CN115887295B

CN115887295B - Preparation for skin isolation protection and preparation method thereof

Info

Publication number: CN115887295B
Application number: CN202211739553.XA
Authority: CN
Inventors: 赵冲
Original assignee: Guangzhou Aiqi Biotechnology Co ltd
Current assignee: Guangzhou Aiqi Biotechnology Co ltd
Priority date: 2022-12-30
Filing date: 2022-12-30
Publication date: 2023-07-04
Anticipated expiration: 2042-12-30
Also published as: CN115887295A

Abstract

The invention discloses a preparation for skin isolation protection and a preparation method thereof, wherein the preparation comprises the following active ingredients in parts by weight: 25-65 parts of betalain composite particles; leucine 1-10 parts; 12-30 parts of sodium carboxymethylcellulose; the betalain composite particle comprises: polyurethanes, betalains, and hyaluronic acid; coating betalain and hyaluronic acid by polyurethane; the preparation method comprises the following steps: adding betalain composite particles and leucine into a solvent, uniformly mixing, and adding sodium carboxymethyl cellulose to obtain a preparation for skin isolation and protection; the preparation is red, can be used as body makeup painting of the offshore sportsman, forms a sunproof and protective coating on the skin when forming makeup, and effectively resists damage of the offshore sunlight to the skin.

Description

Preparation for skin isolation protection and preparation method thereof

Technical Field

The invention relates to a preparation for skin isolation protection and a preparation method thereof, belonging to the technical field of sun-screening agents.

Background

Ultraviolet radiation has a number of adverse effects on human health, which are manifested primarily as serious effects that can cause short-term and long-term effects, which are manifested primarily as sunburn, and long-term effects, which are often cumulative, as skin erythema, photoaging, tissue destruction, skin cancer, and the like. Therefore, how to reduce adverse effects of ultraviolet rays on human health as much as possible by using sun-screening products is one of the most popular topics in the cosmetic industry in recent years.

Sunscreens refer to substances added to cosmetics by means of the absorption, reflection or scattering of light in order to protect the skin from damage caused by specific ultraviolet rays or to protect the product itself. With the knowledge of light, the use scene of the sun-screening agent is more and more refined, blue light is required to be protected indoors, and UVA and UVB are required to be protected outdoors. Under the use scenes such as hiking, climbing, beach, and the like, the functional emphasis requirements on the sunscreens are also higher and higher, and particularly, the sunscreens are positioned on the beach, besides direct sunlight, the sunscreens are required to be more comprehensive and specific in function due to reflection of seawater.

Disclosure of Invention

In order to overcome the defects of the prior art, the first aim of the invention is to provide a preparation for skin isolation protection, which is red, can be used as a body makeup painting of a sportsman at sea, forms a makeup and simultaneously forms a sun-proof and protective coating on the skin, and effectively resists damage of the skin by the sunlight at sea.

A second object of the present invention is to provide a method for preparing the above formulation for skin barrier protection.

The first object of the invention can be achieved by adopting the following technical scheme: a preparation for skin isolation protection, which comprises the following active ingredients in parts by weight:

25-65 parts of betalain composite particles;

leucine 1-10 parts;

12-30 parts of sodium carboxymethylcellulose;

the betalain composite particle comprises: polyurethanes, betalains, and hyaluronic acid; the polyurethane coats betalains and hyaluronic acid.

Further, the betalain composite particles comprise polyurethane, betalain and hyaluronic acid in parts by weight:

5-15 parts of betalain;

1-10 parts of hyaluronic acid;

20-40 parts of polyurethane.

Further, the betalain composite particles also include cocoa butter; the polyurethane coats betalains, hyaluronic acid and cocoa butter.

Further, the composition comprises the following active ingredients in parts by weight:

55 parts of betalain composite particles;

8 parts of leucine;

25 parts of sodium carboxymethylcellulose.

Further, the formulation for skin barrier protection also includes tocopheryl acetate.

Further, the betalain composite particles are prepared by the following method:

mixing polyisocyanate, polyalcohol, betalain and hyaluronic acid, regulating pH to 3-5 with alkaline substance, performing addition polymerization at 70-90deg.C to obtain betalain composite particles, washing with water and ethanol, centrifuging, and filtering.

Further, the viscosity of the polyisocyanate is 1500 to 2500 mPas at 25 ℃.

Further, the polyol is cyclohexanediol.

The second object of the invention can be achieved by adopting the following technical scheme: a preparation method of a preparation for skin isolation and protection comprises adding betalain composite particles and leucine into solvent, mixing, and adding sodium carboxymethylcellulose to obtain the preparation for skin isolation and protection.

Further, the solvent is sodium chloride.

The formula design principle of the invention is as follows:

according to the formula, the betalain composite particles are formed by coating betalain and hyaluronic acid through polyurethane, wherein the betalain is a pyridine compound which is taken as a main isolation component in the preparation, the betalain composite particles have good refraction effect on sunlight by forming a red coating on skin and combining with the surface coating of the polyurethane, the hyaluronic acid has negative charge and viscoelasticity, so that the betalain composite particles are soft and elastic, and the preparation for isolating and protecting the skin has no granular feel; the polyurethane is used as coating, so that the composite particles have smooth surfaces, and the preparation for isolating and protecting the skin is easy to push away;

the polyurethane surface and leucine have good hydrophobicity, and play a role in water resistance in the use fields of beach and the like;

the preparation for skin isolation protection is gel-like texture containing sodium carboxymethylcellulose, and can form negative pressure when being smeared on skin to be attached to the skin for a long time.

Compared with the prior art, the invention has the beneficial effects that:

1. the preparation for skin isolation protection contains betalain composite particles, and a red coating is formed on the skin through betalain, and the preparation is combined with a polyurethane wrapping surface to have good refraction effect on sunlight; the red preparation can easily see the thickness of the preparation coated and the thickness of the preparation coated on the uncovered skin, and can be timely supplemented;

2. the preparation for isolating and protecting the skin is easy to smear when in use by forming gel dressing state by using sodium carboxymethyl cellulose, and is attached to the skin, negative pressure can be formed on the skin rapidly and can be continuously attached to the skin, and particularly, the preparation can play roles of isolating and protecting for a long time when in offshore sports;

3. the betalain composite particles in the skin isolation and protection preparation are wrapped by polyurethane, the surfaces of the composite particles are smooth and are easy to push away, the inside of the composite particles is filled with betalain and hyaluronic acid, the hyaluronic acid is soft and elastic, and the skin isolation and protection preparation has no granular feel and good integrity.

Detailed Description

The invention is further described in connection with the following embodiments:

a preparation for skin isolation protection, which comprises the following active ingredients in parts by weight:

the preparation method comprises the following steps: adding betalain composite particles, leucine and tocopheryl acetate into 0.2-0.5wt% sodium chloride, mixing, and adding sodium carboxymethyl cellulose to obtain preparation for skin isolation and protection.

The sodium chloride is used as a solvent, so that when a user exercises outdoors, an isotonic environment is formed with sweat and seawater, skin moisture is not lost, and a preparation for skin isolation protection is not easy to separate out and can be continuously attached to the skin.

The betalain composite particle comprises: polyurethanes, betalains, and hyaluronic acid; coating betalain, hyaluronic acid and cocoa butter with polyurethane;

the preparation method of the betalain composite particles comprises the following steps: mixing polyisocyanate, cyclohexanediol, betalain, hyaluronic acid and cocoa butter, regulating pH to 3-5 with alkaline substance, performing addition polymerization at 70-90deg.C to obtain betalain composite particles, washing with water and ethanol, centrifuging, and filtering.

Wherein the viscosity of the polyisocyanate is 1500-2500 mPa.s at 25 ℃; the polyurethane prepared under the viscosity has elasticity similar to that of skin, strong adhesive force to skin and good extensibility of preparation for isolation protection;

the betalain composite particles comprise polyurethane, betalain, hyaluronic acid and cocoa butter in parts by weight:

because betalain and cocoa butter are not mutually soluble, the addition of the cocoa butter is used for filling gaps inside betalain composite particles, improving the distribution uniformity of betalain, spreading the preparation for isolation protection to form uniform coverage, and improving the refraction degree of the betalain composite particles to light.

Examples 1-3:

betalain composite particles were prepared, the compositions of which are shown in table 1:

table 1 examples 1-3 betalain composite particles

Composition of the components	Example 1	Example 2	Example 3
				Betalains	10 parts of	13 parts of	7 parts of
Hyaluronic acid	6 parts of	7 parts of	8 parts of
				Polyurethane	37 parts of	25 parts of	33 parts of
Cocoa butter	12 parts of	18 parts of	14 parts of

The preparation method comprises the following steps: mixing polyisocyanate, cyclohexanediol, betalain and hyaluronic acid, regulating pH to 4.5 with alkaline substance, performing addition polymerization at 80deg.C to obtain betalain composite particles, washing with water and ethanol, centrifuging, and filtering. Wherein the polyisocyanate has a viscosity of 2000 mPas at 25 ℃.

Examples 4-6:

examples 4 to 6 are preparations for skin barrier protection, using betalain composite particles prepared in examples 1 to 3, respectively, whose active ingredients are shown in table 2 in parts by weight:

table 2 examples 4-6 parts by weight of formulations for skin barrier protection

The preparation method comprises the following steps: adding betalain composite particles, leucine and tocopheryl acetate into 0.3wt% sodium chloride, mixing, and adding sodium carboxymethyl cellulose to obtain preparation for skin isolation protection.

Comparative example 1:

the main component of the commercial physical sun protection agent is titanium dioxide.

1. Detection of sun protection index using an instrument:

sun protection index test instrument: LABSPHERE UV TRANSMITTANCE AN ALYZER-UV 2000

The sun protection factor test method comprises the following steps: ISO24444-2010

2. Water resistance:

the test subjects take 0.1 gram of sample to be smeared on a designated PMMA plate, after the PMMA plate is naturally dried for 30 minutes, the weight of the plate is recorded, then the plate is placed in a specified 0.35wt% sodium chloride solution (simulated seawater) for soaking for 40 minutes, the plate is taken out and naturally dried for 60 minutes, and then the weight loss rate of the sample on the plate is tested.

Evaluation reference:

o: the loss is less than or equal to 10%;

delta: the loss is less than or equal to 30 percent;

x: the loss is more than 30%.

3. Viscosity:

viscosity was tested to evaluate rapid adhesion to skin and application feel.

The results are shown in Table 3:

table 3 the results of the tests of examples 4-6 and comparative example 1

From Table 3, it is understood that the sun protection factor, water resistance and viscosity of example 5 are all optimal.

Various other corresponding changes and modifications will occur to those skilled in the art from the foregoing description and the accompanying drawings, and all such changes and modifications are intended to be included within the scope of the present invention as defined in the appended claims.

Claims

1. A preparation for skin isolation protection, which is characterized by comprising the following active ingredients in parts by weight:

25-65 parts of betalain composite particles;

leucine 1-10 parts;

12-30 parts of sodium carboxymethylcellulose;

the betalain composite particle comprises: polyurethanes, betalains, and hyaluronic acid; the polyurethane coats betalain and hyaluronic acid;

the betalain composite particles are prepared by the following method:

2. The formulation for skin barrier protection of claim 1, wherein the polyurethane, betalain, and hyaluronic acid in the betalain composite particles are, in parts by weight:

5-15 parts of betalain;

1-10 parts of hyaluronic acid;

20-40 parts of polyurethane.

3. The formulation for skin barrier protection of claim 1, wherein the betalain composite particles further comprise cocoa butter; the polyurethane coats betalains, hyaluronic acid and cocoa butter.

4. The preparation for skin barrier protection according to claim 1, comprising the following active ingredients in parts by weight:

55 parts of betalain composite particles;

8 parts of leucine;

25 parts of sodium carboxymethylcellulose.

5. The formulation for skin barrier protection of claim 1, further comprising tocopheryl acetate.

6. The formulation for skin barrier protection according to claim 1, wherein the polyisocyanate has a viscosity of 1500-2500 mPa-s at 25 ℃.

7. The formulation for skin barrier protection of claim 1, wherein the polyol is cyclohexanediol.

8. A method for preparing the preparation for skin isolation and protection according to claim 1, wherein betalain composite particles and leucine are added into a solvent, and sodium carboxymethyl cellulose is added after uniform mixing, so as to obtain the preparation for skin isolation and protection.

9. The method of preparing a formulation for skin barrier protection of claim 8, wherein the solvent is a sodium chloride solution.