CN115836129A - 用于治疗tdp-43蛋白病的组合物和方法 - Google Patents

用于治疗tdp-43蛋白病的组合物和方法 Download PDF

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CN115836129A
CN115836129A CN202180045995.1A CN202180045995A CN115836129A CN 115836129 A CN115836129 A CN 115836129A CN 202180045995 A CN202180045995 A CN 202180045995A CN 115836129 A CN115836129 A CN 115836129A
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菱谷彰德
圭三古屋
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Sola Biosciences Ltd
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2227/10—Mammal
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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CN202180045995.1A 2020-04-28 2021-04-27 用于治疗tdp-43蛋白病的组合物和方法 Pending CN115836129A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063016707P 2020-04-28 2020-04-28
US63/016707 2020-04-28
US202063035437P 2020-06-05 2020-06-05
US63/035437 2020-06-05
PCT/US2021/029289 WO2021222168A2 (en) 2020-04-28 2021-04-27 Compositions and methods for the treatment of tdp-43 proteinopathies

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CN115836129A true CN115836129A (zh) 2023-03-21

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US (1) US20240327477A1 (https=)
EP (1) EP4143215A2 (https=)
JP (1) JP2023524414A (https=)
KR (1) KR20230025659A (https=)
CN (1) CN115836129A (https=)
AU (1) AU2021265088A1 (https=)
BR (1) BR112022021604A2 (https=)
MX (1) MX2022013288A (https=)
TW (1) TW202206446A (https=)
WO (1) WO2021222168A2 (https=)

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JP2023548632A (ja) * 2020-10-26 2023-11-17 ソラ・バイオサイエンシズ・エルエルシー アルツハイマー病の処置のための組成物および方法
WO2023147473A2 (en) * 2022-01-27 2023-08-03 The Trustees Of Columbia University In The City Of New York Systems, methods, and compositions for rescuing protein misfolding
WO2023185017A1 (zh) * 2022-03-30 2023-10-05 呈诺再生医学科技(珠海横琴新区)有限公司 经修饰的rnf112或包含其的外泌体递送系统
CN114874332B (zh) * 2022-03-30 2023-01-10 呈诺再生医学科技(珠海横琴新区)有限公司 经修饰的rnf112作为治疗als药物的应用
AR133834A1 (es) * 2023-09-15 2025-11-05 Prothena Biosciences Ltd Agentes de penetración célular y sus usos
WO2025264861A1 (en) * 2024-06-18 2025-12-26 Yale University Compositions of bi-functional alpha helical peptides and methods thereof for treating tdp-43 proteinopathies

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WO2014089375A1 (en) * 2012-12-05 2014-06-12 Boston Strategics Corporation Protein expression enhancing polypeptides
WO2016086320A1 (en) * 2014-12-05 2016-06-09 UNIVERSITé LAVAL Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases
CN106163540A (zh) * 2013-09-13 2016-11-23 安达卢西亚进步与健康公共基金会 用于治疗蛋白病或构象病的聚集蛋白和分子伴侣的组合

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JP2023524414A (ja) 2023-06-12
KR20230025659A (ko) 2023-02-22
EP4143215A2 (en) 2023-03-08
AU2021265088A1 (en) 2022-11-03
WO2021222168A3 (en) 2021-12-30
MX2022013288A (es) 2023-02-22
BR112022021604A2 (pt) 2022-12-06
TW202206446A (zh) 2022-02-16
US20240327477A1 (en) 2024-10-03
WO2021222168A2 (en) 2021-11-04

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