CN1159328A - Preparation method for lyophilized human placenta - Google Patents
Preparation method for lyophilized human placenta Download PDFInfo
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- CN1159328A CN1159328A CN96116281A CN96116281A CN1159328A CN 1159328 A CN1159328 A CN 1159328A CN 96116281 A CN96116281 A CN 96116281A CN 96116281 A CN96116281 A CN 96116281A CN 1159328 A CN1159328 A CN 1159328A
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- placenta
- placenta hominis
- human placenta
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to a preparation method of freeze-dried human placenta retaining active substances of human placenta. It is characterized by that the fresh human placenta is processed by spray-type ice-bath cleaning treatment by using 1 deg.C sterile physiological saline, then the slice placenta is processed by liquid-nitrogen immersion and spraying treatment, and quick prefreezed at 40 deg.C below zero, then the temp. is risen to 10 deg.C below zero, and kept for a certain time, then cooled to 40 deg.C below zero, and kept for a certain time, and repeated twice to four times, then freezed, sublimed and dried, finally vacuum packed under the condition of zero deg.C.
Description
The present invention relates to medicine field, belong to the manufacture method that a kind of people's placental preparations of treatment and tonic effect is arranged through lyophilization specifically.
The processing and fabricating method of people's Placenta Hominis has two types at present, a kind of is with after people's Placenta Hominis clean, steam or put in the boiling water and boil through high temperature, by 105 ℃ of dryings, also have subsequently, be ground into powdery at last through 60 ℃～70 ℃ long dryings, this type of processing method is because high temperature, substantially destroyed the multiple bioactive substance that is had in people's Placenta Hominis,, fallen the treatment and the tonic effect of people from end Placenta Hominis comprising enzyme classes, hormone, somatomedin etc.Another kind is made raw material with people's Placenta Hominis, extracts placenta interstitial fluid, gamma seroglobulinum humanum placentae in Placenta Hominis, placental blood albumin etc., this type of processing method can't be extracted active substances whole in people's Placenta Hominis, so cause a large amount of wastes of people's Placenta Hominis resource, reduce treatment and tonic effect again.Above-mentioned two kinds of processing methods, pharmacy of Chinese materia medica and 95 editions Chinese Pharmacopoeias of publishing in Shanghai science tech publishing house all have report.
The purpose of this invention is to provide and a kind ofly promptly do not destroy the multiple bioactive substance that has in people's Placenta Hominis, keep the preparation method for lyophilized human placenta of people's Placenta Hominis due therapeutic effect and tonic effect in medicine without the conventional high-temperature drying.
The fabrication techniques scheme that the present invention taked; People's Placenta Hominis is made the fountain clean under fresh state, soak pouring through-196 ℃ of liquid nitrogen, people's Placenta Hominis molecule is arranged by natural preface shape, liquid nitrogen soaks Placenta Hominis after the pouring through quick-freezing, in placenta tissue, form a large amount of ice crystals, under vacuum state, make the easier solid-state sublimation drying of water in the Placenta Hominis.The all biological active substance that can keep people's Placenta Hominis is at last fully realized the due treatment of people's Placenta Hominis and is grown the pouring effect, stops the wasting of resources simultaneously.
The present invention is described in detail by following examples.
Embodiment one; Freshman Placenta Hominis after healthy puerpera exsomatized, 1 ℃ of physiological saline solution is made the fountain clean under ice bath, subsequently people's Placenta Hominis is processed into lamellar or pasty state, the Placenta Hominis of processing is put in-196 ℃ of liquid nitrogen and soaks pouring, in the rearmounted dry freeze dryer, be lower than-40 ℃ of pre-freezes rapidly, subsequently temperature is elevated between-10 ℃ to-5 ℃ from-40 ℃, keep 60～90 fens kinds, again temperature is reduced to subsequently and is lower than-40 ℃, and kept 60～90 minutes, above-mentionedly be lower than-40 ℃ and rise to-10 ℃ to-5 ℃, the operation that again temperature is reduced to less than-40 ℃ repeats 2～4 times, and Placenta Hominis is carried out repeatedly drying bu sublimation repeatedly.0～5 ℃ of descending dried of condition, get final product vacuum packaging at last, in whole freeze-drying process, the vacuum in the freeze dryer vacuum chamber can not be higher than 0.1mmHg,
Embodiment two: in the manufacture method according to embodiment one, remove-196 ℃ of liquid nitrogen and soak the pouring operation, directly with Placenta Hominis pre-freeze rapidly below-40 ℃, can reach the purpose of invention equally.
Embodiment three; With the manufacture method of embodiment one, the Placenta Hominis pasty state is lower than-40 ℃ rises to-10 ℃ to-5 ℃, again temperature is reduced to operation less than-40 ℃, 2～4 times, change drying bu sublimation into one time.
Advantage of the present invention: with traditional people's placenta preparation method substantial difference is arranged, to fresh The liquid nitrogen of people's placenta soaks and drenches and freeze drying processing. Make and play treatment and tonic effect in people's placenta Bioactivator is kept fully, and can all utilize whole man's placenta and thoroughly do away with resource Waste.
Claims (2)
1, a kind of preparation method for lyophilized human placenta, Freshman Placenta Hominis after it is characterized in that healthy puerpera exsomatized, make the fountain clean with the following 1 ℃ of physiological saline solution of ice bath, subsequently people's tire is processed into lamellar or pasty state, Placenta Hominis after the processing is put in-196 ℃ of liquid nitrogen and soaks pouring, be placed in the freeze dryer and be lower than-40 ℃ of pre-freezes rapidly, subsequently temperature is elevated between-10 ℃ to-5 ℃ from-40 ℃, kept 60～90 minutes, temperature being reduced to-40 ℃ kept 60～90 minutes again, above-mentioned be lower than-40 ℃ and rise to-10 ℃ to-5 ℃, the two procedures that again temperature is reduced to again less than-40 ℃ repeats 2～4 times, Placenta Hominis is carried out repeatedly drying bu sublimation repeatedly, under 0～5 ℃ condition, carry out dried and vacuum-packed at last again.
2, preparation method for lyophilized human placenta according to claim 1, it is characterized in that the fountain clean is processed into lamellar or pasty state people Placenta Hominis, remove-196 ℃ of liquid nitrogen and soak pouring, directly place freeze dryer to be lower than-40 ℃ of pre-freezes rapidly, and repeatedly freeze sublimation drying repeatedly, until vacuum packaging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96116281A CN1159328A (en) | 1996-03-13 | 1996-03-13 | Preparation method for lyophilized human placenta |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96116281A CN1159328A (en) | 1996-03-13 | 1996-03-13 | Preparation method for lyophilized human placenta |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1159328A true CN1159328A (en) | 1997-09-17 |
Family
ID=5123400
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96116281A Pending CN1159328A (en) | 1996-03-13 | 1996-03-13 | Preparation method for lyophilized human placenta |
Country Status (1)
| Country | Link |
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| CN (1) | CN1159328A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054513C (en) * | 1998-04-14 | 2000-07-19 | 姚炳坤 | Method for production of frozen dry extracts of sheep embryo |
| CN104258069A (en) * | 2014-09-11 | 2015-01-07 | 董海斌 | Traditional Chinese medicine for treating phlegm stagnation type amenorrhea |
| CN107582569A (en) * | 2017-09-02 | 2018-01-16 | 发贵科技（贵州）有限公司 | A kind of vacuum-packed dried human placenta |
-
1996
- 1996-03-13 CN CN96116281A patent/CN1159328A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054513C (en) * | 1998-04-14 | 2000-07-19 | 姚炳坤 | Method for production of frozen dry extracts of sheep embryo |
| CN104258069A (en) * | 2014-09-11 | 2015-01-07 | 董海斌 | Traditional Chinese medicine for treating phlegm stagnation type amenorrhea |
| CN107582569A (en) * | 2017-09-02 | 2018-01-16 | 发贵科技（贵州）有限公司 | A kind of vacuum-packed dried human placenta |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |