CN114287439A - Nematicidal composition containing trifluromiazinamide and fluazinam - Google Patents
Nematicidal composition containing trifluromiazinamide and fluazinam Download PDFInfo
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- CN114287439A CN114287439A CN202111675991.XA CN202111675991A CN114287439A CN 114287439 A CN114287439 A CN 114287439A CN 202111675991 A CN202111675991 A CN 202111675991A CN 114287439 A CN114287439 A CN 114287439A
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- fluazinam
- nematicidal composition
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- trifloxystrobin
- nematicidal
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a nematicidal composition containing trifluroimidamide and fluazinam, wherein the active ingredients of the nematicidal composition comprise trifluroimidamide and fluazinam, and the balance is auxiliary ingredients. Wherein the mass ratio of the triflumidine amide to the fluazinam is 1-20: 20-1, the mass part ratio of active ingredients triflumidine amide and fluazinam in the preparation is 1-80%, and the auxiliary ingredient comprises sodium alginate. The nematicidal composition provided by the invention can overcome the defect that resistance is easy to generate after long-term single use, and the service life of the medicament is prolonged; meanwhile, the sodium alginate is used as a specific auxiliary agent, so that the soil granular structure can be improved and increased, after the nematicidal composition is applied, the nematicidal composition permeating into a soil layer enters and is stored in capillary gaps under the action of capillary force, so that small drug depots are formed, and the effects of long-acting prevention and control of soil nematodes and reduction of the base number of the soil nematodes are achieved.
Description
Technical Field
The invention belongs to the technical field of pesticide application, and particularly relates to a nematicidal composition containing trifluroimidamide and fluazinam.
Background
The nematodes belong to the phylum of the phylum nematoda, are tiny in shape and can be observed under a microscope. About 3000 kinds of nematodes harmful to plants live in the soil, and some nematodes live in the plant. The nematode is spread through soil or seeds, can damage the root system of the plant or invade the organs of the overground part, influences the growth and development of crops, and indirectly spreads diseases caused by other microorganisms, thereby causing great economic loss.
The use of agents for the control of nematodes is an effective method commonly used in modern agriculture, and is generally used for soil treatment or seed treatment, and nematicides are volatile and nonvolatile, the former has a fumigating effect, and the latter has a contact killing effect. Generally, it should have good lipophilicity and environmental stability, and can diffuse in the soil in liquid or gas state to penetrate from the nematode epidermis to have poisoning effect. Most nematicides occupy a leading position by high-toxicity pesticides, have high toxicity to people and livestock, and have phytotoxicity to crops in some varieties. With the enhancement of environmental awareness of people and higher requirements on agricultural product safety, highly toxic pesticides are forbidden and eliminated in succession. However, in the current market, the prevention and control agents for root knot nematode disease are few, the main varieties are concentrated on abamectin, fosthiazate, thiodicarb and other agents, and the overall prevention and control effect is not ideal due to drug resistance. Therefore, the development of a nematicide with high efficiency, low toxicity and environmental friendliness is a problem to be solved urgently.
Triflumidine amide (fluazaindolizine), the chemical name of which is 8-chloro-N- [ (2-chloro-5-methoxyphenyl) sulfonyl ] -6- (trifluoromethyl) -imidazo [1,2a ] pyridine-2-formamide, belongs to a non-fumigant nematicide, is a newly developed amide nematicide by DuPont, and has good control effects on tobacco root-knot nematodes, soybean cyst nematodes, strawberry leaf nematodes, potato stem nematodes, pine nematodes, granulosis nematodes, brachycete (root rot) nematodes and the like. High efficiency and high selectivity, and can provide lasting protection for crop roots. As an environment-friendly product, triflumidine amide is harmless to beneficial nematodes and pollination media, has low use frequency, and is an effective tool for comprehensive treatment of soil.
Fluazinam is a novel substituted aniline broad-spectrum bactericide developed by Japan Stone Industrial Co. Has no treatment effect and systemic activity, and is a broad-spectrum and efficient protective bactericide. Is very effective against alternaria, phytophthora, plasmopara, sclerotinia and cladosporium. Has good effect on resisting botrytis cinerea of benzimidazole and dicarboximide bactericides and also has good effect on rice damping-off caused by rhizopus. It is resistant to rain wash and has long residual effect period. In addition, it also has the function of controlling phytophagous mites. The beta-trifluoromethyl aminopyridine part plays a unique role in conveying compounds to active points of pathogenic bacteria, can inhibit the germination and infiltration of pathogen spores, the growth of hyphae and the formation of spores in the infection process, and has certain prevention and control effect on nematodes.
Sodium alginate is a polysaccharide carbohydrate extracted from brown algae such as herba Zosterae Marinae or Sargassum, and is white or light yellow powder, which is dissolved in water to form viscous colloid. Sodium alginate is a natural polymer substance and is widely applied to the fields of chemistry, biology, medicines, foods and the like due to good biodegradability and biocompatibility, and good thickening property, film-forming property, stability and chelating property.
When the single pesticide is used for a long time, pests are easy to generate drug resistance, the pesticide dosage is increased, the adverse effects of high toxicity, large dosage, more residues, poor pesticide effect and the like are caused, and the action field is single. The research and development of compound structure screening work is very complicated, the research and development period is long, and non-common research and development mechanisms can bear the burden. However, chemical components with different action mechanisms and no cross resistance are reasonably mixed according to a certain proportion, so that the disease prevention effect of crops can be improved, the dosage is reduced, the residue is less, the environmental pollution is reduced, the drug resistance of crops is effectively reduced, and the method is a research hotspot of small and medium-sized research and development institutions at present. The reasonable compounding or mixing of chemical preparations has the positive characteristics of improving the control effect, prolonging the application suitable period, reducing the dosage, reducing the phytotoxicity, reducing the residue, delaying the occurrence and the development of the drug resistance and the drug resistance of pests and the like, and the compounding or mixing is one of the most effective methods for solving the problems.
The other difficulty of nematode control is the problem of leaching of the medicament, particularly, the medicament is difficult to store in a plough layer after being applied to the land with serious soil hardening and desertification, particularly, the medicament is difficult to store around the root system, and the medicament effect is difficult to exert, so that the medicament can be kept in the soil plough layer and even around the root system while the medicament is applied to control, and plays a crucial role in exerting the medicament effect. At present, no report exists about a nematicidal composition compounded by trifluroimidamide and fluazinam and application thereof.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a nematicidal composition containing trifluroimidamide and fluazinam, which achieves a synergistic effect through compounding so as to improve the drug effect, reduce the production cost and reduce the pollution to the environment.
The technical problem to be solved by the invention is realized by adopting the following technical scheme:
the effective components of the nematicidal composition comprise triflumidine amide and fluazinam, and the balance is auxiliary components.
And the weight ratio of the active ingredients of triflumidine amide to fluazinam is 1-20: 20 to 1.
Moreover, the preferable mass ratio of the active ingredients triflumidine amide to fluazinam is 5: 1-1: more preferably, the nematicidal composition containing trifloxystrobin and fluazinam comprises the following components in a mass ratio of 3: 2 triflumidine amide and fluazinam.
Moreover, the total weight of the triflumidine amide and the fluazinam accounts for 0.1 to 80 percent of the pesticide composition.
Moreover, the total weight of the triflumidine amide and the fluazinam accounts for 0.1 to 50 percent of the pesticide composition.
Moreover, the dosage form of the nematicidal composition is missible oil, a suspending agent, a microemulsion, an aqueous emulsion, a water dispersible granule, a wettable powder and a granule.
And the auxiliary components comprise an auxiliary agent, wherein the thickening agent, the binder and the stabilizing agent in the auxiliary agent are sodium alginate, and the weight percentage of the auxiliary agent in the nematicidal composition is 0.1-10%.
An application of a nematicidal composition containing trifluromiazinamide and fluazinam in the prevention and treatment of plant pathogenic nematodes.
The invention has the advantages and positive effects that:
1. the active ingredients of the nematicidal composition provided by the invention are trifluroimidamide and fluazinam, and the action mechanisms of the trifluroimidamide and the fluazinam are not completely consistent, so that the nematicidal composition prepared by compounding the trifluroimidamide and the fluazinam can overcome the defect that resistance is easy to generate due to long-term single use, the service life of the medicament is prolonged, and the nematicidal composition has important significance in comprehensive treatment of nematode resistance.
2. According to the invention, trifluromiazinoamide and fluazinam are used as effective components, the balance is an auxiliary component, sodium alginate is used as a specific auxiliary agent in the auxiliary component, the addition of the sodium alginate can improve and increase the soil aggregate structure, and capillary pores in the soil aggregate structure have the capacity of preserving water, so that after the nematicidal composition is applied, the nematicidal composition permeating into a soil layer enters and is preserved in the capillary pores under the action of capillary force to form small drug depots, and the effects of long-acting prevention and control of soil nematodes and reduction of the base number of the soil nematodes are achieved. Meanwhile, the sodium alginate is polysaccharide carbohydrate extracted from natural seaweed, can provide nutrition for crops, promotes root growth, and has the effect of enhancing resistance to nematode infection.
3. The active ingredients of the nematicidal composition provided by the invention are trifluroimidamide and fluazinam, and experimental results show that the nematicidal composition has a remarkably improved prevention and treatment effect on nematodes compared with a single dose, and meanwhile, the application dose of pesticides is reduced, the application frequency is reduced, the application cost is reduced, and the adverse effect of the pesticides on the ecological environment is reduced. Compared with a single dose, the nematicidal composition has the advantages of quick effect exertion, long lasting period, low use cost, convenient use, time and labor saving, and great economic and social benefits in popularization and application.
Detailed Description
The present invention will be described in further detail with reference to examples.
The effective components of the nematicidal composition comprise triflumidine amide and fluazinam, and the balance is auxiliary components.
Wherein the weight ratio of the active ingredients of triflumidine amide to fluazinam is 1-20: 20 to 1. The preferable mass ratio of the triflumidine amide and the fluazinam as the effective components is 5: 1-1: more preferably, the nematicidal composition containing trifloxystrobin and fluazinam comprises the following components in a mass ratio of 3: 2 triflumidine amide and fluazinam.
The total weight of the triflumidine amide and the fluazinam accounts for 0.1 to 80 percent of the pesticide composition. The preferable weight percentage of the sum of the weights of the triflumidine amide and the fluazinam in the pesticide composition is 0.1-50%.
The dosage form of the nematicidal composition is missible oil, a suspending agent, a microemulsion, an aqueous emulsion, a water dispersible granule, a wettable powder and a granule.
The auxiliary component of the nematicidal composition comprises an auxiliary agent, wherein a thickening agent, a binding agent and a stabilizing agent in the auxiliary agent are sodium alginate, and the weight percentage of the thickening agent, the binding agent and the stabilizing agent in the nematicidal composition is 0.1-10%.
The nematicidal composition is mainly used for preventing and controlling plant pathogenic nematodes, and particularly has a good effect of preventing and controlling root-knot nematodes of ginger, solanaceous vegetables and melon vegetables.
The effect of the present invention on the control of phytopathogenic nematodes is illustrated by the following examples according to the above nematicidal composition comprising trifloxystrobin and fluazinam.
First, preparation examples
Formulation example 1: 40% trifluroimidamide fluazinam missible oil
The nematicidal composition in the embodiment is an emulsifiable concentrate preparation, and the nematicidal composition comprises the following components in parts by weight: 20% of fluazinam, 20% of triflumidine amide, 5% of sodium alginate, 25% of an emulsifier and 30% of a solvent. The specific production steps of the emulsifiable solution preparation are that firstly the effective components containing fluazinam and triflumidine amide are added into solvent to be completely dissolved, then sodium alginate and emulsifier are added to be evenly stirred to form uniform and transparent oily liquid, and the uniform and transparent oily liquid is filled to prepare the emulsifiable solution preparation of the composition.
Formulation example 2: 45% triflumidine amide fluazinam suspension
The nematicidal composition in the embodiment is a suspending agent, and comprises the following components in parts by weight: 15% of fluazinam, 30% of trifluroimidamide, 2% of sodium alginate, 8% of a dispersant, 5% of an antifreeze, 1% of an antifoaming agent, 8% of a penetration enhancer, 2% of a pH value regulator and water, wherein the water is supplemented to 100%. The specific production steps of the suspending agent are that other auxiliary agents are mixed, the mixture is uniformly mixed through high-speed shearing, the active ingredients containing fluazinam and triflumidine amide are added, and the mixture is ground for 2-3 hours in a ball grinding machine, so that the particle diameter is below 5 mu m, and the suspending agent of the composition can be prepared.
Formulation example 3: 6% trifluroimidamide fluazinam granules
The nematicidal composition in the embodiment is a granule, and comprises the following components in parts by weight: 1% of fluazinam, 5% of trifluro-imidazole amide, 5% of sodium alginate, 8% of a dispersing agent, 5% of a wetting agent, 3% of an inducer, 0.5% of a warning color and the balance of a particle carrier to 100%. Mixing the active ingredients of fluazinam, triflumidine amide, sodium alginate, a dispersing agent, a wetting agent and a warning color into a mother solution according to the proportion of the formula, adding carrier particles into a coating granulator according to the weight ratio, pouring the mother solution, rolling and stirring until the surface of the carrier is uniformly wetted, and drying to obtain the finished product of the coated granule.
Formulation example 4: 30% trifluroimidamide fluazinam wettable powder
The nematicidal composition in the embodiment is wettable powder and comprises the following components in parts by weight: 20% of fluazinam, 10% of triflumidine amide, 0.5% of sodium alginate, 10% of a dispersing agent, 5% of a wetting agent and the balance of fillers to 100%. The wettable powder has the specific production steps as follows: the effective components of fluazinam, triflumidine amide, sodium alginate, a dispersing agent, a wetting agent and a filler are mixed according to the formula, uniformly stirred in a stirring kettle, and uniformly mixed after passing through an air flow pulverizer to prepare the wettable powder of the composition.
Formulation example 5: 25% trifluroimidamide fluazinam water dispersible granule
The nematicidal composition in the embodiment is a water dispersible granule, and comprises the following components in parts by weight: 20% of fluazinam, 5% of triflumidine amide, 8% of sodium alginate, 6% of a dispersing agent, 10% of a wetting agent, 5% of a disintegrating agent and the balance of a filler to 100%. The water dispersible granule comprises the following specific production steps: the water dispersible granule of the composition can be prepared by uniformly mixing the active ingredients fluazinam, triflumidine amide, sodium alginate, a dispersing agent, a wetting agent, a disintegrating agent and a filler according to the formula, crushing by using an ultramicro jet mill, kneading, adding into a fluidized bed granulation dryer for granulation, drying, screening and sampling and analyzing.
Formulation example 6: microemulsion of 19% triflumiridamide fluazinam
The nematicidal composition in the embodiment is a microemulsion, and the components in parts by weight are as follows: 1% of fluazinam, 18% of trifluro-imidazole amide, 6% of sodium alginate, 18% of emulsifier, 6% of antifreezing agent and 25% of solvent. The fluazinam and the trifluroimidamide are completely dissolved by using a cosolvent, other components such as sodium alginate, an emulsifier, an antifreezing agent and the like are added, and the mixture is uniformly mixed, and finally, water is added, and the mixture is fully stirred to prepare the microemulsion of the composition.
Second, indoor toxicity determination and field efficacy test examples
1. Indoor toxicity assay
Indoor toxicity determination method for cucumber root-knot nematode
Test targets: root knot nematode of cucumber
The evaluation method comprises the following steps: soaking in medicinal liquid. Selecting eggs of root-knot nematodes from cucumber roots, washing with sterile water, placing on wet filter paper of a culture dish, adding 20ml of sterile water, incubating at 20-25 deg.C to obtain 2-instar larvae of consistent age, and diluting with sterile water to 200 pieces/ml for later use. Dissolving the original drug by acetone, and preparing a proper amount of active ingredients of triflumidine amide and fluazinam according to the results of preliminary experiments, wherein the active ingredients are 18: 1. 8: 1. 5: 1. 4: 1. 3: 2. 2: 1. 1: 1. 1: 6. 1: and 12, diluting each treatment with acetone into a plurality of concentration gradients, injecting 100ul of solution into each hole of a 96-hole plate, adding an equal amount of meloidogyne suspension, placing the solution in a dark place at 25 ℃ for one week, and counting survival number and death number of nematodes in each hole by using a microscope, wherein the meloidogyne is dead and the meloidogyne is live. Mortality was calculated and corrected.
Death number (%) - (number of live insects before drug-number of live insects after drug/number of live insects before drug) × 100;
corrected mortality (%) × 100 (treatment-control mortality/100-control mortality);
the corrected mortality of pests was converted into a probability value (y), the treated concentration (. mu.g/ml) was converted into a logarithmic value (x), a virulence regression equation was obtained by the least square method, and a value of each agent was calculated therefrom. Calculating a co-toxicity coefficient CTC according to a Sun cloud Peel formula method:
namely, the CTC is less than or equal to 80, the CTC is less than 80 and less than 120, and the CTC is more than or equal to 120.
Measured virulence index (ATI) ═ LC50 for standard agent/LC 50 for test agent x 100;
the theoretical virulence index TTI is the virulence index of the A medicament multiplied by the percentage of the A medicament in the mixed preparation plus the virulence index of the B medicament multiplied by the percentage of the B medicament in the mixed preparation;
co-toxicity coefficient (CTC) ═ measured toxicity index (ATI) of the mixture/Theoretical Toxicity Index (TTI) of the mixture x 100
TABLE 1 indoor virulence determination of triflumiridamide fluazinam compositions for meloidogyne cucumerinum
| Reagent for testing | Proportioning | LC50(mg/L) | CTC |
| Trifluoropyrimidinamides (A) | —— | 3.36 | —— |
| Fluazinam (B) | —— | 7.14 | —— |
| A：B | 25：1 | 3.03 | 125.68 |
| A：B | 10：1 | 3.57 | 128.00 |
| A：B | 5：1 | 3.82 | 133.34 |
| A：B | 4：1 | 2.99 | 130.85 |
| A：B | 3：2 | 2.56 | 172.84 |
| A：B | 2：1 | 2.31 | 170.00 |
| A：B | 1：1 | 2.79 | 127.96 |
| A：B | 1：6 | 4.48 | 151.27 |
| A：B | 1：12 | 4.99 | 126.36 |
As can be seen from table 1, when trifluromiazinamide and fluazinam are mixed in different proportions, the synergistic effect on killing of 2-instar larvae of meloidogyne cucurbitae is achieved, CTCs are all larger than 120, wherein the ratio of trifluromiazinamide to fluazinam is 3: 2 has a co-toxicity coefficient CTC of at most 172.84.
2. Test of field drug effect
Field efficacy test for preventing and treating cucumber root-knot nematode
The root-knot nematode damage is serious when the cucumber is tested in Liaoning Lingyuan winter greenhouse cucumber. In the experiment, 9 treatments are carried out, the composition in the preparation example in the 6, two control agents 500g/L trifluropyrimidinamide suspending agent, 50% fluazinam suspending agent and a blank control are adopted for treatment, after the treatment of the agents, a random sampling method is adopted, sampling is carried out at 5 points in each cell, 2 cucumber seedlings are randomly investigated at each point, total L0 cucumber roots are excavated, and the root-knot nematode damage level is investigated and recorded. The investigation method is carried out according to the pesticide field efficacy test criteria.
The nematode hazard classification adopts a plant pulling percentage method:
level 0: no visible nodules or egg masses;
level 1: the total length of the root nodules accounts for 1% -24% of the total root length;
and 2, stage: the total length of the root nodules accounts for 25% -49% of the total root length;
and 3, level: the total length of the root nodules accounts for 50% -74% of the total root length;
4, level: the total length of the root nodules accounts for 75% -100% of the total root length.
Disease index [ Σ (number of disease roots at each stage × number of relative stage)/(total number of investigated plants × 4) ] × 100;
the control effect (%) is [ 1- (treatment disease index/control disease index) ] x 100.
TABLE 2 field efficacy of triflumiridamide-fluazinam compositions on meloidogyne cucumerinum
As can be seen from the table 2, the field test is carried out on the mixed agents with different proportions according to different dosages, the control effect of the mixed agents on the cucumber root-knot nematodes after the mixed agents are applied is better than that of a control agent, the triflumidine amide and the fluazinam are compounded to control the root-knot nematodes, the effect is fast, the lasting time is long, the control effect is good, and the effect is increased along with the increase of the dosages. Can effectively control the harm of the root-knot nematode to the host, has important significance for improving the quality of the vegetables and increasing the yield, and has stronger popularization and use values.
In conclusion, the nematicidal composition compounded by taking the trifluroimidamide and the fluazinam as the active ingredients has good control effect on nematodes and is safe to target crops.
It should be emphasized that the embodiments described herein are illustrative rather than restrictive, and thus the present invention is not limited to the embodiments described in the detailed description, but also includes other embodiments that can be derived from the technical solutions of the present invention by those skilled in the art.
Claims (8)
1. A nematicidal composition comprising triflumidine amide and fluazinam, characterized in that: the effective components of the nematicidal composition comprise trifluromiazinamide and fluazinam, and the balance of auxiliary components.
2. The nematicidal composition comprising trifloxystrobin and fluazinam according to claim 1, wherein: the weight ratio of the active ingredients of triflumidine amide to fluazinam is 1-20: 20 to 1.
3. The nematicidal composition comprising trifloxystrobin and fluazinam according to claim 2, wherein: the preferable mass ratio of the active ingredients of triflumidine amide to fluazinam is 5: 1-1: more preferably, the nematicidal composition containing trifloxystrobin and fluazinam comprises the following components in a mass ratio of 3: 2 triflumidine amide and fluazinam.
4. The nematicidal composition comprising trifloxystrobin and fluazinam according to claim 1, wherein: the total weight of the triflumidine amide and the fluazinam accounts for 0.1 to 80 percent of the pesticide composition.
5. The nematicidal composition comprising trifloxystrobin and fluazinam according to claim 4, wherein: the preferable weight percentage of the total weight of the triflumidine amide and the fluazinam in the pesticide composition is 0.1-50%.
6. The nematicidal composition comprising trifloxystrobin and fluazinam according to claim 1, wherein: the dosage form of the nematicidal composition is missible oil, a suspending agent, a microemulsion, an aqueous emulsion, a water dispersible granule, a wettable powder and a granule.
7. The nematicidal composition comprising trifloxystrobin and fluazinam according to claim 1, wherein: the auxiliary components comprise an auxiliary agent, wherein a thickening agent, a binder and a stabilizing agent in the auxiliary agent are sodium alginate, and the weight percentage of the thickening agent, the binder and the stabilizing agent in the auxiliary agent in the nematicidal composition is 0.1-10%.
8. An application of a nematicidal composition containing trifluromiazinamide and fluazinam in the prevention and treatment of plant pathogenic nematodes.
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| CN102413693A (en) * | 2009-05-04 | 2012-04-11 | 杜邦公司 | Nematocidal sulfonamides |
| WO2014005982A1 (en) * | 2012-07-05 | 2014-01-09 | Bayer Cropscience Ag | Insecticide and fungicide active ingredient combinations |
| CN106689175A (en) * | 2016-11-26 | 2017-05-24 | 佛山市普尔玛农化有限公司 | Nematicidal composition containing fluazaindolizine and iprodione |
| US20170208811A1 (en) * | 2014-07-22 | 2017-07-27 | Sumitomo Chemical Company, Limited | Method for controlling pests |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102413693A (en) * | 2009-05-04 | 2012-04-11 | 杜邦公司 | Nematocidal sulfonamides |
| WO2014005982A1 (en) * | 2012-07-05 | 2014-01-09 | Bayer Cropscience Ag | Insecticide and fungicide active ingredient combinations |
| US20170208811A1 (en) * | 2014-07-22 | 2017-07-27 | Sumitomo Chemical Company, Limited | Method for controlling pests |
| CN106689175A (en) * | 2016-11-26 | 2017-05-24 | 佛山市普尔玛农化有限公司 | Nematicidal composition containing fluazaindolizine and iprodione |
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