CN115868481A - Perfusion system and transfer system for preserving pancreas - Google Patents
Perfusion system and transfer system for preserving pancreas Download PDFInfo
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- CN115868481A CN115868481A CN202211721807.5A CN202211721807A CN115868481A CN 115868481 A CN115868481 A CN 115868481A CN 202211721807 A CN202211721807 A CN 202211721807A CN 115868481 A CN115868481 A CN 115868481A
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Abstract
The application provides a perfusion system and a transfer system for preserving pancreas, which belong to the technical field of mechanical perfusion, wherein the perfusion system comprises a perfusion assembly and a control module; the perfusion assembly comprises a storage device, a perfusion pipeline, an oxygenation module and a driving piece; the preservation device is used for containing pancreas and perfusate and is communicated with the perfusion pipeline; the oxygenation module is communicated with the perfusion pipeline and is used for dissolving oxygen into the perfusion liquid; the driving piece is arranged on the perfusion pipeline between the oxygenation module and the storage device; the number of the perfusion assemblies is two, the two perfusion assemblies are respectively a first perfusion assembly and a second perfusion assembly, a perfusion pipeline of the first perfusion assembly is used for being communicated with the splenic artery, and a perfusion pipeline of the second perfusion assembly is used for being communicated with the superior mesenteric artery; the control module is electrically connected with the driving piece of the first perfusion component and the driving piece of the second perfusion component.
Description
Technical Field
The application relates to the technical field of mechanical perfusion, in particular to a perfusion system and a transfer system for preserving pancreas.
Background
Pancreas transplantation is one of the most effective treatments for type 1 diabetes. It is transplanted simultaneously with the kidney, and is beneficial to improving morbidity and mortality of type 1 diabetes patients with end stage renal disease. It can also be implanted alone to provide a treatment regimen for a small fraction of uremic patients who suffer unconsciousness from hypoglycemia. In the past, pancreas transplantation surgery has not been widely accepted in clinical practice because of its great difficulty, high sensitivity to ischemic injury, and susceptibility to complications.
The pancreas is a low-flow organ with a complex vascular anatomy and does not have terminal arteries as in other extracorporeal perfused abdominal solid organs (i.e., liver and kidneys). Ex vivo perfusion protocols for liver and kidney involve high perfusion pressures, which are not applicable for pancreatic perfusion and preservation, with the potential for endothelial damage and severe edema. Conversely, if the perfusion pressure is too low, it may not be sufficient to support the metabolism of the pancreas in vitro.
In order to preserve the pancreas, in the early technology, a Simple Cryopreservation (SCS) technology is often used to preserve the organs, which has the advantages of simple operation, low cost and good effect. The strategy is to cool and maintain the organ between 4-8 ℃ to significantly reduce the metabolic demand of the organ. However, when the organ is continuously in an anoxic state, accumulated metabolites cannot be eliminated, which may result in organ damage.
In addition, for some procedures (e.g., VCAs), some donors may not be convenient at the transplant center, and thus require a surgeon to locally procure the pancreas from the donor, which involves problems with remote transport of the pancreas. Therefore, how to ensure the activity of the pancreas in the whole process of pancreas acquisition and transportation to a transplantation center, so that safe and timely delivery is a great engineering problem.
Based on this, the present application is specifically proposed.
Disclosure of Invention
The present application provides a perfusion system and transport system for preserving pancreas to address the current situation 5 In the technique, when the organ is continuously in an anoxic state, the accumulated metabolites can not be removed, which leads to the organ
Technical problem of injury of organs. Simultaneously, the technical problem that pancreas activity cannot be guaranteed in pancreas remote transportation in the prior art is solved.
The present application provides a perfusion system comprising a perfusion assembly and a control module;
the perfusion assembly comprises a storage device, a perfusion pipeline, an oxygenation module and a driving piece; 0 the preservation device is used for containing pancreas and perfusate and is communicated with the perfusion pipeline;
the oxygenation module is communicated with the perfusion pipeline and is used for dissolving oxygen into the perfusion liquid;
the driving piece is arranged on the perfusion pipeline between the oxygenation module and the storage device;
the number of the perfusion assemblies is two, and the two perfusion assemblies are respectively a first perfusion assembly and a second perfusion assembly
A perfusion assembly, a perfusion line of the first perfusion assembly for communicating with the splenic artery, and a perfusion of the second perfusion assembly 5 The pipeline is used for being communicated with the superior mesenteric artery;
the control module is electrically connected with the driving piece of the first perfusion assembly and the driving piece of the second perfusion assembly, and is used for controlling the driving piece of the first perfusion assembly to convey perfusion liquid in the preservation device to the splenic artery of the pancreas through the perfusion pipeline of the first perfusion assembly and controlling the driving piece of the second perfusion assembly to preserve the perfusion liquid
The perfusion liquid in the device is delivered to the superior mesenteric artery of the pancreas through the perfusion pipeline of the second perfusion assembly 0 In (1).
Preferably, the priming assembly further comprises a first filter and a second filter;
the first filter is arranged on the perfusion pipeline between the driving piece and the storage device and is used for filtering perfusion liquid flowing out of the storage device;
the second filter is arranged at the downstream side of the oxygenation module and is arranged between the oxygenation module and the storage device 5 And the perfusion pipeline is used for removing impurities from the perfusion liquid flowing out of the oxygenation module.
Preferably, the accuracy of the first filter is less than the accuracy of the second filter.
Preferably, the perfusion assembly further comprises a buffer box disposed on the downstream side of the oxygenation module and on the perfusion line between the oxygenation module and the storage device for smoothing the perfusion liquid pressure in the perfusion line.
Preferably, be provided with the sample connection on the buffer box, the sample connection is used for taking a sample the perfusate.
Preferably, the perfusion device further comprises a sensor assembly, wherein the sensor assembly is arranged on the perfusion pipeline on the upstream side of the storage device and is used for monitoring perfusion parameters of the perfusion liquid;
the control module comprises a first control unit and a second control unit, the first control unit is in communication connection with the sensor assembly, and the second control unit is in communication connection with the first control unit;
the first control unit is used for acquiring monitoring data of the sensor assembly and transmitting the monitoring data to the second control unit, and the second control unit is used for controlling the driving piece to work according to the monitoring data.
Preferably, the sensor assembly includes at least one of a bubble sensor, a flow sensor, a pressure sensor, and a temperature sensor;
the bubble sensor is used for monitoring bubble information of the perfusate, the flow sensor is used for monitoring the flow rate of the perfusate, the pressure sensor is used for monitoring the perfusion pressure of the perfusate, and the temperature sensor is used for monitoring the temperature in the storage device.
Preferably, the preservation apparatus comprises an organ chamber for holding the pancreas and perfusate and an ice bank disposed outside the organ chamber for cooling the organ chamber.
Preferably, the perfusion system further comprises an alarm, and the alarm is electrically connected with the second control unit;
the second control unit is also used for controlling the alarm to work according to the monitoring data.
Preferably, the perfusion system further comprises a battery and a battery management module, the battery is used for supplying power to the perfusion system, the battery management module is electrically connected to the second control unit, and the second control unit is further used for managing the use of the battery through the battery management module; and/or
The perfusion system also comprises a touch display module which is electrically connected with the second control unit, and the second control unit is also used for selecting the perfusion mode and displaying the perfusion parameters of the perfusion liquid in the current perfusion mode through the touch display module; and/or
The perfusion system also comprises a communication module which is electrically connected with the second control unit, and the second control unit is also used for uploading perfusion parameters and state information of the perfusion liquid in the transfer process to the cloud end through the communication module; and/or
The perfusion system further comprises a GPS module which is electrically connected with the second control unit, and the second control unit is further used for acquiring address information in the transfer process in real time through the GPS module.
In summary, the perfusion system provided by the present application includes a perfusion assembly and a control module. Wherein, fill the subassembly and include save set, fill pipeline, oxygenation module and driving piece. The preservation device is used for containing pancreas and perfusate. Because the pancreas has the spleen artery and the superior mesentery artery, consequently, adopt two sets of perfusion subassemblies (first perfusion subassembly and second perfusion subassembly) respectively through oxygenation module and perfusate matched with mode, can dissolve oxygen in the perfusate, then will have the oxygen of perfusate to input spleen artery and superior mesentery artery respectively to make the organ continuously be in aerobic state, and then get rid of accumulational metabolite effectively, play certain guard action to the pancreas.
In addition, set up above-mentioned sensor subassembly on the infusion pipeline, can monitor the state of perfusate effectively.
In addition, the first filter and the second filter are arranged, so that impurities in the perfusate and oxygen can be effectively removed, and the perfusate is purer.
Drawings
In order to more clearly illustrate the detailed description of the present application or the technical solutions in the prior art, the drawings used in the detailed description or the prior art description will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a schematic diagram of a perfusion system for preserving a pancreas according to an embodiment of the present disclosure; and
FIG. 2 is a schematic view of a perfusion system for preserving a pancreas according to another embodiment of the present application.
In the above figures, the list of parts represented by the various reference numerals is as follows:
1. a storage device; 2. a filling pipeline; 3. an oxygenation module; 4. a drive member; 5. a first filter; 6. a second filter; 7. a first infusion assembly; 8. a second infusion assembly; 9. a buffer box; 10. a sampling port; 11. a bubble sensor; 12. a pressure sensor; 13. a temperature sensor; 14. a flow sensor; 15. an oxygen tank;
111. an organ chamber; 121. an ice box;
100. a first control unit; 101. a second control unit; 1021. a speaker; 1022. an LED lamp; 103. a battery; 104. a battery management module; 105. a touch display module; 106. a communication module; 107. a GPS module; 108. a Hall sensor;
2000. a pancreas; 2001. the splenic artery; 2002. the superior mesenteric artery.
Detailed Description
In the description of the present application, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the present application and to simplify the description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the present application.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present application, "plurality" means at least two, e.g., two, three, etc., unless explicitly specified otherwise.
In this application, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can include, for example, fixed connections, removable connections, or integral parts; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be interconnected within two elements or in a relationship where two elements interact with each other unless otherwise specifically limited. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art as appropriate.
In this application, unless expressly stated or limited otherwise, a first feature is "on" or "under" a second feature such that the first and second features are in direct contact, or the first and second features are in indirect contact via an intermediary. Also, a first feature "on," "above," and "over" a second feature may be directly on or obliquely above the second feature, or simply mean that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
In the description herein, reference to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Referring to fig. 1-2, in an alternative embodiment, the present application provides a transport system including a perfusion system for preserving a pancreas 2000 and a transport apparatus capable of transporting the perfusion system. It should be noted that the transfer device can be convenient for carrying, and the movable transfer device can be carried into transportation vehicles such as airplanes and high-speed railways.
In one embodiment provided herein, a perfusion system includes a perfusion assembly and a control module. Wherein, the perfusion assembly comprises a storage device 1, a perfusion pipeline 2, an oxygenation module 3 and a driving piece 4. One end of the perfusion pipeline 2 is connected with the preservation device 1 for containing pancreas 2000 and perfusate (not shown in the figure), and the other end is connected with the artery corresponding to the pancreas 2000, namely, the perfusate flows in the perfusion pipeline 2 under the action of the driving piece 4, and finally flows into the pancreas 2000 through the artery. The oxygenation module 3 is communicated with the perfusion pipeline 2, and when the perfusion fluid flows in the perfusion pipeline 2, oxygen is released into the perfusion pipeline 2 through the oxygenation module 3 so as to be melted into the perfusion fluid. The utility model discloses a two sets of perfusion subassemblies (first perfusion subassembly and second perfusion subassembly) are adopted and are passed through oxygenation module 3 respectively and the perfusate matched with mode, can dissolve oxygen in the perfusate, then will have the oxygen of perfusate to input spleen artery 2001 and mesentery upper artery 2002 respectively to make pancreas 2000 continuously be in aerobic state, and then get rid of accumulational metabolite effectively, play certain guard action to pancreas 2000.
Furthermore, the driver 4 and the control module are electrically connected, i.e. the driver 4 is controlled by the control module, i.e. the control module is able to control the driver 4 to deliver the perfusion fluid in the preservation apparatus 1 via the perfusion line 2 into the pancreas 2000.
In an alternative embodiment, the drive member 4 may be a peristaltic pump. Wherein the peristaltic pump may be connected to the perfusion line 2 by a pump tube to enable perfusion fluid to flow into the pancreas 2000.
In an alternative embodiment, one end of the oxygenation module 3 is connected to an oxygen tank 15, wherein the oxygen tank 15 is a disposable consumable, and is capable of supplying oxygen to the oxygenation module 3.
In an alternative embodiment, the oxygenation module 3 is a disposable consumable, and when the perfusion circuit 2 is cyclically perfused at a certain flow rate, the perfusate is passed through the oxygenation module 3 at a constant flow rate, while the oxygen from the oxygen tank 15 is fed into the oxygenation abrasion block at a certain flow rate and pressure, so that the oxygen is dissolved in the perfusate, thereby delivering the oxygen required for metabolism to the organ.
Alternatively, the oxygenation module 3 may be a membrane oxygenation module 3.
In a preferred embodiment, the priming assembly further comprises a first filter 5 and a second filter 6. Wherein, first filter 5 sets up on filling line 2, and its one end is connected with driving piece 4, and the other end is connected with save set 1, can be when the perfusate flows through first filter 5, clears up the great impurity of diameter in the perfusate to prevent that filling line 2 from being blockked up. The second filter 6 is arranged on the perfusion pipeline 2, one end of the second filter is connected with the oxygenation module 3, the other end of the second filter is communicated with the storage device 1, and when the perfusate flows through the second filter 6, impurities with small diameters in the perfusate can be cleaned, so that the small impurities are prevented from entering the organ, and the organ is prevented from being damaged.
In an alternative embodiment, the first filter 5 may be a coarse filter and the second filter 6 may be a fine filter, wherein the accuracy of the first filter is less than the accuracy of the second filter.
Optionally, the filter element aperture of the second filter 6 may be 40um.
In a preferred embodiment, the infusion assembly further comprises a buffer cassette 9. When the perfusion assembly comprises a buffer cassette 9, the buffer cassette 9 is arranged on the perfusion line 2 between the oxygenation module 3 and the preservation apparatus 1, which effectively smoothes the perfusion fluid pressure, resulting in smaller perfusion pressure fluctuations.
In an optional embodiment, the buffer box 9 is provided with a sampling port 10, when the perfusate flows through the buffer box 9, the perfusate can be sampled through the sampling port 10, so that the quality of the perfusate can be evaluated, and when the quality of the perfusate is not satisfactory, the control module controls the driving member 4 to stop the flow of the perfusate.
In a preferred embodiment, the perfusion apparatus further comprises a sensor assembly. Wherein the sensor assembly is arranged on the filling line 2 at the upstream side of the holding device 1. The perfusion parameters of the perfusate (such as the flow rate of the perfusate, the temperature of the perfusate, the pressure of the perfusate and the like) can be monitored when the perfusate circulates in the perfusion pipeline 2.
In addition, the control module comprises a first control unit 100 and a second control unit 101, wherein the first control unit 100 establishes a communication relationship with the sensor assembly, the second control unit 101 establishes a communication relationship with the first control unit 100, and the second control unit 101 establishes a communication relationship with the driving member 4, that is, the first control unit 100 can receive the perfusion parameters of the perfusion fluid monitored by the sensor assembly, and then transmit the data of the monitored perfusion parameters to the second control unit 101, and the second control unit 101 controls the driving member 4 to perform corresponding work according to the data. Such as: when the sensor assembly monitors that bubbles exist in the perfusate, the sensor assembly transmits the data of the bubbles existing in the perfusate to the first control unit 100, the first control unit 100 transmits the data of the bubbles existing in the perfusate to the second control unit 101, and the second control unit 101 controls the oxygenation module 3 to stop after receiving the data of the bubbles existing in the perfusate.
In a preferred embodiment, the sensor assembly includes at least one of a bubble sensor 11, a flow sensor 14, a pressure sensor 12, and a temperature sensor 13, such as: the bubble sensor 11, the flow sensor 14; for another example: bubble sensor 11, flow sensor 14, pressure sensor 12. The bubble sensor 11 is configured to monitor bubble information of the perfusate, that is, the bubble sensor 11 can monitor whether bubbles exist in the perfusate; the flow sensor 14 is capable of monitoring the flow rate of the perfusate; the pressure sensor 12 is capable of monitoring the perfusion of the perfusion fluid; the temperature sensor 13 is capable of monitoring the temperature of the holding set 1.
It should be noted that the second control unit 101 also records the flow information in real time, stores the flow information in a memory, and facilitates the user to export the flow information at any time, so as to analyze and evaluate the perfusion effect of the pancreas 2000.
In an alternative embodiment, when the sensor assembly comprises the bubble sensor 11, the flow sensor 14, the pressure sensor 12 and the temperature sensor 13, one end of the bubble sensor 11 is connected with the buffer box 9, and the other end is connected with the flow sensor 14; one end of the pressure sensor 12 is connected with the temperature sensor 13, and the other end is connected with the artery of the pancreas 2000; a temperature sensor 13 is connected to the storage module for monitoring the temperature of the perfusion fluid in a tray (not shown in the figures) in the preservation apparatus 1.
In a preferred embodiment, the preservation apparatus 1 comprises an organ chamber 111 and an ice bin 121, the ice bin 121 being disposed outside the organ chamber 111, such as: the ice bank 121 is disposed at the bottom of the organ chamber 111, or the ice bank 121 is disposed at a circumference side of the organ chamber 111. Wherein organ chamber 111 is for holding pancreas 2000 and perfusate; ice bank 121 is capable of cooling organ chamber 111.
In an alternative embodiment, organ chamber 111 further comprises an insulation layer, and ice bin 121 is capable of maintaining organ chamber 111 at a temperature of between 2 ℃ and 8 ℃, the insulation layer being capable of maintaining organ chamber 111 at a temperature of no less than 10 hours.
It should be noted that when the temperature is close to or higher than 8 ℃, an alarm in the perfusion system gives an alarm and prompts the addition of ice to maintain low-temperature perfusion.
In some more preferred embodiments, the perfusion system further comprises an alarm, which is electrically connected to the second control unit 101; when the sensor assembly monitors that the perfusate is abnormal, the second control unit 101 controls the alarm to give an alarm.
In an alternative embodiment, the alarm comprises LED lights 1022 and/or a speaker 1021. When the sensor assembly monitors that the perfusate is abnormal, the second control unit 101 can send an alarm instruction to the alarm controller, and after the alarm controller receives the alarm instruction, the loudspeaker 1021 is controlled to send out sound to alarm and/or the LED lamp 1022 is controlled to flicker, so that a prompt effect on a user is achieved.
In some more preferred embodiments, the perfusion system further comprises a battery 103 and a battery management module 104, the battery 103 is used for supplying power to the perfusion system, the battery management module 104 is electrically connected to the second control unit 101, and the second control unit 101 is further used for managing the use of the battery 103 through the battery management module 104; and/or the perfusion system further comprises a touch display module 105, the touch display module 105 is electrically connected to the second control unit 101, and the second control unit 101 is further configured to select a perfusion mode through the touch display module 105 and display perfusion parameters of the perfusion fluid in the current perfusion mode; and/or the perfusion system further comprises a communication module 106, the communication module 106 is electrically connected to the second control unit 101, and the second control unit 101 is further configured to upload perfusion parameters and state information of the perfusion fluid in the transfer process to the cloud end through the communication module 106; and/or the perfusion system further comprises a GPS module 107, the GPS module 107 is electrically connected to the second control unit 101, and the second control unit 101 is further used for acquiring address information in the transfer process in real time through the GPS module 107.
In an alternative embodiment, the perfusion mode is selected by operating the touch display module 105, wherein the second control unit 101 may send a command to the driver 4 to start rotating at a certain speed, thereby initiating perfusion. When constant-pressure perfusion is selected, the second control unit 101 acquires a pressure value transmitted from the first control unit 100 in real time, and when the pressure value is higher than a target pressure value, the second control unit 101 sends a deceleration command to the driving part 4; when the pressure value is lower than the target pressure value, the second control unit 101 sends an acceleration command to the driving member 4, and so on to achieve constant pressure perfusion.
In an alternative embodiment, the perfusion system comprises a communication module 106, a battery 103 and a GPS 5 When the module 107 and the touch display module 105 are used, the power supply for the perfusion system is needed during the transportation of the pancreas 2000 to achieve perfusionThe purpose of the system operation is noted. In the pancreas 2000 transportation process, but second control unit 101 real-time detection battery 103 electric quantity, when the electric quantity is not enough, will send out the warning to pop out the suggestion on touching display module 105, inform the user that should change battery 103. Pancreas 2000
During the transit, the second control unit 101 may send a positioning acquisition command to the GPS module 107 in real time, 0 and then sending the acquired positioning information to the communication module 106, and sending the information to the server by the communication module 106, so that the user can view the information in the mobile phone app in real time. In the pancreas 2000 transfer process, the second control unit 101 sends the perfusion parameters acquired by the first control unit 100 to the communication module 106, the communication module 106 sends the information to the server, and the user can check the information in the mobile phone app in real time.
In an alternative embodiment, the communication module 106 may be a 4G mode communication module 106. 5 It should be noted that the user can operate the touch display module 105 to implement different functions, such as rows
And (3) inflating, starting perfusion and the like, historical transfer data and a current perfusion parameter curve can be checked, the electric quantity, perfusion pressure, perfusion flow, organ chamber 111 temperature and group hysteresis dynamic curve of the battery 103 can be checked in real time, and the selected perfusion data can be exported by inserting a USB flash disk.
In an alternative embodiment, the filling system further comprises a cover (not shown), a tank (not shown) 0 Not shown in the figure) and a hall sensor 108, wherein the box body (not shown in the figure) is used for accommodating the perfusion assembly, the upper cover (not shown in the figure) is used for covering the box body (not shown in the figure), and the hall sensor 108 is used for sensing the covering state of the upper cover (not shown in the figure) and the box body (not shown in the figure); the second control unit 101 is electrically connected to the hall sensor 108, and is used for touching according to the high and low levels output by the hall sensor 108
The display module 105 sends a corresponding instruction. The method comprises the following specific application steps: upper cover (not shown in the figure) 5 A Hall sensor 108 is provided, the second control unit 101 detects the state of the Hall sensor 108 in real time, and when detecting that the output of the Hall sensor 108 is low level, the second control unit indicates that the upper cover(s) ((Not shown in the figure), the second control unit 101 sends a sleep entering command to the touch display module 105 to save power; when detecting that the output of the hall sensor 108 is at a high level, indicating that the upper cover (not shown in the figure) is not covered, the second control unit 101 sends an activation instruction to the touch display module 105, and reminds the user that the upper cover (not shown in the figure) should be covered.
Alternatively, the flow sensor 14 may be an ultrasonic flow sensor 14.
In an alternative embodiment, in order to meet the perfusion requirement of the pancreas 2000, the controllable range of the pressure of the perfusion system can be set to 5-45 mmHg, and in the actual perfusion, if the constant pressure perfusion mode is selected, the second control unit 101 can maintain the perfusion pressure within ± 2mmHg from the set value; if the pulse perfusion mode is selected, the second control unit 101 may maintain the perfusion pressure within ± 8mmHg from the set value.
In some more preferred embodiments, pancreas 2000 includes the splenic artery 2001 and superior mesenteric artery 2002; the perfusion assembly comprises a first perfusion assembly 7 and a second perfusion assembly 8, the other end of the perfusion line 2 of the first perfusion assembly 7 is used for communicating with the splenic artery 2001 of the pancreas 2000, and the other end of the perfusion line 2 of the second perfusion assembly 8 is used for communicating with the superior mesenteric artery 2002 of the pancreas 2000; the control module is electrically connected with the driving member 4 of the first perfusion assembly 7 and the second perfusion assembly 8, and is used for controlling the driving member 4 of the first perfusion assembly 7 to convey the perfusion fluid in the preservation device 1 to the splenic artery 2001 of the pancreas 2000 through the perfusion pipeline 2 of the first perfusion assembly 7, and controlling the driving member 4 of the second perfusion assembly 8 to convey the perfusion fluid in the preservation device 1 to the superior mesenteric artery 2002 of the pancreas 2000 through the perfusion pipeline 2 of the second perfusion assembly 8. That is, two sets of perfusion assemblies (first perfusion assembly 7 and second perfusion assembly 8) are provided for the splenic artery 2001 and superior mesenteric artery 2002 of pancreas 2000.
The two independent perfusion assemblies perfuse the spleen artery 2001 and the superior mesenteric artery 2002 of the pancreas 2000, so that the cold ischemia time can be prolonged, the reperfusion injury can be relieved, and the life activity of the isolated pancreas 2000 can be ensured, thereby promoting the preservation of the isolated pancreas 2000 and improving the success rate of the isolated pancreas 2000 transplantation or the islet transplantation. On the basis of separation pancreas 2000 perfusion and save, simultaneously also have the transportation function to can acquire perfusion parameter (temperature, pressure, flow, stagnation power etc.) and positional information in real time at the transportation, then through the automatic server of uploading of 4G communication, the doctor accessible removes end APP and knows separation pancreas 2000 save state at any time.
Although embodiments of the present application have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present application, and that variations, modifications, substitutions and alterations may be made to the above embodiments by those of ordinary skill in the art within the scope of the present application.
Claims (11)
1. A perfusion system for preserving a pancreas, the pancreas including a splenic artery and an superior mesenteric artery, the perfusion system comprising a perfusion assembly and a control module;
the perfusion assembly comprises a storage device, a perfusion pipeline, an oxygenation module and a driving piece;
the preservation device is used for containing pancreas and perfusate and is communicated with the perfusion pipeline;
the oxygenation module is communicated with the perfusion pipeline and is used for dissolving oxygen into a perfusion solution; the driving piece is arranged on a perfusion pipeline between the oxygenation module and the storage device;
the number of the perfusion assemblies is two, the two perfusion assemblies are respectively a first perfusion assembly and a second perfusion assembly, a perfusion pipeline of the first perfusion assembly is used for being communicated with the splenic artery, and a perfusion pipeline of the second perfusion assembly is used for being communicated with the superior mesenteric artery;
the control module is electrically connected with the driving piece of the first perfusion component and the driving piece of the second perfusion component and used for controlling the driving piece of the first perfusion component to convey the perfusion liquid in the storage device to the spleen artery of the pancreas through the perfusion pipeline of the first perfusion component and controlling the driving piece of the second perfusion component to convey the perfusion liquid in the storage device to the superior mesenteric artery of the pancreas through the perfusion pipeline of the second perfusion component.
2. The perfusion system for preserving a pancreas according to claim 1,
the priming assembly further comprises a first filter and a second filter;
the first filter is arranged on the perfusion pipeline between the driving piece and the storage device and is used for filtering the perfusion liquid flowing out of the storage device;
the second filter is arranged on the downstream side of the oxygenation module and on a perfusion pipeline between the oxygenation module and the storage device and is used for removing impurities from perfusion liquid flowing out of the oxygenation module.
3. The perfusion system for preserving pancreas according to claim 2, wherein an accuracy of the first filter is less than an accuracy of the second filter.
4. The perfusion system for preserving a pancreas according to claim 1,
the perfusion assembly further comprises a buffer box, wherein the buffer box is arranged on the downstream side of the oxygenation module and on a perfusion pipeline between the oxygenation module and the storage device and used for smoothing the pressure of perfusion liquid in the perfusion pipeline.
5. The perfusion system for preserving pancreas according to claim 4, wherein a sampling port is provided on the buffer box for sampling the perfusate.
6. The perfusion system for preserving a pancreas according to claim 1,
the perfusion system also comprises a sensor assembly, wherein the sensor assembly is arranged on the perfusion pipeline on the upstream side of the storage device and is used for monitoring perfusion parameters of the perfusion liquid;
the control module comprises a first control unit and a second control unit, the first control unit is in communication connection with the sensor assembly, and the second control unit is in communication connection with the first control unit;
the first control unit is used for acquiring monitoring data of the sensor assembly and transmitting the monitoring data to the second control unit, and the second control unit is used for controlling the driving piece to work according to the monitoring data.
7. The perfusion system for preserving pancreas according to claim 6,
the sensor assembly includes at least one of a bubble sensor, a flow sensor, a pressure sensor, and a temperature sensor;
the bubble sensor is used for monitoring bubble information of the perfusate, the flow sensor is used for monitoring the flow velocity of the perfusate, the pressure sensor is used for monitoring the perfusion pressure of the perfusate, and the temperature sensor is used for monitoring the temperature in the storage device.
8. The perfusion system for preserving pancreas as claimed in claim 1, wherein the preservation apparatus comprises an organ chamber for holding pancreas and perfusate, and an ice bank disposed outside the organ chamber for cooling the organ chamber.
9. The perfusion system for preserving pancreas according to claim 6,
the perfusion system further comprises an alarm which is electrically connected with the second control unit;
the second control unit is also used for controlling the alarm to work according to the monitoring data.
10. The perfusion system for preserving a pancreas according to claim 6,
the perfusion system further comprises a battery and a battery management module, the battery is used for supplying power to the perfusion system, the battery management module is electrically connected to the second control unit, and the second control unit is further used for managing the use of the battery through the battery management module; and/or
The perfusion system further comprises a touch display module which is electrically connected to the second control unit, and the second control unit is further used for selecting a perfusion mode and displaying perfusion parameters of the perfusion liquid in the current perfusion mode through the touch display module; and/or
The perfusion system further comprises a communication module which is electrically connected to the second control unit, and the second control unit is further used for uploading perfusion parameters and state information of the perfusion liquid in the transfer process to a cloud end through the communication module; and/or;
the perfusion system further comprises a GPS module which is electrically connected with the second control unit, and the second control unit is further used for acquiring address information in the transfer process in real time through the GPS module.
11. A transport system comprising the perfusion system for preserving a pancreas of any one of claims 1-10.
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