CN112088879A - Quaternary ammonium salt compound disinfectant and preparation method thereof - Google Patents
Quaternary ammonium salt compound disinfectant and preparation method thereof Download PDFInfo
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- CN112088879A CN112088879A CN202011118158.0A CN202011118158A CN112088879A CN 112088879 A CN112088879 A CN 112088879A CN 202011118158 A CN202011118158 A CN 202011118158A CN 112088879 A CN112088879 A CN 112088879A
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- quaternary ammonium
- ammonium salt
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
Abstract
The invention provides a quaternary ammonium salt compound disinfectant and a preparation method thereof, belonging to the technical field of disinfectants. The invention adopts the principle of compound synergy, the benzalkonium chloride which belongs to the same cationic surfactant and the polyhexamethylene biguanide are compounded into the compound disinfectant, the compound disinfectant is ionized in a water solution to generate strong electropositivity, bacteria and viruses with negative charges can be adsorbed, and the coconut oil fatty acid diethanolamide and the glycerol are cooperatively used to promote the positive charges ionized by the benzalkonium chloride and the polyhexamethylene biguanide to penetrate cell walls, so that the bacteria and the viruses can be killed, and the great danger and the influence on the environment on the safety of people can be avoided. The quaternary ammonium salt compound disinfectant provided by the invention has the advantages of easily available raw materials, easily operated preparation process, lower production cost, no corrosion to the surfaces of human bodies and objects, no odor, no toxicity, environmental protection and convenient use, and is an ideal disinfectant.
Description
Technical Field
The invention relates to the technical field of disinfectants, in particular to a quaternary ammonium salt compound disinfectant and a preparation method thereof.
Background
At present, the demand of disinfection products is explosive, and chlorine disinfectant, alcohol disinfectant, peroxide disinfectant, aldehyde disinfectant, quaternary ammonium salt disinfectant, iodine disinfectant, phenol disinfectant and guanidine disinfectant are widely applied.
However, although all of the above disinfectants can kill bacteria and viruses, they have toxic side effects, are dangerous in use, and have various effects on the ecological environment. For example, chlorine-containing disinfectants, peracetic acid disinfectants kill bacteria and viruses, but are far more corrosive to the surface of metal objects than other products, and severely discolor colored clothing; the alcohol disinfectant can kill bacteria and viruses, but is flammable and explosive when exposed to open fire and high temperature, and has great danger in use and storage; the aldehyde disinfectant, the iodine disinfectant and the phenol disinfectant can also kill bacteria and viruses, but the toxic and side effects of the aldehyde disinfectant, the iodine disinfectant and the phenol disinfectant are large, and the residue of the aldehyde disinfectant, the iodine disinfectant and the phenol disinfectant has large influence on the ecological environment; only the quaternary ammonium salt disinfectant and the guanidine disinfectant have no corrosiveness on metal, do not fade colored clothes, are nonflammable and non-explosive, have small toxic and side effects, have small influence on the ecological environment, but have weaker sterilization capability.
Disclosure of Invention
The invention aims to provide a quaternary ammonium salt compound disinfectant and a preparation method thereof.
In order to achieve the above object, the present invention provides the following technical solutions:
the invention provides a quaternary ammonium salt compound disinfectant, which comprises the following components in percentage by mass: 0.09-0.11% of benzalkonium chloride, 0.01-0.02% of polyhexamethylene biguanide, 0.18-0.22% of coconut oil fatty acid diethanolamide, 0.2% of glycerol and the balance of water; the pH value of the quaternary ammonium salt compound disinfectant is 5.5-7.5.
Preferably, the quaternary ammonium salt compound disinfectant comprises the following components in percentage by mass: 0.1% of benzalkonium chloride, 0.015% of polyhexamethylene biguanide, 0.2% of coconut oil fatty acid diethanolamide, 0.2% of glycerol and the balance of water.
Preferably, the mass concentration of the benzalkonium chloride is 40-50%.
Preferably, the mass concentration of the polyhexamethylene biguanide is 25%.
Preferably, the coconut oil fatty acid diethanolamide has a solid content of 95%.
Preferably, the glycerol has a purity of 99%.
The invention provides a preparation method of a quaternary ammonium salt compound disinfectant in the technical scheme, which comprises the following steps:
mixing water, coconut oil fatty alcohol diethanolamide and glycerol to obtain a mixed solution;
and mixing the mixed solution, benzalkonium chloride and polyhexamethylene biguanide, adjusting the pH value to 5.5-7.5, and filtering to obtain the quaternary ammonium salt compound disinfectant.
The invention provides a quaternary ammonium salt compound disinfectant, which comprises the following components in percentage by mass: 0.09-0.11% of benzalkonium chloride, 0.01-0.02% of polyhexamethylene biguanide, 0.18-0.22% of coconut oil fatty acid diethanolamide, 0.2% of glycerol and the balance of water; the pH value of the quaternary ammonium salt compound disinfectant is 5.5-7.5. The invention adopts the principle of compound synergy, the benzalkonium chloride which belongs to the same cationic surfactant and the polyhexamethylene biguanide are compounded into the compound disinfectant, the compound disinfectant is ionized in a water solution to generate strong electropositivity, bacteria and viruses with negative charges can be adsorbed, and the coconut oil fatty acid diethanolamide and the glycerol are cooperatively used to promote the positive charges ionized by the benzalkonium chloride and the polyhexamethylene biguanide to penetrate cell walls, so that the bacteria and the viruses can be killed, and the great danger and the influence on the environment on the safety of people can be avoided.
The quaternary ammonium salt compound disinfectant provided by the invention has the advantages of easily available raw materials, easily operated preparation process, lower production cost, no corrosion to the surfaces of human bodies and objects, no odor, no toxicity, environmental protection and convenient use, and is an ideal disinfectant.
The quaternary ammonium salt compound disinfectant provided by the invention comprises the following main effective components in percentage by weight: the disinfectant is prepared by taking quaternary ammonium salt and polyhexamethylene biguanide as main components, wherein the content of the quaternary ammonium salt is 1.0g/L +/-0.1 g/L, the content of the polyhexamethylene biguanide is 0.1-0.2 g/L, the disinfectant can kill escherichia coli, staphylococcus aureus and candida albicans, and is suitable for disinfecting sanitary hands, surfaces of stainless steel objects, surfaces of daily necessities in household public places, surfaces of general objects in contact with human bodies on vehicles and the like, wherein the surfaces of the stainless steel objects, such as elevators, subways and the like; daily articles in domestic public places, such as: tables and chairs, bedside cabinets, sanitary ware, etc.; vehicle object surfaces such as automotive interiors, steering wheels, and the like.
Drawings
FIG. 1 is the data of the inspection report of the quaternary ammonium salt compound disinfectant of the present invention;
fig. 2 is inspection report data of the quaternary ammonium salt compound disinfectant of the present invention.
Detailed Description
The invention provides a quaternary ammonium salt compound disinfectant, which comprises the following components in percentage by mass: 0.09-0.11% of benzalkonium chloride, 0.01-0.02% of polyhexamethylene biguanide, 0.18-0.22% of coconut oil fatty acid diethanolamide, 0.2% of glycerol and the balance of water; the pH value of the quaternary ammonium salt compound disinfectant is 5.5-7.5.
In the present invention, the components required are all commercially available products well known to those skilled in the art, unless otherwise specified.
The quaternary ammonium salt compound disinfectant provided by the invention comprises 0.09-0.11% of benzalkonium chloride (namely dodecyl dimethyl ammonium chloride), and preferably 0.1% by mass. In the invention, the mass concentration of benzalkonium chloride is preferably 45%, and the pH value is preferably 8.0-9.0; the benzalkonium chloride is preferably commercially available. The benzalkonium chloride used in the invention is a cationic quaternary ammonium salt surfactant, and plays roles of sterilization, antisepsis, disinfection and algae removal.
The quaternary ammonium salt compound disinfectant provided by the invention comprises, by mass, 0.01-0.02% of polyhexamethylene biguanide, and preferably 0.015%. In the present invention, the mass concentration of polyhexamethylene biguanide is preferably 25%, and is preferably a commercially available product. The polyhexamethylene biguanide used in the invention is polyguanidine high molecular polymer, is easy to dissolve in water, and the aqueous solution is nontoxic, colorless, odorless, non-combustible and non-explosive, and plays roles of sterilization, disinfection, fresh keeping and corrosion prevention.
The quaternary ammonium salt compound disinfectant provided by the invention comprises 0.18-0.22% of coconut oil fatty acid diethanolamide, and preferably 0.2% by mass. In the present invention, the coconut oil fatty acid diethanolamide preferably has a solids content of 95%, and is preferably a commercially available product. The coconut oil fatty acid diethanolamide used in the invention belongs to a zwitterionic surfactant, has no cloud point, is easily soluble in water, and has good functions of foaming, foam stabilization, penetration degreasing decontamination, hard water resistance and the like; has low toxicity and small irritation to eyes and skin, and can be combined with yin and yang surfactants.
The quaternary ammonium salt compound disinfectant provided by the invention comprises 0.2% of glycerol by mass percentage. In the present invention, the purity of the glycerin is preferably 99%. The glycerol used in the invention has strong wettability, is used as a solvent, and has no corrosion to metals.
The quaternary ammonium salt compound disinfectant comprises the balance of water in percentage by mass. In the present invention, the water is preferably deionized water.
In the quaternary ammonium salt compound disinfectant provided by the invention, benzalkonium chloride and polyhexamethylene biguanide are both cationic bactericides, strong electropositivity is generated by ionization in an aqueous solution, bacteria and viruses with negative charges can be adsorbed, but a certain time is required for entering a cell membrane to penetrate through the cell wall.
The invention provides a preparation method of a quaternary ammonium salt compound disinfectant in the technical scheme, which comprises the following steps:
mixing water, coconut oil fatty alcohol diethanolamide and glycerol to obtain a mixed solution;
and mixing the mixed solution, benzalkonium chloride and polyhexamethylene biguanide, adjusting the pH value to 5.5-7.5, and filtering to obtain the quaternary ammonium salt compound disinfectant.
According to the invention, water, coconut oil fatty alcohol diethanolamide and glycerol are mixed to obtain a mixed solution. The process of mixing the water, coconut oil fatty alcohol diethanolamide and glycerol is not particularly limited in the present invention, and the raw materials can be uniformly mixed according to the process well known in the art.
After the mixed solution is obtained, the mixed solution, benzalkonium chloride and polyhexamethylene biguanide are mixed, the pH value is adjusted to be 5.5-7.5, and the mixture is filtered to obtain the quaternary ammonium salt compound disinfectant. The process of mixing the mixed solution, benzalkonium chloride and polyhexamethylene biguanide is not particularly limited, and the raw materials can be uniformly mixed according to the process well known in the art. In the invention, the reagent used for adjusting the pH value is preferably analytically pure hydrochloric acid (the mass concentration is preferably 36.5%), and the pH value sterilization range of benzalkonium chloride is 4.0-10.0, and the pH value sterilization range of polyhexamethylene biguanide is 5.50-7.50, so that the optimal action state of the disinfectant can be ensured by adjusting the pH value to 5.5-7.5.
The filtration process is not particularly limited in the present invention, and the filtration may be performed according to a process well known in the art. The invention removes the residue in the raw material by filtration.
After the filtration is finished, the invention preferably also comprises the step of inspecting the liquid phase obtained by the filtration, and obtaining the quaternary ammonium salt compound disinfectant after the liquid phase is qualified. In the present invention, the indicators of the test include product appearance, benzalkonium chloride content, polyhexamethylene biguanide content, and pH; the qualified requirements are as follows: the product appearance is as follows: colorless or pale yellow liquid, uniform and without impurities; content of benzalkonium chloride: 0.09-0.11%; content of polyhexamethylene biguanide: 0.01-0.02%; pH value: 5.5 to 7.5.
The technical solution of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the following examples, the contents of the components are expressed by mass percentage, and the content is not limited to specific mass, and may satisfy the mass percentage ratio.
In the following examples, benzalkonium chloride was used at a mass concentration of 45%, polyhexamethylene biguanide was used at a mass concentration of 25%, and coconut oil fatty acid diethanolamide was used at a solid content of 95%; the purity of the glycerol used was 99%.
The qualified requirements are as follows: the product appearance is as follows: colorless or pale yellow liquid, uniform and without impurities; content of benzalkonium chloride: 0.09-0.11%; content of polyhexamethylene biguanide: 0.01-0.02%; pH value: 5.5 to 7.5.
Example 1
The quaternary ammonium salt compound disinfectant comprises the following components: 0.1% of benzalkonium chloride, 0.02% of polyhexamethylene biguanide, 0.2% of coconut oil fatty acid diethanolamide, 0.2% of glycerol and the balance of deionized water.
The preparation method comprises the following steps:
adding deionized water, coconut oil fatty alcohol diethanolamide and glycerol in proportion and uniformly stirring to obtain a mixed solution;
adding benzalkonium chloride and polyhexamethylene biguanide into the mixed solution in proportion, stirring uniformly, adjusting the pH value to 6.0, filtering, and inspecting the obtained liquid phase to obtain the qualified quaternary ammonium salt compound disinfectant.
Comparative example 1
Benzalkonium chloride 0.1 wt% and deionized water for the rest;
the preparation method comprises the following steps: mixing benzalkonium chloride and deionized water in proportion to obtain the disinfectant.
Comparative example 2
0.02% of polyhexamethylene biguanide and the balance of deionized water;
the preparation method comprises the following steps: mixing the polyhexamethylene biguanide and the deionized water according to the proportion to obtain the disinfectant.
Comparative example 3
0.1% of benzalkonium chloride, 0.02% of polyhexamethylene biguanide and the balance of deionized water;
the preparation method comprises the following steps: mixing benzalkonium chloride, polyhexamethylene biguanide and deionized water according to a proportion to obtain the disinfectant.
Performance testing
1) The disinfectant solutions of example 1 and comparative examples 1 to 3 were tested for disinfection effect according to the suspension quantification method in GB15979-2002 hygienic Standard for Disposable sanitary articles, and the results are shown in Table 1.
TABLE 1 Disinfection Effect of the Disinfection solutions of example 1 and comparative examples 1 to 3
As can be seen from table 1, compared with the benzalkonium chloride disinfectant alone (comparative example 1), the polyhexamethylene biguanide disinfectant alone (comparative example 2) and the disinfectant compounded by the benzalkonium chloride disinfectant and the polyhexamethylene biguanide disinfectant (comparative example 3), the quaternary ammonium salt compound disinfectant provided by the invention has more excellent disinfection effect.
2) The four disinfectants of the embodiment 1 and the comparative examples 1 to 3 are adopted to detect the hand washing and disinfecting effects of medical staff:
2.1) detecting an object: respectively detecting I, II-class environment-conforming persons and III-class environment-conforming persons, wherein the persons comprise doctors and nurses; (I, II type environmental worker means that the number of viable bacteria of natural bacteria detected by hands of the environmental worker is less than or equal to 5CFU/cm2The class III environment person means that the number of the survival bacteria of the natural bacteria detected by hands of the environment person is less than or equal to 10CFU/cm2。)
2.2) dividing the four disinfectants into 4 experimental groups, and randomly sampling and detecting the hands before and after washing the hands after medical care operation, wherein the grouping conditions are as follows:
test group I: the disinfectant of comparative example 1 was used: the hand washing method comprises the steps of opening a water tap, washing hands with flowing water to fully soak wrists, palms and fingers, putting a proper amount of disinfectant into the palms to fully soak the seams among the palms, the fingers and the fingers, repeatedly rubbing the wrists of the two hands for a time of more than or equal to 10s, finally washing the wrists of the two hands with flowing tap water, repeating the method for two times, washing with the water with the fingers downward and the two hands drooping, washing foam with the water along the fingers, and naturally airing the cleaned hands.
Test group II: hand washing was carried out according to test group I using the disinfectant of comparative example 2.
Test group III: hand washing was carried out according to test group I using the disinfectant of comparative example 3.
Test group IV: the quaternary ammonium salt compound disinfectant of example 1 was used to wash hands according to the method of test group I.
Description of the drawings: the standard of hand hygiene of medical staff is required by the Hospital infection management Standard, and the number of naturally surviving bacteria is less than or equal to 5CFU/cm2(I, II type environment) or less than or equal to 10CFU/cm2(class III environment); and pathogenic bacteria cannot be detected.
2.3) hand washing effect analysis: sampling for 160 times in total, wherein 60 times of the persons who accord with I, II types of environments are detected, and 100 times of the persons who accord with III types of environments are detected; the doctors took 60 times, the nurses took 100 times, and the patients were randomly divided into 4 groups, and each group took 40 times.
2.3.1) number of colonies (CFU/cm) before and after washing with the disinfectant different from the disinfectant of example 1 and comparative examples 1 to 32) And the sterilization rate were compared, and the results are shown in Table 2.
TABLE 2 bacterial colony count (CFU/cm) before and after washing with different disinfectants2) And comparison of Sterilization rates
| Case(s) | Number of examples | Bacterial colony count before washing hands | Bacterial colony count after washing hands | Sterilizing rate (%) |
| Comparative example 1 | 40 | 202.8±10.5 | 31.2±16.3 | 84.6 |
| Comparative example 2 | 40 | 198.9±12.6 | 29.6±14.8 | 85.1 |
| Comparative example 3 | 40 | 199±12.8 | 20.0±8.0 | 89.1 |
| Example 1 | 40 | 205.6±9.6 | 2.7±2.1 | 97.2 |
The detection results in table 2 show that, in the 4 types of detected disinfectants in the example 1 and the comparative examples 1 to 3, the quaternary ammonium salt compound disinfectant in the example 1 has the highest effect, and the differences of the bactericidal effects of the disinfectants in the comparative examples 1 to 3 are not significant.
2.3.2) comparing the qualification rates of the different disinfectants in the example 1 and the comparative examples 1-3, and determining that the secondary qualification rate of the hand washing example is up to 90% according to the hand hygiene requirement of the disinfection technical specification (2002 edition), and the results are shown in Table 3.
TABLE 3 comparison of the percent of pass of different disinfectants
| Case(s) | Number of test examples | Number of qualified examples | Percent pass (%) |
| Comparative example 1 | 40 | 32 | 80.0 |
| Comparative example 2 | 40 | 33 | 82.5 |
| Comparative example 3 | 40 | 34 | 85.0 |
| Example 1 | 40 | 39 | 97.5 |
The detection results in table 3 show that, among the 4 disinfectants detected, the quaternary ammonium salt compound disinfectant in the example 1 has the highest qualification rate, and other differences have no significance, and only the hand washing example using the quaternary ammonium salt compound disinfectant in the example 1 meets the qualified requirement of hand hygiene.
2) The quaternary ammonium salt compound disinfectant of the embodiment 1 of the invention is detected according to the disinfection technical specification 2002 edition, the cosmetic safety technical specification 2015 edition and Q/WDK062-2020 Cleaner quaternary ammonium salt compound disinfectant, and the result is shown in figures 1-2. As can be seen from FIGS. 1-2, the quaternary ammonium salt compound disinfectant provided by the invention meets the requirements of 'disinfection technical specification' (2002 edition) and enterprise standard Q/WDK062-2020 'Jiejingjing quaternary ammonium salt compound disinfectant'.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (7)
1. The quaternary ammonium salt compound disinfectant is characterized by comprising the following components in percentage by mass: 0.09-0.11% of benzalkonium chloride, 0.01-0.02% of polyhexamethylene biguanide, 0.18-0.22% of coconut oil fatty acid diethanolamide, 0.2% of glycerol and the balance of water; the pH value of the quaternary ammonium salt compound disinfectant is 5.5-7.5.
2. The quaternary ammonium salt compound disinfectant as claimed in claim 1, which comprises the following components in percentage by mass: 0.1% of benzalkonium chloride, 0.015% of polyhexamethylene biguanide, 0.2% of coconut oil fatty acid diethanolamide, 0.2% of glycerol and the balance of water.
3. The quaternary ammonium salt compound disinfectant as set forth in claim 1 or 2, wherein the mass concentration of benzalkonium chloride is 40-50%.
4. The quaternary ammonium salt compound disinfectant as set forth in claim 1 or 2, wherein the mass concentration of the polyhexamethylene biguanide is 25%.
5. The quaternary ammonium salt compound disinfectant as set forth in claim 1 or 2, wherein the coconut oil fatty acid diethanolamide has a solid content of 95%.
6. The quaternary ammonium salt compound disinfectant as set forth in claim 1 or 2, wherein the purity of the glycerol is 99%.
7. The preparation method of the quaternary ammonium salt compound disinfectant as claimed in claims 1-6, which is characterized by comprising the following steps:
mixing water, coconut oil fatty alcohol diethanolamide and glycerol to obtain a mixed solution;
and mixing the mixed solution, benzalkonium chloride and polyhexamethylene biguanide, adjusting the pH value to 5.5-7.5, and filtering to obtain the quaternary ammonium salt compound disinfectant.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114931138A (en) * | 2021-10-13 | 2022-08-23 | 深圳市华宝生物材料科技有限公司 | Sterilization disinfectant and preparation method thereof |
| CN116035028A (en) * | 2022-12-28 | 2023-05-02 | 上海南椿新材料科技有限公司 | Composite disinfectant doped with nano silver particles, and preparation method and application thereof |
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| CN102018634A (en) * | 2009-09-17 | 2011-04-20 | 上海利康消毒高科技有限公司 | Compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method |
| CN102382728A (en) * | 2010-08-26 | 2012-03-21 | 周强 | Special underwear laundry detergent and preparation method for same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102018634A (en) * | 2009-09-17 | 2011-04-20 | 上海利康消毒高科技有限公司 | Compound polyhexamethylene guanidine antibacterial hand sanitizer and preparation method |
| CN102382728A (en) * | 2010-08-26 | 2012-03-21 | 周强 | Special underwear laundry detergent and preparation method for same |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114931138A (en) * | 2021-10-13 | 2022-08-23 | 深圳市华宝生物材料科技有限公司 | Sterilization disinfectant and preparation method thereof |
| CN114931138B (en) * | 2021-10-13 | 2023-10-20 | 拓腾华宝(苏州)生物技术有限公司 | Sterilization disinfectant and preparation method thereof |
| CN116035028A (en) * | 2022-12-28 | 2023-05-02 | 上海南椿新材料科技有限公司 | Composite disinfectant doped with nano silver particles, and preparation method and application thereof |
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