial effects:

1: the wet towel is adopted, the whole package is packaged in an extraction way, the whole package is light and handy, is easy to carry and store, has no limit of using places, can be used for emergency treatment in nuclear and radiation accidents, complexing and adsorbing radionuclides, and can also be used for epidemic disease epidemic prevention treatment, disinfection and sterilization and blocking of transmission paths; in the nuclear biochemical decontamination process, a tedious instrument cleaning process is avoided, the treatment can be realized by finding and taking along with the use, the reaction speed of the treatment in the nuclear biochemical process is improved, the personnel injury caused by nuclear biochemical accidents is shortened, and the further diffusion of the nuclear biochemical accidents is effectively inhibited.

2: in the aspect of radionuclide decontamination, rapid complexation and adsorption can be realized, the single wiping decontamination effect is more than 80%, and the multiple wiping decontamination effects are more than 90%; in the aspect of sterilization, the sterilization can be performed in various types, the sterilization speed is high, and the duration time after sterilization is not less than 6 hours.

3: the cationic disinfectant is adopted for disinfection and sterilization, has good disinfection effect when the action concentration is low, and belongs to a long-acting disinfectant, the performance is stable, the disinfectant is light-resistant and heat-resistant, is easy to store, has low toxicity to people, is easy to sink together with organic matters, and can effectively resist the sink together by adopting the formula and the process, and the prepared decontamination solution is still stable in a cold-hot cycle stability experiment (-5 ℃ to 40 ℃) for 3 months, so that the stability effective period of the product is not less than 2 years.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

Optimum ratio analysis pre-experiment

1. Optimum ratio experiment of complexing agent and synergistic complexing agent

By adopting a controlled variable method, only changing the adding mole ratio of the complexing agent to the synergistic complexing agent, and exploring to decontaminate the radiouranium nuclides under the same experimental conditions, thereby obtaining the optimal complexing decontamination effect; the complexing agent adopts one or two of disodium ethylenediamine tetraacetate or sodium hexametaphosphate, the synergistic complexing agent adopts pentasodium diethylenetriamine pentaacetic acid, the complexing agent is dissolved in purified water, the pH is controlled in the range of 6.0+/-1.0, the decontamination mode is that the same non-woven fabric is adopted to soak 5H, the non-woven fabric after soaking is adopted to carry out decontamination on the 304 stainless steel which is polluted by the same volume of the same radiation amount for 12H and is 20 x 1cm, the single Zhang Xi is used for 5min, the surface pollution meter of Germany SEAcomo170 is adopted to respectively measure the background C0 of the 304 stainless steel, the surface count rate C1 after 12H pollution is carried out, and the decontamination effect is calculated according to the following formula one for the surface count rate C2 after decontamination:

equation one:

decontamination rate

Wherein: c0:304 stainless steel background; c1: the count rate of the stainless steel surface before decontamination is 304; c2: the count rate of the surface of the 304 stainless steel after decontamination; the decontamination effect is as follows in table one:

table shows the decontamination effect of complexing agents with different mole ratios

Molar ratio of

5：1

5：2

5：3

5:4

4:1

4:2

Decontamination rate

53％

62％

70％

67％

65％

78％

Molar ratio of

4:3

4：5

3：1

3：2

3：4

3：5

Decontamination rate

73％

56％

59％

79％

70％

64％

Molar ratio of

2:3

2:4

2:5

1:0

1：1

1：3

Decontamination rate

74％

66％

60％

47％

75％

58％

Molar ratio of

1：4

1：5

0:1

/

Decontamination rate

60％

55％

43％

/

The method comprises the following steps: too large a molar ratio would allow the complexing agent to reach solubility, so explore 5:1 or more or 1: the following is of no practical significance, and the invention focuses on discussion 1:5-5:1 molar ratio range.

From the above experiments, it can be seen that the molar ratio of complexing agent to co-complexing agent is 2:1 or 3:2, the optimal complexing and decontaminating effect is achieved during complexing.

2. Optimum proportion experiment of disinfectant and synergistic disinfectant

The disinfectant adopts polyhexamethylene biguanide hydrochloride, the synergistic disinfectant adopts didecyl dimethyl ammonium chloride, and the disinfectant concentration is controlled to be 0.01g/L because the disinfectant concentration influences the disinfection effect, so that the high-concentration disinfection effect can not be distinguished when the concentration of the whole disinfectant is controlled, and the influence of the whole concentration on a disinfection experiment is controlled, so that the optimal disinfection proportion can be obtained, and the maximum disinfection effect can be achieved according to the minimum disinfectant addition after that. Quantitative killing experiments (including neutralizer identification experiments) are carried out on staphylococcus aureus according to 2002 edition of disinfection technical specification under the same environmental condition, the experiments are repeated for 3 times under the constant temperature condition of 20+/-1 ℃, the killing logarithmic value of 4.0ml of decontamination stock solution under the action time of 1.0min is detected, and positive and negative controls are simultaneously set in the experiments; the following table two is the average kill rate for staphylococcus aureus at each mass ratio:

disinfection with different mass ratios and killing rate of staphylococcus aureus

Mass ratio

9:1

9:2

9:3

9:4

9:5

9:6

9:7

9:8

9:9

Killing rate of

86％

87％

90％

89％

91％

93％

92％

95％

97％

Mass ratio

8:1

8:2

8:3

8:4

8:5

8:6

8:7

8:9

7:1

Killing rate of

88％

94％

89％

92％

95％

94％

91％

93％

84％

Mass ratio

7:2

7:3

7:4

7:5

7:6

7:8

7:9

6:1

6:5

Killing rate of

86％

88％

94％

90％

91％

89％

93％

87％

88％

Mass ratio

6:7

6:8

6:9

5:1

5:2

5:3

5:4

5:6

5:7

Killing rate of

91％

93％

96％

90％

96％

99％

98％

95％

91％

Mass ratio

5:8

5:9

4:1

4:5

4:7

4:8

4:9

3:1

3:5

Killing rate of

90％

88％

91％

94％

97％

99％

89％

91％

95％

Mass ratio

3:7

3:8

3:9

2:1

2:5

2:6

2:7

2:8

2:9

Killing rate of

93％

90％

94％

93％

94％

91％

90％

87％

Mass ratio

1:4

1:5

1:6

1:7

1:8

1:9

1:0

0:1

/

Killing rate of

92％

91％

89％

88％

86％

84％

77％

81％

/

Through the experiment, the disinfectant adopts polyhexamethylene biguanide hydrochloride, the synergistic disinfectant adopts didecyl dimethyl ammonium chloride, and the method for controlling the adding mass ratio of the disinfectant to the synergistic disinfectant is used for comparison and practicability, and the disinfectant and the synergistic disinfectant are found to be added according to the mass ratio of 5:3 or 1:2, the killing rate is 99 percent, and the disinfection effect is optimal.

3. Stability test of decontamination solution formula and process optimization

Stability experiments after mixing the different ingredients were investigated in groups:

group one: 2% -10% of complexing agent, 3% -6% of synergistic complexing agent, 0.05% -0.2% of disinfectant, 0.01% -0.3% of synergistic disinfectant, 1% -4% of humectant and 1% of efficacy substance: 0.2% -6%, efficacy 2:0.05 to 1 percent, 0.2 to 2 percent of auxiliary agent, 4 to 8 percent of surfactant, 0.05 to 2 percent of plant extract and the like; the production process is produced according to the requirements of the invention;

grouping II: 2% -10% of complexing agent, 3% -6% of synergistic complexing agent, 0.05% -0.2% of disinfectant, 0.01% -0.3% of synergistic disinfectant, 1% -4% of humectant and 1% of efficacy substance: 0.2% -6%, efficacy 2:0.05 to 1 percent, 0.2 to 2 percent of auxiliary agent, 4 to 8 percent of surfactant, 0.05 to 2 percent of plant extract and the like; adding clear water into a stirrer according to the production process to stir and produce;

grouping III: 2% -10% of complexing agent, 3% -6% of synergistic complexing agent, 0.05% -0.2% of disinfectant, 0.01% -0.3% of synergistic disinfectant and 1% of functional substance: 0.2% -6%, efficacy 2:0.05% -1% and the like;

grouping four: 2 to 10 percent of complexing agent, 3 to 6 percent of synergistic complexing agent, 0.05 to 0.2 percent of disinfectant, 0.01 to 0.3 percent of synergistic disinfectant, 1 to 4 percent of humectant, 0.2 to 2 percent of auxiliary agent, 4 to 8 percent of surfactant, 0.05 to 2 percent of plant extract and the like;

grouping five: humectant 1% -4%, efficacy 1:0.2% -6%, efficacy 2:0.05 to 1 percent, 0.2 to 2 percent of auxiliary agent, 4 to 8 percent of surfactant, 0.05 to 2 percent of plant extract and the like;

the stability test method comprises the following steps: referring to the cold and hot cycle stability test method in pharmacopoeia 2020 of the people's republic of China, the cold (-5 ℃), hot (40 ℃) and cycle are carried out according to the same atmospheric pressure and the same relative humidity (75%): cold (-5 ℃) to normal temperature-heat (40 ℃) to normal temperature, wherein one month is a period, three periods are carried out, the decontaminating liquid in different states in each period is observed during the period, the judgment standard is no color change, no precipitation, no suspended matters, the content reduction rate of the disinfectant is not more than 10%, and the following table three is a record table of the grouping stability.

Table three stability experiments

The method comprises the following steps: OK is expressed as pass and NG is expressed as non-conforming;

through the analysis of the stability experimental results, the system can be more stable by adopting a special production process for the first group and the second group, and the settlement reaction of the cationic disinfectant and the organic matters can be overcome by adopting a special formula ratio for the first group, the third group, the fourth group and the fifth group. The process of the invention is adopted, and the dissolution of various materials is accelerated by using different temperatures and stirring speeds, and the surfactant and the humectant are used as the buffer of a system, so that the precipitation reaction generated by the cationic disinfectant and the organic matters can be avoided, the prepared decontamination solution has certain viscosity when the temperature reaches normal temperature, and the decontamination solution is transparent and has plant fragrance, namely the decontamination solution with a disinfection function.

Example 1

The disinfection and decontamination liquid is prepared according to the mass proportion: adding 40% of purified water in a formula into a stirring tank A, adding 4.5% of disodium ethylenediamine tetraacetate, 4.5% of diethylene triamine penta sodium pentaacetate, 0.15% of polyhexamethylene biguanide hydrochloride, 0.09% of didecyl dimethyl ammonium chloride and 0.5% of citric acid, heating to 70 ℃, stirring for 20min at 4000rap/min, and completely dissolving, wherein the material is prepared liquid A; adding 35% of purified water in a formula into a stirring tank B, heating to 90 ℃, adding 0.1% of sodium alginate when the water temperature is higher than 85 ℃, stirring at a high speed for 20min to enable the sodium alginate to be completely dissolved, closing heating, suspending stirring, adding 15% of purified water in the formula, reducing the temperature to 55 ℃, adding 1% of sodium hyaluronate and 3% of xylitol, stirring for 10min by using 5000rap/min, adding 6% of cocamidopropyl betaine and 0.08% of honeysuckle extract according to the formula proportion, stirring for 10min to enable the sodium alginate to be completely dissolved, and obtaining a preparation liquid B;

pumping the preparation liquid A into the preparation liquid B by a pump, wherein in the process, heating is not needed, the preparation liquid A can be completely dissolved by stirring for 10min only at 4000rap/min, and the pH value is 6.5, namely the disinfection and decontamination liquid; sterilizing the spunlaced nonwoven fabric by an air shower ultraviolet lamp, cutting out 22cm by 20cm by adopting automatic slitting equipment, folding up and down and left and right, adding liquid by adopting automatic liquid adding equipment, and enabling the mass ratio of the decontaminating liquid to the nonwoven fabric to be 3.5:1, a step of; and carrying out non-stop weighing by using an online weight weighing device, removing products with quality not up to standard, and ensuring that foreign matters are not in the products by using an online metal detector.

Example 2

The disinfection and decontamination liquid is prepared according to the mass proportion: adding 40% of purified water in a formula into a stirring tank A, adding 7.3% of sodium hexametaphosphate, 3% of diethylene triamine penta sodium pentaacetate, 0.06% of polyhexamethylene biguanide hydrochloride, 0.12% of didecyl dimethyl ammonium chloride and 0.4% of sodium carbonate, heating to 70 ℃, stirring for 20min at 4000rap/min, and completely dissolving, wherein the material is prepared liquid A; adding 35% purified water in the formula into a stirring tank B, heating to 90deg.C, adding 0.2% water-soluble chitosan when the water temperature is higher than 85deg.C, stirring at 8500rap/min for 20min at high speed to dissolve completely, closing heating, suspending stirring, adding 15% purified water in the formula, reducing the temperature to 55deg.C, adding 1.2% vitamin A and 3.5%

Glycerol is stirred for 10min by 5000rap/min, 4% of alkyl glycoside and 0.1% of lemon extract in the formula proportion are added, and the glycerol can be completely dissolved by 4000rap/min and stirred for 10min, and the material is prepared liquid B; pumping the preparation liquid A into the preparation liquid B by a pump, wherein in the process, heating is not needed, and the preparation liquid A can be completely dissolved only by stirring for 10min at 4000rap/min, and the pH value is 7.5, namely the disinfection and decontamination liquid;

sterilizing the spun-bonded non-woven fabric by an air shower ultraviolet lamp, cutting out 20cm by 18cm by adopting automatic cutting equipment, folding up and down and left and right, soaking for 5H by adopting a soaking sterilization decontamination solution mode, automatically packaging, carrying out non-stop weighing by utilizing an online weight weighing equipment, removing products with quality not up to standard, and ensuring that no foreign matters exist in the products by an online metal detector.

Example 3

The disinfection and decontamination liquid is prepared according to the mass proportion: adding 40% of purified water in a formula into a stirring tank A, adding 3.4% of disodium ethylenediamine tetraacetate, 6.1% of sodium hexametaphosphate, 5% of diethylene triamine penta-acetic acid pentasodium, 0.15% of polyhexamethylene biguanide hydrochloride, 0.09% of didecyl dimethyl ammonium chloride and 1% of citric acid, heating to 70 ℃, stirring for 20min at 4000rap/min to completely dissolve, and obtaining a preparation liquid A; adding 35% of purified water in a formula into a stirring tank B, heating to 90 ℃, adding 0.1% of sodium alginate and 0.2% of water-soluble chitosan when the water temperature is higher than 85 ℃, stirring at a high speed for 20min at 8500rap/min, completely dissolving, closing heating, suspending stirring, adding 15% of purified water in the formula, reducing the temperature to 55 ℃, adding 0.5% of sodium hyaluronate, 0.5% of vitamin A, 1.5% of xylitol and 1.5% of glycerol, stirring for 10min by 5000rap/min, adding 2% of alkyl glycoside, 3% of N-acyl sarcosinate, 0.08% of honeysuckle extract and 0.02% of chamomile extract according to the formula proportion, and stirring for 10min at 4000rap/min to completely dissolve, wherein the material is the preparation liquid B; pumping the preparation liquid A into the preparation liquid B by a pump, wherein in the process, heating is not needed, and the preparation liquid A can be completely dissolved only by stirring for 10min at 4000rap/min, and the pH value is 7.0, namely the disinfection and decontamination liquid;

the method comprises the steps of sterilizing a spun-laced non-woven fabric and a hot-rolled non-woven fabric by an air shower ultraviolet lamp, adopting a sandwich structure, wherein the outer layer is the spun-laced non-woven fabric, the inner layer is the hot-rolled non-woven fabric, combining through a spunbond technology, cutting out 22cm x 20cm by adopting automatic cutting equipment, folding up and down and left and right, adding liquid by adopting automatic liquid adding equipment, and the mass ratio of the decontaminating liquid to the non-woven fabric is 3.0:1, a step of; and carrying out non-stop weighing by using an online weight weighing device, removing products with quality not up to standard, and ensuring that foreign matters are not in the products by using an online metal detector.

Test case

Disinfection effect experiments were performed for examples one, two and three: according to the requirements of the 2002 edition of the disinfection technical specification, carrying out quantitative killing experiments (including neutralizer identification experiments) on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, candida albicans, herpes simplex virus (HSV-1), influenza A virus (H1N 1), adenovirus (AdV 3) and poliomyelitis virus type 1 vaccine strains, repeating the experiments for 3 times under the constant temperature condition of 20+/-1 ℃, detecting the killing logarithmic value of 4.0ml decontamination stock solution under the action time of 1.0min, and setting positive and negative controls at the same time; the detection results are shown in Table IV: the killing rate of various pathogenic bacteria/viruses by each implementation;

table four: disinfection effect detection

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The method comprises the following steps: the sterilization efficiency is higher than 99.99, the sterilization efficiency is higher than 3.00, and the sterilization efficiency is higher than 99.9, which can be demonstrated by the sterilization efficiency of >3.00 and the sterilization efficiency of >99.9 according to the requirements in 2002 edition of the sterilization technical specification;

meanwhile, a disinfection duration experiment is carried out on the natural bacteria on site, and the detection result is shown in a fifth table.

Table five: disinfection duration detection

Duration of time

1H

2H

3H

4H

5H

6H

7H

8H

9H

Implement one

>4.00

>3.00

>2.00

>1.00

>0.00

Implement two

>4.00

>3.00

>2.00

>1.00

>0.00

Implementation three

>4.00

>3.00

>2.00

>1.00

>0.00

According to the results of the disinfection effect experiments and the disinfection duration detection experiments performed in the first, second and third embodiments, the disinfection wet tissue has various pathogenic bacteria/viruses which can be disinfected, has obvious disinfection effects in the time of 0.5min, 1.0min and 1.5min, has the duration longer than 6 hours after disinfection, and can have obvious disinfection effects on biological weapons and epidemic disease epidemic prevention in nuclear biochemistry.

Decontamination radionuclide effect experiments were performed for examples one, two, and three: by using ²³⁵ U、 ²³² Th、 ²³⁹ Pu、 ¹⁴⁴ Ce、 ⁶⁰ The method comprises the steps of taking five radionuclides of Co as representative nuclides of actinides, lanthanides and transition metal nuclides, taking 20 x 1cm of 304 stainless steel as a receptor, cleaning and drying in the early stage of an experiment, respectively measuring 304 stainless steel background C0 by using a German SEAcomo170 surface contamination instrument, respectively measuring the surface count rate C1 by using a certain amount of radionuclides to pollute the stainless steel for 12H in the middle, performing single wiping and multiple wiping for 5min on the receptor by using wet tissues produced in the first, second and third embodiments, respectively measuring the surface count rate C2 after the decontamination, and calculating the decontamination effect according to a formula I; performing decontamination effect detection on representative nuclides of actinide, lanthanide and transition metal nuclides as shown in Table six;

detection of effect of surface six-decontamination radionuclide

As can be seen from the above detection results, the one, two and three steps of decontamination of radionuclides are performed ²³⁵ U、 ²³² Th、 ²³⁹ Pu、 ¹⁴⁴ Ce、 ⁶⁰ Co five kinds of radionuclides representing actinides, lanthanides and transition metal nuclides have good decontamination effects, the decontamination effects of single wiping for 5min are all more than 80%, and the decontamination effects of multiple wiping for 5min are all more than 90%. The decontamination liquid has good complexing effect.

The embodiment of the invention can be seen that the invention adopts a wet towel mode, the whole package is packaged in an extraction way, the whole package is light and handy, the portable and the storage are easy, the limit of the application place is avoided, the invention can be used for emergency treatment in nuclear and radiation accidents, complexation and radionuclide adsorption, epidemic disease epidemic prevention treatment, disinfection and sterilization and blocking of transmission paths; in the nuclear biochemical decontamination process, a tedious instrument cleaning process is avoided, the treatment can be realized by finding and taking along with the use, the reaction speed of the treatment in the nuclear biochemical process is improved, the personnel injury caused by nuclear biochemical accidents is shortened, and the further diffusion of the nuclear biochemical accidents is effectively inhibited. The invention can realize rapid complexing and adsorption on the aspect of decontaminating radionuclides, the decontaminating effect of single wiping is more than 80%, and the decontaminating effect of multiple wiping is more than 90%; in the aspect of sterilization, the sterilization can be performed in various types, the sterilization speed is high, and the duration time after sterilization is not less than 6 hours; furthermore, the cationic disinfectant is adopted for disinfection and sterilization, has good disinfection effect when the action concentration is low, and the cationic disinfectant belongs to a long-acting disinfectant, has stable performance, is light-resistant, heat-resistant, easy to store and low in toxicity to human, but is easy to sink together with organic matters, the anti-sink aggregation can be effectively realized by adopting the formula and the process, and the decontamination solution prepared and treated is still stable in a cold and hot cycle stability experiment (-5-40 ℃) for 3 months, so that the stability effective period of the product is not less than 2 years.

The invention solves the problems about decontamination of radioactive contamination in nuclear biochemistry and epidemic prevention of biological warfare agents or major epidemic diseases in nuclear biochemistry, realizes disinfection and sterilization of the nuclear radionuclide contamination while the nuclear radionuclide contamination is decontaminated, and can also independently treat the nuclear radionuclide contamination or disinfect and sterilize.

The foregoing examples are of a limited number of preferred embodiments of the invention, which are described in more detail and detail, but are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention.

Claims

1. A decontaminating liquid for a wiped radionuclide, which has broad-spectrum sterilization and disinfection, and is characterized by comprising a complexing agent, a synergistic complexing agent, a disinfectant, a synergistic disinfectant, a humectant, an efficacy substance 1, an efficacy substance 2, an auxiliary agent, a surfactant, a plant extract and purified water;

2. A decontaminating liquid for a erasable radionuclide having broad spectrum sterilization and disinfection according to claim 1, wherein the decontaminating liquid comprises, in mass percent: 2% -10% of complexing agent, 3% -6% of synergistic complexing agent, 0.05% -0.2% of disinfectant, 0.01% -0.3% of synergistic disinfectant, 1% -4% of humectant and 1% of efficacy substance: 0.2% -6%, efficacy 2:0.05 to 1 percent of auxiliary agent 0.2 to 2 percent, surfactant 4 to 8 percent, plant extract 0.05 to 2 percent and the balance of purified water.

3. The decontaminating liquid for a erasable radionuclide having broad-spectrum sterilization and disinfection according to claim 1, wherein the adding ratio of the complexing agent to the synergistic complexing agent is 2:1 or 3:2.

4. the decontaminating liquid for a erasable radionuclide with broad-spectrum sterilization and disinfection according to claim 1, wherein the addition ratio of the disinfectant to the synergistic disinfectant is 5:3 or 1:2.

5. a decontaminating liquid for a erasable radionuclide having broad spectrum sterilization and disinfection according to claim 1, wherein the pH of the decontaminating liquid is in the range of 5.0-8.0.

6. A process for the preparation of a decontamination solution according to any one of claims 1 to 5, comprising the steps of:

s3, pumping the preparation liquid A into the preparation liquid B by a pump, and stirring the preparation liquid A at 3000-5000rap/min until the preparation liquid A is completely dissolved, thus obtaining the decontamination liquid.

7. A wet wipe characterized by being prepared from a nonwoven fabric and the decontaminating liquid according to any one of claims 1 to 5.

8. The wet wipe of claim 7 wherein the nonwoven is selected from one or more of a spunlaced nonwoven, a hot rolled nonwoven, and a spunbond nonwoven.

9. The process for preparing a wet wipe according to claim 8, comprising the steps of: sterilizing the non-woven fabrics by using an air shower ultraviolet lamp, cutting out the non-woven fabrics by using automatic cutting equipment, and folding the non-woven fabrics up and down and left and right; the automatic liquid adding equipment is adopted for adding liquid, and the mass ratio of the decontamination liquid to the non-woven fabric is 2-5:1.

10. use of a wet wipe according to claim 7 for sterilization or decontamination of radionuclides of actinide, lanthanide or transition metal species.