CN116033910A - 编辑b细胞中b2m基因座的方法和组合物 - Google Patents

编辑b细胞中b2m基因座的方法和组合物 Download PDF

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CN116033910A
CN116033910A CN202180047549.4A CN202180047549A CN116033910A CN 116033910 A CN116033910 A CN 116033910A CN 202180047549 A CN202180047549 A CN 202180047549A CN 116033910 A CN116033910 A CN 116033910A
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cells
cell
modified
gene
nuclease
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大卫·J·罗林斯
理查德·G·詹姆斯
克莱尔·玛瑞亚·斯托弗斯
彼得·J·库克
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Seattle Childrens Hospital
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Seattle Childrens Hospital
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CN202180047549.4A 2020-07-03 2021-06-30 编辑b细胞中b2m基因座的方法和组合物 Pending CN116033910A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063047978P 2020-07-03 2020-07-03
US63/047,978 2020-07-03
US202063114131P 2020-11-16 2020-11-16
US63/114,131 2020-11-16
PCT/US2021/039953 WO2022006309A1 (en) 2020-07-03 2021-06-30 Methods and compositions for editing the b2m locus in b cells

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Publication Number Publication Date
CN116033910A true CN116033910A (zh) 2023-04-28

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CN202180047549.4A Pending CN116033910A (zh) 2020-07-03 2021-06-30 编辑b细胞中b2m基因座的方法和组合物

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EP (1) EP4175651A4 (https=)
JP (1) JP2023532917A (https=)
KR (1) KR20230035048A (https=)
CN (1) CN116033910A (https=)
AU (1) AU2021300358A1 (https=)
BR (1) BR112022026534A2 (https=)
CA (1) CA3186620A1 (https=)
IL (1) IL299491A (https=)
MX (1) MX2022015788A (https=)
WO (1) WO2022006309A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250222138A1 (en) * 2022-03-28 2025-07-10 Ramot At Tel-Aviv University Ltd. Site-specific in vivo t cell engineering, systems, compositions and methods thereof
CA3261942A1 (en) * 2022-08-01 2024-02-08 Idexx Laboratories, Inc. FRACTIONAL ABUNDANCE DOSES OF HUMAN MOUSE
EP4698226A2 (en) * 2023-04-17 2026-02-25 Be Biopharma, Inc. Engineered cell preparations for treatment of hemophilia
CN120866304A (zh) * 2024-04-23 2025-10-31 南京奇迹生物科技有限公司 对b2m基因座的基因编辑方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016073955A2 (en) * 2014-11-06 2016-05-12 President And Fellows Of Harvard College Cells lacking b2m surface expression and methods for allogeneic administration of such cells
IL297018A (en) * 2015-12-18 2022-12-01 Sangamo Therapeutics Inc Directed cleavage of cell mhc receptor
US12144825B2 (en) * 2017-06-30 2024-11-19 Cellectis Cellular immunotherapy for repetitive administration
US20200407713A1 (en) * 2017-11-16 2020-12-31 Mogam Institute For Biomedical Research Transformed human cell and use thereof
US12378572B2 (en) * 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
CA3122131A1 (en) * 2018-09-21 2020-03-26 Zonghai Li Method for gene editing of cell on the basis of crispr/cas system
UY38427A (es) * 2018-10-26 2020-05-29 Novartis Ag Métodos y composiciones para terapia con células oculares

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Publication number Publication date
KR20230035048A (ko) 2023-03-10
JP2023532917A (ja) 2023-08-01
CA3186620A1 (en) 2022-01-06
EP4175651A1 (en) 2023-05-10
MX2022015788A (es) 2023-02-27
WO2022006309A1 (en) 2022-01-06
AU2021300358A1 (en) 2023-02-02
EP4175651A4 (en) 2024-08-14
IL299491A (en) 2023-02-01
BR112022026534A2 (pt) 2023-04-18

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