CN115969765A - Composition with skin sensitivity relieving function and cosmetic thereof - Google Patents

Abstract

The invention relates to a composition for relieving skin sensitivity and a cosmetic thereof, wherein the composition comprises icariin, corosolic acid, tetrandrine and lactobacillus soybean fermentation product. The skin care product has the effects of repairing skin barriers, moisturizing, soothing allergy and resisting inflammation, can balance pruritus possibly caused by the common application of various components, and can effectively relieve symptoms of desquamation, flushing, pruritus, dryness, stabbing pain, burning sensation and the like of the skin.

Description

Composition with skin sensitivity relieving function and cosmetic thereof

Technical Field

The invention relates to the field of cosmetics, and particularly relates to a composition capable of relieving skin sensitivity and a cosmetic thereof.

Background

Sensitive skin is a common clinical complaint with a global prevalence of 36.9%, and sensitive skin prevalence in europe, north america, south america and asia of 41.0%, 33.7%, 44.6% and 34.2%, respectively. In 2016, the international forum for the study of pruritus defined sensitive skin as: the syndrome of skin producing unpleasant sensations to external stimuli, including stinging, burning, pain, itching, stinging and tingling, which normally do not cause such symptoms to the skin. These discomfort can affect the skin of the whole body, especially the face. In 2017, china formulated the consensus of Chinese experts for sensitive skin diagnosis and treatment, which considers that: the sensitive skin refers to a high-response state of the skin under physiological or pathological conditions, mainly occurs on the face, and is clinically manifested by subjective symptoms such as burning, stabbing pain, itching and tightness of the skin easily appearing when the skin is stimulated by physical, chemical and mental factors, and objective signs such as erythema, scaling and telangiectasia are accompanied or not accompanied. In most patients, symptoms appear within 1 hour after exposure to the trigger and may persist for minutes or hours.

There are many factors that cause skin sensitivity, such as oxidative stress caused by ultraviolet irradiation, excessive loss of skin lipids caused by improper use of cleansing products, breakdown of skin barrier function, air pollution, stress, etc., and even season changes. The study shows that the expression of Claudin-5 on the Claudin in the skin lesion of the sensitive skin patient is reduced, which indicates that the skin barrier is damaged, and vanilloid transient sensory receptor-1 can be activated after the skin barrier is damaged, so that the skin vascular and neural hyperreactivity is caused, the inflammation and the immune response are promoted, and the clinical symptoms of the sensitive skin are caused. Thus, at present, it is widely studied that the development of sensitive muscles is a complex process involving the cutaneous barrier-neurovascular-immunoinflammation.

Considering that the occurrence mechanism of sensitive skin is related to the skin barrier damage, inflammatory reaction, vascular and nerve hyperreactivity, the active ingredients in the selected functional skin care products not only need the efficacy of repairing the skin barrier and moisturizing, but also need the active ingredients with the functions of relieving allergy and inflammation and reducing vascular and nerve hyperreactivity. Thus, a combination of components is often used for the care or treatment of sensitive skin. Currently, CN106138077A discloses the application of icariin in preparing a medicament for treating dermatitis, TNF-alpha/IFN-gamma stimulation skin keratinocytes (HaCaT cells) are taken as an in vitro model of dermatitis, and the icariin is given for intervention, and the result shows that: icariin can effectively inhibit the increase of the levels of HaCaT cell inflammatory factors (IL-6, IL-1 beta and IL-8) induced by TNF-alpha/IFN-gamma; the icariin has the function of antagonizing skin inflammation and is related to the inhibition of the expression of phosphorylated p38 and phosphorylated ERK; icariin antagonism of skin inflammation is associated with increased cortisol secretion from skin keratinocytes. However, the patent mainly studies the anti-inflammatory effect of icariin on the molecular level in vitro, but the complex mechanism of sensitive skin and the effectiveness of symptoms are still unknown. CN103908461B discloses the application of tetrandrine/dipotassium glycyrrhizinate in preparing antiallergic drugs, and tetrandrine and dipotassium glycyrrhizinate are compounded together, so that the tetrandrine and dipotassium glycyrrhizinate have mutual promotion effect on antiallergic effect, the antiallergic effect is remarkably improved, the anti-allergic effect on the skin allergy after 2,4-Dinitrochlorobenzene (DNCB) skin induction contact is realized, and the erythema and pruritus are improved. JP2008255085a discloses the use of decocted leaves of loquat leaves for improvement of skin diseases, and the leaves are rich in triterpenic acid active ingredients such as ursolic acid, corosolic acid, etc. CN105816368a discloses a suspension extract prepared from loquat leaf cells for use in antibacterial and anti-inflammatory cosmetics, which is rich in pentacyclic triterpenic acid active ingredients such as ursolic acid, corosolic acid, etc. However, the current cosmetics for relieving sensitive skin have single efficacy or more efficacy components. For the sensitive characteristics of sensitive skin, the use of more effective components may bring new problems or solve some symptoms, and other symptoms may be aggravated, so how to balance the above problems still lacks an effective solution.

Disclosure of Invention

In order to solve the problems, the cosmetic composition for relieving skin sensitivity disclosed by the invention is composed of multiple active components, has the effects of repairing skin barriers, moisturizing, relieving sensitivity and resisting inflammation, can balance pruritus possibly caused by the common application of multiple components, and can effectively relieve symptoms such as desquamation, flushing, pruritus, dryness, stabbing pain, burning sensation and the like of skin.

Further, the present invention provides a cosmetic composition for soothing skin sensitivity comprising:

the composition comprises, by weight, 4-8 parts of icariin, 1-4 parts of corosolic acid, 1-4 parts of tetrandrine and 10-30 parts of lactobacillus soybean fermentation product.

The composition preferably comprises 5-7 parts of icariin, 1-3 parts of corosolic acid, 1-3 parts of tetrandrine and 10-20 parts of lactobacillus soybean fermentation product in parts by weight.

The icariin is selected from one or more of icariin A, icariin B and icariin C.

Preferably, the icariin consists of icariin A, icariin B and icariin C, or consists of icariin A and icariin B, or consists of icariin A and icariin C.

Preferably, the composition comprises 1-2 parts of icariin A, 1-2 parts of icariin B and 1-2 parts of icariin C by weight.

More preferably, the composition comprises 2 parts of icariin A, 2 parts of icariin B and 2 parts of icariin C.

The lactobacillus soybean fermentation product is a solid of fermentation liquor of a soybean extract fermented by lactobacillus, and the solid is prepared by concentrating, vacuum drying, spray drying or freeze drying the fermentation liquor.

The soybean extract is soybean water extract containing soybean isoflavone 5-15%, preferably soybean isoflavone 7%, 8%, 9%, 10%, 11%, 12%, 13%, 1%.

The cosmetic composition of the present invention can be used for skin care of face, hand, foot, etc., and can be made into conventional cosmetic forms such as gel or foam, moisturizing water, gel, lotion, cream, etc.

When the cosmetic composition of the present invention is an emulsion (cream), the oil phase constitutes less than 50% of the total weight of the composition, preferably 5%, 8%, 10%, 15%, 20%, 25%, 30%, 35%, 40% of the oil phase.

The oil phase of the present invention comprises: such as synthetic oils selected from isopropyl myristate, ethylhexyl palmitate, isooctyl palmitate, caprylic capric glyceride, stearyl alcohol, monoglycerides, paraffins, carnauba wax and beeswax. It may also be selected from silicone compounds such as polydimethylsiloxanes. Vegetable oils, such as peanut oil, sunflower oil and almond oil. Animal oils, such as perhydrosqualene, squalane. The oil phase further preferably includes isooctyl palmitate, caprylic capric glyceride, stearyl alcohol, monoglyceride, and polydimethylsiloxane.

In the early research and development, the soybean extract can improve the solubility of insoluble components after being fermented by lactobacillus, and is beneficial to the dispersion of the icariin, the corosolic acid and the tetrandrine in the water phase. In comparative studies, icariin, corosolic acid and tetrandrine are found to be capable of better relieving symptoms of sensitive skin, improving moisture retention, repairing skin barrier damage and the like, and the improvement effect on desquamation, flushing, dryness, prickling and burning of skin is better, but the improvement effect on pruritus is not obvious, and in follow-up studies, the pruritus frequency of some patients is found to be increased. After the lactobacillus soybean fermentation product is added, the effects of icariin, corosolic acid and tetrandrine on preventing and treating pruritus can be better improved, and the defect of improving sensitive skin by multiple components is balanced.

The water phase accounts for more than 40-90% of the total weight of the composition, and preferably 50%, 60%, 70% and 80% of the water phase.

The cosmetic and/or dermatological composition according to the invention may also further comprise adjuvants commonly used in the field of dermatological products, such as preservatives: methyl paraben, ethyl paraben and propyl paraben; antioxidant: a vitamin E; solvent: butanediol, water, propanol, humectant: glycerol; fragrances, antimicrobial agents, and pH adjusters. The amount of such adjuvants is conventional in the art and is, for example, from 0.01 to 20% by weight of the total composition. And adjuvants may be added to the oil phase and/or the water phase depending on its properties.

The invention further provides a cream of the skin composition, wherein the oil phase comprises 0.5-2% of octadecanol, 0.5-2% of hexadecanol, 2-5% of isooctyl palmitate, 2-6% of squalane, 3-6% of caprylic/capric glyceride and 2-5% of polydimethylsiloxane;

the water phase comprises 5-10% of polyalcohol, 0.1-0.5% of thickening agent, solution containing lactobacillus and soybean fermentation product, and the balance of deionized water; the polyalcohol is one or more selected from glycerol and butanediol, and the thickener is one selected from xanthan gum, xanthan gum and sodium hyaluronate.

The solution containing lactobacillus soybean fermented product contains icariin, corosolic acid, tetrandrine, lactobacillus soybean fermented product, and water; preferably, the solution contains 0.03-0.12% icariin, 0.01-0.1% corosolic acid, 0.01-0.1% tetrandrine and 0.1-0.3% lactobacillus soybean fermentation product in terms of the concentration (g/100 ml) of the solution containing lactobacillus soybean fermentation product. The icariin consists of icariin A, icariin B and icariin C, preferably according to the weight ratio, wherein the weight ratio of the icariin A to the icariin B to the icariin C is (1-3) to (1-3).

The invention further provides the following scheme: the cosmetic composition provided by the invention is used for preparing a cosmetic for relieving sensitive skin.

The soothing sensitive skin is used for improving one or more symptoms of desquamation, flush, pruritus, dryness, prickling and burning of the skin.

The cosmetic composition of the present invention is used for preparing cosmetics for moisturizing and improving skin barrier.

The cosmetic with skin sensitivity relieving function of the invention has the following application in the field of beauty.

(1) Has obvious relieving effect on red, itchy, painful, dry, tight, water-deficient and desquamation of skin caused by various reasons, and can improve the water content of the skin and reduce the water loss of the skin.

(2) Promoting skin cell proliferation, effectively promoting epidermal cell metabolism, improving skin self-renewal ability, recovering skin barrier function, and improving skin resistance to external irritation.

The present invention is further explained with reference to the following examples, which are not intended to limit the present invention in any way.

Description of the drawings:

FIG. 1 Effect of the cosmetic composition of the present invention on HaCaT cell proliferation.

FIG. 2 shows the hyaluronidase inhibitory effect of the cosmetic composition of the present invention.

FIG. 3 example 6 of the present invention shows an improvement in the red zone area of sensitive skin before and after use.

The left side is before use and the right side is after use.

FIG. 4 improvement of red zone area on sensitive skin before and after use of comparative example 1 of the present invention.

The left side is before use and the right side is after use.

FIG. 5 example 6 of the present invention shows an improvement in red area on sensitive skin before and after use of the blank matrix.

The left side is before use and the right side is after use.

Example 1

Respectively weighing icariin A2 mg, icariin B2 mg, icariin C2 mg, corosolic acid 2mg, tetrandrine 2mg and lactobacillus soybean fermentation product 15mg, adding 10ml deionized water, vortexing for 30s, and mixing to obtain mixed solution.

Wherein, the preparation of lactobacillus soybean fermentation liquor: 10g of the soybean extract was mixed with 100mL of ultrapure water in a 500mL Erlenmeyer flask and sterilized at 121 ℃ for 30min. Inoculating lactobacillus liquid into the mixed liquid of the soybean extract and water in a sterile operating platform, and performing shake culture in a shaking table at 37 ℃ for 48 hours to obtain a soybean extract fermentation product; sterilizing the product at 100 deg.C for 30min, centrifuging at 5000r/min for 10min, collecting supernatant, concentrating, and drying to obtain lactobacillus soybean fermented product.

Wherein the soybean extract is water-extracted soybean extract containing 8% soybean isoflavone.

Example 2

Respectively weighing icariin A1 mg, icariin B2 mg, icariin C3 mg, corosolic acid 3mg, tetrandrine 1mg and lactobacillus soybean fermentation product 20mg, adding 10ml deionized water, vortexing for 30s, and mixing to obtain mixed solution.

Wherein, the preparation of lactobacillus soybean fermentation liquor: 10g of the soybean extract was mixed with 100mL of ultrapure water in a 500mL Erlenmeyer flask and sterilized at 121 ℃ for 30min. Inoculating lactobacillus liquid into the mixed liquid of the soybean extract and water in a sterile operating platform, and performing shake culture in a shaking table at 37 ℃ for 48 hours to obtain a soybean extract fermentation product; sterilizing the product at 100 deg.C for 30min, centrifuging at 5000r/min for 10min, and collecting supernatant as soybean extract fermentation product filtrate.

Wherein the soybean extract is an aqueous extract of soybean containing 10% of soybean isoflavone.

Example 3

Respectively weighing icariin A1 mg, icariin B2 mg, icariin C1 mg, corosolic acid 3mg, tetrandrine 4mg and lactobacillus soybean fermentation product 25mg, adding 10ml deionized water, vortexing for 30s, and mixing to obtain mixed solution.

Wherein, the preparation of lactobacillus soybean fermentation liquor: 10g of the soybean extract was mixed with 100mL of ultrapure water in a 500mL Erlenmeyer flask and sterilized at 121 ℃ for 30min. Inoculating lactobacillus liquid into the mixed liquid of the soybean extract and water in a sterile operating platform, and performing shake culture in a shaking table at 37 ℃ for 48 hours to obtain a soybean extract fermentation product; sterilizing the product at 100 deg.C for 30min, centrifuging at 5000r/min for 10min, and collecting supernatant as soybean extract fermentation product filtrate.

Wherein the soybean extract is water-extracted soybean extract containing 5% soybean isoflavone.

Example 4

Respectively weighing icariin A1 mg, icariin B2 mg, corosolic acid 3mg, tetrandrine 4mg, and lactobacillus soybean fermented product 15mg, adding 10ml deionized water, swirling for 30s, and mixing to obtain mixed solution.

Wherein, the preparation of lactobacillus soybean fermentation liquor: 10g of the soybean extract was mixed with 100mL of ultrapure water in a 500mL Erlenmeyer flask and sterilized at 121 ℃ for 30min. Inoculating lactobacillus liquid into the mixed liquid of the soybean extract and water in a sterile operation table, and performing shake culture in a shaking table at 37 ℃ for 48 hours to obtain a soybean extract fermentation product; sterilizing the product at 100 deg.C for 30min, centrifuging at 5000r/min for 10min, and collecting supernatant as soybean extract fermentation product filtrate.

Wherein the soybean extract is water-extracted soybean extract containing soybean isoflavone 15%.

Example 5

A method of preparing a soothing skin sensitive emulsion comprising the steps of:

(1) The oil phase was weighed according to the formulation in table 1 and dissolved by heating in water bath at 80 ℃.

(2) After the oil phase was placed in a water bath, the water phase was weighed: firstly, dispersing xanthan gum into glycerol, and uniformly grinding for later use; adding butanediol and the active ingredients in the embodiment 1 into deionized water, uniformly mixing, then continuously adding the xanthan gum and glycerol mixed solution, and continuously stirring uniformly to obtain a water phase; heating the prepared water phase at 80 deg.C and maintaining for 10min.

(3) Mixing the two phases (80 deg.C), emulsifying under stirring for 10min, stirring with homogenizer, naturally cooling to 45 deg.C, and cooling to room temperature.

TABLE 1 emulsion formulation

Example 6

Preparation of an oil-in-water cream for soothing sensitive skin, comprising the steps of:

(1) The oil phase was weighed according to the formulation in table 3, dissolved in water bath at 80 ℃ and mixed well.

(2) After the oil phase was placed in a water bath, the water phase was weighed: firstly, dispersing xanthan gum into glycerol, and uniformly grinding; then adding butanediol and the active component in the embodiment 1 into deionized water, stirring uniformly, then continuously adding the mixed solution of xanthan gum and glycerol, and continuously stirring uniformly; heating and keeping the temperature at 80 ℃ for 15min.

(3) Mixing the two phases (adding oil phase to water phase at 80 deg.C), emulsifying under stirring for 15min, stirring with homogenizer, and naturally cooling to 45 deg.C.

(4) Adding essence, stirring, mixing, and cooling to room temperature.

TABLE 2O/W cream formulations

Example 7

Preparation of a moisturizing lotion for relieving skin sensitivity, comprising the following steps:

(1) Weighing xanthan gum according to the formula in the table 3, dispersing into glycerol with the formula amount, uniformly grinding, and adding the components in the example 1, butanediol, panthenol and deionized water; stirring and dissolving at 70 ℃, and cooling to about 45 ℃.

(2) Adding hyaluronic acid, sodium hyaluronate and trehalose into the solution (1), stirring for dissolving, and cooling to room temperature.

TABLE 3 moisturizing formula

Composition (I)	Weight ratio (%)
		Glycerol	2.0
Butanediol	3.0
		Hyaluronic acid	0.2
Hyaluronic acid sodium salt	0.1
		Chinese gum	0.35
Trehalose	1.0
		Panthenol	0.1
Liquid mixture of example 1	15
		Deionized water	The rest (to 100)

Comparative example 1

Preparation of soothing sensitive oil-in-water cream, which is the same as example 6 except that the active ingredient is different; the active components comprise icariin A2 mg, icariin B2 mg, icariin C2 mg, corosolic acid 2mg and tetrandrine 2mg.

Experimental example 1 Effect on HaCaT cell proliferation

1. Experimental methods

The MTT experiment is divided into a control group and a dosing group. The HaCaT cells were prepared as single cell suspensions at appropriate concentrations and seeded into 96-well plates at 100 μ L per well. After culturing for a suitable period of time, the medium was discarded, washed with PBS, and the control group was not treated, and the drug solution of example 1 was administered to the administration group at different concentrations, and culturing was continued for 24 hours. After completion of the incubation, the medium was removed, washed with PBS, and 10. Mu.L of MTT solution was added to each well, and the incubation was continued for 4 hours. Subsequently, the solution was discarded and 150. Mu.L of DMSO (analytical grade) solution was added to each well. The absorbance OD of each well was measured at 490nm and the relative activity of each group of cells was calculated according to the following formula.

A: control group

B: administration set

2. Results of the experiment

HaCaT cells were incubated with different concentrations of example 1 for 24h and the effect of example 1 on cell viability was assessed using the MTT assay. As can be seen from fig. 1: when the concentration of example 1 was less than or equal to 20 μ M, it had a significant proliferation effect on HaCaT cells compared to the untreated group (a very significant difference was indicated by p < 0.01 compared to the untreated group), indicating that the composition of the invention can promote the proliferation of HaCaT cells, favoring the restoration of the skin barrier.

Experimental example 2 inhibition experiment of hyaluronidase

1. Experimental method

Preparing an experimental solution:

1.1 hyaluronidase solution: accurately weighing 0.01g of hyaluronidase, adding 4mL of acetic acid buffer solution to obtain a final concentration of 1250 mug/mL, and preparing the hyaluronidase in situ.

1.2 0.5mg/mL sodium hyaluronate solution: accurately weighing 0.005g of sodium hyaluronate, adding the sodium hyaluronate into 10mL of acetic acid buffer solution, and fully dissolving for later use.

1.3 calcium chloride solution: accurately weighing 0.0277g of anhydrous calcium chloride, and diluting to 100mL with ultrapure water to obtain 2.5mmol/L calcium chloride solution.

1.4 acetic acid buffer solution (pH = 5.6): weighing 1.155mL of glacial acetic acid, diluting to 100mL, uniformly mixing, and taking 4.8mL of glacial acetic acid as A solution; weighing 2.72g of sodium acetate crystal, adding water to dissolve the crystal, fixing the volume to 100mL, uniformly mixing, and taking 45.2mL of the solution as a B solution; the solution A, B was mixed with water to 100 mL. The pH value is precisely measured and adjusted to 5.6 by using the solution A or B.

1.5 Ehrlich reagent: accurately weighing 0.8g of p-dimethylaminobenzaldehyde, dissolving the p-dimethylaminobenzaldehyde in 15mL of concentrated hydrochloric acid and 15mL of absolute ethyl alcohol for standby, and keeping out of the sun.

1.6 1mol/L sodium carbonate solution: 5.3g of sodium carbonate is accurately weighed and added into 50mL of distilled water, and the sodium carbonate is fully dissolved for standby.

1.7 acetylacetone solution: exactly 3.5mL of acetylacetone was dissolved in 50mL of 1.0mol/L sodium carbonate solution and prepared as it is.

1.8 sample solution: accurately weighing 100mg of sample, and diluting to 10mL with ultrapure water to obtain 10% extract. Then diluted into 5 percent and 1 percent of extracting solution in turn.

TABLE 3 reaction systems

A is the absorbance value of the control solution (the sample solution is replaced by acetic acid buffer solution);

b is the absorbance value of the blank control solution (acetic acid buffer solution is used for replacing the sample solution and the enzyme solution);

c is the absorbance value of the tested sample solution;

d is the absorbance value of the sample blank solution (the enzyme solution is replaced by acetic acid buffer solution)

During the experiment, the A group of samples are subjected to wavelength scanning in a wavelength range of 450-700nm to determine the maximum absorption wavelength, deionized water is used as a reference, and ABS values of other samples are respectively measured under the maximum absorption wavelength.

2. Results of the experiment

As shown in FIG. 2, the hyaluronidase activity inhibition ratio of example 1 was significantly increased in the volume concentration range of 0.1-2.4mL, and was maximized to 66.9% at 2.4 mL. The composition of the present invention has a lower rate of inhibition of hyaluronidase activity than ascorbic acid. The above results indicate that the cosmetic composition of the present invention can effectively inhibit the activity of hyaluronidase, maintain the level of hyaluronic acid in the skin, thereby preventing the loss of water in the skin and promoting the process of exchanging nutrients with metabolic waste.

Experimental example 3 soothing effect on sensitive skin

1. Experimental methods

Subject inclusion criteria: the subject states the skin to be sensitive, the lactic acid stabbing pain test is positive (the total score is more than or equal to 3), the clinical skin shows itching, the skin is easy to be sensitive with red blood streak, and the skin is frequently allergic reaction.

Grouping experiments: after screening, 60 eligible subjects were randomly divided into 3 groups of 20 persons each, namely, example 6 group, example 6 blank matrix control group, and comparative example 1 group.

The research method comprises the following steps: after the face is cleaned by the daily facial cleanser, a proper amount of the cosmetic is coated on the skin or sensitive parts, 1 time is respectively carried out in the morning and at night, 1 month is 1 treatment course, and a test subject carries out 1 treatment course test. The subjects had to use no cosmetics, drugs and nutraceuticals that had an effect on the outcome during the trial. Each subject was followed by a professional investigator before use and one month later. Each subject should avoid vigorous exercise before each test and take a rest for 20min in a stable indoor environment.

Measuring the water content of the skin stratum corneum:

the change of the moisture content of the skin before and after use is tested by adopting a skin oil and fat moisture and pH value tester of German CK company, and the moisturizing effect of the skin is further evaluated.

Analysis of skin red zone area:

VISCIA-CR of canfeid, usa was used, image acquisition was performed with the vicinity of the center point of the cheek of the subject as an analysis target site, red zone area was analyzed using professional skin analysis software, and the soothing and repairing effects were evaluated by comparing the change in red zone area of the skin before and after use of the product.

Subject self-rating:

subjects were subjectively scored for improvement in skin desquamation, flushing, itching, dryness, stinging, burning after application of the product, with no improvement =0, mild improvement =1, moderate improvement =2, and overt improvement =3. (wherein no improvement, no improvement of symptoms; mild improvement, slight reduction of symptoms; moderate improvement, reduction of symptoms; significant improvement, significant reduction of symptoms) was followed in the form of questionnaires to assist in the assessment of moisturizing, repairing and soothing effects of the product.

2. Results of the experiment

The result shows that the cosmetic disclosed by the invention can obviously improve the water content of the skin, reduce the area of a skin red area, and has better moisturizing effect and soothing and repairing effects. Meanwhile, compared with the soybean extract without lactobacillus fermentation, the active ingredients only use icariin, corosolic acid and tetrandrine, the soybean extract also has similar moisturizing, soothing and repairing effects. Fig. 3 and 4 illustrate the change in the red zone area before and after use for a portion of subjects.

TABLE 4 moisture content of skin and red zone area changes before and after use of the product

In the evaluation of various indexes of a subject, the result shows that the cosmetic has better improvement effect on desquamation, flushing, pruritus, dryness, stabbing pain and burning of skin. Through comparison, the combination of icariin, corosolic acid and tetrandrine has poor effect on improving the pruritus, and in the group of the comparative example 1, the follow-up shows that the pruritus of the patients without improving the pruritus is slightly aggravated; however, in the group of example 6, after lactobacillus and soybean fermentation liquor is added, the pruritus is remarkably improved, and the pruritus of most of subjects is remarkably improved. There was no significant difference between the example 6 group and the comparative example 1 group with respect to symptoms of skin desquamation, flushing, dryness, stinging, burning.

TABLE 5 improvement rates of the various indices of the subjects

The above examples are only intended to illustrate the technical solution of the present invention, and not to limit it; those of ordinary skill in the art will understand that: it can be modified from the technical solutions described in the foregoing embodiments, or some technical features of the technical solutions can be equivalently replaced. And such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention, which is defined by the appended claims and their equivalents.

Claims (10)

1. A cosmetic composition for relieving skin sensitivity is characterized by comprising, by weight, 4-8 parts of icariin, 1-4 parts of corosolic acid, 1-4 parts of tetrandrine and 10-30 parts of lactobacillus soybean fermentation product.

2. The cosmetic composition according to claim 1, wherein the composition comprises, by weight, 5-7 parts of icariin, 1-3 parts of corosolic acid, 1-3 parts of tetrandrine, and 10-20 parts of lactobacillus soy fermentation product.

3. The cosmetic composition according to claim 1, wherein the icariin is selected from one or more of icariin a, icariin B, and icariin C.

4. The cosmetic composition as claimed in claim 3, wherein icariin consists of icariin A, icariin B and icariin C; preferably, the composition comprises 1-2 parts of icariin A, 1-2 parts of icariin B and 1-2 parts of icariin C by weight.

5. The cosmetic composition of claim 1, wherein the lactobacillus soy fermentation product is a fermentation broth of a soy extract fermented with lactobacillus.

6. The cosmetic composition as claimed in claim 5, wherein the soybean extract is an aqueous soybean extract containing 5-15% of soybean isoflavone.

7. The cosmetic composition of any one of claims 1 to 6, wherein the cosmetic composition is one of a moisturizing lotion, a gel, an emulsion, and a cream.

8. The cosmetic composition of claim 7, wherein said cream is an oil-in-water cream wherein the oil phase comprises stearyl alcohol, monoglycerides, glyceryl caprylate caprinate and dimethicone and the aqueous phase comprises glycerin, butylene glycol, xanthan gum, icariin, corosolic acid, tetrandrine, and lactobacillus soy fermentate.

9. Use of the cosmetic composition according to any one of claims 1 to 8 for the preparation of a soothing sensitive skin cosmetic.

10. Use according to claim 9, wherein the soothing sensitive skin is an improvement in one or more symptoms of desquamation, flushing, itching, dryness, stinging, burning of the skin.

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