CN110403851A - A kind of antiallergic sense toothpaste - Google Patents
A kind of antiallergic sense toothpaste Download PDFInfo
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- CN110403851A CN110403851A CN201910811413.0A CN201910811413A CN110403851A CN 110403851 A CN110403851 A CN 110403851A CN 201910811413 A CN201910811413 A CN 201910811413A CN 110403851 A CN110403851 A CN 110403851A
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- antiallergic sense
- toothpaste
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- hydroxyapatite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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Abstract
The invention discloses a kind of antiallergic sense toothpaste, the antiallergic sense toothpaste includes rubbing agent and water, it is characterized in that: the rubbing agent mainly by for blocking dentinal tubule microcrystalline cellulose and hydroxyapatite form, based on the weight of antiallergic sense toothpaste, the content of the microcrystalline cellulose is 1%~50%, and the content of the hydroxyapatite is 1%~50%.Compared with prior art, the microcrystalline cellulose of antiallergic sense toothpaste of the present invention can play the role of cooperateing with hydroxyapatite blocks dentinal tubule, toothpaste is set to obtain the more longlasting firm effect for blocking dentinal tubule, 70~90% are reached to the sealing ratiod of dentinal tubule, sealing ratiod can reach 60~80% after acid etching.
Description
Technical field
The invention belongs to field of oral care, and in particular to a kind of antiallergic sense toothpaste.
Background technique
Sensitivity of tooth is outside being exposed to because of the canaliculi dentales on dentine, so that dentine is to cold and hot sour-sweet or brusher
The pain symptom that the generations stimulation such as agomphiasis work occurs.Anti- sensitive technology for toothpaste mainly has: one, blocking dentinal tubule;
Two, the sensibility of Intradental nerve is reduced by potassium ion.
The technology of mode two can only benumb nerve in short term, cannot have long-range lasting in the presence of cannot really completely cut off environmental stimuli
Curative effect.Mode one can block dentinal tubule to a certain extent at present, but most closure and insecure, cause originally
The aperture blocked exposes again, and sealing ratiod reduces, and anti-sensitizing effect also decreases.
Microcrystalline cellulose is made of plant fiber through sour water solution, and CN1325676A, which discloses one kind, to prevent tooth from grinding
Damage, and can clean the novel toothpaste of tooth, and it for 15~50 μm of microcrystalline cellulose is grinding agent which, which uses partial size, but this article
It offers and does not disclose whether its toothpaste has anti-sensitive property.
Hydroxyapatite is a kind of bone renovating material of classics, and CN105640788A discloses a kind of hydroxyapatite tooth
Cream, the hydroxy agustite tooth-paste include micron order hydroxyapatite, nanometer hydroxyapatite and fluoride.Although the toothpaste can
Dentine is effectively repaired, but there are excess intake fluorine, leads to the problem of dental fluorosis.
Summary of the invention
According to above-mentioned the deficiencies in the prior art, has the object of the present invention is to provide one kind and preferably block dentinal tubule
Antiallergic sense toothpaste.
To achieve the above object, the technical solution adopted in the present invention is as follows:
A kind of antiallergic sense toothpaste, including rubbing agent and water, it is characterized in that: the rubbing agent is mainly by for blocking tooth sheet
The microcrystalline cellulose and hydroxyapatite of matter tubule form, based on the weight of antiallergic sense toothpaste, the content of the microcrystalline cellulose
It is 1%~50%, the content of the hydroxyapatite is 1%~50%.
Preferably, the content of the microcrystalline cellulose is 5%~20%, the content of the hydroxyapatite is 2%~
15%.
Preferably, the weight ratio of the microcrystalline cellulose and hydroxyapatite is 1:0.2~1:1.5, and specific example is such as
1:0.2、1:0.3、1:0.4、1:0.5、1:0.6、1:0.7、1:0.8、1:0.9、1:1、1:1.1、1:1.2、1:1.3、1:1.4、
1:1.5。
Preferably, the antiallergic sense toothpaste also contains moisturizer, thickener, foaming agent, sweetener, aromatic, bacteriostatic agent
At least one of with pigment.
Preferably, based on the weight of antiallergic sense toothpaste, the content of the moisturizer is 20%~75%, the thickener
Content is 0.5%~2%, and the content of the foaming agent is 0%~3%, and the content of the sweetener is 0~0.5%, the virtue
The content of pastil is 0~2%, and the content of the bacteriostatic agent is 0~0.5%, and the content of the pigment is 0~0.5%.
Preferably, the moisturizer is selected from sorbierite, glycerol etc.;The thickener is selected from cellulose gum, modified cellulose
Glue, xanthan gum etc.;The foaming agent is selected from laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine etc.;The sweetener is selected from
Saccharin sodium, Sucralose etc.;The aromatic is selected from natural perfume material, synthetic perfume or essence;The bacteriostatic agent is selected from benzoic acid
Sodium, methyl p-hydroxybenzoate etc..
The modified cellulose gum such as carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, Methyl cellulose
Element, ethyl cellulose etc..
The preparation method of above-mentioned antiallergic sense toothpaste, comprising:
(1) moisturizer and sweetener are first dissolved in water, obtain liquid phase;
(2) liquid phase is added in rubbing agent and thickener again, be mixed;
(3) foaming agent, aromatic, bacteriostatic agent and pigment is then added, degassing obtains the antiallergic sense toothpaste.
It is a kind of for blocking the composition of dentinal tubule, sign point in: the composition mainly by microcrystalline cellulose and
Hydroxyapatite composition, wherein the weight ratio of the microcrystalline cellulose and hydroxyapatite is 1:0.2~1:1.5.
Above-mentioned composition is preparing the application in antiallergic sense toothpaste as the active constituent for blocking dentinal tubule.
Preferably, weight percent content of the composition in antiallergic sense toothpaste is 15%~20%.
Antiallergic sense toothpaste of the invention reaches 70~90% to the sealing ratiod of dentinal tubule, and sealing ratiod can reach after acid etching
60~80%, and it is not necessary that fluoride is added.
In the present invention, the fiber strip structure (see Fig. 1) of microcrystalline cellulose can form frame structure, and hydroxyapatite is then
It is filled in frame structure, dentinal tubule is deposited on as reinforced concrete, the work for blocking dentinal tubule is played in collaboration
With more longlasting firm closure dentinal tubule is higher than independent microcrystalline cellulose, hydroxy-apatite to the sealing ratiod of dentinal tubule
Sealing ratiod after the sealing ratiod and acid etching of stone or bio-vitric.
Detailed description of the invention
Fig. 1 is the electron microscope of microcrystalline cellulose.
Specific embodiment
Technical solution of the present invention is described in further detail below by specific embodiment.
A kind of antiallergic sense toothpaste, including rubbing agent and water, the rubbing agent is mainly by for blocking the micro- of dentinal tubule
Crystalline cellulose and hydroxyapatite composition, based on the weight of antiallergic sense toothpaste, the content of the microcrystalline cellulose is 1%~
50%, the content of the hydroxyapatite is 1%~50%.
The total weight of microcrystalline cellulose and hydroxyapatite at least accounts for the 80% of rubbing agent weight, preferably comprise from 90% with
On.
The diameter of the microcrystalline cellulose is preferably 1~50 μm, and more preferably 5~20 μm.
The rubbing agent further includes silica and/or calcium carbonate, in the antiallergic sense toothpaste, silica and/or
The content of calcium carbonate is no more than 2wt%.
The antiallergic sense toothpaste also contains in moisturizer, thickener, foaming agent, sweetener, aromatic, bacteriostatic agent and pigment
At least one.
Embodiment 1:
Sorbierite 60wt%
Cellulose gum 1wt%
Microcrystalline cellulose 10wt%
Hydroxyapatite 8wt%
Laruyl alcohol sodium sulfovinate 2wt%
Essence 1wt%
Saccharin sodium 0.2wt%
Excess water.
Preparation process: sweetener (saccharin sodium) addition is gone in water, stirs to being completely dissolved, moisturizer (mountain is then added
Pears alcohol) stirring 5min liquid phase is made.Microcrystalline cellulose, hydroxyapatite, thickener (cellulose gum) are added to the container and are stirred
It mixes and powder uniformly is made, then powder is added in liquid phase, stir 20min.It is eventually adding essence, foaming agent (laruyl alcohol sulfuric acid
Ester sodium) it deaerates afterwards, that is, make the toothpaste of white.
Embodiment 2:
Glycerol 40wt%
Xanthan gum 0.9wt%
Microcrystalline cellulose 15wt%
Hydroxyapatite 3wt%
Cocoamidopropyl betaine 2.5wt%
Essence 1wt%
Sucralose 0.2wt%
Excess water.
Preparation process: sweetener (Sucralose) addition is gone in water, stirs to being completely dissolved, moisturizer is then added
Liquid phase is made in (glycerol) stirring 5min.Microcrystalline cellulose, hydroxyapatite, thickener (xanthan gum) are added to the container and are stirred
Powder uniformly is made, then powder is added in liquid phase, stirs 20min.It is eventually adding essence, foaming agent (cocamidopropyl propyl amide
Glycine betaine) it deaerates afterwards, that is, make the toothpaste of white.
Embodiment 3:
Sorbierite 58wt%
Glycerol 5wt%
Cellulose gum 0.6wt%
Xanthan gum 0.3wt%
Microcrystalline cellulose 8wt%
Hydroxyapatite 12wt%
Silica 2wt%
Laruyl alcohol sodium sulfovinate 1.5wt%
Cocoamidopropyl betaine 1wt%
Essence 1wt%
Saccharin sodium 0.2wt%
Excess water.
Preparation process: sweetener (saccharin sodium) addition is gone in water, stirs to being completely dissolved, moisturizer (mountain is then added
Pears alcohol, glycerol) stirring 5min liquid phase is made.By microcrystalline cellulose, hydroxyapatite, silica, thickener (cellulose gum,
Xanthan gum) it is added to the container and stirs evenly powder is made, then powder is added in liquid phase, stirs 20min.It is eventually adding perfume (or spice)
Essence, foaming agent (laruyl alcohol sodium sulfovinate, Cocoamidopropyl betaine) deaerate afterwards, that is, make the toothpaste of white.
Comparative example 1
Sorbierite 60wt%
Cellulose gum 1wt%
Bio-vitric 18wt%
Laruyl alcohol sodium sulfovinate 2wt%
Essence 1wt%
Saccharin sodium 0.2wt%
Excess water.
Preparation process: sweetener (saccharin sodium) addition is gone in water, stirs to being completely dissolved, moisturizer (mountain is then added
Pears alcohol) stirring 5min liquid phase is made.Bio-vitric, thickener (cellulose gum) are added to the container and are stirred evenly and powder is made
Then material powder is added in liquid phase, stir 20min.Be eventually adding essence, foaming agent (laruyl alcohol sodium sulfovinate) deaerates afterwards,
Make the toothpaste of white.
Comparative example 2
Sorbierite 60wt%
Cellulose gum 1wt%
Microcrystalline cellulose 18wt%
Laruyl alcohol sodium sulfovinate 2wt%
Essence 1wt%
Saccharin sodium 0.2wt%
Excess water.
Preparation process: sweetener (saccharin sodium) addition is gone in water, stirs to being completely dissolved, moisturizer (mountain is then added
Pears alcohol) stirring 5min liquid phase is made.Microcrystalline cellulose, thickener (cellulose gum) are added to the container and are stirred evenly and powder is made
Then material powder is added in liquid phase, stir 20min.Be eventually adding essence, foaming agent (laruyl alcohol sodium sulfovinate) deaerates afterwards,
Make the toothpaste of white.
Comparative example 3
Sorbierite 60wt%
Cellulose gum 1wt%
Hydroxyapatite 18wt%
Laruyl alcohol sodium sulfovinate 2wt%
Essence 1wt%
Saccharin sodium 0.2wt%
Excess water.
Preparation process: sweetener (saccharin sodium) addition is gone in water, stirs to being completely dissolved, moisturizer (mountain is then added
Pears alcohol) stirring 5min liquid phase is made.Hydroxyapatite, thickener (cellulose gum) are added to the container and are stirred evenly and powder is made
Then material powder is added in liquid phase, stir 20min.Be eventually adding essence, foaming agent (laruyl alcohol sodium sulfovinate) deaerates afterwards,
Make the toothpaste of white.
Comparative example 4
Sorbierite 60wt%
Cellulose gum 1wt%
Microcrystalline cellulose 10wt%
Silica 8wt%
Laruyl alcohol sodium sulfovinate 2wt%
Essence 1wt%
Saccharin sodium 0.2wt%
Excess water.
Preparation process: sweetener (saccharin sodium) addition is gone in water, stirs to being completely dissolved, moisturizer (mountain is then added
Pears alcohol) stirring 5min liquid phase is made.Microcrystalline cellulose, silica, thickener (cellulose gum) are added to the container and are stirred
Powder uniformly is made, then powder is added in liquid phase, stirs 20min.It is eventually adding essence, foaming agent (laurel alcohol sulfuric ester
Sodium) it deaerates afterwards, that is, make the toothpaste of white.
Comparative example 5
Sorbierite 60wt%
Cellulose gum 1wt%
Microcrystalline cellulose 10wt%
Calcium carbonate 8wt%
Laruyl alcohol sodium sulfovinate 2wt%
Essence 1wt%
Saccharin sodium 0.2wt%
Excess water.
Preparation process: sweetener (saccharin sodium) addition is gone in water, stirs to being completely dissolved, moisturizer (mountain is then added
Pears alcohol) stirring 5min liquid phase is made.Microcrystalline cellulose, calcium carbonate, thickener (cellulose gum) are added to the container and stirred
It is even that powder is made, then powder is added in liquid phase, stirs 20min.It is eventually adding essence, foaming agent (laruyl alcohol sodium sulfovinate)
After deaerate, that is, make white toothpaste.
Block test
Toothpaste prepared by embodiment 1-3, comparative example 1-5 is as follows to the closure test process of dentinal tubule:
1. taking the fresh ox incisor cutting polishing pulled out, it is fabricated to dentine block, and observe under polarization microscope, really
It is abundant to protect canaliculi dentales exposure.
2. several pieces of dentine samples are assigned randomly to blank control group, negative control group, positive controls and experiment
In group.
3., as non-process area, half region in addition, which is used as, brushes teeth with the dentine sample in tape-stripping half region
Experiment process area.
4. blank control group uses common commercial toothpastes, positive controls use pair using deionized water, negative control group
Toothpaste prepared by ratio 1-5, experimental group use toothpaste prepared by embodiment 1-3.Each group dentine sample is placed in accordingly
It in treatment conditions, is brushed teeth using automation Tooth-brushing device, is then sufficiently cleaned with deionized water, be soaked in artificial saliva later
60min.It repeats the above steps 6 times.
5. dry dentine sample is taken out to observe under a scanning electron microscope, it is each respectively at treatment region and non-process area
The picture (2000 times) for taking three visuals field carries out exposed canaliculi dentales and counts C.
6. calculating each group canaliculi dentales sealing ratiod R:
R (%)=/ ∑ non-process area C × 100 (∑ non-process area C- ∑ treatment region C)
7. the solution of the pH ≈ 3 configured again with citric acid impregnates sample 10 minutes.
8. repeating 5,6 steps, sealing ratiod R is calculated.
Toothpaste sample | Sealing ratiod | Sealing ratiod after acid etching | Retention rate |
Embodiment 1 | 88% | 79% | 90% |
Embodiment 2 | 80% | 71% | 89% |
Embodiment 3 | 72% | 64% | 89% |
Comparative example 1 | 63% | 45% | 71% |
Comparative example 2 | 55% | 37% | 67% |
Comparative example 3 | 64% | 47% | 73% |
Comparative example 4 | 49% | 33% | 67% |
Comparative example 5 | 51% | 30% | 59% |
Negative control group | 34% | 18% | 53% |
Blank control group | 2% | 1% | 50% |
Sealing ratiod/sealing ratiod × 100% after retention rate=acid etching
Toothpaste of the invention reaches 70~90% to the sealing ratiod of dentinal tubule it can be seen from experimental result, acid etching
Sealing ratiod can reach 60~80% afterwards, compared with independent microcrystalline cellulose or hydroxyapatite, have more longlasting firm closure
Effect.
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention,
Although the present invention is described in detail referring to the foregoing embodiments, for those skilled in the art, still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.
All within the spirits and principles of the present invention, any modification, equivalent replacement, improvement and so on should be included in of the invention
Within protection scope.
Claims (10)
1. a kind of antiallergic sense toothpaste, including rubbing agent and water, it is characterised in that: the rubbing agent is mainly by for blocking dentine
The microcrystalline cellulose and hydroxyapatite of tubule form, and based on the weight of antiallergic sense toothpaste, the content of the microcrystalline cellulose is
1%~50%, the content of the hydroxyapatite is 1%~50%.
2. antiallergic sense toothpaste according to claim 1, it is characterised in that: the content of the microcrystalline cellulose be 5%~
20%, the content of the hydroxyapatite is 2%~15%.
3. antiallergic sense toothpaste according to claim 2, it is characterised in that: the weight of the microcrystalline cellulose and hydroxyapatite
Amount is than being 1:0.2~1:1.5.
4. any antiallergic sense toothpaste according to claim 1~3, it is characterised in that: the antiallergic sense toothpaste also contains guarantor
At least one of humectant, thickener, foaming agent, sweetener, aromatic, bacteriostatic agent and pigment.
5. antiallergic sense toothpaste according to claim 4, it is characterised in that: based on the weight of antiallergic sense toothpaste, the moisturizing
The content of agent is 20%~75%, and the content of the thickener is 0.5%~2%, and the content of the foaming agent is 0%~3%,
The content of the sweetener is 0~0.5%, and the content of the aromatic is 0~2%, the content of the bacteriostatic agent is 0~
0.5%, the content of the pigment is 0~0.5%.
6. antiallergic sense toothpaste according to claim 5, it is characterised in that: the moisturizer is selected from sorbierite and/or glycerol;
The thickener is selected from cellulose gum, modified cellulose gum and/or xanthan gum;The foaming agent is selected from laruyl alcohol sodium sulfovinate
And/or Cocoamidopropyl betaine.
7. the preparation method of antiallergic sense toothpaste as claimed in claim 4, comprising:
(1) moisturizer and sweetener are first dissolved in water, obtain liquid phase;
(2) liquid phase is added in rubbing agent and thickener again, be mixed;
(3) foaming agent, aromatic, bacteriostatic agent and pigment is then added, degassing obtains the antiallergic sense toothpaste.
8. a kind of for blocking the composition of dentinal tubule, sign is: the composition is mainly by microcrystalline cellulose and hydroxyl
Base apatite composition, wherein the weight ratio of the microcrystalline cellulose and hydroxyapatite is 1:0.2~1:1.5.
9. the purposes of composition according to any one of claims 8, it is characterised in that: the composition is as the work for blocking dentinal tubule
Property ingredient preparation antiallergic sense toothpaste in application.
10. purposes according to claim 9, it is characterised in that: weight percent of the composition in antiallergic sense toothpaste
It is 15%~20% than content.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112870109A (en) * | 2021-02-26 | 2021-06-01 | 杭州致英日用百货有限公司 | Antibacterial whitening dentifrice and preparation method thereof |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102429832A (en) * | 2011-11-28 | 2012-05-02 | 广州立白企业集团有限公司 | Novel abrasive compound and toothpaste comprising same |
CN103120623A (en) * | 2012-12-01 | 2013-05-29 | 云南白药集团股份有限公司 | Dentin sensitivity preventing oral hygiene nursing preparation |
CN104306298A (en) * | 2014-09-30 | 2015-01-28 | 青岛叁鼎卫生制品有限公司 | Whitening and tooth-protecting toothpaste |
CN105640788A (en) * | 2016-01-27 | 2016-06-08 | 杭州皎洁口腔保健用品有限公司 | Hydroxyapatite toothpaste and preparation method thereof |
CN105902409A (en) * | 2016-05-13 | 2016-08-31 | 广东龙湖科技股份有限公司 | Toothpaste with good mild thixotropy and preparation method of toothpaste |
CN106074195A (en) * | 2016-07-06 | 2016-11-09 | 杭州皎洁口腔保健用品有限公司 | A kind of toothpaste of hydroxyl apatite and calcium carbonate and preparation method thereof |
CN108721140A (en) * | 2018-07-19 | 2018-11-02 | 无锡青禾小贝科技有限公司 | A kind of oral care implement and preparation method thereof |
-
2019
- 2019-08-29 CN CN201910811413.0A patent/CN110403851B/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102429832A (en) * | 2011-11-28 | 2012-05-02 | 广州立白企业集团有限公司 | Novel abrasive compound and toothpaste comprising same |
CN103120623A (en) * | 2012-12-01 | 2013-05-29 | 云南白药集团股份有限公司 | Dentin sensitivity preventing oral hygiene nursing preparation |
CN104306298A (en) * | 2014-09-30 | 2015-01-28 | 青岛叁鼎卫生制品有限公司 | Whitening and tooth-protecting toothpaste |
CN105640788A (en) * | 2016-01-27 | 2016-06-08 | 杭州皎洁口腔保健用品有限公司 | Hydroxyapatite toothpaste and preparation method thereof |
CN105902409A (en) * | 2016-05-13 | 2016-08-31 | 广东龙湖科技股份有限公司 | Toothpaste with good mild thixotropy and preparation method of toothpaste |
CN106074195A (en) * | 2016-07-06 | 2016-11-09 | 杭州皎洁口腔保健用品有限公司 | A kind of toothpaste of hydroxyl apatite and calcium carbonate and preparation method thereof |
CN108721140A (en) * | 2018-07-19 | 2018-11-02 | 无锡青禾小贝科技有限公司 | A kind of oral care implement and preparation method thereof |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112870109A (en) * | 2021-02-26 | 2021-06-01 | 杭州致英日用百货有限公司 | Antibacterial whitening dentifrice and preparation method thereof |
CN112870109B (en) * | 2021-02-26 | 2023-08-25 | 云南诺特金参口腔护理用品有限公司 | Antibacterial whitening dentifrice and preparation method thereof |
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