CN115943964A - Spirotetramat-flonicamid pesticide suspending agent - Google Patents
Spirotetramat-flonicamid pesticide suspending agent Download PDFInfo
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- CN115943964A CN115943964A CN202211672849.4A CN202211672849A CN115943964A CN 115943964 A CN115943964 A CN 115943964A CN 202211672849 A CN202211672849 A CN 202211672849A CN 115943964 A CN115943964 A CN 115943964A
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- Prior art keywords
- spirotetramat
- flonicamid
- pesticide
- agent
- parts
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- 239000005900 Flonicamid Substances 0.000 title claims abstract description 62
- 239000000575 pesticide Substances 0.000 title claims abstract description 50
- 239000000375 suspending agent Substances 0.000 title claims abstract description 25
- 239000005931 Spirotetramat Substances 0.000 claims abstract description 42
- RLQJEEJISHYWON-UHFFFAOYSA-N flonicamid Chemical compound FC(F)(F)C1=CC=NC=C1C(=O)NCC#N RLQJEEJISHYWON-UHFFFAOYSA-N 0.000 claims abstract description 42
- CLSVJBIHYWPGQY-GGYDESQDSA-N spirotetramat Chemical compound CCOC(=O)OC1=C(C=2C(=CC=C(C)C=2)C)C(=O)N[C@@]11CC[C@H](OC)CC1 CLSVJBIHYWPGQY-GGYDESQDSA-N 0.000 claims abstract description 42
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000002270 dispersing agent Substances 0.000 claims abstract description 24
- 239000000080 wetting agent Substances 0.000 claims abstract description 18
- 239000004480 active ingredient Substances 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 7
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- 239000000203 mixture Substances 0.000 claims description 27
- 239000000725 suspension Substances 0.000 claims description 27
- 239000002245 particle Substances 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 14
- 229920001400 block copolymer Polymers 0.000 claims description 11
- 229920013747 hydroxypolyethylene Polymers 0.000 claims description 11
- 239000002518 antifoaming agent Substances 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 5
- 239000003945 anionic surfactant Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 229920000570 polyether Polymers 0.000 claims description 5
- 238000010008 shearing Methods 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 229920001296 polysiloxane Polymers 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 abstract description 21
- 239000003814 drug Substances 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 11
- 230000000607 poisoning effect Effects 0.000 abstract description 10
- 241000607479 Yersinia pestis Species 0.000 abstract description 9
- 231100000572 poisoning Toxicity 0.000 abstract description 7
- 230000009885 systemic effect Effects 0.000 abstract description 7
- 238000013329 compounding Methods 0.000 abstract description 6
- 230000001887 anti-feedant effect Effects 0.000 abstract description 5
- 210000005036 nerve Anatomy 0.000 abstract description 5
- 210000002784 stomach Anatomy 0.000 abstract description 5
- 230000009471 action Effects 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 230000002035 prolonged effect Effects 0.000 abstract description 3
- 238000001228 spectrum Methods 0.000 abstract description 3
- 238000012360 testing method Methods 0.000 description 26
- 241001124076 Aphididae Species 0.000 description 12
- 230000008021 deposition Effects 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 240000007124 Brassica oleracea Species 0.000 description 8
- 241000982105 Brevicoryne brassicae Species 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- 241000238631 Hexapoda Species 0.000 description 7
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 6
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 6
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 6
- 231100000419 toxicity Toxicity 0.000 description 6
- 230000001988 toxicity Effects 0.000 description 6
- 230000001018 virulence Effects 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- 241000196324 Embryophyta Species 0.000 description 4
- 241000258937 Hemiptera Species 0.000 description 4
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 4
- 239000002917 insecticide Substances 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000007865 diluting Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000012452 mother liquor Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000011343 solid material Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 235000011303 Brassica alboglabra Nutrition 0.000 description 2
- 235000011302 Brassica oleracea Nutrition 0.000 description 2
- 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 description 2
- 235000000536 Brassica rapa subsp pekinensis Nutrition 0.000 description 2
- 241000499436 Brassica rapa subsp. pekinensis Species 0.000 description 2
- 241001465977 Coccoidea Species 0.000 description 2
- 241000208822 Lactuca Species 0.000 description 2
- 235000003228 Lactuca sativa Nutrition 0.000 description 2
- 241000526145 Psylla Species 0.000 description 2
- 241001414989 Thysanoptera Species 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 230000002457 bidirectional effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 239000013530 defoamer Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 239000003630 growth substance Substances 0.000 description 2
- 235000003642 hunger Nutrition 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000004557 technical material Substances 0.000 description 2
- QFMDFTQOJHFVNR-UHFFFAOYSA-N 1-[2,2-dichloro-1-(4-ethylphenyl)ethyl]-4-ethylbenzene Chemical group C1=CC(CC)=CC=C1C(C(Cl)Cl)C1=CC=C(CC)C=C1 QFMDFTQOJHFVNR-UHFFFAOYSA-N 0.000 description 1
- 241001600407 Aphis <genus> Species 0.000 description 1
- 241000273311 Aphis spiraecola Species 0.000 description 1
- RZXLPPRPEOUENN-UHFFFAOYSA-N Chlorfenson Chemical compound C1=CC(Cl)=CC=C1OS(=O)(=O)C1=CC=C(Cl)C=C1 RZXLPPRPEOUENN-UHFFFAOYSA-N 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- IPGANOYOHAODGA-UHFFFAOYSA-N dilithium;dimagnesium;dioxido(oxo)silane Chemical group [Li+].[Li+].[Mg+2].[Mg+2].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O IPGANOYOHAODGA-UHFFFAOYSA-N 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000009969 flowable effect Effects 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000001023 inorganic pigment Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000012860 organic pigment Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- -1 styryl phenol Chemical compound 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides a spirotetramat-flonicamid pesticide suspending agent which comprises the following components in parts by weight: 10-50 parts of pesticide active ingredients; 5-20 parts of a dispersing agent; 0.2-10 parts of a wetting agent; 0.1-5 parts of thickening agent; 50-80 parts of water; the effective components of the pesticide comprise spirotetramat and flonicamid. The spirotetramat has two-way systemic activity, flonicamid has contact poisoning and stomach poisoning effects, and also has good nerve agent and quick antifeedant effect, and the two agents are mixed, so that the action mode of the pesticide can be increased, and the control effect is improved; the prevention and treatment spectrum can be expanded by compounding the two medicaments; the using amount of a single medicament is reduced, and the using time of the piercing-sucking pests can be prolonged. Saving labor and material resources and reducing the influence on the environment.
Description
Technical Field
The invention relates to the field of pesticides, and particularly relates to a spirotetramat-flonicamid pesticide suspending agent.
Background
Spirotetramat is one of modern insecticides with bidirectional systemic conduction performance so far; it can be used for preventing and treating various sucking pests such as aphid, thrips, psylla, mealybug, whitefly and scale insect; the compound can move upwards and downwards in the whole plant body to reach leaf surfaces and barks so as to control pests on inner leaves of lettuce and Chinese cabbage and fruit tree barks, the unique systemic property can protect new stems, leaves and roots and prevent the eggs and larvae of the pests from growing, and the compound has the other characteristic of long lasting period and can provide effective control for up to 8 weeks. Flonicamid is a novel low-toxicity pyridine amide insect growth regulator pesticide, has the effects of contact poisoning and stomach poisoning, and also has good nerve agent and quick antifeedant effect. After sucking plant juice with flonicamid, aphids and other sucking mouth parts are sucked, juice sucking is rapidly stopped, no excrement appears within 1 hour, and finally death is caused by hunger.
The suspending agent is a silk-sticky flowable suspension which is prepared by mixing an original pesticide, a carrier and a dispersing agent and carrying out superfine grinding by a wet method. The liquid-solid system is formed by dispersing solid raw medicine which is insoluble or slightly soluble in water uniformly through superfine grinding by means of certain auxiliary agents. The suspending agent is generally composed of active ingredients, a dispersing agent, a thickening agent, an anti-settling agent, an antifoaming agent, an antifreezing agent, water and the like. The content of the effective components is generally 5 to 50 percent. The average particle size is generally around 3 microns. Is a new formulation for processing pesticides.
After the spirotetramat is stored in the suspending agent for a long time, the problems of particle growth and crystallization can occur, and the content of the original drug can be reduced by 8-30%.
In order to solve the above problems, the invention provides a spirotetramat-flonicamid pesticide suspending agent.
Disclosure of Invention
The invention provides a spirotetramat-flonicamid pesticide suspending agent which comprises the following components in parts by weight:
10-50 parts of pesticide active ingredients;
5-20 parts of a dispersing agent;
0.2-10 parts of a wetting agent;
0.1-5 parts of a thickening agent;
50-80 parts of water;
the effective components of the pesticide comprise spirotetramat and flonicamid.
As an example, the weight ratio of spirotetramat to flonicamid is selected from 1:6, 1: 2. 1:1, 2:1 or 6:1.
As an example, the weight ratio of spirotetramat to flonicamid is selected from 1: 2. 1:1, 2:1 or 6:1.
as an example, the weight ratio of the spirotetramat to the flonicamid is 2:1.
As an example, the dispersant comprises Agrilan 788.
As one example, the wetting agent includes a hydroxy polyethylene oxide block copolymer.
As an example, the hydroxypolyethylene oxide block copolymer comprises an EO/PO ratio of 1:1.71 of a hydroxypolyethylene oxide block copolymer.
As an example, the dispersant further comprises an anionic surfactant.
As an example, the defoamer is selected from silicone defoamers and/or polyether defoamers.
As an example, the preparation process of the spirotetramat-flonicamid pesticide suspending agent is as follows: mixing the pesticide active ingredient with a wetting agent, a dispersing agent and part of water, shearing and sanding the mixture until the particle size is less than 5 microns, and filtering the mixture to obtain a water concentrated suspension and a filtrate;
and mixing the rest auxiliary materials and the filtrate, and uniformly mixing the treated mixture with the water concentrated suspension to obtain the suspending agent.
Advantageous effects
1. The spirotetramat has two-way systemic activity, flonicamid has contact poisoning and stomach poisoning effects, and also has good nerve agent and quick antifeedant effect, and the two agents are mixed, so that the action mode of the pesticide can be increased, and the control effect is improved;
2. the prevention and treatment spectrum can be expanded by compounding the two medicaments;
3. the using amount of a single medicament is reduced, and the using time of the piercing-sucking pests can be prolonged. Labor and material resources are saved, and the influence on the environment is reduced;
4. the invention researches a new preparation process, and can prepare the particle size and the particle size distribution which are fine enough; the suspending agent has good stability and higher suspension rate; meanwhile, the viscosity is appropriate, the fluidity is good, and the production is convenient.
Detailed Description
The invention provides a spirotetramat-flonicamid pesticide suspending agent which comprises the following components in parts by weight:
10-50 parts of pesticide active ingredients;
5-20 parts of a dispersing agent;
0.2-10 parts of a wetting agent;
0.1-5 parts of a thickening agent;
50-80 parts of water;
the effective components of the pesticide comprise spirotetramat and flonicamid.
Active ingredient of pesticide
In the invention, the weight ratio of the spirotetramat to the flonicamid is selected from 1: 6. 1:2, 1:1. 2:1 or 6:1; more preferably, the weight ratio of the spirotetramat to the flonicamid is selected from 1: 2. 1:1. 2:1 or 6:1; preferably, the weight ratio of the spirotetramat to the flonicamid is 2:1.
in the invention, the spirotetramat: flonicamid =1: 6. 1: 2. 1:1. 2:1 and 6:1 in a virulence assay for aphids of brassica oleracea at different ratios, the co-toxicity coefficients are 118.03, 130.09, 160.36, 186.57 and 140.86, respectively, wherein 1: 2. 1:1. 2:1 and 6: the co-toxicity coefficients are all larger than 120 under the proportion of 1, which shows that the spirotetramat and flonicamid in the proportions have synergistic effects on cabbage aphids in different degrees, wherein the synergistic effect is most obvious when the proportion of the spirotetramat to the flonicamid is 2.
In the present invention, the spirotetramat and flonicamid are purchased as raw chemicals from vas crop protection limited in the south of Henan.
Dispersing agent
The dispersant is a surfactant which has two opposite properties of lipophilicity and hydrophilcity in a molecule. The amphiphilic agent is capable of uniformly dispersing solid and liquid particles of inorganic and organic pigments which are difficult to dissolve in liquids, and also preventing settling and agglomeration of the particles to form stable suspensions.
The dispersant can maintain the dispersed state in the solid-liquid dispersion system for a long period of time in the whole system, thereby maintaining the suspended state for a long period of time.
In the storage and transportation process of the pesticide, even the suspending agent can be precipitated or seriously caked due to long-term standing or over-high/over-low environmental temperature; to avoid these situations, the dispersant of the present invention includes Agrilan 788.
Meanwhile, considering that the finer the particle size of the preparation, the higher the suspension rate, the invention is matched with a specific preparation process, and meanwhile, the dispersant also comprises an anionic surfactant, considering the fineness and the particle size distribution of the preparation, the anionic surfactant used in the invention is styryl phenol polyoxyethylene ether sulfonate which is specifically purchased from Nantong Deyi chemical industry Co., ltd, the model is DYY601SA, and the cas number is 119432-41-6.
Wetting agent
The wetting agent is a substance which can enable solid materials to be more easily wetted by water; the solid material is wetted by reducing its surface tension or interfacial tension, allowing water to spread on or penetrate the surface of the solid material.
In the invention, the suspending agent is in the form of aqueous suspension, and the active ingredients of the pesticide are often hydrophobic, and can be agglomerated, precipitated, agglomerated and the like in water.
From the standpoint of considering the product suspension rate, the wetting agent of the present invention comprises a hydroxypolyethylene oxide block copolymer.
Meanwhile, since the target crop of the present invention is cabbage leaves, the hydroxypolyethylene oxide block copolymer used in the present invention comprises, from the viewpoint of surface tension, a copolymer having an EO/PO ratio of 1:1.71 a hydroxy polyethylene oxide block copolymer; in particular to Ethyllan NS-500LQ.
From the viewpoint of improving the stability of the active ingredients of the product pesticide after being stored for a period of time, the hydroxy polyethylene oxide block copolymer also comprises 1603# hydroxy block polyether; the reason is that when the wetting agent and the dispersing agent are compounded for use, the steric hindrance effect and the electrostatic repulsion effect can be provided, so that the whole suspension system is stable, and more contact points can be anchored on the surface of the original drug during compounding for use, so that the stable suspension effect is provided.
However, the overall system balance is easily disturbed because steric hindrance and electrostatic repulsion in the system are relatively unstable when different types of wetting agents and dispersants are used, i.e., the electrical layers are relatively different in polarity strength groups due to the microstructure, and the chains are also different in length.
The inventors of the present invention have found that the use of anionic surfactants in combination with two different types of hydroxypolyethylene oxide block copolymers improves the above phenomenon, possibly because of matching with a specific preparation process, which increases the contact surface of the raw drug particles, thereby improving stability.
Defoaming agent
Defoamers are substances that reduce the surface tension of water, solutions, suspensions, etc., prevent the formation of foam, or reduce or eliminate the original foam.
The defoaming agent is selected from a silicone defoaming agent and/or a polyether defoaming agent.
In order to match the preparation process, the defoaming agent is selected from SAG 1522 defoaming agent of Nanjing Jieron technologies, inc. The reason for this is because SAG 1522 defoamer, although having excellent dispersibility, did not form free surface grease or non-dispersed particles. But the using condition needs to be fully stirred evenly or used immediately, and the effect is reduced if the stirring is not fully stirred during long-term storage or use. The invention adopts a two-step process, and can prepare the suspending agent with excellent suspending effect although the production steps are increased.
Preparation process
As an example, the preparation process of the spirotetramat-flonicamid pesticide suspending agent is as follows: mixing the pesticide active ingredient with a wetting agent, a dispersing agent and part of water, shearing and sanding the mixture until the particle size is less than 5 microns, and filtering the mixture to obtain a water concentrated suspension and a filtrate;
and mixing the rest auxiliary materials and the filtrate, and uniformly mixing the treated mixture with the water concentrated suspension to obtain the suspending agent.
Examples
Example 1: the embodiment provides a spirotetramat-flonicamid pesticide suspending agent which comprises the following components in parts by weight:
30 parts of pesticide active ingredients;
5 parts of a dispersing agent;
0.9 part of wetting agent;
1.1 parts of a thickening agent;
and 63 parts of water.
Wherein the pesticide comprises 20 parts of spirotetramat and 10 parts of flonicamid as effective components.
The dispersant is compounded by Acksonobel Agrilan 788 and Nantong Deyi DYY601SA in a ratio of 2:1.
the wetting agent is Ethylan NS-500LQ and 1603# hydroxyl block polyether, and the proportion is 0.9:0.1.
the thickener is lithium magnesium silicate.
The preparation process comprises the following steps: mixing the effective components of the pesticide with a wetting agent, a dispersing agent and half weight of water, shearing and sanding the mixture until the particle size is less than 5 microns, and filtering the mixture to obtain a water concentrated suspension and a filtrate;
and mixing the rest auxiliary materials, the filtrate and the rest water, and uniformly mixing the treated mixture and the water concentrated suspension to obtain the suspending agent.
Example 2: the difference from example 1 is that the dispersant is only aksunobel Agrilan 788.
Example 3: the difference from example 1 is that the wetting agent is only Ethyllan NS-500LQ.
Example 4: the difference from example 1 is that the preparation process is as follows: mixing the pesticide active ingredient, the auxiliary material and water in proportion, shearing and sanding the mixture until the particle size is less than 5 microns to obtain the water dispersible suspending agent.
Testing
Test 1:
indoor toxicity determination report of spirotetramat and flonicamid on brevicoryne brassicae
(2019 years)
The test name is:indoor toxicity determination method for compounding spirotetramat and flonicamid
Test subjects:
the cabbage aphid Brevicoryne brassicae (Linnaeus).
Test agents:
indoor toxicity measurement report of optimal compounding ratio of spirotetramat and flonicamid suspending agent
Purpose of the test
According to the agricultural industry standard NY/T1154.7-2006 of the people's republic of China issued by the Ministry of agriculture of the people's republic of China, an excellent pesticide formula is screened for effectively preventing and treating the cabbage aphids, and the optimal proportion of the spirotetramat and flonicamid mixture is screened. The results are reported as follows:
2. test conditions
2.1 Test target
The cabbage aphid Brevicoryne brassicae (Linnaeus).
2.3 instrumentation
Can control sunlight greenhouse; electronic balance (sensory 0.1 mg); feeding boxes; a glass rod; filtering paper; glass slide; tweezers; a culture dish; a writing brush; a biological microscope; a set of precision pipetting gun of 100-1000 mul, 20-100 mul and 1-20 mul; a plurality of beakers and measuring cylinders, etc.
Design of the experiment
3.1 preparation of test specimens
The test insect source is collected from Beibei Yan region Ganlian of Chongqing, the cultivation management of the garden is consistent, no pesticide is used in the near term, the leaf with more aphids is collected on the day of pesticide application, the leaf is put into an insect culturing box (phi: 25cm multiplied by 20 cm) paved with absorbent paper and is brought back to the room, and healthy and active aphids with medium size, basically consistent body color, consistent physiological state are selected for test.
Selecting cabbage leaves with consistent growth, cleaning the cabbage leaves in a shade place, and airing the cabbage leaves until no water mark exists on the surfaces of the cabbage leaves to prepare proper leaf sections for later use.
3.2 Agents
96% Spirotetramat technical product chemical Co., ltd
Jiangxi Hui and chemical Co Ltd of 97% flonicamid technical product
3.3 test procedure
3.3.1 test formulations
Weighing 0.0156g of spirotetramat technical material and 0.0103g of flonicamid technical material, dissolving with acetone respectively, and diluting to 1000mL with 0.1% tween-80 water solution to obtain mother liquor for later use;
and diluting the prepared mother liquor of the spirotetramat respectively to prepare five concentration gradients of 3mg/L, 6mg/L, 9mg/L, 12mg/L and 15 mg/L.
Diluting the prepared flonicamid mother liquor respectively to prepare five concentration gradients of 2mg/L, 4mg/L, 6mg/L, 8mg/L and 10 mg/L.
The spirotetramat and flonicamid are mixed according to the following proportion, and a 0.1% Tween-80 aqueous solution is set for comparison.
3.3.2 treatment with pharmaceutical Agents
The measurement was carried out by the leaf dipping method. Soaking the prepared cabbage leaves in a reagent solution to be detected for 10 seconds, taking out, airing, placing in a culture dish of moisturizing filter paper, inoculating the test insects, repeating for about 30 times, repeating for 4 times, wherein each treatment is not less than 120 times, and placing in a culture room (the temperature is 25 +/-1 ℃, the relative humidity is 60-80%, and the illumination L: D = 14).
4 survey
The number of dead and live Aphis citricola on each treatment was checked 48h after the treatment with the agent. The dead and live insect numbers are recorded by taking the complete immobility of the appendage of the brush body as death. Test results with a control mortality rate of more than 10% were discarded.
5. Data statistics and analysis
5.1 Calculation method
The corrected mortality for each treatment was calculated from the survey data, using spirotetramat as the standard insecticide and calculating the co-toxicity coefficient (CTC value) of the blend according to the grandsinope method. The corrected mortality is calculated as the following formulas (1) and (2) in percentage (%), and the calculation results retain two decimal places:
P 1 ＝K/N*100 (1)
in the formula:
P 1 -mortality rate;
k is the number of dead insects;
n-total number of treated worms.
P 2 ＝(P t -P 0 /(1-P 0 ) *100 (2)
In the formula:
P 2 -correcting mortality;
P t -addressing mortality;
P 0 blank control mortality.
If the control mortality rate is less than 5%, correction is not needed; the control mortality rate is between 5% and 20%, and the correction is carried out according to the formula (2); control mortality was > 20% and the test was redone.
5.2 statistical analysis
Analyzing with software such as Statistical Analysis System (SAS) and Data Processing System (DPS), and calculating LC of each medicine 50 And b value.
The co-toxicity coefficient (CTC value) of the mixture is calculated according to the formulas (3), (4) and (5):
ATI＝S/M*100 (3)
in the formula:
ATI-actually measured toxicity index of mixed agent;
S-LC of Standard insecticide 50 In milligrams per liter (mg/L);
LC of M-mixtures 50 In milligrams per liter (mg/L).
TTI＝TI A *P A +TI B *P B (4)
In the formula:
TTI-mixture theory virulence index;
TI A -agent virulence index a;
P A -the percentage of agent a in the mixture in units of percentage (%);
TI B -agent B virulence index;
P B the percentage content of the medicament B in the mixture is in percentage (%);
CTC＝ATI/TTI*100 (5)
in the formula:
CTC-co-toxicity coefficient;
ATI-actually measured toxicity index of mixed agent;
TTI-mixture theory virulence index.
The co-toxicity coefficient (CTC) of the compound agent is more than or equal to 120, which shows a synergistic effect; CTC < 80 is shown as antagonistic and CTC < 120 is shown as additive.
6. As a result, the
After the spirotetramat and the flonicamid are mixed, the cabbage aphid Aphis similis is treated, and the toxicity measurement results of the mixed agents with different proportions on the aphid are shown in tables 1-2.
TABLE 1 toxicity test results of Spirotetramat and flonicamid mixed agent with different mixture ratios for treating aphid brassicae nymphs
TABLE 2 corrected mortality of aphid brassicae nymphs treated with spirotetramat and flonicamid in different mixture ratios
As can be seen from table 1, spirotetramat: flonicamid =1: 6. 1: 2. 1:1. 2:1 and 6:1 in a virulence assay for aphids of brassica oleracea at different ratios, the co-toxicity coefficients are 118.03, 130.09, 160.36, 186.57 and 140.86, respectively, wherein 1: 2. 1:1. 2:1 and 6: the co-toxicity coefficients are all larger than 120 under the proportion of 1, which shows that the spirotetramat and flonicamid in the proportions have synergistic effects on cabbage aphids in different degrees, wherein the synergistic effect is most obvious when the proportion of the spirotetramat to the flonicamid is 2.
Spirotetramat is one of modern insecticides with bidirectional systemic conduction performance so far; it can be used for preventing and treating various sucking pests, such as aphid, thrips, psylla, mealybug, whitefly, scale insect, etc.; the compound can move upwards and downwards in the whole plant body to reach leaf surfaces and barks so as to control pests on inner leaves of lettuce and Chinese cabbage and fruit tree barks, the unique systemic property can protect new stems, leaves and roots and prevent the eggs and larvae of the pests from growing, and the compound has the other characteristic of long lasting period and can provide effective control for up to 8 weeks. Flonicamid is a novel low-toxicity pyridine amide insect growth regulator pesticide, has the effects of contact poisoning and stomach poisoning, and also has good nerve agent and quick antifeedant effect. After sucking plant juice with flonicamid, aphids and other sucking mouth parts are sucked, juice sucking is rapidly stopped, no excrement appears within 1 hour, and finally death is caused by hunger.
The spirotetramat and the flonicamid are compounded, firstly, the spirotetramat has two-way systemic activity, the flonicamid has contact poisoning and stomach poisoning effects, and also has good nerve toxicant and quick antifeedant effects, and the two agents are mixed, so that the action mode of the pesticide can be increased, and the control effect is improved; secondly, the prevention and treatment spectrum can be expanded by compounding the two medicaments; thirdly, the use amount of a single medicament is reduced, and the use time of the piercing-sucking pests can be prolonged. Therefore, spirotetramat is suggested: flonicamid =2: the composition of 1 is suitable.
Attached table 1 survey results of original data of different proportions of spirotetramat and flonicamid on aphids of cabbage aphids
And (3) testing 2: and (3) suspension rate determination: measurements were carried out according to GB/T14825-2006.
And (3) testing: the deposition condition of the product after being placed at high temperature (45 ℃) for 12 months is divided into non-deposition, small-part deposition, most deposition and total deposition.
And (4) testing: dispersibility tests, see the dispersibility determination of patent CN 103461329B.
| Examples | Test 2 | Test 3 | Test 4 |
| Example 1 | 97.9％ | Small part deposition | Super grade |
| Example 2 | 96.5％ | Most of the deposit | Good grade |
| Example 3 | 96.1％ | Most of the deposit | Good grade |
| Example 4 | 91.3％ | Most of the deposit | Inferior grade |
Meanwhile, the suspending agent prepared by the invention can recover a better suspension state after deposition through stirring, and the test is as follows:
and (5) testing: and (4) stirring the embodiment after the test 3, wherein the stirring mode is wood rod stirring, the stirring speed is 10 circles/min, the stirring is 10 circles, and the uniform dispersion condition after stirring is checked and divided into non-deposition, small-part deposition, large-part deposition and total deposition.
| Examples | Test 5 |
| Example 1 | Does not deposit |
| Example 2 | Does not deposit |
| Example 3 | Does not deposit |
| Example 4 | Small part deposition |
The foregoing is illustrative of embodiments only.
Claims (10)
1. A spirotetramat-flonicamid pesticide suspending agent is characterized in that: the composition comprises the following components in parts by weight:
10-50 parts of pesticide active ingredients;
5-20 parts of a dispersing agent;
0.2-10 parts of a wetting agent;
0.1-5 parts of thickening agent;
50-80 parts of water;
the effective components of the pesticide comprise spirotetramat and flonicamid.
2. The spirotetramat-flonicamid pesticide suspension as claimed in claim 1, wherein: the weight ratio of the spirotetramat to the flonicamid is selected from 1: 6. 1: 2. 1:1. 2:1 or 6:1.
3. the spirotetramat-flonicamid pesticide suspension as defined in claim 1, wherein: the weight ratio of the spirotetramat to the flonicamid is selected from 1: 2. 1:1. 2:1 or 6:1.
4. the spirotetramat-flonicamid pesticide suspension as claimed in claim 1, wherein: the weight ratio of the spirotetramat to the flonicamid is 2:1.
5. the spirotetramat-flonicamid pesticide suspension as set forth in any one of claims 1 to 4, wherein: the dispersant comprises Agrilan 788.
6. The spirotetramat-flonicamid pesticide suspension as set forth in any one of claims 1 to 4, wherein: the wetting agent includes a hydroxy polyethylene oxide block copolymer.
7. The spirotetramat-flonicamid pesticide suspension as claimed in claim 6, wherein: the hydroxypolyethylene oxide block copolymer comprises an EO/PO ratio of 1:1.71 of a hydroxypolyethylene oxide block copolymer.
8. The spirotetramat-flonicamid pesticide suspension as defined in claim 1, wherein: the dispersant also includes an anionic surfactant.
9. The spirotetramat-flonicamid pesticide suspension as defined in claim 1, wherein: the defoaming agent is selected from a silicone defoaming agent and/or a polyether defoaming agent.
10. The process for preparing the spirotetramat-flonicamid pesticide suspension as claimed in any one of claims 1-9, wherein the process comprises the following steps:
mixing the pesticide active ingredient with a wetting agent, a dispersing agent and part of water, shearing and sanding the mixture until the particle size is less than 5 microns, and filtering the mixture to obtain a water concentrated suspension and a filtrate;
and mixing the rest auxiliary materials and the filtrate, and uniformly mixing the treated mixture with the water concentrated suspension to obtain the suspending agent.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101489386A (en) * | 2006-07-11 | 2009-07-22 | 拜尔农作物科学股份公司 | Active ingredient combinations with insecticidal and acaricidal properties |
| CN102349504A (en) * | 2011-09-13 | 2012-02-15 | 广西田园生化股份有限公司 | Flonicamid-containing ultralow volume liquid agent |
| CN113812414A (en) * | 2021-09-16 | 2021-12-21 | 吉林大学 | Pesticide composition containing spirotetramat and flonicamid |
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2022
- 2022-12-26 CN CN202211672849.4A patent/CN115943964A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101489386A (en) * | 2006-07-11 | 2009-07-22 | 拜尔农作物科学股份公司 | Active ingredient combinations with insecticidal and acaricidal properties |
| CN102349504A (en) * | 2011-09-13 | 2012-02-15 | 广西田园生化股份有限公司 | Flonicamid-containing ultralow volume liquid agent |
| CN113812414A (en) * | 2021-09-16 | 2021-12-21 | 吉林大学 | Pesticide composition containing spirotetramat and flonicamid |
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