CN115943950A - Preparation method of natural preservative extracted from folium artemisiae argyi and application of natural preservative in traditional Chinese medicine decoction medicinal materials - Google Patents
Preparation method of natural preservative extracted from folium artemisiae argyi and application of natural preservative in traditional Chinese medicine decoction medicinal materials Download PDFInfo
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- CN115943950A CN115943950A CN202211151419.8A CN202211151419A CN115943950A CN 115943950 A CN115943950 A CN 115943950A CN 202211151419 A CN202211151419 A CN 202211151419A CN 115943950 A CN115943950 A CN 115943950A
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 24
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- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 description 2
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- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides a preparation method for extracting a natural preservative from folium artemisiae argyi, and particularly relates to a method for accelerating the reaction process of ions in internal water and an auxiliary agent solution by means of the action of a magnetic field in the process of extracting the natural preservative, weakening adhesion and accumulation, effectively improving the activity of components such as volatile oil, camphor and the like in the folium artemisiae argyi, improving the sterilization and preservation effects of the components, improving the ion transport capacity of a biological membrane of the folium artemisiae argyi by the influence of an external magnetic field, accelerating the dissolution of the components such as the volatile oil, the camphor and the like in the folium artemisiae argyi, remarkably improving the dissolution amount, and improving the extraction efficiency and quality. Meanwhile, more bacteriostatic components which can be applied to the traditional Chinese medicine decoction can be efficiently obtained, the components also obviously reduce the PH value of the preservative, and the preservative has obvious sterilization capability on aspergillus flavus; by the preparation method, the extraction efficiency can be obviously improved, the extraction time is shortened, and the amount of the extracted effective components is obviously improved.
Description
Technical Field
The invention relates to a preparation method of a preservative for folium artemisiae argyi extraction traditional Chinese medicine decoction, and belongs to the technical field of preparation of preservatives for traditional Chinese medicine decoction medicinal materials.
Background
The folium Artemisiae Argyi contains volatile oil and Camphora, and has different degrees of inhibiting effect on Staphylococcus aureus, alpha-hemolytic streptococcus, diplococcus, diptheria bacillus, shigella sonnei, typhoid and paratyphoid bacillus, vibrio cholerae, etc. The invention discloses a moxa antibacterial band-aid which comprises a breathable adhesive tape layer, an adhesive layer, a cotton yarn layer and an isolation protective film, wherein the adhesive layer is arranged on the upper surface of the breathable adhesive tape layer, the cotton yarn layer is arranged in the middle of the upper surface of the adhesive layer, the isolation protective film is adhered to two ends of the upper surface of the adhesive layer and extends towards the middle of the upper surface of the adhesive layer, the isolation protective film is vertically and crossly covered on the cotton yarn layer, a moxa layer is sandwiched between the adhesive layer and the cotton yarn layer, a plurality of moxa layer branches extend towards the cotton yarn layer from the moxa layer, and reinforcing ribs are uniformly distributed between the adhesive layer and the cotton yarn layer. The moxa layer arranged on the band-aid is obtained by drying and mashing folium artemisiae argyi, so that natural and pure moxa smell is kept, the band-aid has good antibacterial property, a wound can be protected from being infected, the effect of moxa health care can be achieved, and the band-aid has positive effects on promoting blood circulation of the wound, clearing and activating the channels and collaterals, stopping bleeding and resisting coagulation, so that the wound healing can be effectively accelerated, the design of the moxa layer branch can play a shunting role, the isolation effect of the cotton yarn layer is reduced, and the permeation of the moxa smell is enhanced. However, the specific application form is to directly adopt moxa, extraction and improvement of effective components of the folium artemisiae argyi are not involved, the moxa cannot be directly used on the fresh-keeping and storage resistance of traditional Chinese medicine materials, and active components of the moxa cannot be released and efficiently utilized in the form of the moxa.
In addition, as disclosed in patent CN107261191A, wangyiping, etc., a sanitary napkin for resisting bacteria and preventing and treating gynecological inflammation, which is made of artemisia leaf extract, has the following characteristics that firstly, the safety is high, the property of the artemisia leaf extract is mild, the artemisia leaf extract has good conditioning effect on the physiological period of women, and the toxicity of the artemisia leaf can be eliminated and the effect of the artemisia leaf can be more fully exerted by matching with other traditional Chinese medicine components; secondly, antibacterial property: the traditional Chinese medicine formula is used for resisting bacteria, and experiments show that the sanitary towel provided by the invention has the advantages that the sterilization rate of escherichia coli reaches 100%, the sterilization rate of staphylococcus aureus reaches more than 98%, and the sterilization rate of candida albicans reaches more than 90%. And thirdly, the sanitary towel provided by the invention has good conditioning property and antibacterial property, and application investigation shows that the sanitary towel has good effect of preventing and treating gynecological inflammation after being used for a long time, and can also be applied to postpartum care, thereby effectively preventing postpartum infection. Although the application relates to the application of wormwood extract for antibacterial sterilization, the application only discloses that the adopted antibacterial agent comprises the following components in percentage by mass: 25% of wormwood extract, 20% of dogwood, 20% of sargentgloryvine stem, 10% of divaricate saposhnikovia root, 10% of Chinese pulsatilla root, 5% of brucea javanica, 5% of Chinese magnoliavine fruit and 5% of chrysanthemum; the preparation method of the wormwood extract comprises the following steps: cleaning, airing and crushing the wormwood, heating, refluxing and extracting for three times by using 25 times of water as an extraction solvent for 2 hours each time, combining the extracting solutions, concentrating and spray-drying to obtain the wormwood extract; the preparation method of the antibacterial agent comprises the following steps: cleaning Corni fructus, caulis Sargentodoxae, radix Saposhnikoviae, radix Pulsatillae, fructus Bruceae, fructus Schisandrae chinensis and flos Chrysanthemi, air drying, pulverizing, adding 30 times of water, decocting at 98 deg.C until the volume of water is half of the original volume, stopping decocting, cooling, filtering to obtain Chinese medicinal liquid, and spray drying to obtain Chinese medicinal powder and folium Artemisiae Argyi extract. Therefore, the conventional hot water extraction process is adopted for the wormwood extracting solution, the process is not only long in time and low in efficiency, but also cannot release the active antibacterial component in the wormwood to the maximum extent with the maximum efficiency, and further cannot efficiently utilize the active component of the wormwood.
In another invention patent, cn201910877126.x, huangjian, a bacteriostatic and itching-relieving shampoo containing folium artemisiae argyi essential oil and a preparation method thereof, the preparation method comprises the following steps: (1) Respectively carrying out ultrasonic cleaning on folium artemisiae argyi, astragalus membranaceus and dandelion, then drying in a constant-temperature drying oven until the moisture content is less than 10% by mass, and then crushing to 80-100 meshes by using a crusher to obtain traditional Chinese medicine powder; (2) Collecting folium Artemisiae Argyi powder, steam distilling to collect volatile oil and residue, decocting the residue with water, filtering, collecting filtrate, mixing the filtrate with the residue, concentrating to obtain folium Artemisiae Argyi essential oil, heating and refluxing radix astragali powder and herba Taraxaci powder with ethanol respectively, collecting extractive solution, and concentrating to obtain radix astragali extract and herba Taraxaci extract; (3) Putting deionized water, sodium laureth sulfate, C9-15 fluoroalcohol phosphate, potassium alcohol phosphate, PEG-7 glyceryl cocoate, PEG-150 dilaurate, PEG-150 distearate, cocamidopropyl betaine, cocamidomethyl MEA and disodium EDTA into a reaction pot, mixing and heating to 70-80 ℃ to obtain a cleaning matrix; (4) Cooling the cleaning matrix to 40-50 deg.C, adding folium Artemisiae Argyi extract, radix astragali extract, herba Taraxaci extract and antiseptic, mixing, adding sodium chloride to adjust liquid viscosity, and adjusting pH with citric acid to obtain antibacterial and antipruritic shampoo containing folium Artemisiae Argyi essential oil. However, the extraction process is not perfect, the extraction time is long, the extraction rate of the effective active ingredients of the folium artemisiae argyi is low, the utilization rate of the folium artemisiae argyi raw materials is low, and the preparation method is difficult to be directly applied to the medicinal materials of the traditional Chinese medicine decoction to be used as the preservative because the above are all daily chemical products such as shampoo, sanitary towel and the like, the content and the extraction efficiency of the effective ingredients of the folium artemisiae argyi of the preservative are improved, meanwhile, no toxic or side effect is brought to the traditional Chinese medicine materials, and the drug effect of the medicinal materials is not reduced.
Disclosure of Invention
In order to solve the problems in the prior art, the extraction cost of the effective components of the folium artemisiae argyi is reduced, the extraction time is shortened, the extraction efficiency is improved, the sterilization capability of the volatile oil, the camphor and other components in the folium artemisiae argyi is explored, and the sterilization capability is applied to the preservative of the medicinal materials used for the traditional Chinese medicine decoction.
Therefore, the invention specifically proposes the following scheme:
a preparation method for extracting a natural preservative from folium artemisiae argyi is characterized by comprising the following preparation processes:
(1) Selecting raw materials, wherein the raw materials and the mass ratio specifically comprise: 15-30% of folium artemisiae argyi powder, 5-7% of an auxiliary agent, 3-5% of sodium carboxymethyl cellulose, 50-70% of deionized water, 0.1-0.15% of a pH value regulator and 0.05-0.2% of a buffering agent;
(2) Uniformly mixing the folium artemisiae argyi powder, the auxiliary agent, sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose, deionized water and a pH value regulator according to the mass ratio in the step (1) to form a raw material liquid, enabling the raw material liquid to enter a wet method reaction tank body through a plurality of small-caliber shunt controlled reaction channels, wherein the wet method reaction tank body is arranged in an external magnetic field, the direction of a magnetic induction line of the external magnetic field is vertically intersected with the movement direction of the raw material liquid in the reaction channels, and the raw material liquid flows through the reaction channels at a certain speed and enters the wet method reaction tank body;
(3) Adding sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose into a raw material solution in a wet-process reaction tank, adding a buffering agent, maintaining the pH value in the wet-process reaction tank at 5.5-6.5, and controlling the reaction temperature in the wet-process reaction tank to be maintained at 15 +/-2 ℃ by using a cooling device.
(4) And extracting and purifying the reaction liquid in the wet reaction tank body by an extracting agent through an extracting device to obtain the natural artemisia leaf preservative, and filling the natural artemisia leaf preservative into a glass bottle for sealing and storage for later use.
As an improvement of the scheme, the external magnetic field is a permanent magnet static magnetic field.
As an improvement of the proposal, the intensity of the external magnetic field is 5600 GS-6000 GS, and the frequency is 20 Hz-90 Hz.
As an improvement of the scheme, the folium artemisiae argyi powder is the folium artemisiae argyi powder which passes through a sieve of 40-60 meshes.
As an improvement of the scheme, the auxiliary agent comprises an ethylene diamine tetraacetic acid disodium solution with the mass fraction of 0.5-1.2%.
As an improvement of the scheme, the buffering agent is one of sodium citrate, sodium bicarbonate and sodium diacetate solution or a mixed solution of at least 2 of the sodium citrate, the sodium bicarbonate and the sodium diacetate solution.
As a modification of the above, the velocity of the raw material liquid flowing through the channel is 0.1m/s to 0.25m/s.
As an improvement of the scheme, the cooling device is an ice water bath or a circulating condensed water cooling device, and/or the extracting agent is ethanol, petroleum ether, butane or n-hexane.
As an improvement of the scheme, in the step (3), the pH value in the wet reaction tank body is maintained at 5.9-6.2.
The invention also simultaneously protects the application of the natural preservative extracted by the preparation method for extracting the natural preservative from the folium artemisiae argyi in the traditional Chinese medicine decoction.
Advantageous effects
Compared with the prior art, the invention creatively enables the hydrogen bond structure in the solution of a wet system (containing folium artemisiae argyi, water and an auxiliary agent) to twist through the external magnetic field. The hydrogen bond angle decreases and the large clusters become small clusters. The strength of an external magnetic field is 5600 GS-6000 GS, the frequency is 20-90 Hz, magnetic lines of force are perpendicular to the cutting direction of a wet-process reaction channel, dipole moments of molecules of water in folium artemisiae argyi and an auxiliary agent solution deflect, the reaction process of ions in the water and the auxiliary agent solution is accelerated, adhesion and accumulation are weakened, and the activities of components such as volatile oil and camphor in the folium artemisiae argyi are obviously changed, namely, the activities of the components such as the volatile oil and the camphor in the folium artemisiae argyi are effectively improved, the sterilization and preservation effects of the components are improved, meanwhile, the ion transport capacity of a biological membrane of the folium artemisiae argyi can be improved under the influence of an external magnetic field, the dissolution of the components such as the volatile oil and the camphor in the folium artemisiae argyi is accelerated, the dissolution amount is obviously improved, and the extraction efficiency and quality are improved.
Meanwhile, under the condition of not changing the chemical components of the system, the hydrogen bond structure of the substances in the solution is changed, the further decomposition of active ingredients such as volatile oil, camphor and the like is reduced, and the higher activity of the effective substances and the stability of the molecular structure are ensured. When the natural preservative is applied to traditional Chinese medicine materials, the antibacterial property, the storage property and the quality guarantee period of the traditional Chinese medicine materials can be obviously improved, and natural components are non-toxic and harmless and cannot influence the release and the efficacy of the property of the traditional Chinese medicine.
Meanwhile, additives such as an auxiliary agent and an extracting agent in the extraction process and reaction condition parameters such as pH value, raw material liquid flow rate, magnetic field intensity, frequency and the like are optimized, so that the additives and the extracting agent all reach the optimal or more appropriate range, and the additives and the extracting agent are cooperatively matched to promote the smooth extraction reaction process and achieve the aim of obtaining the natural active preservative to the maximum extent.
Detailed Description
The technical solutions of the embodiments of the present invention will be described clearly and completely in the following description of the technical solutions of the present invention in combination with various embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention. The experimental methods described in the following examples are all conventional methods unless otherwise specified; the reagents and materials, unless otherwise indicated, are readily available from ordinary commercial sources.
The invention claims a preparation method for extracting a natural preservative from folium artemisiae argyi, which specifically comprises the following preparation processes:
(1) Selecting raw materials, wherein the raw materials and the mass ratio specifically comprise: 15-30% of folium artemisiae argyi powder, 5-7% of an auxiliary agent, 3-5% of sodium carboxymethyl cellulose, 50-70% of deionized water, 0.1-0.15% of a pH value regulator and 0.05-0.2% of a buffering agent;
(2) Uniformly mixing the blumea balsamifera powder, the auxiliary agent, sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose, deionized water and a pH value regulator according to the mass ratio in the step (1) to form a raw material solution, feeding the raw material solution into a wet-process reaction tank body through a plurality of small-caliber shunt controlled reaction channels, wherein the wet-process reaction tank body is arranged in an external magnetic field, the direction of a magnetic induction line of the external magnetic field is vertically intersected with the movement direction of the raw material solution in the reaction channels, and the raw material solution flows through the reaction channels at a certain speed and then enters the wet-process reaction tank body;
(3) Adding sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose into a raw material solution in a wet-process reaction tank, simultaneously adding a buffering agent, maintaining the pH value in the wet-process reaction tank at 5.5-6.5, and controlling the reaction temperature in the wet-process reaction tank to be maintained at 15 +/-2 ℃ by using a cooling device.
(4) And extracting and purifying the reaction liquid in the wet reaction tank body by an extracting agent through an extracting device to obtain the natural folium artemisiae argyi preservative, and filling the natural folium artemisiae argyi preservative into a glass bottle for sealing and storage for later use.
Specifically, the external magnetic field is a permanent magnet static magnetic field, and the intensity of the external magnetic field is 5600GS to 6000GS, specifically 5600GS, 5700GS, 5800GS, 5900GS, 6000GS, and the like; the frequency is 20-90 Hz, specifically 20Hz, 30Hz, 40Hz, 50Hz, 60Hz, 70Hz, 80Hz, 90Hz, etc.; through the optimization of the form, the strength and the frequency of the magnetic field, the hydrogen bond structure in the wet system raw material solution can be twisted. The hydrogen bond angle is reduced, the macromolecular groups are changed into small molecular groups, and meanwhile, the molecular dipole moments of the folium artemisiae argyi internal water and the auxiliary agent solution deflect in cooperation with the magnetic force lines vertical to the cutting direction of the wet-process reaction channel, so that the reaction process of ions in the internal water and the auxiliary agent solution is accelerated, the adhesion and accumulation are weakened, and the activities of components such as volatile oil and camphor in the folium artemisiae argyi are obviously changed, namely, the activities of the components such as the volatile oil and the camphor in the folium artemisiae argyi are effectively improved, the sterilization and preservation effects of the folium artemisiae argyi are improved, meanwhile, the ion transport capacity of a folium artemisiae argyi biological membrane can be improved under the influence of an external magnetic field, the dissolution of the components such as the volatile oil and the camphor in the folium artemisiae argyi is accelerated, the dissolution amount is obviously improved, and the extraction efficiency and quality are improved; under the condition of not changing the chemical components of the system, the hydrogen bond structure of the substances in the solution is optimally or optimally changed, the further decomposition of active ingredients such as volatile oil, camphor and the like is reduced, and the higher activity of the effective substances and the stability of the molecular structure are ensured. When the natural preservative is applied to traditional Chinese medicine materials, the antibacterial property, the storage property and the quality guarantee period of the traditional Chinese medicine materials can be obviously improved, and natural components are non-toxic and harmless and cannot influence the release and the efficacy of the property of the traditional Chinese medicine.
The folium artemisiae argyi powder is preferably folium artemisiae argyi powder passing through a 40-60-mesh sieve, and particularly can be folium artemisiae argyi powder with the meshes of 40 meshes, 50 meshes, 60 meshes and the like, so that the problems of dust and raw material loss caused by too fine folium artemisiae argyi powder are solved, or the defects of incomplete reaction and low extraction rate of active substances caused by too coarse folium artemisiae argyi powder are overcome, and the preferable mesh range can avoid the defects to the greatest extent to improve the reaction efficiency and the extraction rate.
The auxiliary agent comprises disodium ethylene diamine tetraacetate solution with the mass fraction of 0.5 to 1.2 percent; the buffer is one of sodium citrate, sodium bicarbonate and sodium diacetate solution or a mixture of at least 2 of the sodium citrate, the sodium bicarbonate and the sodium diacetate solution. Through the screening and optimization of the auxiliary agent and the buffering agent, the requirement that the reaction is fully promoted and participated in a synergistic manner is met, for example, the wetting expansion of the folium artemisiae argyi powder can be well promoted by the disodium ethylene diamine tetraacetate, the extraction reaction is promoted, the extraction quality and efficiency can be synergistically promoted, meanwhile, the addition of macromolecular and toxic chemical reagents is reduced as much as possible by selecting the auxiliary agent and the buffering agent, and the toxic and side effects of the extracted active substances and the adverse side effects of the traditional Chinese medicine materials applied to the extracted active substances are reduced.
The speed of the raw material liquid flowing through the channel is 0.1-0.25 m/s, specifically 0.1m/s, 0.15m/s, 0.2m/s, 0.25m/s and the like, and the quality of the extract is ensured and the loss of the sterilization performance is minimized on the premise of ensuring that the extraction reaction efficiency is maximally improved by reasonably controlling the flow speed of the raw material liquid.
The cooling device is an ice water bath or circulating condensed water cooling device, and/or the extracting agent is ethanol, petroleum ether, butane or n-hexane; by arranging an ice water bath or a circulating condensed water cooling device, the optimal temperature of the reaction tank body is ensured, and the optimal extraction efficiency and the optimal quality of the extract can be achieved synergistically.
In the step (3), the pH value in the wet reaction tank body is maintained at 5.9-6.2, and the balance and stability of an extraction system and the change of the property of the extract are seriously influenced by the pH value. Therefore, the preferable pH value ranges are 5.9, 6.0, 6.1, 6.2 and the like, so that the stability of a reaction system in the reaction tank body is ensured, the stability of the reaction and the improvement of the efficiency are assisted, and the quality of the extracted natural preservative is improved.
The invention also protects the application of the natural preservative obtained by the preparation method for extracting the natural preservative from the folium artemisiae argyi in the traditional Chinese medicine decoction. The natural preservative can be sprayed or coated or dipped on the surface of the medicinal materials for the Chinese medicinal decoction, so that the antibacterial property and the storage property of the medicinal materials for the Chinese medicinal decoction are improved, and no toxic or side effect is generated on the medicinal properties of the medicinal materials.
The invention is further described below with reference to specific examples.
Example 1
This example 1 provides a preparation method of a natural preservative extracted from artemisia argyi, which is prepared by the following preparation methods:
a preparation method for extracting a natural preservative from folium artemisiae argyi is characterized by comprising the following preparation processes:
(1) Selecting raw materials, wherein the raw materials and the mass ratio specifically comprise: 30% of folium artemisiae argyi powder, 7% of an auxiliary agent, 5% of sodium carboxymethylcellulose, 57.65% of deionized water, 0.15% of a pH value regulator and 0.2% of a buffering agent;
(2) Uniformly mixing the folium artemisiae argyi powder, the auxiliary agent, sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose, deionized water and a pH value regulator according to the mass ratio in the step (1) to form a raw material liquid, enabling the raw material liquid to enter a wet method reaction tank body through a plurality of small-caliber shunt controlled reaction channels, wherein the wet method reaction tank body is arranged in an external magnetic field, the direction of a magnetic induction line of the external magnetic field is vertically intersected with the movement direction of the raw material liquid in the reaction channels, and the raw material liquid flows through the reaction channels at a certain speed and enters the wet method reaction tank body;
(3) Adding sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose into a raw material solution in a wet-process reaction tank, simultaneously adding a buffering agent, maintaining the pH value in the wet-process reaction tank at 6.5, and controlling the reaction temperature in the wet-process reaction tank to be maintained at 15 +/-2 ℃ by using a cooling device.
(4) And extracting and purifying the reaction liquid in the wet reaction tank body by an extracting agent through an extracting device to obtain the natural folium artemisiae argyi preservative, and filling the natural folium artemisiae argyi preservative into a glass bottle for sealing and storage for later use.
Wherein, the external magnetic field is a permanent magnet static magnetic field; and the magnetic field strength was 6000GS at a frequency of 90Hz.
Wherein the folium Artemisiae Argyi powder is 60 mesh folium Artemisiae Argyi powder.
Wherein the auxiliary agent comprises 1.2 mass percent of disodium ethylene diamine tetraacetate solution.
Wherein the buffer is a mixed solution of sodium citrate and sodium bicarbonate.
Wherein the velocity of the raw material liquid flowing through the channel is 0.25m/s, and the mass ratio of the auxiliary agent is 7%.
Wherein the cooling device is an ice water bath or a circulating condensed water cooling device, and the extracting agent is ethanol.
Wherein, in the step (3), the pH value in the wet reaction tank body is maintained at pH6.2.
The embodiment also comprises the application of the natural preservative obtained by the preparation method of the natural preservative extracted from the folium artemisiae argyi in traditional Chinese medicine decoction medicinal materials. The natural preservative can be sprayed or coated or dipped on the surface of the medicinal materials for the Chinese medicinal decoction, so that the antibacterial property and the storage resistance of the medicinal materials for the Chinese medicinal decoction are improved, and no toxic or side effect is generated on the medicinal properties of the medicinal materials.
Example 2
This example 2 provides a preparation method of a natural preservative extracted from artemisia argyi, which is prepared by the following preparation methods:
a preparation method for extracting a natural preservative from folium artemisiae argyi is characterized by comprising the following preparation processes:
(1) Selecting raw materials, wherein the raw materials and the mass ratio specifically comprise: 20% of folium artemisiae argyi powder, 6% of an auxiliary agent, 4% of sodium carboxymethylcellulose, 69.76% of deionized water, 0.12% of a pH value regulator and 0.12% of a buffering agent;
(2) Uniformly mixing the folium artemisiae argyi powder, the auxiliary agent, sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose, deionized water and a pH value regulator according to the mass ratio in the step (1) to form a raw material liquid, enabling the raw material liquid to enter a wet method reaction tank body through a plurality of small-caliber shunt controlled reaction channels, wherein the wet method reaction tank body is arranged in an external magnetic field, the direction of a magnetic induction line of the external magnetic field is vertically intersected with the movement direction of the raw material liquid in the reaction channels, and the raw material liquid flows through the reaction channels at a certain speed and enters the wet method reaction tank body;
(3) Adding sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose into a raw material solution in a wet-process reaction tank, simultaneously adding a buffering agent, maintaining the pH value in the wet-process reaction tank at pH5.9, and controlling the reaction temperature in the wet-process reaction tank to be maintained at 15 +/-2 ℃ by using a cooling device.
(4) And extracting and purifying the reaction liquid in the wet reaction tank body by an extracting agent through an extracting device to obtain the natural folium artemisiae argyi preservative, and filling the natural folium artemisiae argyi preservative into a glass bottle for sealing and storage for later use.
Wherein, the external magnetic field is a permanent magnetic static magnetic field; and the strength of the magnetic field is 5800GS, with a frequency of 70Hz. The folium Artemisiae Argyi powder is 50 mesh folium Artemisiae Argyi powder;
wherein the auxiliary agent comprises 0.9 mass percent of disodium ethylene diamine tetraacetate solution.
Wherein the buffer is a mixed solution of sodium citrate and sodium diacetate solution.
Wherein the velocity of the raw material liquid flowing through the channel is 0.15m/s, and the mass ratio of the auxiliary agent is 6%.
Wherein the cooling device is an ice water bath or a circulating condensed water cooling device, and the extracting agent is ethanol.
Wherein, in the step (3), the pH value in the wet reaction tank body is maintained at 6.
The embodiment also comprises the application of the natural preservative obtained by the preparation method of the natural preservative extracted from the folium artemisiae argyi in traditional Chinese medicine decoction medicinal materials. The natural preservative can be sprayed or coated or dipped on the surface of the medicinal materials for the Chinese medicinal decoction, so that the antibacterial property and the storage property of the medicinal materials for the Chinese medicinal decoction are improved, and no toxic or side effect is generated on the medicinal properties of the medicinal materials.
Example 3
This example 3 provides a preparation method of a natural preservative extracted from artemisia argyi, which is prepared by the following preparation methods:
a preparation method for extracting a natural preservative from folium artemisiae argyi is characterized by comprising the following preparation processes:
(1) Selecting raw materials, wherein the raw materials and the mass ratio specifically comprise: 15% of folium artemisiae argyi powder, 5% of an auxiliary agent, 3% of sodium carboxymethylcellulose, 76.85% of deionized water, 0.1% of a pH value regulator and 0.05% of a buffering agent;
(2) Uniformly mixing the blumea balsamifera powder, the auxiliary agent, sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose, deionized water and a pH value regulator according to the mass ratio in the step (1) to form a raw material solution, feeding the raw material solution into a wet-process reaction tank body through a plurality of small-caliber shunt controlled reaction channels, wherein the wet-process reaction tank body is arranged in an external magnetic field, the direction of a magnetic induction line of the external magnetic field is vertically intersected with the movement direction of the raw material solution in the reaction channels, and the raw material solution flows through the reaction channels at a certain speed and then enters the wet-process reaction tank body;
(3) Adding sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose into a raw material solution in a wet-process reaction tank, simultaneously adding a buffering agent, maintaining the pH value in the wet-process reaction tank at pH5.5, and controlling the reaction temperature in the wet-process reaction tank to be maintained at 15 +/-2 ℃ by using a cooling device.
(4) And extracting and purifying the reaction liquid in the wet reaction tank body by an extracting agent through an extracting device to obtain the natural folium artemisiae argyi preservative, and filling the natural folium artemisiae argyi preservative into a glass bottle for sealing and storage for later use.
Wherein, the external magnetic field is a permanent magnet static magnetic field; and the strength of the magnetic field is 5600GS at 20Hz. The folium Artemisiae Argyi powder is 40 mesh folium Artemisiae Argyi powder;
wherein the auxiliary agent comprises 0.5 mass percent of disodium ethylene diamine tetraacetate solution.
Wherein the buffer is a mixed solution of sodium citrate and sodium diacetate solution.
Wherein the velocity of the raw material liquid flowing through the channel is 0.1m/s.
Wherein the cooling device is an ice water bath or a circulating condensed water cooling device, and the extracting agent is ethanol.
Wherein, in the step (3), the pH value in the wet reaction tank body is maintained at 5.9.
The embodiment also comprises the application of the natural preservative obtained by the preparation method of the natural preservative extracted from the folium artemisiae argyi in traditional Chinese medicine decoction medicinal materials. The natural preservative can be sprayed or coated or dipped on the surface of the medicinal materials for the Chinese medicinal decoction, so that the antibacterial property and the storage property of the medicinal materials for the Chinese medicinal decoction are improved, and no toxic or side effect is generated on the medicinal properties of the medicinal materials.
Performance testing
Through a comparative experiment, the method specifically comprises the following steps: the antibacterial agent solution prepared by the invention is sprayed on the cultivated traditional Chinese medicinal material with aflatoxin on the surface, and compared with the traditional Chinese medicinal material which is cultured under the same condition and does not spray any antibacterial agent solution and has aflatoxin on the surface, the specific experimental data are as follows:
from the comparison, it can be seen that after being left under the same environmental conditions for 2 hours, the bacteria on the surface of the Chinese medicinal material is reduced by 30% or more, and after 4 hours, the bacteria is reduced by 39% or more, compared with the antibacterial agent not sprayed with the present invention. The total inhibition rate of the aflatoxin mycelia reaches 81 percent or more. Meanwhile, the storage time of the same kind of fresh dried Chinese medicinal materials which are sprayed with the antibacterial agent solution prepared by the invention and are not sprayed with any antibacterial agent solution is compared, and the storage time of the same kind of fresh dried Chinese medicinal materials which are not sprayed with any antibacterial agent solution and are not mildewed is 1.3-1.8 times of the storage time of the same kind of fresh dried Chinese medicinal materials which are not sprayed with any antibacterial agent solution.
Compared with the prior art, the preparation method provided by the invention can obviously improve and change the activity of volatile oil, camphor and other components in the folium artemisiae argyi, further improve the sterilization and preservation effects of the folium artemisiae argyi, and meanwhile, under the influence of an external magnetic field, the ion transport capacity of a biological membrane of the folium artemisiae argyi can be improved, the dissolution of the volatile oil, the camphor and other components in the folium artemisiae argyi is accelerated, the dissolution amount is obviously improved, and the extraction efficiency and the quality are improved. Meanwhile, under the condition of not changing the chemical components of the system, the hydrogen bond structure of the substances in the solution is changed, the further decomposition of the active ingredients such as volatile oil, camphor and the like is reduced, and the higher activity of the effective substances and the stability of the molecular structure are ensured.
The above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the corresponding technical solutions.
Claims (10)
1. A preparation method for extracting a natural preservative from folium artemisiae argyi is characterized by comprising the following preparation processes:
(1) Selecting raw materials, wherein the raw materials and the mass ratio specifically comprise: 15 to 30 percent of folium artemisiae argyi powder, 5 to 7 percent of auxiliary agent, 3 to 5 percent of sodium carboxymethyl cellulose, 50 to 70 percent of deionized water, 0.1 to 0.15 percent of pH value regulator and 0.05 to 0.2 percent of buffering agent;
(2) Uniformly mixing the blumea balsamifera powder, the auxiliary agent, sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose, deionized water and a pH value regulator according to the mass ratio in the step (1) to form a raw material solution, feeding the raw material solution into a wet-process reaction tank body through a plurality of small-caliber shunt controlled reaction channels, wherein the wet-process reaction tank body is arranged in an external magnetic field, the direction of a magnetic induction line of the external magnetic field is vertically intersected with the movement direction of the raw material solution in the reaction channels, and the raw material solution flows through the reaction channels at a certain speed and then enters the wet-process reaction tank body;
(3) Adding sodium hydroxymethyl cellulose accounting for 50% of the total addition amount of the sodium hydroxymethyl cellulose into a raw material solution in a wet-process reaction tank, simultaneously adding a buffering agent, maintaining the pH value in the wet-process reaction tank at 5.5-6.5, and controlling the reaction temperature in the wet-process reaction tank to be maintained at 15 +/-2 ℃ by using a cooling device;
(4) And extracting and purifying the reaction liquid in the wet reaction tank body by an extracting agent through an extracting device to obtain the natural artemisia leaf preservative, and filling the natural artemisia leaf preservative into a glass bottle for sealing and storage for later use.
2. The preparation method of the folium artemisiae argyi extracted natural preservative according to claim 1, which is characterized by comprising the following steps of: the external magnetic field is a permanent magnetic static magnetic field.
3. The preparation method of the folium artemisiae argyi extracted natural preservative according to claim 1 or 2, which is characterized by comprising the following steps of: the intensity of the external magnetic field is 5600 GS-6000 GS, and the frequency is 20 Hz-90 Hz.
4. The preparation method of the folium artemisiae argyi extracted natural preservative according to claim 1 or 2, which is characterized by comprising the following steps of: the folium artemisiae argyi powder is the folium artemisiae argyi powder which passes through a 40-60-mesh sieve.
5. The preparation method of the folium artemisiae argyi extracted natural preservative according to claim 1 or 2, which is characterized by comprising the following steps of: the auxiliary agent comprises 0.5-1.2% of disodium ethylene diamine tetraacetate solution by mass.
6. The preparation method of the folium artemisiae argyi extracted natural preservative according to claim 1 or 2, which is characterized by comprising the following steps of: the buffer is one of sodium citrate, sodium bicarbonate and sodium diacetate solution or a mixture of at least 2 of the sodium citrate, the sodium bicarbonate and the sodium diacetate solution.
7. The preparation method of the folium artemisiae argyi extracted natural preservative according to claim 1 or 2, which is characterized by comprising the following steps of: the speed of the raw material liquid flowing through the channel is 0.1-0.25 m/s.
8. The preparation method of the folium artemisiae argyi extracted natural preservative according to claim 1 or 2, which is characterized by comprising the following steps of: the cooling device is an ice water bath or circulating condensed water cooling device, and/or the extracting agent is ethanol, petroleum ether, butane or n-hexane.
9. The preparation method of the folium artemisiae argyi extracted natural preservative according to claim 1 or 2, which is characterized by comprising the following steps of: in the step (3), the pH value in the wet reaction tank body is maintained to be 5.9-6.2.
10. An application of the natural preservative extracted by the preparation method of the natural preservative extracted from the folium artemisiae argyi according to any one of claims 1 to 9 in traditional Chinese medicine decoction medicinal materials.
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