CN115919669A - Low-ethanol compound hand-washing-free disinfectant applicable to low temperature and preparation method thereof - Google Patents
Low-ethanol compound hand-washing-free disinfectant applicable to low temperature and preparation method thereof Download PDFInfo
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- CN115919669A CN115919669A CN202211545095.6A CN202211545095A CN115919669A CN 115919669 A CN115919669 A CN 115919669A CN 202211545095 A CN202211545095 A CN 202211545095A CN 115919669 A CN115919669 A CN 115919669A
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- Prior art keywords
- ethanol
- low
- parachlorometaxylenol
- washing
- applicable
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 87
- 239000000645 desinfectant Substances 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title abstract description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 51
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 50
- OSDLLIBGSJNGJE-UHFFFAOYSA-N 4-chloro-3,5-dimethylphenol Chemical compound CC1=CC(O)=CC(C)=C1Cl OSDLLIBGSJNGJE-UHFFFAOYSA-N 0.000 claims abstract description 27
- -1 ethoxylated alkyl sodium sulfate Chemical compound 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229910052938 sodium sulfate Inorganic materials 0.000 claims abstract description 3
- 235000011152 sodium sulphate Nutrition 0.000 claims abstract description 3
- 238000003756 stirring Methods 0.000 claims description 39
- 238000005303 weighing Methods 0.000 claims description 14
- 230000008014 freezing Effects 0.000 abstract description 5
- 238000007710 freezing Methods 0.000 abstract description 5
- 235000011187 glycerol Nutrition 0.000 description 13
- 239000007788 liquid Substances 0.000 description 6
- 239000000344 soap Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- 241000711573 Coronaviridae Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a low-ethanol compound hand-free disinfectant applicable to low temperature and a preparation method thereof, and the low-ethanol compound hand-free disinfectant comprises the following components in percentage by weight: 30-35% of ethanol; 0.4 to 0.5 percent of parachlorometaxylenol; ethoxylated alkyl sodium sulfate 0.2-0.5%; 1-1.1% of glycerol; citric acid 0.0002-0.0005%; the balance being water. The invention has the advantages that: the problem that the disinfectant with low ethanol content can not be used due to freezing under the low-temperature condition is solved.
Description
Technical Field
The invention relates to the technical field of chemical industry, in particular to a preparation method of a disinfectant.
Background
At present, the new coronavirus epidemic situation enters a relatively severe and complex period, and in order to resist the spread of the virus by hands, the frequent washing of hands is one of simple, feasible and effective methods for controlling the spread of diseases and preventing infection. In many cases, there is no condition of flowing water in many public places and in some daily medical operations and examinations, so that the hand-washing-free disinfectant is widely used.
In the north, the temperature can reach minus 20 to minus 30 ℃ outdoors in winter, icing can be avoided due to high ethanol content (namely, the weight ratio of ethanol in the components of the hand sanitizer reaches more than 40%), but the higher the ethanol content is, the more irritation the skin is, and the hand can be dried and even cracked due to the fact that the hand is used for a long time, and the grease on the skin of the hand can be removed.
Disclosure of Invention
In order to solve the technical problems, the invention aims to provide the hand sanitizer which has low ethanol content (namely, the weight ratio of the ethanol in the hand sanitizer is less than 35%) and has a sterilization effect. The specific technical scheme is as follows:
a low-ethanol compound hand-washing-free disinfectant applicable to low temperature comprises the following components in percentage by weight:
30-35% of ethanol;
0.4 to 0.5 percent of parachlorometaxylenol;
ethoxylated alkyl sodium sulfate 0.2-0.5%;
1-1.1% of glycerol;
citric acid 0.0002-0.0005%;
the balance being water.
The purity of the ethanol is 95%; the purity of the ethoxylated sodium alkyl sulfate is 70%.
Preferably, the components and weight percentage are as follows:
30% of ethanol;
0.4 percent of parachlorometaxylenol;
ethoxylated sodium alkyl sulfate 0.5%;
1% of glycerol;
0.0005% of citric acid;
the balance being water.
The invention further discloses a preparation method of the composition, which comprises the following steps:
a. accurately weighing the water in the formula into a stirring tank, and adding 90% of ethanol in the formula for later use.
b. Accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
The invention has the advantages that: the problem that the disinfectant with low ethanol content can not be used due to freezing under the low-temperature condition is solved.
Drawings
FIG. 1 is a photograph showing the results of a vector quantitative killing test on Candida albicans;
FIG. 2 is a photograph showing the results of a vector quantitative killing test for Staphylococcus aureus;
FIG. 3 is a photograph showing the results of a vector quantitative killing test for Pseudomonas aeruginosa;
FIG. 4 is a photograph showing the results of the quantitative killing test of the vector for Escherichia coli.
Detailed Description
The present invention will be specifically described below with reference to examples.
Example 1:
a. accurately weighing the water in the formula according to the proportion in the table 1, adding 90 percent of ethanol in the formula into the stirring tank, and keeping the mixture for later use.
b. Accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
The liquid soap is frozen for 2 hours to 3 months, and the state of the liquid soap is shown in table 1.
TABLE 1
Example 2
a. The water in the formula is accurately weighed into a stirring tank according to the proportion in the table 2, and ethanol with the amount of 90% of the formula is added for standby.
b. Accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
The liquid soap is frozen for 2 hours to 3 months, and the state of the liquid soap is shown in table 2.
TABLE 2
Example 3
a. The water in the formula is accurately weighed into a stirring tank according to the proportion in the table 3, and ethanol with the amount of 90% of the formula is added for standby.
b. Accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
After being frozen for 2 hours to 3 months, the state of the hand sanitizer is shown in table 3.
TABLE 3
Example 4
a. The water in the formula is accurately weighed into a stirring tank according to the proportion of table 4, and ethanol with the amount of 90% of the formula is added for standby.
b. Accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
The liquid soap is frozen for 2 hours to 3 months, and the state of the liquid soap is shown in table 4.
TABLE 4
Example 5
a. The water in the formula was accurately weighed into a stirred tank according to the ratio in table 5, and 90% ethanol of the formula was added for future use.
b. Accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
After being frozen for 2 hours to 3 months, the state of the hand sanitizer is shown in table 5.
TABLE 5
Example 6
a. The water in the formula is accurately weighed according to the proportion in the table 6, and then 90% of ethanol in the formula is added for standby.
b. Accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
After freezing for 2 hours to 3 months, the state of the hand sanitizer is shown in table 6.
TABLE 6
Example 7
a. The water in the formula was accurately weighed into a stirred tank according to the ratio of table 7, and 90% ethanol of the formula was added for future use.
b. Accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
After freezing for 2 hours to 3 months, the state of the hand sanitizer is shown in table 7.
TABLE 7
Example 8
a. The water in the formula was accurately weighed into a stirred tank according to the proportions in table 8, and 90% ethanol of the formula was added for future use.
b. Accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
After being frozen for 2 hours to 3 months, the state of the hand sanitizer is shown in table 8.
TABLE 8
Example 9
a. The water in the formula was accurately weighed into a stirred tank according to the ratio in table 9, and 90% ethanol of the formula was added for future use.
b. Accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
After freezing for 2 hours to 3 months, the state of the hand sanitizer is shown in table 9.
TABLE 9
As can be seen from examples 1 to 9, the antifreeze effect is gradually increased with the increase of the alcohol content; although icing can be avoided by increasing the alcohol content, the higher the alcohol content, the greater the irritation to the skin, and the hand can be dried and even cracked due to the removal of oil from the skin of the hand after long-term use. Therefore, under the condition of low alcohol content, such as less than 35%, the content of ethoxylated sodium alkyl sulfate needs to be increased, and citric acid is used for adjusting the pH value to be closer to the pH value of human skin, and glycerin is used for moisturizing and protecting the skin.
The invention changes the former water-soluble preparation method and adopts ethanol for dissolution in the aspect of preparation process, thereby shortening the preparation time, improving the productivity and saving the energy.
FIGS. 1 to 4 are photographs of the log of the sterilization test conducted on the product of example 8 as a stock solution.
Claims (4)
1. A low-ethanol compound hand-washing-free disinfectant applicable to low temperature is characterized by comprising the following components in percentage by weight:
30-35% of ethanol;
0.4 to 0.5 percent of parachlorometaxylenol;
ethoxylated alkyl sodium sulfate 0.2-0.5%;
1-1.1% of glycerol;
citric acid 0.0002-0.0005%;
the balance being water.
2. The low-ethanol compound hand-washing-free disinfectant suitable for low temperature according to claim 1, wherein: the purity of the ethanol is 95%; the purity of the ethoxylated sodium alkyl sulfate is 70%.
3. The low-ethanol compound hand-washing-free disinfectant applicable to low temperature according to claim 1, which is characterized by comprising the following components in percentage by weight:
30% of ethanol;
0.4 percent of parachlorometaxylenol;
ethoxylated sodium alkyl sulfate 0.5%;
1% of glycerol;
0.0005% of citric acid;
the balance being water.
4. The low-ethanol compound hand-washing-free disinfectant applicable to low temperature according to claim 1, which is characterized by comprising the following steps:
a. accurately weighing water in the formula into a stirring tank, and adding 90% ethanol of the formula for later use;
b. accurately weighing ethoxylated sodium alkyl sulfate, adding the rest 10% ethanol, stirring uniformly, adding parachlorometaxylenol, pouring into a stirring tank after all the parachlorometaxylenol is dissolved, adding citric acid and glycerol, and stirring uniformly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211545095.6A CN115919669A (en) | 2022-11-21 | 2022-11-21 | Low-ethanol compound hand-washing-free disinfectant applicable to low temperature and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211545095.6A CN115919669A (en) | 2022-11-21 | 2022-11-21 | Low-ethanol compound hand-washing-free disinfectant applicable to low temperature and preparation method thereof |
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| Publication Number | Publication Date |
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| CN115919669A true CN115919669A (en) | 2023-04-07 |
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| CN202211545095.6A Pending CN115919669A (en) | 2022-11-21 | 2022-11-21 | Low-ethanol compound hand-washing-free disinfectant applicable to low temperature and preparation method thereof |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101353615A (en) * | 2007-07-24 | 2009-01-28 | 成都思摩纳米技术有限公司 | Preparation of efficient neutral laundry liquid containing water-soluble proteinase |
| CN103655267A (en) * | 2013-11-19 | 2014-03-26 | 青岛汇而通商贸有限公司 | Hand sanitizer having no irritation to skin |
| CN106465715A (en) * | 2016-09-22 | 2017-03-01 | 长兴净安环保科技有限公司 | A kind of multi-functional bacteria-removing liquid and preparation method thereof |
| CN109464322A (en) * | 2018-11-20 | 2019-03-15 | 娇时日化（杭州）股份有限公司 | A kind of hand cleanser and its preparation process containing plant component |
| CN109574883A (en) * | 2018-11-29 | 2019-04-05 | 四川金桐精细化学有限公司 | A kind of preparation method of ethoxylated alkyl sulfate |
| CN112913847A (en) * | 2021-01-18 | 2021-06-08 | 海韵一剑大卫生科技有限公司 | Chlorine-containing disinfectant for low-temperature environment and preparation method thereof |
| CN114146033A (en) * | 2021-12-07 | 2022-03-08 | 安美科技股份有限公司 | Traditional Chinese medicine hand sanitizer and preparation method thereof |
-
2022
- 2022-11-21 CN CN202211545095.6A patent/CN115919669A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101353615A (en) * | 2007-07-24 | 2009-01-28 | 成都思摩纳米技术有限公司 | Preparation of efficient neutral laundry liquid containing water-soluble proteinase |
| CN103655267A (en) * | 2013-11-19 | 2014-03-26 | 青岛汇而通商贸有限公司 | Hand sanitizer having no irritation to skin |
| CN106465715A (en) * | 2016-09-22 | 2017-03-01 | 长兴净安环保科技有限公司 | A kind of multi-functional bacteria-removing liquid and preparation method thereof |
| CN109464322A (en) * | 2018-11-20 | 2019-03-15 | 娇时日化（杭州）股份有限公司 | A kind of hand cleanser and its preparation process containing plant component |
| CN109574883A (en) * | 2018-11-29 | 2019-04-05 | 四川金桐精细化学有限公司 | A kind of preparation method of ethoxylated alkyl sulfate |
| CN112913847A (en) * | 2021-01-18 | 2021-06-08 | 海韵一剑大卫生科技有限公司 | Chlorine-containing disinfectant for low-temperature environment and preparation method thereof |
| CN114146033A (en) * | 2021-12-07 | 2022-03-08 | 安美科技股份有限公司 | Traditional Chinese medicine hand sanitizer and preparation method thereof |
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