CN115737746A - Medicine and food homologous spleen-invigorating decoction improved substance and preparation method thereof, medicine and food composition - Google Patents
Medicine and food homologous spleen-invigorating decoction improved substance and preparation method thereof, medicine and food composition Download PDFInfo
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Abstract
The invention discloses an improved medicine-food homologous spleen-invigorating soup and a preparation method thereof, a medicine and a food composition, and relates to the technical field of medicine-food homologous and herbal preparation. The medicine-food homologous Guipi decoction improved substance comprises, by weight, 1-5 parts of ginseng, 1-5 parts of arillus longan, 0.1-3 parts of Chinese angelica, 1-5 parts of polygonatum odoratum, 1-5 parts of mulberry, 1-7 parts of spina date seed, 1-5 parts of poria cocos, 1-5 parts of lily and 1-5 parts of liquorice. Ginseng and longan pulp are used as monarch drugs, so that the health-care wine has the effects of tonifying heart and spleen, nourishing blood and soothing nerves; the angelica and the mulberry are used as ministers to enhance the effects of benefiting qi and nourishing blood; poria, semen Ziziphi Spinosae and Bulbus Lilii can calm heart and tranquilize mind, have effects of regulating qi-flowing and invigorating spleen, make tonifying without stagnation, rhizoma Polygonati Odorati nourish yin and moisten dryness, make tonifying without dryness, act as adjuvant drugs together; licorice root, radix Glycyrrhizae can strengthen the middle-jiao and replenish qi, and harmonize the effects of the other drugs in the recipe. The invention improves the symptoms of deficiency of both heart and spleen by replenishing qi and enriching blood, strengthening spleen and nourishing heart, thereby having the function of improving qi-blood insomnia.
Description
Technical Field
The invention relates to the technical field of medicine and food homology and herbal preparation, and particularly relates to a medicine and food homology spleen-invigorating soup improved substance and a preparation method thereof, a medicine and a food composition.
Background
Generally, the sleep problems are mainly manifested as difficult falling asleep, dreaminess, easy waking, insomnia, unconsciousness after waking, poor sleep quality and the like, and all belong to the category of insufficient sleep, in China, the proportion of people affected by the sleep problems is more than 40%, and the problem of somnolence is only 7.62%, so that how to effectively relieve the ubiquitous problem of insufficient sleep of people becomes a long-standing technical problem in the field.
Because the sleep deficiency is a long-term symptom which is difficult to be cured radically and is very easy to repeat, long-time conditioning and treatment are needed, the existing treatment method for improving the sleep problem is mainly the sedative hypnotic of western medicines and the traditional Chinese medicine preparation, and the medicines have certain toxic and side effects and are not suitable for long-term daily eating.
In view of this, the invention is particularly proposed.
Disclosure of Invention
The invention aims to provide a medicine-food homologous spleen-invigorating decoction improved substance, a preparation method thereof, a medicine and a food composition.
The invention is realized by the following steps:
the invention provides a medicine-food homologous spleen-invigorating soup modifier which comprises, by weight, 1-5 parts of ginseng, 1-5 parts of arillus longan, 0.1-3 parts of Chinese angelica, 1-5 parts of polygonatum odoratum, 1-5 parts of mulberry, 1-7 parts of spina date seed, 1-5 parts of poria cocos, 1-5 parts of lily and 1-5 parts of liquorice.
In an optional embodiment, the beverage further comprises 2-10 parts of a flavoring agent, wherein the flavoring agent comprises at least one of erythritol, mogroside or white sugar.
In an optional embodiment, the beverage comprises 2-4 parts of ginseng, 2-3 parts of arillus longan, 0.5-1.5 parts of angelica, 1-3 parts of polygonatum odoratum, 1-3 parts of mulberry, 1-5 parts of red date, 3-4 parts of spina date seed, 1-3 parts of poria cocos, 1-3 parts of lily, 0.1-2 parts of dried orange peel, 2-3 parts of liquorice, 2-4 parts of erythritol and 3-6 parts of mogroside.
In an optional embodiment, the traditional Chinese medicine composition comprises 3 parts of ginseng, 2.5 parts of arillus longan, 1 part of angelica, 2 parts of polygonatum, 2 parts of mulberry, 2 parts of red date, 3.5 parts of spina date seed, 2 parts of poria cocos, 2 parts of lily, 0.5 part of dried orange peel, 2.5 parts of liquorice, 3 parts of erythritol and 5 parts of mogroside.
In a second aspect, the present invention provides a method for preparing an improved product of gui pi tang as one of the aforementioned embodiments, comprising mixing arillus longan, angelica sinensis, polygonatum odoratum, mulberry, red dates, spine date seeds, poria cocos, lily, dried orange peel and licorice in parts by weight, leaching, filtering, collecting the filtrate, adding ginseng extract, and mixing.
In an alternative embodiment, the leach liquor comprises either water, ethanol, preferably water.
Preferably, the leaching is carried out twice, and the medicinal materials are crushed and soaked for 20-40 min before the first leaching.
Preferably, the leaching time is 2-4 h each time, the temperature is 70-90 ℃, and the adding amount of the leaching liquor is 8-12 times of the total weight of the medicinal materials.
In an alternative embodiment, the method comprises performing a first concentration on the filtrate, wherein the solid content of the filtrate after the first concentration is 12-18%.
Preferably, the flavoring agent is added to the filtrate after the first concentration and mixed according to the parts by weight.
In an optional embodiment, the method further comprises performing second concentration on the filtrate, wherein the solid content in the filtrate after the second concentration is 50-70%.
Preferably, the ginseng extract is added to the filtrate after the second concentration and mixed according to the weight part.
In a third aspect, the invention provides a pharmaceutical composition, which includes the modified product of the medicine-food homologous spleen-invigorating decoction according to any one of the foregoing embodiments or the modified product of the medicine-food homologous spleen-invigorating decoction prepared by the preparation method according to any one of the foregoing embodiments.
In a fourth aspect, the present invention provides a food composition, including the modified product of the homology of medicine and food spleen-invigorating decoction according to any one of the foregoing embodiments or the modified product of the homology of medicine and food spleen-invigorating decoction prepared by the preparation method according to any one of the foregoing embodiments.
The invention has the following beneficial effects:
the invention provides a medicine-food homologous spleen-invigorating soup modifier and a preparation method thereof, a medicine and a food composition, wherein the medicine-food homologous spleen-invigorating soup modifier is prepared by adding ginseng, arillus longan, chinese angelica, radix polygonati officinalis, mulberry, spina date seed, poria cocos, lily and liquorice, wherein the ginseng and the arillus longan are monarch and have the effects of tonifying heart and spleen, nourishing blood and calming nerves; the angelica and the mulberry are used as ministers to enhance the effects of benefiting qi and nourishing blood; poria, semen Ziziphi Spinosae and Bulbus Lilii can calm heart and tranquilize mind, rhizoma Polygonati Odorati can nourish yin and moisten dryness, and is used as adjuvant drug; licorice root, radix Glycyrrhizae can strengthen the middle-jiao and replenish qi, and harmonize the effects of the other drugs in the recipe. The invention improves the symptoms of deficiency of both heart and spleen by replenishing qi and enriching blood, strengthening spleen and nourishing heart, thereby having the function of improving qi-blood insomnia.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
Fig. 1 is a distribution diagram of sleep improvement provided in test example 3 of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are conventional products which are not indicated by manufacturers and are commercially available.
The invention provides a medicine-food homologous spleen-invigorating soup modifier which comprises, by weight, 1-5 parts of ginseng, 1-5 parts of arillus longan, 0.1-3 parts of Chinese angelica, 1-5 parts of polygonatum odoratum, 1-5 parts of mulberry, 1-7 parts of spina date seed, 1-5 parts of poria cocos, 1-5 parts of lily and 1-5 parts of liquorice.
Ginseng is root of Panax ginseng C.A. Meyer belonging to Araliaceae family, contains various ginsenosides, has effects of invigorating primordial qi, restoring pulse, relieving depletion, invigorating spleen, benefiting lung, promoting fluid production, and tranquilizing mind, and can be used for treating asthenia, collapse, cold limbs, slight pulse, spleen deficiency, anorexia, lung deficiency, cough, asthma, body fluid consumption, and thirst.
The longan pulp has the efficacies of tonifying heart and spleen, nourishing blood and tranquillizing mind. It is commonly used for deficiency of qi and blood, palpitation, amnesia, insomnia, blood deficiency and sallow complexion.
The angelica has the effects of enriching and activating blood, regulating menstruation and relieving pain, and loosening bowel to relieve constipation. It is commonly used for blood deficiency and sallow complexion, vertigo and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, deficiency cold and abdominal pain, rheumatic arthralgia, traumatic injury, superficial infection, pyocutaneous disease, intestinal dryness and constipation.
Yuzhu has the functions of nourishing yin, moistening dryness, promoting the production of body fluid and quenching thirst. It is commonly used for yin deficiency of lung and stomach, cough due to dryness-heat, dry throat and thirst, and diabetes due to internal heat.
The mulberry has the effects of nourishing yin and blood, benefiting joints of the five internal organs, promoting blood circulation, calming soul and tranquilizing mind, reducing blood pressure and quenching thirst, improving hearing and vision, relieving alcoholism and the like.
The spina date seed has the effects of nourishing heart and liver, calming heart and tranquilizing mind, arresting sweating and promoting fluid production. It is commonly indicated for restlessness of deficiency type, insomnia, palpitation, dreaminess, asthenia, hyperhidrosis, body fluid consumption and thirst.
Poria has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.
The lily has the effects of nourishing yin, moistening lung, clearing away heart fire and soothing nerves. It is commonly indicated for dry cough due to yin deficiency, cough with blood, restlessness and pavor due to deficiency, insomnia and dreaminess, absentmindedness.
The liquorice has the effects of tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the medicines. It is indicated for spleen and stomach deficiency, lassitude and hypodynamia, palpitation and shortness of breath, cough with profuse sputum, spasm and pain of abdomen and limbs, carbuncle and sore, and to relieve toxicity and strong action of drugs.
The medicine and food homology spleen-invigorating decoction modifier provided by the invention is mainly used for treating heart-spleen qi-blood deficiency, can be used for effectively treating anxiety, is mainly used for treating amnesia, insomnia, depression and other diseases with heart-spleen qi-blood deficiency, and has a good improvement and regulation effect on heart-spleen qi-blood deficiency insomnia caused by excessive anxiety. The health care wine is prepared by adding ginseng, arillus longan, chinese angelica, radix polygonati officinalis, mulberry, spina date seed, poria cocos, lily and liquorice, wherein the ginseng and the arillus longan are monarch and have the effects of tonifying heart and spleen, nourishing blood and soothing nerves; the angelica and the mulberry are used as ministers to enhance the effects of benefiting qi and nourishing blood; poria, semen Ziziphi Spinosae and Bulbus Lilii can tranquilize mind, rhizoma Polygonati Odorati can nourish yin and moisten dryness to tonify without dryness, and are used as adjuvant drugs; licorice root, radix Glycyrrhizae can strengthen the middle-jiao and replenish qi, and harmonize the effects of the other drugs in the recipe. Through the mutual matching of the raw material medicines and the proportion, the medicine-food homologous spleen-invigorating decoction improved substance provided by the invention can improve the symptoms of deficiency of both heart and spleen from the aspects of replenishing qi and enriching blood, invigorating spleen and nourishing heart, thereby having the effect of improving qi-blood insomnia.
In an optional embodiment, the beverage further comprises 2-10 parts of a flavoring agent, wherein the flavoring agent comprises at least one of erythritol, mogroside or white sugar. In other embodiments, the flavoring agent may also be selected from other products having a sweet taste, such as sucrose, honey, etc., as is conventional and desired.
In an optional embodiment, the beverage comprises 2-4 parts of ginseng, 2-3 parts of arillus longan, 0.5-1.5 parts of angelica, 1-3 parts of polygonatum odoratum, 1-3 parts of mulberry, 1-5 parts of red date, 3-4 parts of spina date seed, 1-3 parts of poria cocos, 1-3 parts of lily, 0.1-2 parts of dried orange peel, 2-3 parts of liquorice, 2-4 parts of erythritol and 3-6 parts of mogroside.
The red date contains rich nutrient components such as protein, saccharides, organic acid, vitamin A, vitamin C, various trace calcium, amino acid and the like, and has the functions of tonifying middle-jiao and Qi, nourishing blood and soothing nerves and relieving drug property.
The pericarpium Citri Tangerinae has effects of regulating qi-flowing, invigorating spleen, eliminating dampness and eliminating phlegm. Can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm.
Wherein, the red date, the angelica and the mulberry are used as ministers to enhance the effects of benefiting qi and nourishing blood; poria cocos, spina date seed and lily can calm heart and calm nerves, dried orange peel has the effects of regulating qi and tonifying spleen, so that the tonifying is not stagnant, and polygonatum odoratum has the effects of nourishing yin and moistening dryness, so that the tonifying is not dry, and the dried orange peel and the spina date seed are used as adjuvant drugs together.
In an optional embodiment, in order to better improve the symptom of heart-spleen deficiency, the medicine-food homologous spleen-tonifying decoction modifier comprises 3 parts of ginseng, 2.5 parts of arillus longan, 1 part of angelica sinensis, 2 parts of polygonatum odoratum, 2 parts of mulberry, 2 parts of red date, 3.5 parts of spina date seed, 2 parts of poria cocos, 2 parts of lily, 0.5 part of dried orange peel, 2.5 parts of liquorice, 3 parts of erythritol and 5 parts of mogroside.
In a second aspect, the present invention provides a method for preparing an improved product of gui pi tang as one of the aforementioned embodiments, comprising mixing arillus longan, angelica sinensis, polygonatum odoratum, mulberry, red dates, spine date seeds, poria cocos, lily, dried orange peel and licorice in parts by weight, leaching, filtering, collecting the filtrate, adding ginseng extract, and mixing.
In alternative embodiments, the ginseng extract includes ginseng lyophilized powder or ginseng extract, and the like. It is understood that the ginseng extract may be obtained by itself or by purchase. In addition, ginseng radix can also be extracted together with arillus longan, radix Angelicae sinensis, rhizoma Polygonati Odorati, etc.
In an alternative embodiment, the leach solution comprises any one of water, ethanol, preferably water.
Preferably, the leaching is carried out twice, and the steps of crushing the medicinal materials and soaking for 20-40 min before the first leaching are carried out, so that the medicinal materials are fully wetted, and active substances are conveniently dissolved out.
Preferably, the leaching time is 2-4 h each time, the temperature is 70-90 ℃, and the adding amount of the leaching liquor is 8-12 times of the total weight of the medicinal materials.
In an alternative embodiment, the method comprises performing a first concentration of the filtrate, wherein the solid content of the filtrate after the first concentration is 12-18%.
Preferably, the flavoring agent is added to the filtrate after the first concentration and mixed according to the parts by weight.
In an optional embodiment, the filtrate is subjected to second concentration, the solid content of the filtrate after the second concentration is 50-70%, the filtrate is concentrated to the range, the water content of the modified product of the medicinal and edible spleen tonifying decoction is reduced, and the active ingredients are gradually dissolved out in the form of the solid, so that the edible and storage of the modified product of the medicinal and edible spleen tonifying decoction are facilitated.
Preferably, the ginseng extract is added to the filtrate after the second concentration and mixed according to the weight part.
In a third aspect, the invention provides a pharmaceutical composition, which includes the modified product of the medicine-food homologous spleen-invigorating decoction according to any one of the foregoing embodiments or the modified product of the medicine-food homologous spleen-invigorating decoction prepared by the preparation method according to any one of the foregoing embodiments.
In a fourth aspect, the present invention provides a food composition, including the modified product of the homology of medicine and food spleen-invigorating decoction according to any one of the foregoing embodiments or the modified product of the homology of medicine and food spleen-invigorating decoction prepared by the preparation method according to any one of the foregoing embodiments.
In alternative embodiments, the food composition comprises a beverage, particularly a plant beverage, a frozen tea block, a jelly, a soft candy, and the like, for human consumption.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The embodiment provides a medicine-food homologous spleen-invigorating soup modifier, which comprises 3 parts of ginseng, 2.5 parts of arillus longan, 1 part of angelica sinensis, 2 parts of polygonatum odoratum, 2 parts of mulberry, 2 parts of red date, 3.5 parts of spina date seed, 2 parts of poria cocos, 2 parts of lily, 0.5 part of dried orange peel, 2.5 parts of liquorice, 3 parts of erythritol and 5 parts of mogroside, and the preparation method comprises the following steps:
mixing raw medicinal materials of arillus longan, angelica sinensis, polygonatum odoratum, mulberry, red date, spina date seed, poria cocos, lily, dried orange peel and liquorice according to parts by weight, crushing, adding clear water with the weight being 10 times that of the raw medicinal materials, soaking for 30min, fully wetting the raw medicinal materials, and facilitating dissolution of active substances. Leaching at 80 deg.C for 3 hr, filtering to obtain filtrate, adding 10 times of clear water to the residue, leaching at 80 deg.C for 3 hr, filtering to obtain filtrate, and mixing the filtrates.
Heating and concentrating the filtrate for the first time, wherein the solid content in the filtrate after the first concentration is 15%, adding 3 parts of erythritol and 5 parts of mogroside into the filtrate after the first concentration, uniformly mixing, concentrating for the second time, wherein the solid content in the filtrate after the second concentration is 50-70%, adding 3 parts of freeze-dried ginseng powder into the filtrate after the second concentration, and uniformly mixing to obtain the medicine-food homologous spleen-invigorating decoction improved substance.
Example 2
The embodiment provides a medicine-food homologous spleen-invigorating decoction modifier, which comprises the following components: 3 parts of ginseng, 2.5 parts of longan aril, 1 part of angelica, 2 parts of polygonatum odoratum, 2 parts of mulberry, 3.5 parts of spina date seed, 2 parts of poria cocos, 2 parts of lily and 2.5 parts of liquorice, and the preparation method is the same as that of example 1.
Wherein the ginseng and the arillus longan are monarch drugs and have the effects of tonifying heart and spleen, nourishing blood and soothing nerves; the angelica and the mulberry are used as ministers to enrich the blood, nourish the heart and nourish yin; poria cocos, spina date seed and lily bulb are used as adjuvant drugs for tonifying spleen, calming heart and soothing nerves, and polygonatum odoratum is used for nourishing yin and moistening dryness to tonify but not dry; licorice root, radix Glycyrrhizae is used to tonify heart and spleen qi and to harmonize the other drugs in the recipe. Through the mutual matching of the raw material medicines and the proportion, the spleen-invigorating decoction provided by the invention can improve the symptoms of deficiency of both heart and spleen from the aspects of replenishing qi and enriching blood, invigorating spleen and nourishing heart, thereby having the effect of improving qi-blood insomnia.
Comparative example 1
The comparative example provides a medicine and food homologous spleen-invigorating decoction modifier, which comprises the following components: 1 part of ginseng, 1 part of arillus longan, 1 part of astragalus membranaceus, 1 part of bighead atractylodes rhizome, 1 part of spina date seed, 1 part of poria cocos, 5 parts of costustoot, 3 parts of honey-fried licorice root, 1 part of angelica sinensis and 1 part of polygala tenuifolia, and the preparation method is the same as in example 1.
Wherein, the astragalus and the arillus longan are monarch drugs and have the effects of tonifying heart and spleen, nourishing blood and tranquilization; the ginseng and the white atractylodes rhizome can tonify spleen and qi, help the astragalus root to tonify qi and generate blood, the angelica can enrich blood and nourish heart, and the arillus longan can nourish blood and calm nerves, and are ministerial drugs; spina date seed, polygala root and poria cocos calm heart and calms nerves, and elecampane regulates qi and invigorates spleen, which are used as adjuvant drugs; prepared licorice root, radix Glycyrrhizae Praeparata, as an adjuvant and guiding drug, has the effects of replenishing qi, strengthening the middle-jiao, and harmonizing the effects of the other drugs in the recipe.
Test example 1
The modified product of the medicinal and edible spleen-invigorating decoction prepared in example 1 was administered to mice via oral gavage, and the sleep of the mice was observed.
The mice are divided into a negative control group, a low-dose group, a medium-dose group and a high-dose group, wherein each group comprises 10 mice, the negative control group is orally gazed with 20ml/kg of physiological saline, the low-dose group is orally gazed with 1.7g/kg of modified drug-food homologous Chinese angelica spleen decoction, the medium-dose group is orally gazed with 3.3g/kg of modified drug-food homologous Chinese angelica spleen decoction, and the high-dose group is orally gazed with 10g/kg of modified drug-food homologous Chinese angelica spleen decoction.
1) When the treatment object was a normal mouse, the results shown in table 1 were obtained.
TABLE 1 influence of improved medicinal and edible decoction on sleep of normal mice
| Number of animals/animal | Number of sleeping animals/animal | P value | Time to sleep/s | P value | |
| Negative control group | 10 | 0 | / | 0 | / |
| Low dose group | 10 | 0 | ＞0.05 | 0 | ＞0.05 |
| Middle dose group | 10 | 0 | ＞0.05 | 0 | ＞0.05 |
| High dose group | 10 | 0 | ＞0.05 | 0 | ＞0.05 |
2) The method for obtaining the pentobarbital sodium induced mice by intraperitoneal injection of the pentobarbital sodium is adopted, the effects of the medicine-food homologous spleen-invigorating decoction ameliorant on the mice are observed by taking the pentobarbital sodium induced mice as a treatment object, and the results shown in the table 2 are obtained.
TABLE 2 sleep effects of modified Homepodial decoction on pentobarbital sodium induced mice
| Number of animals/animal | Time to sleep/s | P value | |
| Negative control group | 10 | 3056.5±67 | / |
| Low dose group | 10 | 3410±25 | ＜0.05 |
| Middle dose group | 10 | 3705±135 | ＜0.05 |
| High dose group | 10 | 4179±59 | ＜0.05 |
3) Mice with subthreshold dose of barbital sodium are obtained by adopting a method of intraperitoneal injection of barbital sodium, and the influence of the medicine-food homologous spleen-invigorating decoction ameliorant on the mice is observed by taking the mice as a treatment object, so that the results shown in table 3 are obtained.
TABLE 3 sleep impact of modified Homomedicinal and edible Guipi decoction on mice with subthreshold dose of barbital sodium
| Number of animals/animal | Incidence of sleep | P value | |
| Negative control group | 10 | 10％ | / |
| Low dose group | 10 | 15％ | ＞0.05 |
| Middle dose group | 10 | 40％ | ＞0.05 |
| High dose group | 10 | 70％ | ＞0.05 |
4) The method of intraperitoneal injection of barbital sodium is adopted to obtain barbital sodium induced mice, the barbital sodium induced mice are taken as treatment objects, the influence of the medicine-food homologous Guipi decoction ameliorant on the mice is observed, and the results shown in the table 4 are obtained.
TABLE 4 sleep effects of modified Homoku decoction on barbiturate sodium induced mice
| Number of animals/animal | Sleep latency/s | P value | |
| Negative control group | 10 | 2438±74 | / |
| Low dose group | 10 | 2291±105 | ＞0.05 |
| Middle dose group | 10 | 2020±19 | ＞0.05 |
| High dose group | 10 | 1990±5 | ＞0.05 |
The data show that the medicine-food homologous spleen-invigorating decoction modifier provided by the invention can obviously prolong the sleep time of mice induced by pentobarbital sodium, improve the sleep incidence of the mice, reduce the sleep latency of the mice and have an obvious sleep improvement effect.
Test example 2
The modified product of the medicinal and edible spleen-invigorating decoction prepared in example 2 was administered to mice via oral gavage, and the sleep status of the mice was observed.
The mice are divided into a negative control group, a low-dose group, a medium-dose group and a high-dose group, wherein each group comprises 10 mice, the negative control group is orally gazed with 20ml/kg of physiological saline, the low-dose group is orally gazed with 1.7g/kg of modified drug-food homologous Chinese angelica spleen decoction, the medium-dose group is orally gazed with 3.3g/kg of modified drug-food homologous Chinese angelica spleen decoction, and the high-dose group is orally gazed with 10g/kg of modified drug-food homologous Chinese angelica spleen decoction.
1) When the treatment object was a normal mouse, the results shown in table 5 were obtained.
TABLE 5 influence of improved medicinal and edible decoction for invigorating spleen on sleep of normal mice
| Number of animals/animal | Number of animals falling asleep/animal | P value | Time to sleep/s | P value | |
| Negative control group | 10 | 0 | / | 0 | / |
| Low dose group | 10 | 0 | ＞0.05 | 0 | ＞0.05 |
| Medium dose group | 10 | 0 | ＞0.05 | 0 | ＞0.05 |
| High dose group | 10 | 0 | ＞0.05 | 0 | ＞0.05 |
2) The method for obtaining the pentobarbital sodium induced mice by intraperitoneal injection of the pentobarbital sodium is adopted, the effects of the medicine-food homologous spleen-invigorating decoction ameliorant on the mice are observed by taking the pentobarbital sodium induced mice as a treatment object, and the results shown in the table 6 are obtained.
TABLE 6 decoction for spleen invigorating with homology of medicine and foodSleep effects of the ameliorants on pentobarbital sodium induced mice
3) Mice with subthreshold dose of barbital sodium are obtained by adopting a method of intraperitoneal injection of barbital sodium, and the influence of the medicine-food homologous spleen-invigorating decoction ameliorant on the mice is observed by taking the mice as a treatment object, so that the results shown in table 7 are obtained.
TABLE 7 sleep impact of modified Homomedicinal and edible Guipi decoction on mice with subthreshold dose of barbital sodium
| Number of animals/animal | Incidence of sleep | P value | |
| Negative control group | 10 | 10％ | / |
| Low dose group | 10 | 20％ | ＞0.05 |
| Medium dose group | 10 | 50％ | ＞0.05 |
| High dose group | 10 | 80％ | ＞0.05 |
4) The barbiturate-induced mice were obtained by intraperitoneal injection of barbiturate sodium, and the effect of the improved drug-food homologous Guipi decoction on the mice was observed using the barbiturate sodium as the treatment target, resulting in the results shown in Table 8.
TABLE 8 sleep effects of improved medicinal and edible Guipi decoction on barbital sodium induced mice
| Number of animals/animal | Sleep latency/s | P value | |
| Negative control group | 10 | 2401±52.5 | / |
| Low dose group | 10 | 2232±74.5 | ＞0.05 |
| Middle dose group | 10 | 2021±14 | ＞0.05 |
| High dose group | 10 | 2009±4 | ＞0.05 |
The data show that the medicine-food homologous spleen-invigorating decoction modifier provided by the invention can obviously prolong the sleep time of mice induced by pentobarbital sodium, improve the sleep incidence of the mice, reduce the sleep latency of the mice and have an obvious sleep improvement effect.
Test example 3
13 persons with similar sleep conditions are selected as research objects, the improved medicinal and edible spleen-invigorating decoction of the example 1 is eaten 1 to 2 hours before sleeping every night, 1 time is taken every day, 30 ml/bag is taken every time, and the sleep conditions of the patients are observed to obtain the results shown in figure 1 and table 9.
TABLE 9 sleep conditions
| Sleep improvementSituation(s) | Onset time | Number of people |
| Dream less and |
The third day | 1 |
| Dream-disturbed sleep, deep sleep and |
The third day | 2 |
| |
Day one | 2 |
| 104 quick sleep and good spirit | The third day | 5 |
| No |
No special perception for 15 days | 2 |
| Stubborn insomnia falling asleep 106 | Day 7 | 1 |
As can be seen from fig. 1 and table 9, the food and medicine homology gui pi decoction improver of example 1 had a good sleep improvement effect, wherein 11 people had different degrees of improvement in sleep after eating it, particularly, the intractable insomnia had a primary change, and only 2 people had no effect of improving sleep after trying to eat it, and as is known, 1 person had a feeling related to the personal pressure during their eating. From the overall results, the sleep condition of the improved medicine-food homologous spleen-tonifying decoction is correspondingly improved according to different individual conditions, and particularly, the improved medicine-food homologous spleen-tonifying decoction can be used for improving the people with poor sleep from the aspects of getting sleepy early, falling asleep quickly, sleeping at a low dream, being good in daytime spirit and the like, so that the improved medicine-food homologous spleen-tonifying decoction provided by the invention has a good sleep improvement effect, can take effect within one week, takes effect quickly and has a good sleep improvement effect.
In summary, the improved substance of medicinal and edible spleen-invigorating decoction provided by the embodiments of the present invention, the preparation method thereof, the medicament and the food composition at least have the following advantages:
by taking ginseng and longan pulp as monarch drugs, the Chinese herbal medicine has the effects of tonifying heart and spleen, nourishing blood and soothing nerves; the red dates, the angelica and the mulberry are used as ministers to enhance the effects of benefiting qi and nourishing blood; poria cocos, spina date seed and lily can calm heart and calm nerves, dried orange peel has the effects of regulating qi and tonifying spleen, so that the tonifying is not stagnant, and polygonatum odoratum has the effects of nourishing yin and moistening dryness, so that the tonifying is not dry, and the dried orange peel and the spina date seed are used as adjuvant medicines together; licorice root, radix Glycyrrhizae is used to strengthen the middle-jiao and replenish qi, and to harmonize the actions of the other drugs in the recipe. The composition can improve the symptoms of deficiency of both heart and spleen by replenishing qi and blood, invigorating spleen and nourishing heart, thereby improving qi-blood insomnia.
The above is only a preferred embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes will occur to those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A medicine-food homologous Guipi decoction modifier is characterized by comprising, by weight, 1-5 parts of ginseng, 1-5 parts of arillus longan, 0.1-3 parts of Chinese angelica, 1-5 parts of polygonatum odoratum, 1-5 parts of mulberry, 1-7 parts of spina date seed, 1-5 parts of poria cocos, 1-5 parts of lily and 1-5 parts of liquorice.
2. The improved medicine-food homologous spleen-invigorating decoction as claimed in claim 1, further comprising 2-10 parts of a flavoring agent, wherein the flavoring agent comprises at least one of erythritol, mogroside or white sugar.
3. The improved medicine-food homologous spleen-invigorating soup according to claim 2, which comprises 2-4 parts of ginseng, 2-3 parts of arillus longan, 0.5-1.5 parts of angelica sinensis, 1-3 parts of polygonatum odoratum, 1-3 parts of mulberry, 1-5 parts of red date, 3-4 parts of spina date seed, 1-3 parts of poria cocos, 1-3 parts of lily, 0.1-2 parts of dried orange peel, 2-3 parts of liquorice, 2-4 parts of erythritol and 3-6 parts of mogroside.
4. The improved medicine-food homologous spleen-invigorating soup according to claim 2, which comprises 3 parts of ginseng, 2.5 parts of arillus longan, 1 part of angelica sinensis, 2 parts of polygonatum odoratum, 2 parts of mulberry, 2 parts of red date, 3.5 parts of spina date seed, 2 parts of poria cocos, 2 parts of lily, 0.5 part of dried orange peel, 2.5 parts of liquorice, 3 parts of erythritol and 5 parts of mogroside.
5. A preparation method of the medicine-food homologous Guipi decoction modifier according to any one of claims 1 to 4, which is characterized by comprising the steps of mixing arillus longan, angelica sinensis, polygonatum odoratum, mulberry, red dates, spina date seeds, poria cocos, lily, dried orange peel and liquorice in parts by weight, leaching, filtering, taking filtrate, adding a ginseng extract, and mixing to obtain the medicine.
6. The method according to claim 5, wherein the extracted liquid comprises any one of water, ethanol, preferably water;
preferably, the leaching is carried out twice, and the step of crushing the medicinal materials and soaking for 20-40 min is further carried out before the first leaching;
preferably, the leaching time is 2-4 h each time, the temperature is 70-90 ℃, and the adding amount of the leaching liquor is 8-12 times of the total weight of the medicinal materials.
7. The preparation method according to claim 5, comprising performing a first concentration on the filtrate, wherein the filtrate after the first concentration has a solid content of 12 to 18%;
preferably, flavoring agents are added to the filtrate after the first concentration according to parts by weight for mixing.
8. The method according to claim 7, further comprising a second concentration of the filtrate, wherein the filtrate after the second concentration has a solid content of 50 to 70%;
preferably, the ginseng extract is added to the filtrate after the second concentration according to parts by weight and mixed.
9. A pharmaceutical composition comprising the modified product of medicinal and edible spleen-invigorating decoction according to any one of claims 1 to 4 or the modified product of medicinal and edible spleen-invigorating decoction prepared by the preparation method according to any one of claims 5 to 7.
10. A food composition comprising the improved substance of the homology of medicine and food gui pii decoction of any one of claims 1 to 4 or the improved substance of the homology of medicine and food gui pii decoction prepared by the preparation method of any one of claims 5 to 7.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106109669A (en) * | 2016-08-18 | 2016-11-16 | 上海颂露医药科技有限公司 | Renshen Guipi Wan and preparation method thereof |
| CN108671140A (en) * | 2018-07-05 | 2018-10-19 | 天津益倍元天然产物技术有限公司 | It is a kind of to improve the composition slept and its application |
| CN110354212A (en) * | 2018-04-09 | 2019-10-22 | 北京博医研康健康管理有限公司 | A kind of pharmaceutical composition and preparation method thereof for treating insomnia |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106109669A (en) * | 2016-08-18 | 2016-11-16 | 上海颂露医药科技有限公司 | Renshen Guipi Wan and preparation method thereof |
| CN110354212A (en) * | 2018-04-09 | 2019-10-22 | 北京博医研康健康管理有限公司 | A kind of pharmaceutical composition and preparation method thereof for treating insomnia |
| CN108671140A (en) * | 2018-07-05 | 2018-10-19 | 天津益倍元天然产物技术有限公司 | It is a kind of to improve the composition slept and its application |
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| 陈克年: "归脾汤的作用机理及临证应用", 《中医药学刊》, no. 03, pages 38 - 39 * |
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