CN115968979A - Feed additive for improving intestinal health and reducing diarrhea of weaned piglets and preparation method thereof - Google Patents
Feed additive for improving intestinal health and reducing diarrhea of weaned piglets and preparation method thereof Download PDFInfo
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- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 35
- 239000003674 animal food additive Substances 0.000 title claims abstract description 32
- 230000007413 intestinal health Effects 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims abstract description 75
- 229910052901 montmorillonite Inorganic materials 0.000 claims abstract description 75
- 229910000365 copper sulfate Inorganic materials 0.000 claims abstract description 16
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims abstract description 16
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- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 13
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- 239000010949 copper Substances 0.000 claims description 37
- 238000006243 chemical reaction Methods 0.000 claims description 17
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- 238000000034 method Methods 0.000 claims description 14
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- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
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- 229910001431 copper ion Inorganic materials 0.000 description 2
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- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- BECGPAPCGOJSOT-UHFFFAOYSA-N [O-2].O.S.[Zn+2] Chemical compound [O-2].O.S.[Zn+2] BECGPAPCGOJSOT-UHFFFAOYSA-N 0.000 description 1
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- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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- Fodder In General (AREA)
Abstract
The invention relates to the technical field of feeds, in particular to a feed additive for improving intestinal health and reducing diarrhea of weaned piglets and a preparation method thereof; a feed additive for improving intestinal health and reducing diarrhea of weaned piglets comprises the following raw materials in parts by mass: 40-55 parts of montmorillonite, 1-6 parts of copper sulfate, 8-15 parts of dandelion, 8-12 parts of gallnut, 10-16 parts of long pepper, 5-9 parts of trumpet creeper, 3-8 parts of liquorice and 5-10 parts of astragalus membranaceus; according to the application, copper-carrying montmorillonite is obtained after ion exchange treatment is carried out on copper sulfate and montmorillonite, a bacteriostatic function is carried, and after acid treatment, the copper-carrying montmorillonite is subjected to comprehensive compatibility use after being intercalated with dandelion, gallnut, piper longum, trumpet creeper, liquorice and astragalus membranaceus, so that the action time of traditional Chinese medicines in gastrointestinal tracts is prolonged, the synergistic effect is enhanced, the use effect is enhanced, and the intestinal health state of piglets is effectively improved, so that the diarrhea of weaned piglets is reduced.
Description
Technical Field
The invention relates to the technical field of feeds, in particular to a feed additive for improving intestinal health and reducing diarrhea of weaned piglets and a preparation method thereof.
Background
The intestinal tract development of piglets is not complete and the digestion function is not complete in the weaning process, and the problems of piglet diarrhea, growth speed reduction, survival rate reduction and the like are caused by stress easily due to the change of the feeding environment and the feed type. In actual production, high-dose zinc oxide is mainly added to inhibit diarrhea and relieve weaning stress, but the high-dose zinc oxide not only causes environmental pollution and increase of antibiotic resistance, but also influences the health of piglets.
At present, part of feed factories may use montmorillonite or Chinese herbal medicine extracts and the like alone to solve the problems of diarrhea and weaning stress caused by weaning of piglets, but the montmorillonite only has adsorption and no sterilization effect, the Chinese herbal medicine extracts are high in price, and when the montmorillonite is used alone, the montmorillonite has a single effect and a common effect.
Therefore, the finding of a green and safe feed additive for improving the intestinal health and reducing the diarrhea of weaned piglets is of great significance.
Disclosure of Invention
Aiming at the defects in the prior art, the application provides a feed additive for improving intestinal health and reducing diarrhea of weaned piglets and a preparation method thereof; the feed additive takes copper-loaded montmorillonite as a main carrier, has various characteristics such as ion exchange property, adsorbability and antibacterial property, is synergistic with traditional Chinese medicinal materials, is green, safe and has no side effect.
In a first aspect, the application provides a feed additive for improving intestinal health and reducing diarrhea of weaned piglets, which adopts the following technical scheme:
a feed additive for improving intestinal health and reducing diarrhea of weaned piglets comprises the following raw materials in parts by mass: 40-55 parts of montmorillonite, 1-6 parts of copper sulfate, 8-15 parts of dandelion, 8-12 parts of gallnut, 10-16 parts of long pepper, 5-9 parts of trumpet creeper, 3-8 parts of liquorice and 5-10 parts of astragalus membranaceus.
By adopting the technical scheme, the composite additive is a comprehensive and comprehensive formula and comprises the following components: the montmorillonite can protect intestinal mucosa after being loaded with copper, has the function of bacteriostasis and can reduce the proliferation of harmful bacteria; the dandelion is a heat-clearing and detoxifying medicine, the gallnut is an astringent, and both the gallnut and the gallnut have the functions of bacteriostasis, anti-inflammation and antioxidation; the fructus Piperis Longi has effects of warming spleen and stomach for dispelling cold, and relieving pain, and can be used for treating abdominal pain and diarrhea caused by deficiency-cold of spleen and stomach; the trumpetcreeper contains triterpene and flavone components, and has the effects of promoting qi circulation, dispelling pathogenic wind, resisting inflammation and relieving pain; the liquorice is sweet, tonifies and moistens, and has the effects of tonifying qi, clearing away heat and toxic materials, tonifying spleen and stomach, harmonizing the medicines and the like; radix astragali is a qi invigorating medicine, and has effects of improving immunity and resisting stress; the components can be used for synergized, comprehensively improving beneficial intestinal flora, maintaining intestinal health, improving immunity and anti-stress capability of organisms, reducing diarrhea rate, improving animal growth performance and improving breeding performance.
Preferably, the feed additive for improving intestinal health and reducing diarrhea of weaned piglets comprises the following raw materials in parts by mass: 45-50 parts of montmorillonite, 2-5 parts of copper sulfate, 9-12 parts of dandelion, 9-11 parts of gallnut, 12-14 parts of long pepper, 6-8 parts of trumpet creeper, 5-7 parts of liquorice and 6-8 parts of astragalus membranaceus.
In a second aspect, the application provides a preparation method of a feed additive for improving intestinal health and reducing diarrhea of weaned piglets, which adopts the following technical scheme:
a preparation method of a feed additive for improving intestinal health and reducing diarrhea of weaned piglets comprises the following steps:
(1) Weighing the raw materials of the feed additive according to the proportion;
(2) Mixing copper sulfate and montmorillonite, adding water to obtain rock slurry with mass concentration of 5-10%, mixing, performing ion exchange reaction while stirring, and filtering or centrifuging to remove filtrate to obtain copper-loaded montmorillonite;
(3) Adding water, mixing, adding superfine pulverized herba Taraxaci, galla chinensis, fructus Piperis Longi, flos Campsis, glycyrrhrizae radix and radix astragali, mixing, leaching, filtering, drying filtrate and residue, and mixing to obtain feed additive.
According to the application, copper-carrying montmorillonite is obtained after ion exchange treatment is carried out on copper sulfate and montmorillonite, a bacteriostatic function is carried, and after acid treatment, the copper-carrying montmorillonite is subjected to intercalation treatment with dandelion, gallnut, piper longum, trumpet creeper, liquorice and astragalus membranaceus for comprehensive compatibility use, so that the action time of traditional Chinese medicines in gastrointestinal tracts is prolonged, synergy is realized, the use effect is enhanced, and the intestinal health state of piglets is effectively improved, so that the diarrhea of weaned piglets is reduced.
The slow release effect of the montmorillonite can prolong the acting time of the traditional Chinese medicine in the stomach and intestine and improve the medicine effect; after the montmorillonite carries copper ions, the sterilization and bacteriostasis capability of the product is improved.
The method combines the montmorillonite copper-carrying process with the traditional Chinese medicine effective component extraction process, so that the equipment investment is reduced, the working procedures are saved, and the production cost is reduced; in the application, after the dandelion, the gallnut, the long pepper, the trumpet creeper, the liquorice and the astragalus are subjected to superfine powder and subsequent extraction treatment, the drug effect is better; the copper-loaded montmorillonite, the dandelion, the gallnut, the long pepper, the campsis grandiflora, the liquorice and the astragalus membranaceus are comprehensively compatible for use, the synergistic effect is achieved, the using effect is enhanced, the intestinal health state of piglets is effectively improved, and therefore diarrhea of weaned piglets is reduced.
The product is green and safe, does not cause the increase of antibiotic drug resistance, and does not influence the health of weaned pigs.
Preferably, the temperature of the ion exchange reaction in the step (2) is 40-100 ℃; the reaction time is 6-8 hours.
Preferably, the water added in the step (3) is 5 to 15 times of the mass of the montmorillonite in the step (2).
Preferably, the leaching reaction conditions in step (3) are as follows: leaching at 70-100 deg.C for 2-5 hr.
Preferably, the filtrate filtered in step (2) is added to a mixed solution of copper sulfate and montmorillonite, and the mixing reaction is continued.
In a specific embodiment, the copper-loaded montmorillonite prepared in step (2) is pretreated with an acid solution.
The montmorillonite has the characteristics of high specific surface area, ion exchange property, strong adsorption/desorption force and the like, and can be used as a controlled release carrier of a medicament, the copper-loaded montmorillonite is pretreated and then adsorbs a Chinese medicinal mixture, the pretreated copper-loaded montmorillonite can be rapidly dispersed and covers the mucosal surface of the ulcer surface of the digestive tract to form a stable mucosal barrier, and the Chinese medicinal mixture in the copper-loaded montmorillonite can be continuously released and treats the intestinal tract of a weaned piglet.
In a specific embodiment, the pretreatment step is as follows: dispersing the copper-loaded montmorillonite in phosphoric acid, and performing magnetic stirring for 1-3 hours to obtain the pretreated copper-loaded montmorillonite.
Preferably, the copper-loaded montmorillonite is added in an amount of 15 to 20 parts by mass, and the phosphoric acid is added in an amount of 50 to 60 parts by mass.
Preferably, the temperature of the magnetic stirring is 20-30 ℃.
Montmorillonite has huge specific surface area and adsorption property, can carry medicaments by intercalation, physical chemical adsorption or ion exchange reaction, and has the characteristics of high stability, large adsorption quantity, low price, no toxicity and the like, after the copper-carrying montmorillonite powder is reacted in phosphoric acid, partial traditional Chinese medicine mixture is intercalated between the copper-carrying montmorillonite layers, and the rest traditional Chinese medicine mixture is intercalated into the copper-carrying montmorillonite by physical adsorption; after the feed additive is taken by the weaned piglets, the copper-loaded montmorillonite particles are fine and can be rapidly dispersed and cover the mucosal surface of the ulcer surface of the digestive tract to form a stable mucosal barrier, the damage of an attack factor to the gastric mucosa is reduced and prevented, in addition, the traditional Chinese medicine mixture in the copper-loaded montmorillonite can be continuously released, and the intestinal tract of the weaned piglets is treated.
In summary, the present application includes at least one of the following beneficial technical effects:
1. after the copper ions are carried by the montmorillonite, the sterilization and bacteriostasis capability of the product is improved;
2. according to the application, after the copper sulfate and the montmorillonite are mixed, the mixture is comprehensively compatible with the dandelion, the gallnut, the long pepper, the trumpet creeper, the liquorice and the astragalus, so that the synergy is realized, the using effect is enhanced, and the intestinal health state of piglets is effectively improved, so that the diarrhea of weaned piglets is reduced.
3. The method combines the montmorillonite copper-carrying process with the traditional Chinese medicine effective component extraction process, so that the equipment investment is reduced, the working procedures are saved, and the production cost is reduced.
Detailed Description
The raw materials involved in the application are all products sold in the market, wherein the montmorillonite is purchased from Wuhu Shuihua New Material science and technology company, ltd; the common pig feed is purchased from the bliss biotechnology group limited company; zinc oxide was purchased from biotechnology ltd, fan, chongqing.
The present application will be described in further detail with reference to examples and comparative examples.
Example (b):
examples 1 to 3:
as shown in Table 1, examples 1-3 differ mainly in the starting materials used.
The following description will be given by taking example 1 as an example.
A preparation method of a feed additive for improving intestinal health and reducing diarrhea of weaned piglets comprises the following steps:
(1) Weighing montmorillonite, adding copper sulfate, adding water to prepare magma with mass concentration of 10%, mixing uniformly, and carrying out ion interaction reaction for 8 hours at 65 ℃, wherein the stirring is carried out continuously during the reaction;
(2) Filtering to remove water, and washing with clear water again to obtain wet copper-loaded montmorillonite; adding the filtered filtrate into a mixed solution of copper sulfate and montmorillonite, and continuously carrying out mixing reaction;
(3) Adding 5500g of clear water, adding superfine pulverized herba Taraxaci, galla chinensis, fructus Piperis Longi, campsis grandiflora, glycyrrhrizae radix and radix astragali, extracting at 85 deg.C for 2.5 hr, filtering, collecting filtrate and residue, concentrating the filtrate, evaporating to dryness, drying the residue at about 70 deg.C, and mixing the two dry substances to obtain the copper-loaded montmorillonite-traditional Chinese medicine composite additive.
TABLE 1 feed additive raw material proportioning Table (unit: g)
| Example 1 | Example 2 | Example 3 | |
| Montmorillonite (montmorillonite) | 400 | 480 | 550 |
| Copper sulfate | 10 | 35 | 60 |
| Dandelion | 80 | 100 | 150 |
| Galla chinensis | 80 | 100 | 120 |
| Long pepper | 100 | 130 | 160 |
| Chinese trumpet creeper | 50 | 70 | 90 |
| Licorice root | 30 | 65 | 80 |
| Astragalus membranaceus | 50 | 70 | 100 |
Example 4:
the main differences from example 1 are: the copper-loaded montmorillonite prepared in step (2) was pretreated with an acid solution under the same preparation conditions as in example 1.
The steps of pretreating the copper-loaded montmorillonite are as follows: the pretreated copper-loaded montmorillonite was obtained by dispersing 15g of copper-loaded montmorillonite in 50g of phosphoric acid and magnetically stirring at 20 ℃ for 2 hours.
Example 5:
the main differences from example 2 are: the copper-loaded montmorillonite prepared in step (2) was pretreated with an acid solution under the same conditions as in example 2.
The steps of pretreating the copper-loaded montmorillonite are as follows: the pretreated copper-loaded montmorillonite was obtained by dispersing 18g of copper-loaded montmorillonite in 55g of phosphoric acid and magnetically stirring at 20 ℃ for 2 hours.
Example 6:
the main differences from example 3 are: the copper-loaded montmorillonite prepared in step (2) was pretreated with an acid solution under the same preparation conditions as in example 3.
The steps of pretreating the copper-loaded montmorillonite are as follows: the pretreated copper-loaded montmorillonite was obtained by dispersing 20g of copper-loaded montmorillonite in 60g of phosphoric acid and magnetically stirring at 20 ℃ for 2 hours.
Example 7:
the main differences from example 2 are: the preparation conditions are different, and after the materials are uniformly mixed in the step (1), ion interaction reaction is carried out for 7 hours at the temperature of 80 ℃; in step (3), extraction is carried out at 80 ℃ for 3 hours.
Example 8:
the main differences from example 5 are: the preparation conditions are different, and after the mixture is uniformly mixed in the step (1), ion interaction is carried out for 7 hours at the temperature of 80 ℃; in step (3), extraction is carried out at 80 ℃ for 3 hours.
And (3) performance detection:
the feed additives prepared in examples 1 to 8 were used as samples, and ordinary montmorillonite was used as a comparative example, and the bacteriostatic rates of Salmonella typhimurium (CMCC 50115), escherichia coli (ATCC 25922), and Staphylococcus aureus (ATCC 25923) were examined.
TABLE 4 bacteriostasis rate (addition amount of 2.5 kg/t)
According to the bacteriostatic rates of the common montmorillonite of the examples 1 to 8 and the control sample, the bacteriostatic rates of the feed additives prepared in the examples 1 to 8 are higher than that of the common montmorillonite of the control sample, which means that the feed additives are mixed with copper sulfate and montmorillonite, and then are comprehensively compatible with dandelion, gallnut, long pepper, trumpet creeper, liquorice and astragalus root for synergistic effect, so that the sterilizing and bacteriostatic capacities of the product are improved.
The combination of examples 1-3 and 4-5 shows that the sterilization rate of examples 4-5 is better than that of examples 1-3, which indicates that the sterilization and bacteriostasis capability of the feed additive is enhanced after the pretreatment of montmorillonite.
Combining the example 7 and the example 8, it can be seen that the sterilization rate of the example 8 is better than that of the example 7, which shows that the sterilization and bacteriostasis capability of the feed additive is enhanced after the montmorillonite is pretreated.
Application example:
application example 1:
180 Du's growing healthy weaned piglets which are 24 days old and have the weight of about 6.9kg are selected, randomly divided into 3 groups, each group has 6 repetitions, each repetition has 10 pigs, and divided into a positive control group, a negative control group and a test group, and the positive control group (containing zinc oxide), the negative control group (removing zinc oxide) and the test group (removing zinc oxide +2.5kg/t of copper-loaded montmorillonite-traditional Chinese medicine composite additive) are respectively fed.
Wherein the positive care is a mixture of a zinc oxide additive and a common pig feed; the negative control material is common pig feed; the test feed was a mixture of plain pig feed and the feed additive prepared in example 2.
During the experiment, the patient can take food and drink water freely, and the experiment period is 14 days. No antibiotic anti-diarrhea drugs are additionally added in the experimental process, and diarrhea, feed consumption and initial weight and final weight of the pigs are recorded. The result shows that the cupronite-traditional Chinese medicine composite additive increases the daily gain of piglets by 15.25%, reduces the feed conversion ratio by 10.36% and reduces the diarrhea rate by 8.68%.
Application example 2:
180 Du grown healthy weaned piglets which are 24 days old and have the weight of about 6.9kg are selected and randomly divided into 3 groups, each group has 6 repetitions, each 10 pigs are repeated, and the piglets are divided into a positive control group, a negative control group and a test group, and are respectively fed with a positive control (containing sulfur zinc oxide), a negative control (removing zinc oxide) and a test material (removing zinc oxide +2.5kg/t of copper-loaded montmorillonite-traditional Chinese medicine composite additive).
Wherein the positive care is a mixture of a zinc oxide additive and a common feed; the negative control material is common feed; the test material was a mixture of ordinary feed and the feed additive prepared in example 5.
During the experiment, the patient can take food and drink water freely, and the experiment period is 14 days. In the experimental process, antibiotic anti-diarrhea drugs are not added additionally, and diarrhea, feed consumption and initial weight and final weight of pigs are recorded. The result shows that the cupronite-traditional Chinese medicine composite additive improves the daily gain of piglets by 16.78%, reduces the feed conversion ratio by 16.42% and reduces the diarrhea rate by 14.53%.
Application example 3:
90 Du-growing healthy weaned piglets of 21 days old and with the weight of about 6.3kg are selected and randomly divided into 3 groups, each group has 6 repetitions, each 5 pigs are divided into a positive control group, a negative control group and a test group, and the positive control group (containing zinc oxide), the negative control group (removing zinc oxide) and the test group (removing zinc oxide +2.5kg/t of copper-loaded montmorillonite-traditional Chinese medicine composite additive) are respectively fed.
Wherein the positive control is a mixture of a zinc oxide additive and a common feed; the negative control material is common feed; the test material was a mixture of ordinary feed and the feed additive prepared in example 7.
During the experiment, the patient can freely take food and drink water, and the experiment period is 11 days. No antibiotic anti-diarrhea drugs are additionally added in the experimental process, and diarrhea, feed consumption and initial weight and final weight of the pigs are recorded. The result shows that the cupronite-traditional Chinese medicine composite additive improves the daily gain of piglets by 9.83%, reduces the feed conversion ratio by 7.86% and reduces the diarrhea rate by 8.32%.
Application example 4:
90 young and healthy piglets of 21 days old and about 6.3kg in body weight are selected and randomly divided into 3 groups, each group has 6 repetitions, each repetition has 5 pigs, and the piglets are divided into a positive control group, a negative control group and a test group, and are respectively fed with a positive control (containing zinc oxide), a negative control (removing zinc oxide) and a test (removing zinc oxide +2.5kg/t of copper-loaded montmorillonite-traditional Chinese medicine composite additive).
Wherein the positive care is a mixture of a zinc oxide additive and a common feed; the negative control material is common feed; the test material was a mixture of ordinary feed and the feed additive prepared in example 8.
During the experiment, the patient can freely take food and drink water, and the experiment period is 11 days. No antibiotic anti-diarrhea drugs are additionally added in the experimental process, and diarrhea, feed consumption and initial weight and final weight of the pigs are recorded. The results show that the cupronite-traditional Chinese medicine composite additive improves the daily gain of piglets by 16.25 percent, reduces the feed conversion ratio by 14.31 percent and reduces the diarrhea rate by 11.04 percent.
According to the application examples 1-4, the daily gain of piglets is improved, the feed conversion ratio is reduced, and the diarrhea rate is reduced by taking the copper-loaded montmorillonite-traditional Chinese medicine composite additive, which shows that the copper-loaded montmorillonite-traditional Chinese medicine composite additive prepared by the application is comprehensively compatible with dandelion, gallnut, long pepper, campsis grandiflora, liquorice and astragalus mongholicus after mixing copper sulfate and montmorillonite, so that the synergistic effect is enhanced, the use effect is enhanced, the intestinal health state of piglets is effectively improved, and the diarrhea of weaned piglets is reduced.
The effect of application example 2 is better than that of application example 1, and the effect of application example 4 is better than that of application example 3, which shows that the intestinal health state of piglets is effectively improved by pretreating montmorillonite, so that diarrhea of weaned piglets is reduced.
The present embodiment is only for explaining the present application, and it is not limited to the present application, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present application.
Claims (10)
1. The feed additive for improving intestinal health and reducing diarrhea of weaned piglets is characterized by comprising the following raw materials in parts by mass: 40-55 parts of montmorillonite, 1-6 parts of copper sulfate, 8-15 parts of dandelion, 8-12 parts of gallnut, 10-16 parts of long pepper, 5-9 parts of trumpet creeper, 3-8 parts of liquorice and 5-10 parts of astragalus membranaceus.
2. The feed additive according to claim 2, which comprises the following raw materials in parts by mass: 45-50 parts of montmorillonite, 2-5 parts of copper sulfate, 9-12 parts of dandelion, 9-11 parts of gallnut, 12-14 parts of long pepper, 6-8 parts of trumpet creeper, 5-7 parts of liquorice and 6-8 parts of astragalus membranaceus.
3. A preparation method of a feed additive for improving intestinal health and reducing diarrhea of weaned piglets is characterized by comprising the following steps:
(1) Weighing the raw materials of the feed additive according to the proportion;
(2) Mixing copper sulfate and montmorillonite, adding water to obtain rock slurry with mass concentration of 5-10%, mixing, performing ion exchange reaction, and filtering to obtain copper-loaded montmorillonite;
(3) Adding water, mixing, adding herba Taraxaci, galla chinensis, fructus Piperis Longi, flos Campsis, glycyrrhrizae radix, and radix astragali, mixing, leaching, filtering, drying filtrate and residue, and mixing to obtain feed additive.
4. The production method according to claim 3, characterized in that: the temperature of the ion exchange reaction in the step (2) is 40-100 ℃; the reaction time is 6-8 hours.
5. The production method according to claim 3, characterized in that: the water added in the step (3) is 5-15 times of the mass of the montmorillonite in the step (2).
6. The production method according to claim 3, characterized in that: the leaching reaction conditions in the step (3) are as follows: leaching at 70-100 deg.C for 2-5 hr.
7. The production method according to claim 3, characterized in that: and (3) pretreating the copper-loaded montmorillonite prepared in the step (2) by using an acid solution.
8. The method of claim 7, wherein the step of pretreating comprises: dispersing the copper-loaded montmorillonite in phosphoric acid, and performing magnetic stirring for 1-3 hours to obtain the pretreated copper-loaded montmorillonite.
9. The method of claim 8, wherein: the addition amount of copper-carrying montmorillonite is 15-20 parts by mass, and the addition amount of phosphoric acid is 50-60 parts by mass.
10. The method of claim 8, wherein: the temperature of magnetic stirring is 20-30 ℃.
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| CN1372815A (en) * | 2002-03-18 | 2002-10-09 | 浙江大学 | Feed nano additive with health-care and growth promoting functions and its preparing process |
| CN108125036A (en) * | 2017-12-07 | 2018-06-08 | 常州思宇环保材料科技有限公司 | A kind of preparation method of anti-diarrhea wean additive for feed for porkets |
| CN112998147A (en) * | 2021-02-09 | 2021-06-22 | 广东海洋大学深圳研究院 | Chitosan-loaded copper montmorillonite intercalation composite material and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1372815A (en) * | 2002-03-18 | 2002-10-09 | 浙江大学 | Feed nano additive with health-care and growth promoting functions and its preparing process |
| CN108125036A (en) * | 2017-12-07 | 2018-06-08 | 常州思宇环保材料科技有限公司 | A kind of preparation method of anti-diarrhea wean additive for feed for porkets |
| CN112998147A (en) * | 2021-02-09 | 2021-06-22 | 广东海洋大学深圳研究院 | Chitosan-loaded copper montmorillonite intercalation composite material and preparation method and application thereof |
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