CN115812726A

CN115812726A - Insecticidal composition containing fluxapyroxad

Info

Publication number: CN115812726A
Application number: CN202211575655.2A
Authority: CN
Inventors: 周大伟; 郑敬敏; 刘欢
Original assignee: Agricultural Core Crop Technology Co ltd
Current assignee: Agricultural Core Crop Technology Co ltd
Priority date: 2022-12-09
Filing date: 2022-12-09
Publication date: 2023-03-21
Anticipated expiration: 2042-12-09
Also published as: CN115812726B

Abstract

The invention provides a pesticidal composition containing fluxapyroxad, wherein the effective active ingredients in the composition are fluxapyroxad and nereistoxin pesticides, wherein the mass ratio of the fluxapyroxad to the nereistoxin pesticides is 30-1; the weight percentage content of the fluxapyroxad and the nereistoxin insecticide in the pesticide composition is 0.5-90%, and the dosage form of the pesticide composition is wettable powder, water dispersible granules, aqueous emulsion, microemulsion, suspending agent, dispersible oil suspending agent, suspoemulsion, soluble powder and the like. The insecticidal composition has a certain synergistic effect on agricultural pests, can improve the control effect, reduce the cost, effectively delay the generation of drug resistance of the pests and protect the environment.

Description

Insecticidal composition containing fluxapyroxad

Technical Field

The invention belongs to the technical field of pesticide compounding, and particularly relates to an insecticidal composition containing fluxapyroxad.

Background

Fluxaflutole amide, common english name: fluxamide is an isoxazole pesticide developed by Nissan chemical corporation, has an action mechanism of gamma-aminobutyric acid (GABA) gated chloride channel allosteric modulator, is mainly used for crops such as vegetables, fruit trees, cotton, tea trees and the like, and is used for preventing and treating pests and harmful mites such as thrips, whiteflies, leaf miners, beetles, red spiders, rust mites and the like.

Nereistoxin (nereistoxin) insecticide is a novel organic synthetic bionic insecticide developed in the 60 th century and developed in the rising period of 20 th century, belongs to a nicotinic acetylcholine receptor inhibitor, and acts on synaptosomes of insect nervous systems to enable insect nerve impulses to be blocked at synapse positions and finally die. The nereistoxin pesticide has the characteristics of broad spectrum, high efficiency, low toxicity and the like, has various action modes, has strong stomach toxicity, contact killing, antifeedant and systemic actions, has better control effects on various pests of lepidoptera, coleopteran and dipteran, and is widely used for controlling the pests on various crops such as rice, vegetables, fruit trees and the like. Nereistoxin insecticides mainly comprise cartap, monosultap, thiocyclam and the like.

In the practice process of agricultural production, the use of pesticides brings great benefits to agricultural production and also brings certain problems, wherein the generation of drug resistance of pests is one of the main problems. In a specific chemical control process, because a certain preparation is singly used for a long time, pests are easy to generate drug resistance of different degrees, the dosage of pesticides is increased, the environment is polluted, and the cost is increased.

Disclosure of Invention

The invention aims to provide a pesticide composition containing fluxapyroxad, which is used for controlling agricultural pests.

In order to achieve the purpose, the technical scheme of the invention is as follows:

the insecticidal composition containing the fluxapyroxad is characterized by comprising two active ingredients, wherein the first active ingredient is the fluxapyroxad, and the second active ingredient is one of nereistoxin insecticide monosultap, thiocyclam and cartap;

the weight ratio of the first active ingredient to the second active ingredient is 1; the sum of the contents of the components is 0.5 to 90 percent of the total weight of the composition.

The insecticidal composition containing the fluxapyroxad can be prepared into various agriculturally allowable dosage forms according to the method known by the technical field.

The pesticide composition of the invention can be prepared into various application formulations, and comprises various acceptable auxiliary components which are allowed to be used in different pesticide formulations besides effective active components.

The auxiliary components include, but are not limited to, emulsifiers, dispersants, wetting agents, solvents, antifreezing agents, antifoaming agents, thickeners, disintegrants, synergists, preservatives, fillers and the like, which are commonly used or allowed to be used in pesticide preparations, and are not particularly limited, and specific components and dosage are determined by experiments according to formulation requirements.

The emulsifier can be various emulsifiers known in the field of pesticide formulation, and can be one or more of phenethyl phenol polyoxyethylene polyoxypropylene ether, alkylaryl polyoxyethylene polyoxypropylene ether, fatty acid polyoxyethylene ether, fatty alcohol polyoxyethylene ether, glyceryl laurate polyoxyethylene ether, styryl phenol polyoxyethylene ether, castor oil polyoxyethylene ether, alkylphenol polyoxypropylene polyoxyethylene ether, styryl phenyl polyoxyethylene ether, alkylphenol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, fatty alcohol polyoxyethylene ether sulfonate, alkylphenol polyoxyethylene formaldehyde condensate, calcium dodecyl sulfonate, alkylphenol polyoxyethylene ether succinic acid monoester sulfonate, alkylphenol polyoxyethylene phosphate and alkylphenol polyoxyethylene ether sulfonated succinate.

The dispersant may be any of various dispersants known in the field of pesticide formulations, and may be one or more of alkylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether sulfate, phenethylphenol polyoxyethylene ether phosphate, polyoxyethylene polyoxypropylene ether block copolymer, sodium lignosulfonate, sodium methylenedinaphthalene sulfonate (dispersant NNO), calcium lignosulfonate, polycarboxylate, sodium methylenedinaphthalene sulfonate, sodium methylenebismethylnaphthalenesulfonate, polyvinylpyrrolidone, alkylamido taurate, sodium alkylnaphthalenesulfonate polycondensate, sodium methylenebisnaphthalenesulfonate formaldehyde condensate.

The wetting agent can be various wetting agents known in the field of pesticide preparations, and can be one or more of alkyl naphthalene sodium sulfonate, lauryl sodium sulfate, secondary alkyl sodium sulfate, sodium dodecyl benzene sulfonate, fatty alcohol polyglycol ether sulfate, fatty alcohol polyoxyethylene ether, nonylphenol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, alkyl naphthalene formaldehyde condensate, alkyl naphthalene sulfonate and other wetting agents.

The solvent may be any of various solvents known in the field of pesticide preparations, and the solvent may be one or more of water, methanol, ethanol, N-methylpyrrolidone, N-dimethylformamide, N-dimethylacetamide, tetrahydrofurfuryl alcohol, toluene, xylene, dimethyl sulfoxide, tetrahydrofuran, cyclohexanone, N-butanol, isopropanol, mineral spirits No. 100, no. 150, no. 180, no. 200.

The antifreezing agent can be various antifreezing agents known in the field of pesticide preparations, and the antifreezing agent can be one or more of ethylene glycol, propylene glycol, glycerol, diethylene glycol, urea and inorganic salts.

The defoaming agent can be various defoaming agents known in the field of pesticide preparations, and the defoaming agent can be one or more of silicone compounds, epoxidized soybean oil, emulsified silicone oil and fatty alcohol.

The thickening agent can be various thickening agents known in the field of pesticide preparation, and the thickening agent can be one or more of xanthan gum, polyvinyl alcohol, sodium alginate, gum arabic and magnesium aluminum silicate.

The disintegrant can be various disintegrants known in the field of pesticide preparations, and can be one or more of ammonium sulfate, sodium carboxymethyl starch, urea, low-substituted hydroxypropyl cellulose, croscarmellose sodium, crospovidone, sodium alginate, sodium bicarbonate and sodium chloride.

The carrier can be various carriers known in the field of pesticide preparations, and can be one or more of glucose, white carbon black, kaolin, diatomite, light calcium carbonate, heavy calcium carbonate, attapulgite, soluble starch, urea, maltose, sucrose, citric acid, potassium carbonate, sodium carbonate and anhydrous sodium sulfate.

The preservative can be various preservatives known in the field of pesticide preparations, and can be one or more of cason, sodium benzoate, benzoic acid, potassium sorbate and formaldehyde.

The deionized water is industrial deionized water.

The invention achieves the technical effects that:

1. the two active compounds are compounded, and have obvious synergistic effect on various pests under a certain mixing proportion;

2. the two compounds have different action mechanisms, can effectively delay the generation of drug resistance of pests and prolong the service life of the pesticide;

3. the dosage of the medicament is reduced, the cost is reduced, and the environment is protected.

Detailed Description

The combined action of the fluxapyroxad, cartap, monosultap and thiocyclam on various pests is illustrated by indoor toxicity measurement.

1. Combined action determination of mixing of fluxaflutole and cartap on beet noctuid

Test methods reference section 14 of "indoor bioassay test criteria for pesticides: leaf dipping method. Firstly, preparing the original medicinal organic solvent into 5 liquid medicines with series concentrations for standby, preparing cabbage leaves into leaf sections with the same size, soaking the leaf sections into the liquid medicines for 10s, taking out the leaf sections, airing the leaf sections, placing the leaf sections into culture dishes, inoculating 10 larvae with the same growth in each culture dish, and then placing the culture dishes for normal culture under the conditions of 24-29 ℃ and 82% humidity. Repeat every 4 times, and set the clear water treatment as the blank control. And (4) inspecting the death condition of the test insects after 48h, investigating the death condition by taking the immobility of the test insects as a standard, recording the total number of the insects and the number of the dead insects, and calculating the death rate.

Mortality (%) = number of dead insects/total number of treated insects × 100

Corrected mortality (%) = (treatment mortality-blank)/(1-blank mortality) × 100

Control mortality <5%, no correction required; the control mortality rate is between 5% and 20%, and needs to be corrected; control mortality was >20%, and the test was redone.

The combined action of the composition on beet armyworms is evaluated by adopting a co-toxicity coefficient method, wherein the co-toxicity coefficient is more than 120 and is expressed as a synergistic action, the co-toxicity coefficient is between 80 and 120 and is expressed as an additive action, and the co-toxicity coefficient is less than 80 and is expressed as an antagonistic action.

TABLE 1 toxicity test results of the mixture of fluxaflutole and cartap against beet armyworm

2、

3. Determination of combined action of mixture of fluxapyroxad and monosultap on rice leaf roller

The test method is the leaf dipping method, and the same as the embodiment 1.

TABLE 2 toxicity test results of the mixture of fluxaflutole and monosultap for cnaphalocrocis medinalis

3. Combined action determination of trialeurodes vaporariorum by mixing fluxaflutole and thiocyclam

The test method refers to spraying method of pesticide part 9 of indoor bioassay standard of pesticides. Firstly, preparing the original medicinal organic solvent into medicinal liquid with 5 series concentrations for later use, adjusting the spraying pressure of a potter spraying tower according to the standard, firstly cleaning a spraying head with acetone for 2 times, and then cleaning with distilled water for 2 times for later use. Selecting 10 whiteflies in consistent physiological states by using a writing brush, putting the whiteflies into a culture dish, then putting the culture dish into a bottom plate of a potter spraying tower for spraying, wherein the spraying liquid is ml, taking out the test insects after the liquid medicine is settled for 1min, and under the normal condition, namely, the temperature is 25 ℃, the humidity is 70%, and the illumination period is L: d = (16. Repeat every 4 times, and set the clear water treatment as the blank control. And (4) checking the number of dead insects after 48 hours, recording the total number of the dead insects and the number of the dead insects, and poking the insects by using a writing brush to treat the dead insects as if the tested insects are completely immobilized.

And evaluating the joint action of the mixture of the fluxapyroxad and the thiocyclam on the trialeurodes vaporariorum by adopting a co-toxicity coefficient method, wherein the calculation method and the evaluation method are the same as those of the specific embodiment 1.

TABLE 3 toxicity test results of Fluroxazole amide and thiocyclam mixture against Bemisia alba

4. Joint action determination of mixture of fluxapyroxad and cartap for cotton bollworm

The test method is the leaf dipping method, and the same as the embodiment 1.

TABLE 4 toxicity test results of the mixture of fluxaflutole and cartap against cotton bollworm

5. Combined action determination of mixture of fluxapyroxad and monosultap on rice stem borer

The test method is the leaf dipping method, and the same as the embodiment 1.

TABLE 5 toxicity test results of the mixture of fluxapyroxad and monosultap on rice stem borer

6. Combined action determination of mixed pair of fluxapyroxad and cartap for plutella xylostella

The test method is the leaf dipping method, and the same as the embodiment 1.

TABLE 6 toxicity test results of the mixture of fluxaflutole and cartap against plutella xylostella

7. Determination of combined action of mixture of fluxapyroxad and thiocyclam on rice planthopper

The test method refers to "indoor bioassay of agricultural chemicals standard pesticide part 11 rice stem soaking method". Firstly, preparing the original medicinal organic solvent into medicinal liquids with 5 series concentrations, then selecting rice plants from the tillering stage to the initial stage of the booting, cutting the rice plants into rice stems with roots of 15cm long, and combining three plants into a group for later use. Firstly, the rice stem is treated by a chemical agent, the prepared rice stem is soaked in the prepared chemical liquid for 30s, and then the rice stem is taken out and dried. Wet absorbent cotton is used for wrapping roots to preserve moisture, then a preservative film is used for preserving moisture, and each group is placed into a test tube. Then inoculating the larvae, sucking the three-instar larvae with consistent growth by using a trematode device, putting the larvae into test tubes, standing the test tubes when the larvae all climb onto the rice stems or the walls of the test tubes, removing the damaged individuals, and supplementing 15 larvae. Finally, the pipe orifice is wrapped by gauze, and the pipe orifice is placed under the normal conditions that the temperature is 25 ℃, the humidity is 70%, and the illumination period is L: d = (16. And (4) checking the number of dead insects after 48h, recording the total number of the dead insects and the number of the dead insects, and poking the insect bodies by using a writing brush to judge that the test insects are dead completely.

And evaluating the joint action of the mixture of the fluxapyroxad and the thiocyclam on the rice planthopper by adopting a co-toxicity coefficient method, wherein the calculation method and the evaluation method are the same as those of the specific embodiment 1.

TABLE 7 toxicity test results of the mixture of fluxaflutole and thiocyclam against rice planthopper

The present invention is further illustrated by the following formulation examples.

Formulation example 1

5% of fluxapyroxad, 75% of cartap, 4% of alkylphenol polyoxyethylene ether phosphate, 3% of alkylphenol polyoxyethylene ether sodium sulfonate, 2% of alkyl naphthalene sodium sulfonate, 4% of white carbon black and clay, wherein the weight percentage is 100%. The raw materials are mixed and pulverized by air flow to prepare 80 percent of fluxaflutole cartap wettable powder.

Formulation example 2

8% of fluxapyroxad, 80% of cartap, 2% of sodium lignosulfonate, 2% of fatty alcohol-polyoxyethylene ether phosphate, 1.5% of sodium lignosulfonate, 0.5% of sodium alkyl naphthalene sulfonate, 2% of talcum powder and 100% of kaolin by weight. The raw materials are mixed and pulverized by air flow to prepare the 88 percent fluxaflutole cartap wettable powder.

Formulation example 3

5% of fluxapyroxad, 75% of monosultap, GY-D06, 3% of sodium lignosulfonate, 2% of sodium dibutyl naphthalene sulfonate, 3% of sodium dodecyl sulfate and the balance of light calcium to 100% by weight. The raw materials are prepared into 80 percent of water dispersible granule of fluxapyroxad-monosultap by the conventional method of preparing water dispersible granule, namely mixing, ultramicro airflow crushing, mixing and granulating.

Formulation example 4

5% of fluxapyroxad, 50% of thiocyclam, 5% of sodium lignosulfonate, 3.5% of fatty alcohol-polyoxyethylene ether phosphate, 3% of sodium lignosulfonate, 2.5% of sodium alkyl naphthalene sulfonate, 3% of talcum powder and 100% of kaolin by weight. The above raw materials are mixed and pulverized by air flow to prepare 55% of fluxaflutole amide and thiocyclam wettable powder.

Biological example 1: and (3) field pesticide effect tests for preventing and controlling beet armyworm.

In 2022, the inventor carries out field efficacy tests of the preparation example 1, the preparation example 2, the preparation example 3, the preparation example 4 and a control medicament for preventing and controlling beet armyworms, and verifies the control effect and the safety of the medicament on the beet armyworms.

The test crop is cabbage, and the control object is beet armyworm. 20m per cell ² Repeating the treatment for 4 times, randomly arranging the cell groups, applying 1 time for the cabbage rosette period, and spraying at 510L/hm ² The application method adopts a conventional spraying method, the stem leaves of the cabbage are sprayed conventionally, and the blank control is treated by clear water. Sampling 5 points in each cell before spraying, selecting 2 cabbage tags in each point, and investigating population base number. And (5) investigating the residual worm quantity on the fixed cabbage at 1d, 3d and 7d after application, and calculating the worm reduction rate and the correction control effect.

The efficacy calculation method comprises the following steps:

oral cavity decline rate (%) = (number of insects before application-number of insects after application)/number of insects before application × 100

Control effect (%) = (control area population reduction rate-treatment area population reduction rate)/(100-control area population reduction rate) × 100

TABLE 8 field test results for beet armyworm

The field efficacy test result shows that the control effect of the preparation example 1, the preparation example 2, the preparation example 3 and the preparation example 4 on the beet armyworms reaches more than 85% 3 days after the application, the control effect of the compound preparation reaches more than 90% 14 days after the application, the quick action is good, the lasting period is long, and the control effect of the compound preparation is higher than that of a single control agent, which indicates that the compound preparation has obvious control effect on the beet armyworms.

And (4) observing during the test period, wherein all the test agents are safe to cabbage growth and do not have the phenomenon of phytotoxicity.

Biological example 2: the field pesticide effect test for preventing and controlling the rice stem borers.

The inventor conducts field pesticide effect tests of the preparation example 1, the preparation example 2, the preparation example 3 and the preparation example 4 in 2022 to verify the control effect of the pesticide on the rice stem borers and the safety of the pesticide on the rice.

The test crop is rice, and the control object is rice stem borer. 20m per cell ² Each 4 repetitions of treatment, the cell groups were randomly arranged. The pesticide application time is the stage of the rice stem borers 2-3 instar larvae in full growth, the pesticide application is carried out once, the conventional spraying method is adopted, the control effect is investigated 3d and 7d after the pesticide application, 5 points are investigated along the diagonal line in each cell, 20 clusters are investigated in each cell, 100 clusters of rice are investigated in total, the number of investigated rice plants and the number of stem borers are recorded, the number of live insects is recorded by stripping, and the insecticidal effect is calculated.

The drug effect calculation method comprises the following steps:

the insect prevention effect (%) = (the number of living insects in the control area-the number of living insects in the treatment area)/the number of living insects in the control area is multiplied by 100;

a dead center (white ear) rate (%) = the number of dead centers (white ears)/the number of total plants (ears) to be investigated × 100;

TABLE 9 test results on the field pesticide effect of rice-stem borer

The field efficacy test results show that the control effect of the preparation examples 1, 2, 3 and 4 on the rice stem borers reaches over 88% 7 days after the pesticide application, the control effect reaches over 86% 14 days after the pesticide application, the quick-acting property and the lasting effect are good, the control effect of the compound preparation is higher than that of a single control agent, and the withering rate of the compound preparation is lower than that of the control agent and blank, which indicates that the compound preparation has an obvious control effect on the rice stem borers.

And (4) observing during the test period, wherein all the test agents are safe to the growth of rice and have no phytotoxicity phenomenon.

In conclusion, the invention has great application value in specific agricultural production practice.

Claims

1. An insecticidal composition containing fluxapyroxad, characterized in that: the insecticidal composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is fluxapyroxamide, the active ingredient B is a nereistoxin insecticide, and the weight ratio of the active ingredient A to the active ingredient B is 30.

2. The insecticidal composition containing fluxapyroxad according to claim 1, characterized in that: the weight ratio of the active ingredient A to the active ingredient B is 20.

3. The insecticidal composition containing fluxapyroxad according to claim 1 or 2, characterized in that: the nereistoxin pesticides are as follows: cartap, monosultap, and thiocyclam.

4. The insecticidal composition containing fluxapyroxad according to claim 1 or 2, characterized in that: the nereistoxin pesticide is cartap.

5. The insecticidal composition containing fluxapyroxad according to claim 1, characterized in that: the sum of the weight of the active ingredient A and the active ingredient B in the insecticidal composition accounts for 0.5 to 90 percent of the total weight of the insecticidal composition, and the balance is agriculturally acceptable carriers and auxiliaries.

6. The insecticidal composition containing fluxapyroxad according to claim 5, characterized in that: the dosage form prepared from the insecticidal composition is wettable powder, water dispersible granules, aqueous emulsion, microemulsion, suspending agent, dispersible oil suspending agent, suspoemulsion and soluble powder.

7. The use of a fluorochemical oxazole amide insecticidal composition according to claim 1 for controlling agricultural pests.

8. Use according to claim 7, characterized in that: the agricultural pests are lepidoptera pests and homoptera pests.

9. Use according to claim 8, characterized in that: the lepidoptera pests are as follows: beet armyworm, rice leaf roller, cotton bollworm, rice stem borer, diamond back moth, homopteran pest is rice planthopper.