CN115867554B - Brm靶向化合物和相关使用方法 - Google Patents
Brm靶向化合物和相关使用方法Info
- Publication number
- CN115867554B CN115867554B CN202180049461.6A CN202180049461A CN115867554B CN 115867554 B CN115867554 B CN 115867554B CN 202180049461 A CN202180049461 A CN 202180049461A CN 115867554 B CN115867554 B CN 115867554B
- Authority
- CN
- China
- Prior art keywords
- pyrazino
- ethyl
- hexahydro
- hydroxyphenyl
- pyridazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063036811P | 2020-06-09 | 2020-06-09 | |
| US63/036,811 | 2020-06-09 | ||
| PCT/US2021/036664 WO2021252666A1 (en) | 2020-06-09 | 2021-06-09 | Brm targeting compounds and associated methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115867554A CN115867554A (zh) | 2023-03-28 |
| CN115867554B true CN115867554B (zh) | 2025-09-02 |
Family
ID=76731093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202180049461.6A Active CN115867554B (zh) | 2020-06-09 | 2021-06-09 | Brm靶向化合物和相关使用方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11702423B2 (https=) |
| EP (2) | EP4161935B1 (https=) |
| JP (1) | JP2023529908A (https=) |
| KR (1) | KR20230037549A (https=) |
| CN (1) | CN115867554B (https=) |
| AU (1) | AU2021289730A1 (https=) |
| BR (1) | BR112022025061A2 (https=) |
| CA (1) | CA3185888A1 (https=) |
| DK (1) | DK4161935T3 (https=) |
| ES (1) | ES3034380T3 (https=) |
| FI (1) | FI4161935T3 (https=) |
| IL (1) | IL298933B1 (https=) |
| MX (1) | MX2022015732A (https=) |
| PL (1) | PL4161935T3 (https=) |
| PT (1) | PT4161935T (https=) |
| WO (1) | WO2021252666A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019140380A1 (en) | 2018-01-12 | 2019-07-18 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2020010227A1 (en) | 2018-07-06 | 2020-01-09 | Kymera Therapeutics, Inc. | Protein degraders and uses thereof |
| WO2020251972A1 (en) | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| WO2021133917A1 (en) | 2019-12-23 | 2021-07-01 | Kymera Therapeutics, Inc. | Smarca inhibitors and uses thereof |
| EP4081308A4 (en) | 2019-12-23 | 2024-01-24 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| WO2022099117A1 (en) * | 2020-11-06 | 2022-05-12 | Prelude Therapeutics Incorporated | Brm targeting compounds and associated methods of use |
| EP4259144A4 (en) | 2020-12-09 | 2025-08-20 | Kymera Therapeutics Inc | SMARCA DEGRADING AGENTS AND THEIR USES |
| WO2023278402A1 (en) * | 2021-06-28 | 2023-01-05 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| KR20240046498A (ko) * | 2021-08-09 | 2024-04-09 | 제넨테크, 인크. | Brm의 조절에 사용하기 위한 페놀 유도체 |
| AU2023269778A1 (en) * | 2022-05-10 | 2024-12-12 | Prelude Therapeutics Incorporated | 6,6a,7,8,9,10-hexahydro-5h-pyrazino[1',2':4,5]pyrazino[2,3-c]pyridazine derivatives as smarca4 protein degraders for the treatment of cancer |
| CA3252644A1 (en) * | 2022-05-10 | 2023-11-16 | Foghorn Therapeutics Inc. | PYRAZINE DERIVATIVES AND THEIR USES |
| WO2024064316A1 (en) * | 2022-09-23 | 2024-03-28 | Regents Of The University Of Michigan | Compounds and compositions as smarca2/4 inhibitors and uses thereof |
| WO2024064328A1 (en) * | 2022-09-23 | 2024-03-28 | Regents Of The University Of Michigan | Compounds and compositions as smarca2/4 degraders and uses thereof |
| CN120152970A (zh) * | 2022-10-03 | 2025-06-13 | 普莱鲁德疗法有限公司 | 使用smarca2降解剂和kras靶向疗法的组合实现的癌症治疗 |
| EP4695250A1 (en) | 2023-04-12 | 2026-02-18 | Aurigene Oncology Limited | Tetracyclic compounds as smarca2 and/or smarca4 degraders |
| WO2025076357A1 (en) | 2023-10-04 | 2025-04-10 | Prelude Therapeutics Incorporated | Combination treatment regimens - smarca2 degrader with taxane anticancer agent |
| US20250114353A1 (en) | 2023-10-04 | 2025-04-10 | Prelude Therapeutics Incorporated | Combination Treatment Regimens - SMARCA2 Degrader With Gemcitabine |
| US20250114354A1 (en) | 2023-10-04 | 2025-04-10 | Prelude Therapeutics Incorporated | Combination treatment regimens - smarca2 degrader with pd-1 inhibitors |
| WO2025106482A1 (en) * | 2023-11-13 | 2025-05-22 | Oncopia Therapeutics, Inc. D/B/A Sk Life Science Labs | Compounds and compositions as smarca2/4 degraders and uses thereof |
| US20250276074A1 (en) | 2024-03-01 | 2025-09-04 | Prelude Therapeutics Incorporated | Brm and brg1 targeting antibody-drug conjugates and methods of use thereof |
| CN119638700B (zh) * | 2024-11-01 | 2025-11-14 | 中科中山药物创新研究院 | 一种nsd2降解剂及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016138114A1 (en) * | 2015-02-25 | 2016-09-01 | Genentech, Inc. | Therapeutic pyridazine compounds and uses thereof |
| WO2019195201A1 (en) * | 2018-04-01 | 2019-10-10 | Arvinas Operations, Inc. | Brm targeting compounds and associated methods of use |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3657744A (en) | 1970-05-08 | 1972-04-25 | Univ Minnesota | Method for fixing prosthetic implants in a living body |
| US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5061273A (en) | 1989-06-01 | 1991-10-29 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
| US5040548A (en) | 1989-06-01 | 1991-08-20 | Yock Paul G | Angioplasty mehtod |
| US5350395A (en) | 1986-04-15 | 1994-09-27 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
| US4748982A (en) | 1987-01-06 | 1988-06-07 | Advanced Cardiovascular Systems, Inc. | Reinforced balloon dilatation catheter with slitted exchange sleeve and method |
| US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
| US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
| CA1322628C (en) | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Expandable intraluminal graft |
| US5292331A (en) | 1989-08-24 | 1994-03-08 | Applied Vascular Engineering, Inc. | Endovascular support device |
| US5674278A (en) | 1989-08-24 | 1997-10-07 | Arterial Vascular Engineering, Inc. | Endovascular support device |
| US6344053B1 (en) | 1993-12-22 | 2002-02-05 | Medtronic Ave, Inc. | Endovascular support device and method |
| GB2554071A (en) | 2016-09-14 | 2018-03-28 | Univ Dundee | Small molecules |
| KR20250117470A (ko) | 2016-12-23 | 2025-08-04 | 아비나스 오퍼레이션스, 인코포레이티드 | 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 |
| BR112019015312A2 (pt) | 2017-01-26 | 2020-03-10 | Arvinas Operations, Inc. | Moduladores da proteólise pelo receptor de estrogênio e métodos de uso associados |
| WO2019084026A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HETEROCYCLIC COMPOUNDS AND METHODS OF USE |
| WO2019084030A1 (en) | 2017-10-24 | 2019-05-02 | Genentech, Inc. | (4-HYDROXYPYRROLIDIN-2-YL) -HYDROXAMATE COMPOUNDS AND METHODS OF USE |
| US12539292B2 (en) | 2018-04-01 | 2026-02-03 | Arvinas Operations, Inc. | BRM targeting compounds and associated methods of use |
| WO2020251974A1 (en) | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca inhibitors and uses thereof |
| US20230072658A1 (en) | 2019-06-10 | 2023-03-09 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| WO2020251972A1 (en) | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| WO2020251969A1 (en) | 2019-06-10 | 2020-12-17 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| WO2021133917A1 (en) * | 2019-12-23 | 2021-07-01 | Kymera Therapeutics, Inc. | Smarca inhibitors and uses thereof |
| EP4081308A4 (en) * | 2019-12-23 | 2024-01-24 | Kymera Therapeutics, Inc. | Smarca degraders and uses thereof |
| WO2022099117A1 (en) * | 2020-11-06 | 2022-05-12 | Prelude Therapeutics Incorporated | Brm targeting compounds and associated methods of use |
-
2021
- 2021-06-09 CN CN202180049461.6A patent/CN115867554B/zh active Active
- 2021-06-09 CA CA3185888A patent/CA3185888A1/en active Pending
- 2021-06-09 EP EP21736890.1A patent/EP4161935B1/en active Active
- 2021-06-09 JP JP2022575824A patent/JP2023529908A/ja active Pending
- 2021-06-09 IL IL298933A patent/IL298933B1/en unknown
- 2021-06-09 ES ES21736890T patent/ES3034380T3/es active Active
- 2021-06-09 AU AU2021289730A patent/AU2021289730A1/en active Pending
- 2021-06-09 US US17/343,341 patent/US11702423B2/en active Active
- 2021-06-09 WO PCT/US2021/036664 patent/WO2021252666A1/en not_active Ceased
- 2021-06-09 MX MX2022015732A patent/MX2022015732A/es unknown
- 2021-06-09 PT PT217368901T patent/PT4161935T/pt unknown
- 2021-06-09 DK DK21736890.1T patent/DK4161935T3/da active
- 2021-06-09 PL PL21736890.1T patent/PL4161935T3/pl unknown
- 2021-06-09 BR BR112022025061A patent/BR112022025061A2/pt unknown
- 2021-06-09 KR KR1020237000892A patent/KR20230037549A/ko active Pending
- 2021-06-09 FI FIEP21736890.1T patent/FI4161935T3/fi active
- 2021-06-09 EP EP25173100.6A patent/EP4570319A3/en active Pending
-
2023
- 2023-05-15 US US18/317,352 patent/US20240018158A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016138114A1 (en) * | 2015-02-25 | 2016-09-01 | Genentech, Inc. | Therapeutic pyridazine compounds and uses thereof |
| WO2019195201A1 (en) * | 2018-04-01 | 2019-10-10 | Arvinas Operations, Inc. | Brm targeting compounds and associated methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| CA3185888A1 (en) | 2021-12-16 |
| EP4161935A1 (en) | 2023-04-12 |
| JP2023529908A (ja) | 2023-07-12 |
| FI4161935T3 (fi) | 2025-08-19 |
| BR112022025061A2 (pt) | 2023-01-31 |
| PL4161935T3 (pl) | 2025-09-08 |
| EP4570319A3 (en) | 2025-08-20 |
| US11702423B2 (en) | 2023-07-18 |
| IL298933B1 (en) | 2026-04-01 |
| PT4161935T (pt) | 2025-08-14 |
| EP4570319A2 (en) | 2025-06-18 |
| EP4161935B1 (en) | 2025-05-21 |
| IL298933A (en) | 2023-02-01 |
| DK4161935T3 (da) | 2025-08-18 |
| US20240018158A1 (en) | 2024-01-18 |
| AU2021289730A8 (en) | 2023-02-02 |
| US20220033409A1 (en) | 2022-02-03 |
| MX2022015732A (es) | 2023-02-13 |
| ES3034380T3 (en) | 2025-08-18 |
| CN115867554A (zh) | 2023-03-28 |
| AU2021289730A1 (en) | 2023-01-19 |
| KR20230037549A (ko) | 2023-03-16 |
| WO2021252666A1 (en) | 2021-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN115867554B (zh) | Brm靶向化合物和相关使用方法 | |
| ES2965468T3 (es) | Compuestos heterocíclicos para uso en el tratamiento del cáncer | |
| AU2017207268A1 (en) | Substituted thiohydantoin derivatives as androgen receptor antagonists | |
| KR20190075931A (ko) | 스피로 고리 화합물 | |
| CN119487036A (zh) | 作为smarca4蛋白降解剂用于治疗癌症的6,6a,7,8,9,10-六氢-5h-吡嗪并[1',2':4,5]吡嗪并[2,3-c]哒嗪衍生物 | |
| US20240261418A1 (en) | Sos1 degrading agent and preparation method therefor and application thereof | |
| CN120418251A (zh) | Brm靶向化合物和相关使用方法 | |
| WO2023215482A1 (en) | Tetrahydroisoquinoline heterobifunctional bcl-xl degraders | |
| CN119836416A (zh) | 具有泛素连接酶结合部分的靶向kat6的化合物 | |
| AU2023264537A1 (en) | Tetrahydroisoquinoline heterobifunctional bcl-xl degraders | |
| US20240336612A1 (en) | BRM Targeting Compounds And Associated Methods Of Use | |
| HK40128204A (en) | Brm targeting compounds and associated methods of use | |
| EA048707B1 (ru) | Brm направленные соединения и связанные способы применения | |
| EA050840B1 (ru) | Brm направленные соединения и связанные способы применения | |
| WO2025117881A1 (en) | Compounds and methods for inhibiting autophagy | |
| US20250161289A1 (en) | KAT6 Targeting Compounds | |
| HK40078801B (en) | Heterocyclic compounds for use in the treatment of cancer | |
| HK40078801A (en) | Heterocyclic compounds for use in the treatment of cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant |