CN115916775A - Atr抑制剂及其用途 - Google Patents
Atr抑制剂及其用途 Download PDFInfo
- Publication number
- CN115916775A CN115916775A CN202280003514.5A CN202280003514A CN115916775A CN 115916775 A CN115916775 A CN 115916775A CN 202280003514 A CN202280003514 A CN 202280003514A CN 115916775 A CN115916775 A CN 115916775A
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- Prior art keywords
- alkylene
- alkyl
- hydrogen
- halogen substituted
- halogen
- Prior art date
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- 239000001257 hydrogen Substances 0.000 claims description 154
- 125000003342 alkenyl group Chemical group 0.000 claims description 87
- 125000000304 alkynyl group Chemical group 0.000 claims description 86
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- 125000003118 aryl group Chemical group 0.000 claims description 70
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- 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
- 125000003554 tetrahydropyrrolyl group Chemical group 0.000 description 1
- 125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
- 125000004632 tetrahydrothiopyranyl group Chemical group S1C(CCCC1)* 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- 125000004385 trihaloalkyl group Chemical group 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一类式I所示的具有ATR抑制作用的新化合物及其在制备药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110692546 | 2021-06-22 | ||
| CN2021106925468 | 2021-06-22 | ||
| CN2021108680287 | 2021-07-30 | ||
| CN202110868028 | 2021-07-30 | ||
| CN2021112336352 | 2021-10-22 | ||
| CN202111233635 | 2021-10-22 | ||
| CN202210280941X | 2022-03-22 | ||
| CN202210280941 | 2022-03-22 | ||
| PCT/CN2022/099809 WO2022268025A1 (zh) | 2021-06-22 | 2022-06-20 | Atr抑制剂及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115916775A true CN115916775A (zh) | 2023-04-04 |
Family
ID=84544959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280003514.5A Pending CN115916775A (zh) | 2021-06-22 | 2022-06-20 | Atr抑制剂及其用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN115916775A (zh) |
| WO (1) | WO2022268025A1 (zh) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101511840A (zh) * | 2006-04-26 | 2009-08-19 | 吉宁特有限公司 | 磷酸肌醇3-激酶抑制剂化合物及其使用方法 |
| US20080234262A1 (en) * | 2007-03-21 | 2008-09-25 | Wyeth | Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors |
| JP5781066B2 (ja) * | 2009-05-27 | 2015-09-16 | ジェネンテック， インコーポレイテッド | ｐ１１０δに対して選択的な二環式ピリミジンＰＩ３Ｋ阻害剤化合物及び使用方法 |
| CN115135659B (zh) * | 2021-01-15 | 2024-03-12 | 深圳微芯生物科技股份有限公司 | 一类吗啉衍生物及其制备方法和应用 |
-
2022
- 2022-06-20 CN CN202280003514.5A patent/CN115916775A/zh active Pending
- 2022-06-20 WO PCT/CN2022/099809 patent/WO2022268025A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022268025A1 (zh) | 2022-12-29 |
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