CN115768895A - 用于治疗冠状病毒科感染的适体 - Google Patents

用于治疗冠状病毒科感染的适体 Download PDF

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Publication number
CN115768895A
CN115768895A CN202180041090.7A CN202180041090A CN115768895A CN 115768895 A CN115768895 A CN 115768895A CN 202180041090 A CN202180041090 A CN 202180041090A CN 115768895 A CN115768895 A CN 115768895A
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CN
China
Prior art keywords
aptamer
receptor
seq
cov
leu
Prior art date
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CN202180041090.7A
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English (en)
Chinese (zh)
Inventor
安妮凯萨琳·哈伯兰
J·穆勒
格尔德·瓦卢卡特
P·戈特尔
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Berlin Cures Holding AG
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Berlin Cures Holding AG
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Publication date
Application filed by Berlin Cures Holding AG filed Critical Berlin Cures Holding AG
Priority claimed from PCT/EP2021/059328 external-priority patent/WO2021205012A1/en
Publication of CN115768895A publication Critical patent/CN115768895A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/16—Aptamers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
CN202180041090.7A 2020-04-09 2021-04-09 用于治疗冠状病毒科感染的适体 Pending CN115768895A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP20168929 2020-04-09
EP20168929.6 2020-04-09
EP20176023 2020-05-22
EP20176023.8 2020-05-22
EP20180781.5 2020-06-18
EP20180781 2020-06-18
EP20204036 2020-10-27
EP20204036.6 2020-10-27
PCT/EP2021/059328 WO2021205012A1 (en) 2020-04-09 2021-04-09 Aptamers for use in the treatment of coronaviridae infections

Publications (1)

Publication Number Publication Date
CN115768895A true CN115768895A (zh) 2023-03-07

Family

ID=84191962

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180041090.7A Pending CN115768895A (zh) 2020-04-09 2021-04-09 用于治疗冠状病毒科感染的适体

Country Status (11)

Country Link
US (1) US12606828B2 (https=)
EP (1) EP4133083A1 (https=)
JP (1) JP2023521361A (https=)
KR (1) KR20220166337A (https=)
CN (1) CN115768895A (https=)
AU (1) AU2021252151A1 (https=)
BR (1) BR112022020439A2 (https=)
CA (1) CA3175067A1 (https=)
IL (1) IL297155A (https=)
MX (1) MX2022012618A (https=)
ZA (1) ZA202212179B (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230170931A (ko) * 2021-04-09 2023-12-19 베를린 큐어스 게엠베하 코로나바이러스 감염 치료에 사용하기 위한 압타머
KR102937192B1 (ko) * 2023-01-25 2026-03-17 주식회사 리젠시스랩 사스 코로나 바이러스 2 특이적 압타머 및 이의 용도
WO2025146959A1 (ko) * 2024-01-02 2025-07-10 충북대학교 산학협력단 ＳＡＲＳＣｏＶ２의 외피 단백질에 특이적으로 결합하는 ＤＮＡ 앱타머 및 이의 용도

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103608456A (zh) * 2011-03-07 2014-02-26 柏林夏瑞蒂医科大学 适体在自体免疫疾病的疗法和/或诊断中的用途
CN109983129A (zh) * 2016-11-23 2019-07-05 柏林制药股份有限公司 用于抑制和/或压制tlr9激活的适体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MEP0208A (xx) * 2005-08-26 2010-02-10 Archemix Corp Aptameri koji vezuje trombin sa visokim afininitetom

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103608456A (zh) * 2011-03-07 2014-02-26 柏林夏瑞蒂医科大学 适体在自体免疫疾病的疗法和/或诊断中的用途
CN109983129A (zh) * 2016-11-23 2019-07-05 柏林制药股份有限公司 用于抑制和/或压制tlr9激活的适体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KA TO SHUM等: "Differential Inhibitory Activities and Stabilisation of DNA Aptamers against the SARS Coronavirus Helicase", CHEMBIOCHEM, vol. 9, 21 November 2008 (2008-11-21), pages 3037 *
WANBO TAI等: "Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine", CELLULAR & MOLECULAR IMMUNOLOGY, vol. 17, 19 March 2020 (2020-03-19), pages 613 *
YANLING SONG等: "Discovery of Aptamers Targeting the Receptor-Binding Domain of the SARS-CoV‑2 Spike Glycoprotein", ANAL. CHEM., vol. 92, 18 June 2020 (2020-06-18), pages 9895 *

Also Published As

Publication number Publication date
US20230140490A1 (en) 2023-05-04
ZA202212179B (en) 2025-03-26
KR20220166337A (ko) 2022-12-16
CA3175067A1 (en) 2021-10-14
US12606828B2 (en) 2026-04-21
EP4133083A1 (en) 2023-02-15
IL297155A (en) 2022-12-01
JP2023521361A (ja) 2023-05-24
AU2021252151A1 (en) 2022-12-08
BR112022020439A2 (pt) 2022-11-29
MX2022012618A (es) 2022-11-07

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