CN115969743A - Toothpaste with fresh breath and preparation method thereof - Google Patents
Toothpaste with fresh breath and preparation method thereof Download PDFInfo
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- CN115969743A CN115969743A CN202210983551.9A CN202210983551A CN115969743A CN 115969743 A CN115969743 A CN 115969743A CN 202210983551 A CN202210983551 A CN 202210983551A CN 115969743 A CN115969743 A CN 115969743A
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Abstract
The invention relates to the field of toothpaste, in particular to the field of A61Q11/00, and more particularly relates to toothpaste with fresh breath and a preparation method thereof. The breath freshening toothpaste comprises, by weight, 0.2-0.5 part of fluoride, 0.1-1 part of green coffee composite powder, 10-20 parts of abrasive, 60-80 parts of wetting agent, 3-5 parts of surfactant, 0.5-5 parts of excipient and 0.5-2 parts of sweetener. The toothpaste product has the advantages of effectively removing sulfides, having a remarkable deodorization effect, being superior to the deodorization effect of toothpaste products in the prior art, having a certain whitening effect, being resistant to a certain temperature, and having little viscosity change after being treated at 45 ℃ for a period of time.
Description
Technical Field
The invention relates to the field of toothpaste, in particular to the field of A61Q11/00, and more particularly relates to toothpaste with fresh breath and a preparation method thereof.
Background
Halitosis is an unpleasant phenomenon that not only affects the quality of life, but also brings about social troubles. Oral hygiene products are of a wide variety, including toothpastes, mouthwashes, etc., which are indispensable to our lives. Chinese patent CN201611072146 provides a toothpaste, which has the following components: magnesium hydrogen phosphate, xylitol, protease, sodium alginate, guar gum, sodium fluoride, licorice extract, lemon extract, mint extract, sodium fluoride and cactus extract, which have complex components, are mixed with other raw materials, and have the problem of difficult mixing when being mixed with other raw materials, and the effect of removing dental plaque is unstable. Chinese patent CN201810947508 provides a breath freshening toothpaste, which comprises surfactant, emulsifier, sodium fluoride, plant extract, etc., and its halitosis removing effect is still to be improved, and in addition, its effect is relatively single, but at present multifunctional toothpaste products are more and more favored.
Disclosure of Invention
In order to solve the problems in the prior art, the first aspect of the invention provides a breath freshening toothpaste, which comprises, by weight, 0.2-0.5 parts of fluoride, 0.1-1 parts of green coffee composite powder, 10-20 parts of an abrasive, 60-80 parts of a wetting agent, 3-5 parts of a surfactant, 0.5-5 parts of an excipient and 0.5-2 parts of a sweetener.
In one embodiment, the toothpaste is prepared from 0.2-0.5 part of fluoride, 0.4 part of green coffee composite powder, 16-20 parts of abrasive, 65-70 parts of wetting agent, 3.5 parts of surfactant, 0.5-3 parts of excipient and 1.1 part of sweetener by weight.
In one embodiment, the fluoride is stannous fluoride and/or sodium fluoride.
In one embodiment, the raw materials for preparing the toothpaste further comprise 1-5 parts by weight of a complexing agent.
The complexing agent is not particularly limited in the present application, and sodium gluconate and sodium tripolyphosphate are exemplified.
In one embodiment, the toothpaste further comprises 0.4 parts by weight of sodium dihydrogen phosphate and 0.7 to 0.9 parts by weight of trisodium phosphate.
Preferably, the green coffee composite powder contains laccase.
The green coffee composite powder is purchased from Qingdao vast Pin-sourced International trade company, inc., model Biofresh 4+ complex.
The applicant finds that the green coffee composite powder, particularly the laccase contained in the green coffee composite powder, can have a remarkable halitosis removing effect in experiments, and the applicant considers that the possible reason is that laccase molecules are easy to attach to the surfaces of teeth in the use process of the toothpaste, so that sulfides can be effectively removed under the action of the abrasive molecules, the laccase molecules are utilized more efficiently, and the breath freshening effect is improved.
The green coffee composite powder is unstable in water, and the solution may become brown after several hours or days due to the denaturation problem of the green coffee composite powder. The applicant has found that in low water or anhydrous formulations, the green coffee composite powder can be stably present.
Applicants have found that in low or no water formulations, the green coffee composite powder does not provide good sulfide removal at higher pH (pH > 7.5) for reasons that may be associated with poor stability of the green coffee powder at high pH. The green coffee powder can achieve good sulfide removal effect in the pH range of 6.5-7.5.
In one embodiment, the excipient is selected from one or more of carbomer, carrageenan, hydrated silica, xanthan gum, guar gum, cellulosic materials, sodium alginate.
In the present application, cellulose-based substances are not particularly limited, and sodium carboxymethyl cellulose, hydroxyethyl cellulose, and the like can be exemplified.
In one embodiment, the hydrated silica is selected from
And Jin Sanjiang (Zhaoqing) siliconMT friction type hydrated silica, MI friction type hydrated silica, MIC friction type hydrated silica, MIA high friction type hydrated silica, MIG high friction type hydrated silica, MIGT high friction type hydrated silica, or MIGT high friction type hydrated silica, available from materials Co.
Preferably, the hydrated silica is an MT friction-type hydrated silica.
Preferably, the carrageenan is carrageenan I.
Type i carrageenan was purchased from guangzhou nalin chemical ltd.
Preferably, the excipient is carbomer and carrageenan in a weight ratio of (0.5-1.75) to 1, more preferably the weight ratio of carbomer to carrageenan is 0.75.
The applicant found unexpectedly in experiments that when the excipients are carbomer and carrageenan, the obtained toothpaste not only has better cleaning effect, but also can ensure better shape stability, and the applicant thinks that the possible reason is the carbomer, and the obtained system plays a role in supporting an elastic molecular system formed by a galactose molecular structure in the carrageenan I molecules and calcium ions in the friction agent to a certain extent. In addition, under the action of external force during the use of the toothpaste, the supported stabilizing system can remove stains attached to the surface of teeth in time through the movement of the molecular chain segments. The effect is not ideal when other types of carrageenan are used.
In addition, applicants have unexpectedly found that the combination of carbomer and carrageenan in the present application also avoids the damage to enamel caused by hydrated silica in the abrasive to some extent, and the problems associated with bleeding gums.
The sweetener in the present application is not particularly limited, and examples thereof include sucrose, glucose, saccharin sodium, sorbitol, xylitol, and sucralose.
In one embodiment, the abrasive is selected from one or more of aluminum hydroxide, calcium carbonate, calcium bicarbonate, silicon dioxide, alumina, hydrated silica.
Preferably, the abrasive is hydrated silica.
In one embodiment, the hydrated silica is selected from
And Jin Sanjiang (Zhaoqing) silica materials GmbH MT friction type hydrated silica, MI friction type hydrated silica, MIC friction type hydrated silica, MIA high friction type hydrated silica, MIG high friction type hydrated silica, MIGT high friction type hydrated silica.
Preferably, the hydrated silica is an MT friction-type hydrated silica.
In one embodiment, the humectant is selected from one or more of polyethylene glycol, glycerin, trehalose, sodium hyaluronate, propylene glycol, ethylene glycol, butylene glycol, dextran, sodium lactate.
Preferably, the humectant is glycerol and polyethylene glycol in a weight ratio of 1 (0.06-0.09), more preferably, the humectant is glycerol and polyethylene glycol in a weight ratio of 1.
The applicant unexpectedly finds that when the abrasive is hydrated silica and the wetting agent is glycerol and polyethylene glycol in a weight ratio of 1 (0.06-0.09), inorganic particles such as fluoride and hydrated silica are more easily and uniformly dispersed in the whole system in the preparation process of the toothpaste, so that the operation time of the preparation process is reduced, the production efficiency is improved, and the applicant thinks that the possible reason is the difference of functional group distribution between glycerol and polyethylene glycol, and meanwhile, a structural distribution system formed by long and short molecular chains is more favorable for the dispersion of the inorganic particles. So that the toothpaste can be uniformly mixed in a short time in the preparation process.
In addition, the applicant unexpectedly finds that the compounding of the laccase-containing green coffee compound powder with the abrasive and the humectant can further improve the breath freshening rate, so that a better effect of removing sulfides in breath can be achieved within 5 minutes after the toothpaste product in the application is used.
In one embodiment, the surfactant is selected from one or more of betaine, tween 80, sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, sodium lauryl sulfate, sodium N-lauroyl sarcosinate, and sodium oleate.
Preferably, the surfactant is betaine and sodium dodecyl sulfate, and the weight ratio is (0.5-2): 1, more preferably betaine and sodium lauryl sulphate, in a weight ratio of 1.3:1.
in a second aspect, the present invention provides a method for preparing a breath-freshening toothpaste, comprising: sequentially adding all the preparation raw materials into deionized water, uniformly stirring, and vacuum degassing to obtain the final product.
In one embodiment, deionized water is added in an amount of 0.04 times the weight of all the starting materials prepared.
Compared with the prior art, the invention has the following beneficial effects:
the toothpaste product has the advantages of effectively removing sulfides, having a remarkable deodorization effect, being superior to the deodorization effect of toothpaste products in the prior art, having a certain whitening effect, being resistant to a certain temperature, and having little viscosity change after being placed at 45 ℃ for three months.
Drawings
FIG. 1 is a graph of the sulfide scavenging ability of the toothpaste of example 1;
FIG. 2 is a graph of the ability of the toothpaste of example 2 to scavenge sulfide;
FIG. 3 is a graph of the test of the sulfide scavenging ability of the toothpaste of example 3;
FIG. 4 is a graph of the ability of the toothpaste of example 4 to scavenge sulfide;
FIG. 5 is a graph of the sulfide scavenging ability of the toothpaste of example 5;
figure 6 is a test chart of the sulfide scavenging ability of the toothpaste of example 6.
Detailed Description
The present invention is illustrated by the following specific embodiments, but is not limited to the specific examples given below.
Example 1
A breath freshening toothpaste is prepared from, by weight, 0.243 parts of sodium fluoride, 0.4 parts of sodium dihydrogen phosphate, 0.7 parts of trisodium phosphate, 0.4 parts of green coffee composite powder (available from international trade ltd of vast, product source, national island, model number Biofresh 4+ complex), 17 parts of abrasive (hydrated silica), 69 parts of humectant (glycerol and polyethylene glycol in a weight ratio of 1.
The hydrated silica is an MT friction-type hydrated silica available from Jin Sanjiang (Zhaoqing) Silicone materials, inc. The carrageenan I type carrageenan is purchased from Guangzhou Na Ying chemical industry Co.
This example pH =7.16.
The preparation method of the toothpaste comprises the following steps: adding all the preparation raw materials into deionized water, uniformly stirring, and performing vacuum degassing to obtain the product, wherein the dosage of the deionized water is 0.04 times of the weight of all the preparation raw materials.
Example 2
The specific implementation mode of the toothpaste with fresh breath is the same as that of example 1, except that the green coffee composite powder is not used.
This example pH =7.18.
The preparation method of the toothpaste is the same as that of example 1.
Example 3
A breath freshening toothpaste is prepared from, by weight, 0.454 parts of stannous fluoride, 1.3 parts of sodium gluconate, 0.45 parts of sodium hydroxide, 0.4 parts of green coffee powder complex (purchased from national trade ltd, vast, product source, biofresh 4+ complex), 17 parts of abrasive (hydrated silica), 68 parts of humectant (glycerol and polyethylene glycol in a weight ratio of 1.
The hydrated silica is an MT friction-type hydrated silica available from Jin Sanjiang (Zhaoqing) Silicones, inc. The carrageenan is I-type carrageenan and is purchased from Guangzhou Na-Ying chemical industry Co.
This example pH =6.78.
The toothpaste was prepared in the same manner as in example 1.
Example 4
A breath freshening toothpaste is prepared from, by weight, 0.243 parts sodium fluoride, 0.4 parts sodium dihydrogen phosphate, 0.9 parts trisodium phosphate, 0.4 parts green coffee powder complex (available from national trade ltd of vast, product source, biofresh 4+ complex), 5 parts sodium tripolyphosphate, 16 parts abrasive (hydrated silica), 66 parts humectant (glycerol and polyethylene glycol in a weight ratio of 1.075), 3.5 parts surfactant (betaine solution (29 wt%) and sodium lauryl sulfate in a weight ratio of 2.
The hydrated silica is an MT friction-type hydrated silica available from Jin Sanjiang (Zhaoqing) Silicone materials, inc. The carrageenan is I-type carrageenan and is purchased from Guangzhou Na-Ying chemical industry Co.
This example pH =8.26.
The preparation method of the toothpaste is the same as that of example 1.
Example 5
A certain marketed long-acting breath-resistant toothpaste (containing zinc citrate).
Example 6
Some marketed long-acting breath freshening toothpaste (containing zinc citrate and stannous fluoride).
The toothpastes of examples 1 to 6 were tested:
the samples were tested for sulfide scavenging ability.
The test method is as follows:
1, preparing a PBS solution of sodium sulfide
a) Dissolving a proper amount of sodium sulfide in a 1XPBS solution to prepare a solution of 7 mu M;
b) The volume of the solution is more than 150mL;
2, the solution was divided into two or more sample vials, and 40mL of sodium sulfide in PBS was added to each vial.
3, reserving a sample bottle, and adding 1g of toothpaste sample to be detected into other sample bottles;
4, stirring the toothpaste sample for 5 minutes by using a stirring rod, wherein the toothpaste needs to be completely dissolved in the solution;
and 5, standing the toothpaste solution for 10 minutes, and then developing by using a sulfide developer (comprising a No. 1 solid reagent and a No. 2 liquid reagent) produced by a terrestrial constant organism according to the steps of 6-9.
6, taking 15mL of toothpaste solution and adding the toothpaste solution into a colorimetric tube.
7, adding a No. 1 solid reagent (0.08 g) into the colorimetric tube, slightly shaking the colorimetric tube for more than 20 seconds or visually observing the solid reagent to be completely dissolved, and reducing the generation of foams as much as possible during the process;
8, adding a No. 2 liquid reagent (0.5 mL) into the colorimetric tube, and slightly shaking the colorimetric tube for more than 10 seconds, wherein foam generation is reduced as much as possible;
9, standing the colorimetric tube for 10 minutes, then taking out the colorimetric card to compare colors, and judging the sulfide residues.
The less sulfide residue, the better the breath freshening effect.
10, the sodium sulfide PBS solution left before also needs to repeat the steps of 6-9, and finally, the color comparison ensures that the sodium sulfide PBS solution is prepared correctly.
The test results were as follows:
example 1 toothpaste test results are shown in figure 1; example 2 toothpaste test results are shown in figure 2; example 3 toothpaste test results are shown in figure 3; example 4 toothpaste test results are shown in figure 4; the results of the toothpaste testing for examples 5 and 6 are shown in figures 5-6, respectively.
From examples 1 and 2, only Biofresh 4+ complete, which plays a role in removing sulfides in toothpaste; from example 3, stannous has no influence on the activity of Biofresh 4+ complex, so that the stannous can be compounded with the Biofresh 4+ complex, and the composition can not only utilize the Biofresh 4+ complex to achieve the effect of removing halitosis in a short time, but also utilize the stannous fluoride to inhibit halitosis anaerobic bacteria gas to achieve the effect of inhibiting halitosis in a long time; from the results of example 1 and example 4, pH has a large effect on the activity of Biofresh 4+ complex; from example 1 and a comparison of two contestants (a certain marketed long-acting anti-breath toothpaste and a certain marketed long-acting fresh breath toothpaste), neither zinc citrate nor stannous fluoride are effective in removing sulfides, whereas Biofresh 4+ complex can.
Claims (10)
1. The breath-freshening toothpaste is characterized by comprising, by weight, 0.2-0.5 part of fluoride, 0.1-1 part of green coffee composite powder, 10-20 parts of an abrasive, 60-80 parts of a wetting agent, 3-5 parts of a surfactant, 0.5-5 parts of an excipient and 0.5-2 parts of a sweetening agent.
2. The breath freshening toothpaste of claim 1 wherein the green coffee composite powder comprises a laccase.
3. The breath freshening toothpaste of claim 2 wherein said excipient is selected from one or more of carbomer, carrageenan, hydrated silica, xanthan gum, guar gum, cellulose based materials, sodium alginate.
4. The breath freshening toothpaste of claim 3 wherein said hydrated silica is selected from the group consisting of
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153, and Jin Sanjiang (Zhaoqing) silicon material, inc., one or more of MT friction type hydrated silica, MI friction type hydrated silica, MIC friction type hydrated silica, MIA high friction type hydrated silica, MIG high friction type hydrated silica, MIGT high friction type hydrated silica.
5. The breath freshening toothpaste of claim 4 wherein the carrageenan is carrageenan type I.
6. The breath freshening toothpaste according to any one of claims 1 to 5 wherein the abrasive agent is selected from one or more of the group consisting of aluminium hydroxide, calcium carbonate, calcium bicarbonate, silicon dioxide, aluminium oxide, hydrated silica.
7. The breath freshening toothpaste of claim 6 wherein said humectant is selected from one or more of polyethylene glycol, glycerin, trehalose, sodium hyaluronate, propylene glycol, ethylene glycol, butylene glycol, dextran, sodium lactate.
8. The breath freshening toothpaste of claim 7 wherein said surfactant is selected from the group consisting of one or more of betaine, tween 80, sodium lauryl sulfate, sodium dodecylbenzene sulfonate, sodium lauryl sulfate, sodium N-lauroyl sarcosinate, sodium oleate.
9. The breath freshening toothpaste of claim 8 wherein said fluoride is stannous fluoride and/or sodium fluoride.
10. A method of making a breath freshening toothpaste as claimed in any one of claims 1 to 9 which comprises: sequentially adding all the preparation raw materials into deionized water, uniformly stirring, and vacuum degassing to obtain the final product.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116898741A (en) * | 2023-08-18 | 2023-10-20 | 广州品硬生物科技有限公司 | Gum restoration toothpaste containing lysozyme and probiotics and preparation method thereof |
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2022
- 2022-08-16 CN CN202210983551.9A patent/CN115969743A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116898741A (en) * | 2023-08-18 | 2023-10-20 | 广州品硬生物科技有限公司 | Gum restoration toothpaste containing lysozyme and probiotics and preparation method thereof |
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