CN115837002A - Composition containing pearl extract and mother-of-pearl extract and application thereof - Google Patents
Composition containing pearl extract and mother-of-pearl extract and application thereof Download PDFInfo
- Publication number
- CN115837002A CN115837002A CN202211193339.9A CN202211193339A CN115837002A CN 115837002 A CN115837002 A CN 115837002A CN 202211193339 A CN202211193339 A CN 202211193339A CN 115837002 A CN115837002 A CN 115837002A
- Authority
- CN
- China
- Prior art keywords
- pearl
- composition
- extract
- mother
- pearl extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 230000000694 effects Effects 0.000 claims abstract description 17
- 230000002087 whitening effect Effects 0.000 claims abstract description 7
- 238000005282 brightening Methods 0.000 claims abstract description 5
- 239000011049 pearl Substances 0.000 claims description 109
- 239000000843 powder Substances 0.000 claims description 48
- 239000000725 suspension Substances 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- 239000000126 substance Substances 0.000 claims description 19
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 claims description 18
- 235000019982 sodium hexametaphosphate Nutrition 0.000 claims description 18
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 claims description 18
- 239000002245 particle Substances 0.000 claims description 14
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 11
- 239000002270 dispersing agent Substances 0.000 claims description 11
- 150000001923 cyclic compounds Chemical class 0.000 claims description 10
- 238000000227 grinding Methods 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 6
- 238000001238 wet grinding Methods 0.000 claims description 6
- 238000005119 centrifugation Methods 0.000 claims description 5
- 239000002537 cosmetic Substances 0.000 claims description 5
- 238000012216 screening Methods 0.000 claims description 5
- 239000004115 Sodium Silicate Substances 0.000 claims description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 3
- 239000000047 product Substances 0.000 claims description 3
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 3
- 229910052911 sodium silicate Inorganic materials 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 230000001153 anti-wrinkle effect Effects 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 239000013589 supplement Substances 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims 1
- 229940008099 dimethicone Drugs 0.000 claims 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 1
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
- 229940068065 phytosterols Drugs 0.000 claims 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 abstract description 24
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 230000037303 wrinkles Effects 0.000 abstract description 4
- 208000003351 Melanosis Diseases 0.000 abstract description 3
- 230000006798 recombination Effects 0.000 abstract description 3
- 238000005215 recombination Methods 0.000 abstract description 3
- 230000008929 regeneration Effects 0.000 abstract description 3
- 238000011069 regeneration method Methods 0.000 abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 30
- 235000001014 amino acid Nutrition 0.000 description 26
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 229910000019 calcium carbonate Inorganic materials 0.000 description 8
- 210000003491 skin Anatomy 0.000 description 8
- 125000004432 carbon atom Chemical group C* 0.000 description 7
- 235000018102 proteins Nutrition 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 241000217407 Margaritifera Species 0.000 description 6
- 241001648788 Margarodidae Species 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 108090000145 Bacillolysin Proteins 0.000 description 5
- 102000035092 Neutral proteases Human genes 0.000 description 5
- 108091005507 Neutral proteases Proteins 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- 235000005956 Cosmos caudatus Nutrition 0.000 description 4
- 244000293323 Cosmos caudatus Species 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 102000011782 Keratins Human genes 0.000 description 4
- 108010076876 Keratins Proteins 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000005189 flocculation Methods 0.000 description 4
- 230000016615 flocculation Effects 0.000 description 4
- -1 glycin amino acid Chemical class 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 3
- 238000004925 denaturation Methods 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 102000034240 fibrous proteins Human genes 0.000 description 3
- 108091005899 fibrous proteins Proteins 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- 239000011573 trace mineral Substances 0.000 description 3
- 235000013619 trace mineral Nutrition 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 241000254954 Enoplognatha margarita Species 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 238000002845 discoloration Methods 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical compound CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- BWWAFUZQSLIIIH-UHFFFAOYSA-N 2-phenyl-3H-chromen-3-id-4-one Chemical compound O1C(=[C-]C(=O)C2=CC=CC=C12)C1=CC=CC=C1 BWWAFUZQSLIIIH-UHFFFAOYSA-N 0.000 description 1
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 241000219780 Pueraria Species 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 229930189330 Streptothricin Natural products 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 229960002645 boric acid Drugs 0.000 description 1
- 235000010338 boric acid Nutrition 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000001808 coupling effect Effects 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000018977 lysine Nutrition 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000005341 metaphosphate group Chemical group 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 229940083037 simethicone Drugs 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- BHZOKUMUHVTPBX-UHFFFAOYSA-M sodium acetic acid acetate Chemical compound [Na+].CC(O)=O.CC([O-])=O BHZOKUMUHVTPBX-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- NRAUADCLPJTGSF-VLSXYIQESA-N streptothricin F Chemical compound NCCC[C@H](N)CC(=O)N[C@@H]1[C@H](O)[C@@H](OC(N)=O)[C@@H](CO)O[C@H]1\N=C/1N[C@H](C(=O)NC[C@H]2O)[C@@H]2N\1 NRAUADCLPJTGSF-VLSXYIQESA-N 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910021654 trace metal Inorganic materials 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The composition utilizes the synergistic effect of the pearl extract and the mother-of-pearl extract, wherein various amino acids stimulate skin tissue recombination or regeneration, and has excellent whitening, freckle removing, wrinkle resisting, repairing and brightening effects on skin.
Description
Technical Field
The invention relates to the field of daily cosmetics, A61K8/18, in particular to a composition containing a pearl extract and a mother-of-pearl extract and application thereof.
Background
The pearl and the mother-of-pearl mainly contain calcium carbonate and scleroprotein, the calcium carbonate accounts for 91.59%, the scleroprotein is keratin, is a scleroprotein containing various amino acids and accounts for 3.83% of the pearl component, and as various amino acids such as histidine, arginine, aspartic acid, phenylalanine and the like and various trace metal elements such as manganese, chromium, iron, titanium, zinc and the like which are contained in the pearl and the mother-of-pearl are widely used in the traditional Chinese medicine, the pearl and the mother-of-pearl have the effects of clearing heat and detoxicating, removing nebula and improving eyesight, promoting granulation and beautifying, regulating immunity, delaying senility, calming the nerves and arresting convulsion, and in addition, the pearl and the mother-pearl have excellent skin-care effects of whitening, resisting aging, moisturizing and the like when being applied to the fields of cosmetics and skin-care products.
The traditional usage is that the active ingredients are ground into powder with the particle size less than 2 mu m for oral administration or cosmetic action, but the powder contains a large amount of calcium carbonate which is insoluble in water and is not beneficial to direct absorption of human bodies, and the active proteins, amino acids and trace elements contained in the powder are surrounded by the calcium carbonate, so that the absorption rate of the active ingredients by skin is very limited when the powder is directly used, and therefore, the active ingredients in the powder are directly released and directly absorbed by the skin, so that higher utilization rate is generated; however, in the current extraction process, the surrounding calcium carbonate is generally dissolved by using an acidic substance, but the acidic environment can cause the denaturation of protein or the dissociation of amino acid structure, and the change of the substance structure in the system can not only influence the efficacy, but also influence the stability of the system.
It is generally believed that: the pearl and the mother-of-pearl are similar in type and components, the compatibility of the pearl and the mother-of-pearl is good, and the pearl and the mother-of-pearl can play a synergistic effect when combined, but in the research process, the compatibility and the long-term stability of the pearl and the mother-of-pearl are also the problems which need to be taken into consideration except for paying attention to the improvement of the utilization rate of the effective components when the pearl and the mother-of-pearl are compounded for use, different contents of effective substances and different substances in the components can greatly influence the stability of a system, when the content of certain high-activity amino acids in the pearl and the mother-of-pearl is too high, the system is easy to be oxidized to generate a color change phenomenon, and when the intermolecular force of the internal amino acids is too high, the adverse phenomena of layering, sedimentation, flocculation and the like are easy to occur, and the effects of the pearl and the mother-of-pearl can be influenced.
Patent CN2017111829799 discloses a nano pearl extract and its extraction method, in the method, carbon dioxide is used to extract pearl powder, then acetic acid-sodium acetate buffer solution with pH value of 3-4 is used to acidolyze organic skeleton therein, and then the nano pearl extract is obtained after drying for 2-48 hours at 35-60 ℃, the acidity of the method is too low, which is very easy to cause denaturation and dissociation of protein and charge imbalance of amino acid environment, influences the color of the extract and reduces the oxidation resistance and stability of the extract; patent CN2022102359507 discloses a scalp/hair/skin care composition using seawater pearls as raw material and its preparation method, wherein the pearl extract is prepared by: grinding pearls into powder, then carrying out wet grinding, drying into powder, and then carrying out enzymolysis extraction by adopting a streptothricin protease solution, wherein the drying step in the method can possibly cause denaturation of protein or cross-linking of molecular chains, thereby influencing the decomposition effect.
Disclosure of Invention
In order to solve the technical problems, the invention provides a composition containing a pearl extract and a mother-of-pearl extract and application thereof, the composition has excellent whitening, anti-wrinkle, brightening, repairing and other effects by utilizing the synergistic effect of the pearl extract and the mother-of-pearl extract, and the composition also has excellent stability by optimizing the material composition and the extraction process in the components.
Firstly, the application provides a composition containing pearl extract and mother-of-pearl extract, and the composition comprises the pearl extract, the mother-of-pearl extract and a solvent.
The pearl extract contains 4-14% of keratin, glycin amino acid, alanine amino acid, serine amino acid, glutamic acid, lysine amino acid and other eighteen amino acids, and also contains twenty-one trace elements of iron, aluminum, zinc, selenium, copper, strontium, potassium, germanium and other elements, the mother-of-pearl extract contains keratin, histidine, arginine, threonine, valine, leucine, methionine and other 14 amino acids, and the trace elements are basically consistent with the pearl extract; the large amount of amino acids contained in the two can stimulate skin active factors, induce skin cell recombination and regeneration, and enhance the effects of inhibiting and removing wrinkles, resisting aging, whitening and the like by utilizing the synergistic effect of the two; although the two components are approximately the same, the applicant finds in experiments that: when the pearl extract and the mother-of-pearl extract coexist, the phenomenon of easy oxidation or instability is occasionally generated, which is specifically shown as follows: discoloration, delamination, precipitation or flocculation, etc., which can lead to a decrease in the efficacy of the composition.
Further, the composition also comprises an alcohol substance.
Further, the composition comprises the following components in percentage by total weight: 1-15% of pearl extract, 1-10% of mother-of-pearl extract, 50-95% of alcohol substance and the balance of solvent supplement to total amount of 100%.
Further, the alcohol substance is a cyclic compound with at least one-OH and at least 4 shared C atoms and a C2-C6 linear alkane with at least 2-OH. The composition system contains a large number of different kinds of amino acids, various polar functional groups such as-NH 2, -OH, -COOH and the like exist inside the composition system, the dynamic balance of the system is maintained due to the existence of acting force such as electrostatic action, hydrogen bond and coupling action inside molecules, but the activity degrees of different amino acids in the system are different, and the existence state of the system is influenced when the activity degree of the amino acids in the system is relatively higher or lower under the influence of external temperature; for cyclic compounds with at least one-OH and at least 4 shared C atoms, the connected cyclic structure does not have the rotation property of a C-C bond, the movement capacity of high-activity amino acid molecules in a system can be reduced to a certain extent by increasing steric hindrance, but the cyclic conjugated structure and the-OH bond generate force with the system again to maintain balance; for C2-C6 straight-chain alkane at least having 2-OH groups, the mobility of the straight-chain alkane can control internal acting force due to the short molecular chain, so that the opposite effect caused by excessive increase of the acting force is avoided; the experiment shows that the stability of the composition can be enhanced by using the two components simultaneously, but the situation that the viscosity of the system is slightly changed still exists.
Further, the weight ratio of the cyclic compound with at least one-OH and at least 4 shared C atoms and the C2-C6 linear alkane with at least 2-OH in the alcohol substances is (0.6-2.5): 1; when the cyclic compound at least with one-OH and at least with 4 common C is added too much, the steric hindrance of the system is increased too much, when the activity of the amino acid molecules is reduced at low temperature, the intermolecular force is too large, the coagulation or flocculation phenomenon is easily caused, and the amino acid molecules are difficult to get rid of the force and are not beneficial to being absorbed by the skin; on the other hand, when the amount of the C2-C6 linear alkane having at least 2-OH groups is too large, the chargeability thereof decreases the charge balance of the system and also increases the system force too much.
Preferably, the weight ratio of the cyclic compound having at least one-OH and at least 4 common C atoms and the C2-C6 linear alkane having at least 2-OH is 1.25:1.
further, the cyclic compound which at least has one-OH and at least has 4 shared C atoms is selected from one or more of phytosterol, oryzanol, vitamin B12 and pueraria flavonid.
Further, the cyclic compound having at least one-OH group and at least 4 common C atoms is phytosterol and/or oryzanol.
Preferably, the cyclic compound having at least one-OH group and at least 4 common C atoms is a phytosterol.
Further, the C2-C6 linear alkane at least having 2-OH is one or more of glycerol, hexanediol, butanediol, pentanediol and isoprene glycol.
Further, the C2-C6 linear alkane at least having 2-OH is one or more of glycerol, butanediol and pentanediol.
Preferably, the linear C2-C6 alkane having at least 2-OH groups is glycerol.
Further, the preparation method of the pearl extract and the mother-of-pearl extract comprises the following steps:
s1, screening pearls or nacres;
s2, grinding and dispersing to prepare a suspension of pearl powder or nacre powder;
s3, superfine wet grinding;
and S4, carrying out enzymolysis and centrifugation.
Further, the particle size of the ground particles in the step S2 is less than 200 meshes.
Further, a dispersant is added to the suspension in the step S2, and the dispersant is at least one of sodium dodecyl sulfate, sodium hexametaphosphate, polyacrylamide, simethicone, sodium silicate, and polyethylene glycol.
Further, the dispersant is at least one of sodium dodecyl sulfate, sodium hexametaphosphate and sodium silicate.
Preferably, the dispersant is sodium hexametaphosphate. The experiment shows that when water is used as a solvent, the average particle size of solid particles in the suspension after grinding by S3 is too large, the stability of the prepared final composition is very poor, and when sodium hexametaphosphate is used as a dispersing agent, the composition has the highest active substance content and also shows the best stability; the applicant speculates that the reason is that: the sodium hexametaphosphate can be combined with calcium ions, so that amino acid and protein wrapped by calcium carbonate are fully released, the content of effective active substances in the composition is increased, in addition, the sodium hexametaphosphate contains a cyclic organic structure formed by P-O bonds and an inorganic structure of metaphosphate, the organic end of the sodium hexametaphosphate can be combined with the amino acid, the inorganic end is combined with water more, the dispersibility and the stability of the amino acid in water are better, and the charge performance of the sodium hexametaphosphate can also maintain the charge balance of the system to a certain extent.
Furthermore, the amount of the sodium hexametaphosphate is 5 to 15 percent of the mass of the pearl powder or the nacre powder.
Further, in the step S3, the particles are ground until the average diameter of the particles in the suspension is less than 800 nm.
Further, the enzymolysis adopts neutral protease, the dosage of the neutral protease is 0.08-0.12 percent of the total weight of the pearl powder or the mother-of-pearl powder, and the enzymolysis time is 3-5 hours. The protein in the pearl and the mother-of-pearl is fully hydrolyzed into amino acid.
Further, in the composition, the solvent is at least one selected from water, ethanol and ethyl acetate.
The composition can also comprise an auxiliary agent such as a preservative.
Further, in the composition, the preservative is selected from one or more of 1,3-propylene glycol, benzyl alcohol, benzoic acid, boric acid, sorbic acid and salicylic acid.
Secondly, the application provides the application of the composition containing the pearl extract and the mother-of-pearl extract, and the composition can be used in cosmetics or skin care products with whitening, freckle removing, repairing, wrinkle resisting and brightening effects by utilizing the synergistic effect of the pearl extract and the mother-of-pearl extract.
Advantageous effects
1. The composition of the application utilizes the synergistic effect of the pearl extract and the mother-of-pearl extract, wherein various amino acids stimulate skin tissue recombination or regeneration, and has excellent whitening, freckle removing, wrinkle resisting, repairing and brightening effects on skin.
2. According to the application, the composition shows good stability at normal temperature, high temperature and low temperature and good system compatibility by optimizing the types and relative quality of alcohol substances.
3. The application optimizes the types and the addition amounts of alcohol substances, dispersing agents and the like, weakens the wrapping effect of calcium carbonate on amino acid and protein through the self amphiphilic property, the charging property and the molecular structure of the calcium carbonate, and further improves the content and the stability of effective active substances in the composition.
4. The application makes the keratin fully decomposed into a large number of amino acid molecules by optimizing the preparation processes of the pearl and the mother-of-pearl, such as enzyme adding amount, temperature, pH value and the like in the enzymolysis process, so as to increase the skin absorption of a human body and promote the exertion of the efficacy of the pearl and the mother-of-pearl extract.
Detailed Description
Examples
Example 1:
a composition containing pearl extract and mother-of-pearl extract comprises the following components by weight: 8% of pearl extract, 5% of mother-of-pearl extract, 75% of alcohol substance and the balance of water to 100% of the total amount.
The alcohol substance is a combination of phytosterol (CAS: 85681-87-4) and glycerol (CAS: 56-81-5) in a mass ratio of 1.25: the preparation method of the pearl extract and the mother-of-pearl extract comprises the following steps:
s1, screening pearls or nacres;
s2, grinding and dispersing to prepare a suspension of pearl powder or nacre powder;
wherein, the particle diameter of the ground pearl or nacre powder is less than 200 meshes, the dispersant is sodium hexametaphosphate, the dosage of which is 10 percent of the mass of the pearl powder or nacre powder, the sodium hexametaphosphate (CAS: 10124-56-8) is firstly dissolved in water, then the ground pearl or nacre powder is added, and the suspension is obtained after stirring, dispersion and ultrasonic defoaming; the mass fraction of the pearl powder or nacre powder in the suspension is 45%.
S3, superfine wet grinding; grinding until the average diameter of the particles in the suspension is less than 800 nm.
And S4, carrying out enzymolysis and centrifugation.
Wherein the nanometer suspension in S3 is heated to 35 + -5 deg.C, added with neutral protease (CAS: 9068-59-1) 0.1% of total weight of Margarita powder or Concha Margaritifera powder, stirred for enzymolysis for 4h, inactivated, centrifuged, and supernatant to obtain Margarita extract or Concha Margaritifera extract.
Example 2
A composition containing pearl extract and mother-of-pearl extract comprises the following components by weight: 15% of pearl extract, 1% of mother-of-pearl extract, 50% of alcohol substance and the balance of water to 100% of the total amount.
The alcohol substance is a combination of phytosterol (CAS: 85681-87-4) and glycerol (CAS: 56-81-5), and the mass ratio is 0.6:1;
the preparation method of the pearl extract and the mother-of-pearl extract comprises the following steps:
s1, screening pearls or nacres;
s2, grinding and dispersing to prepare a suspension of pearl powder or nacre powder;
wherein, the particle diameter of the ground pearl or nacre powder is less than 200 meshes, the dispersant is sodium hexametaphosphate, the dosage of which is 5 percent of the mass of the pearl powder or nacre powder, the sodium hexametaphosphate (CAS: 10124-56-8) is firstly dissolved in water, then the ground pearl or nacre powder is added, and the suspension is obtained after stirring, dispersion and ultrasonic defoaming; the mass fraction of the pearl powder or nacre powder in the suspension is 30%.
S3, superfine wet grinding;
grinding until the average diameter of the particles in the suspension is less than 800 nm.
And S4, carrying out enzymolysis and centrifugation.
Wherein the nanometer suspension in S3 is heated to 50 + -5 deg.C, added with neutral protease (CAS: 9068-59-1) 0.12% of total weight of Margarita powder or Concha Margaritifera powder, and subjected to enzymolysis under stirring for 5 hr, and centrifugated to obtain supernatant, i.e. Margarita extract or Concha Margaritifera extract.
Example 3
A composition containing pearl extract and mother-of-pearl extract comprises the following components by weight: 1% of pearl extract, 10% of mother-of-pearl extract, 80% of alcohol substance and the balance of water to 100% of the total amount.
The alcohol substance is a combination of phytosterol (CAS: 85681-87-4) and glycerol (CAS: 56-81-5), and the mass ratio is 2.5:1; the preparation method of the pearl extract and the mother-of-pearl extract comprises the following steps:
s1, screening pearls or nacres;
s2, grinding and dispersing to prepare a suspension of pearl powder or nacre powder;
wherein, the particle diameter of the ground pearl or nacre powder is less than 200 meshes, the dispersant is sodium hexametaphosphate, the dosage of which is 15 percent of the mass of the pearl powder or nacre powder, the sodium hexametaphosphate (CAS: 10124-56-8) is firstly dissolved in water, then the ground pearl or nacre powder is added, and the suspension is obtained after stirring, dispersion and ultrasonic defoaming; the mass fraction of the pearl powder or nacre powder in the suspension is 60%.
S3, superfine wet grinding;
grinding until the average diameter of the particles in the suspension is less than 800 nm.
And S4, carrying out enzymolysis and centrifugation.
Wherein the nanometer suspension in S3 is heated to 30 + -5 deg.C, added with neutral protease (CAS: 9068-59-1) 0.08% of total weight of Margarita powder or Concha Margaritifera powder, and subjected to enzymolysis under stirring for 3 hr, and centrifugated to obtain supernatant, i.e. Margarita extract or Concha Margaritifera extract.
Comparative example 1
Consistent with example 1, the differences are: the alcohol substance is a combination of phytosterol and glycerol, and the mass ratio is 3:1.
comparative example 2
Consistent with example 1, the difference is: the alcohol substance is a combination of phytosterol and glycerol, and the mass ratio of the phytosterol to the glycerol is 0.4:1.
comparative example 3
Consistent with example 1, the differences are: the dispersing agent in the S2 adopts sodium hexametaphosphate, and the dosage of the sodium hexametaphosphate is 25 percent of the mass of the pearl powder or the nacre powder.
The performance test method comprises the following steps:
the compositions of examples and comparative examples were allowed to stand at 25 deg.C, 48 deg.C and-20 deg.C for 3 months, and were observed every 14 days, and after the compositions were returned to room temperature (23 + -2 deg.C), it was judged whether the compositions had undesirable phenomena such as discoloration, delamination, flocculation or thinning-thickening, and the test results are shown in Table 1.
And (3) performance test results:
TABLE 1
Claims (10)
1. A composition containing pearl extract and mother-of-pearl extract is characterized by comprising pearl extract, mother-of-pearl extract and solvent.
2. The composition of claim 1, further comprising an alcohol.
3. The composition containing pearl extract and nacre extract according to claim 2, wherein the composition comprises, by weight: 1-15% of pearl extract, 1-10% of mother-of-pearl extract, 50-95% of alcohol substance and the balance of solvent supplement to total amount of 100%.
4. The composition of claim 2, wherein said alcohols are cyclic compounds with at least one-OH group and at least 4 common C and linear alkanes with at least 2-OH groups and C2-C6.
5. The composition of claim 4, wherein the weight ratio of the cyclic compound with at least one-OH group and at least 4C atoms in common to the linear alkane with at least 2-OH groups and C2-C6 is (0.6-2.5): 1.
6. the composition of claim 5, wherein said alcohol comprises phytosterols.
7. The composition of claim 1, wherein said pearl extract and nacre extract are prepared by:
s1, screening pearls or nacres;
s2, grinding and dispersing to prepare a suspension of pearl powder or nacre powder;
s3, superfine wet grinding;
and S4, carrying out enzymolysis and centrifugation.
8. The composition of claim 7, wherein said milled particles of S2 are less than 200 mesh in size.
9. The composition of claim 7, wherein the dispersing agent used in the suspension of S2 is at least one of sodium lauryl sulfate, sodium hexametaphosphate, polyacrylamide, dimethicone, sodium silicate, and polyethylene glycol.
10. Use of a composition comprising a pearl extract and a nacre extract according to any one of claims 1 to 9, wherein said composition is used in cosmetics or skin care products having whitening, spot-removing, repairing, anti-wrinkle, and brightening effects.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211193339.9A CN115837002A (en) | 2022-09-28 | 2022-09-28 | Composition containing pearl extract and mother-of-pearl extract and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211193339.9A CN115837002A (en) | 2022-09-28 | 2022-09-28 | Composition containing pearl extract and mother-of-pearl extract and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115837002A true CN115837002A (en) | 2023-03-24 |
Family
ID=85574107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211193339.9A Pending CN115837002A (en) | 2022-09-28 | 2022-09-28 | Composition containing pearl extract and mother-of-pearl extract and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115837002A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116585255A (en) * | 2023-04-24 | 2023-08-15 | 广州领衔生物科技有限公司 | Composition containing lactobacillus fermentation product and preparation method and application thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101240460A (en) * | 2008-03-17 | 2008-08-13 | 陈心华 | Ultra-fine pearl slurry for regeneration cellulose fiber mixing and producing method thereof |
| CN101695505A (en) * | 2009-10-19 | 2010-04-21 | 海南京润珍珠生物技术股份有限公司 | Preparation method of enzyme hydrolysis pearl powder |
| CN101697956A (en) * | 2009-10-19 | 2010-04-28 | 海南京润珍珠生物技术股份有限公司 | Anti-acne jelly with pearl hydrolyzate liposome |
| CN102335200A (en) * | 2011-09-28 | 2012-02-01 | 北海阳光药业有限公司 | Preparation method of mother-of-pearl inner-layer powder spray |
| CN105434301A (en) * | 2015-03-17 | 2016-03-30 | 欧诗漫生物股份有限公司 | Whitening essence containing pearl extract |
-
2022
- 2022-09-28 CN CN202211193339.9A patent/CN115837002A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101240460A (en) * | 2008-03-17 | 2008-08-13 | 陈心华 | Ultra-fine pearl slurry for regeneration cellulose fiber mixing and producing method thereof |
| CN101695505A (en) * | 2009-10-19 | 2010-04-21 | 海南京润珍珠生物技术股份有限公司 | Preparation method of enzyme hydrolysis pearl powder |
| CN101697956A (en) * | 2009-10-19 | 2010-04-28 | 海南京润珍珠生物技术股份有限公司 | Anti-acne jelly with pearl hydrolyzate liposome |
| CN102335200A (en) * | 2011-09-28 | 2012-02-01 | 北海阳光药业有限公司 | Preparation method of mother-of-pearl inner-layer powder spray |
| CN105434301A (en) * | 2015-03-17 | 2016-03-30 | 欧诗漫生物股份有限公司 | Whitening essence containing pearl extract |
Non-Patent Citations (1)
| Title |
|---|
| 汕头市绅逸生物科技有限公司: "苏小安妮活酵母养颜冻龄贵妃膏", pages 2, Retrieved from the Internet <URL:《https://hzpba.nmpa.gov.cn/gccx/chakan.html?prodId=932232469409693696&gb=G》> * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116585255A (en) * | 2023-04-24 | 2023-08-15 | 广州领衔生物科技有限公司 | Composition containing lactobacillus fermentation product and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2010257247B2 (en) | Mild leave-on skin care compositions | |
| CN110051617B (en) | Sunscreen emulsion with high sun protection index and preparation method thereof | |
| KR101106344B1 (en) | Mineral ions in structured water | |
| CN107334726B (en) | Acne-removing composition and preparation method and application thereof | |
| KR20150005928A (en) | Exopolysaccharide for the treatment and/or care of the skin, mucous membranes and/or nails | |
| CN115837002A (en) | Composition containing pearl extract and mother-of-pearl extract and application thereof | |
| JP2009539950A (en) | Topical beauty composition containing wasabi | |
| CN113350204A (en) | Physical and chemical combined oil-controlling and soothing shaking toner and preparation method thereof | |
| CN110507551B (en) | Preparation method of permeation-promoting anti-wrinkle essence preparation containing acetyl hexapeptide-8 | |
| CN110755307A (en) | Salt lake black mud active mask and preparation method thereof | |
| JP3513872B2 (en) | External preparation for skin | |
| CN103876948A (en) | Rana japonica oil collagen peptide moisturizing sun cream and preparation process thereof | |
| EP2408319B1 (en) | A process for obtaining insoluble substances from genipap-extract precipitates, substances from genipap-extract precipitates and their uses | |
| JPH03200721A (en) | Composite-type ultraviolet absorber | |
| CN102697696B (en) | Pearl powder sun cream | |
| JPH10182347A (en) | Skin cosmetic | |
| JP2000355515A (en) | Cosmetic composition | |
| CN1286447C (en) | Skin care combination containing liposome of compound fat | |
| CN114557949B (en) | Pickering emulsion composition containing pearl powder and preparation method thereof | |
| CN113081864B (en) | Method for producing cosmetic composition containing micelle complex formed by natural moisturizing factor, and cosmetic composition | |
| CN111632013B (en) | Soothing and repairing composition, soothing and repairing powder preparation and preparation method thereof | |
| JP2022013828A (en) | Surface-treated inorganic particles, manufacturing method of the same, dispersion solution of the same, and cosmetic composition including the same | |
| JPH07101821A (en) | Antibacterial cosmetic | |
| KR100539111B1 (en) | Cosmetic composition comprising paramagnetic gold nanoparticles | |
| WO2008041608A1 (en) | Skin external preparation and hair-care product |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |