CN115737483A - Emulsion gel, emulsion gel composite and preparation method thereof - Google Patents
Emulsion gel, emulsion gel composite and preparation method thereof Download PDFInfo
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- CN115737483A CN115737483A CN202211431420.6A CN202211431420A CN115737483A CN 115737483 A CN115737483 A CN 115737483A CN 202211431420 A CN202211431420 A CN 202211431420A CN 115737483 A CN115737483 A CN 115737483A
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- Colloid Chemistry (AREA)
Abstract
The invention relates to the technical field of pharmaceutical preparations, in particular to emulsion gel, an emulsion gel compound and a preparation method thereof. The raw materials of the emulsion gel comprise, by weight, 5-15 parts of a gel matrix, 1-10 parts of an oil phase substance and 1-5 parts of a surfactant, wherein the oil phase substance is selected from olive oil or an amphiphilic phenol hydroxyl alcohol compound. The emulsion gel has the advantages of good comprehensive performance, no toxicity, high biocompatibility, degradability and the like, has good antioxidant property, can protect bioactive substances and improve the utilization rate, and can be widely applied to the fields of food, cosmetics and the like.
Description
Technical Field
The invention relates to the technical field of pharmaceutical preparations, in particular to emulsion gel, an emulsion gel compound and a preparation method thereof.
Background
The natural products such as 3, 4-dihydroxyphenyl ethanol, curcumin, beta-carotene and the like have excellent inoxidizability, are biological materials with wide application range, and have better application prospects in the fields of food, medicine, chemical industry, agriculture and the like.
However, the natural product has a chemical structure, so that the natural product is hindered in practical application, for example, 3, 4-dihydroxy phenylethanol is easy to oxidize and deteriorate when exposed to air; curcumin is easily degraded under alkaline conditions, resulting in loss of stability and biological activity; beta-carotene is also difficult to use directly due to its extremely low water solubility, chemical and metabolic instability, poor in vivo biological activity, and the like.
Therefore, there is a need in the industry to develop a novel vector to protect natural products, thereby exerting the application value of natural products.
In view of this, the invention is particularly proposed.
Disclosure of Invention
The invention aims to provide an emulsion gel, an emulsion gel compound and a preparation method thereof. The emulsion gel has the advantages of good comprehensive performance, no toxicity, high biocompatibility, degradability and the like, has good antioxidant property, can protect bioactive substances and improve the utilization rate, and can be widely applied to the fields of food, cosmetics and the like.
The invention is realized by the following steps:
according to a first aspect, the invention provides an emulsion gel, which comprises, by weight, 5-15 parts of a gel matrix, 1-10 parts of an oil phase substance and 1-5 parts of a surfactant, wherein the oil phase substance is selected from olive oil or an amphiphilic phenol hydroxyl alcohol compound.
In an alternative embodiment, the amphiphilic phenolic hydroxy alcohol compound is selected from 3, 4-dihydroxybenzyl alcohol.
In an alternative embodiment, the raw materials of the emulsion gel comprise, by weight, 5-15 parts of a gel matrix, 1-5 parts of a surfactant, and 1-10 parts of olive oil or 3, 4-dihydroxyphenylethanol.
In alternative embodiments, the gel matrix comprises a natural polysaccharide and/or protein;
preferably, the natural polysaccharides include starch and chitin, and the proteins include soy protein isolate and whey protein;
preferably, the gel matrix comprises at least one of starch, chitin, soy protein isolate, and whey protein;
preferably, the surfactant comprises a non-ionic surfactant, preferably at least one of fatty acid polyoxyethylene ester, coconut acid monoethanolamide, and sorbitan sesquioleate.
In a second aspect, the present invention provides a method of preparing an emulsion gel according to the previous embodiment, comprising mixing a gel matrix, an oil phase material, and a surfactant.
In an alternative embodiment, the method comprises the following steps: mixing the gel matrix with water to form a gel matrix suspension, then mixing with the oil phase substance and the surfactant, and then carrying out freeze-drying and standing.
In an alternative embodiment, the method comprises the following steps: mixing the gel matrix and the water, and dispersing for 1-5 minutes at the rotating speed of 15000-20000rpm to form gel matrix suspension;
adjusting the pH of the gel matrix suspension to 6.0-7.0, then mixing with the oil phase substance and the surfactant and dispersing at 10000-15000rpm for 1-3 minutes to form a mixture;
then, the mixture is lyophilized for 1-3 hours at-30 to-15 ℃; then standing for 45 minutes to 1.5 hours at the temperature of 25 ℃.
In a third aspect, the present invention provides an emulsion gel complex comprising an active ingredient and an emulsion gel as described in the previous embodiments.
In a fourth aspect, the present invention provides a method for preparing the emulsion gel composite according to the previous embodiment, which comprises: mixing the active substance, gel matrix, oil phase substance and surfactant.
In an alternative embodiment, the method comprises the following steps: mixing the active substance with part of the oil phase substance to form active substance-oil phase system mixed liquid with the mass concentration of 5-10%;
mixing the gel matrix with water to form a gel matrix suspension, then mixing the gel matrix suspension with the active substance-oil phase system mixed solution, the rest oil phase substance and the surfactant, and then freeze-drying and standing; wherein the mass ratio of part of the oil phase substances to the rest of the oil phase substances is always 1.
The invention has the following beneficial effects: the preparation process of the emulsion gel does not use harmful substances, and the emulsion gel is green in production and environment-friendly in process; and the preparation process is simple and the cost is lower. Meanwhile, the olive oil or the amphiphilic phenol hydroxyl alcohol compound is innovatively used as an oil phase substance, so that the emulsion gel has the advantages of good biocompatibility, degradability, nontoxicity and the like, has good antioxidant property, can be used as a carrier of most natural products, can protect bioactive substances and improve the utilization rate, and can be widely applied to the fields of food, cosmetics and the like.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
The embodiment of the invention provides an emulsion gel, which is a gel system consisting of a dispersed phase inner phase and a continuous phase outer phase in the presence of a stabilizer, and is increasingly concerned as an important product system in basic research and practical application. The emulsion gel can be used as a transmission system of active substances such as 3, 4-dihydroxyphenylethanol, curcumin, beta-carotene and the like, the active substances in the system are mainly dissolved in internal phase oil drops of the emulsion, and can be diffused among micro-areas in the emulsion system through a continuous phase, so that the purpose of slow release is achieved, and the stability and the biological activity of the active substances are obviously improved.
Specifically, the raw materials of the emulsion gel provided by the embodiment of the invention comprise 5-15 parts of a gel matrix, 1-10 parts of an oil phase substance and 1-5 parts of a surfactant, wherein the oil phase substance is selected from olive oil or amphiphilic phenolic hydroxyl alcohol compounds. The invention innovatively uses olive oil or amphiphilic phenol hydroxyl alcohol compound as an oil phase substance, so that the emulsion gel not only has the advantages of good biocompatibility, degradability, nontoxicity and the like, but also has good antioxidant property, and simultaneously can be used as a carrier of most natural products, can play a role in protecting bioactive substances and improving the utilization rate, and can be widely applied to the fields of food, cosmetics and the like. The emulsion gel can be used as a carrier of an active substance or used independently.
Further, the amphiphilic phenolic hydroxyl alcohol compound is selected from 3, 4-dihydroxy phenylethanol. In the embodiment of the invention, 3, 4-dihydroxy phenylethanol is used as one of the components of the emulsion gel, so that 3, 4-dihydroxy phenylethanol can be protected and prevented from deteriorating; the 3, 4-dihydroxy phenethyl alcohol has strong antioxidant property, so that the emulsion gel also has certain antioxidant property and can be used as an antioxidant additive component to be applied to various fields; meanwhile, due to the fact that high-activity antioxidant natural ingredients are used in the system, the antibacterial and antiseptic effects are achieved, and additional antiseptic ingredients do not need to be added.
Further, the raw materials of the emulsion gel comprise 5-15 parts by weight of gel matrix, 1-5 parts by weight of surfactant and 1-10 parts by weight of olive oil or 3, 4-dihydroxy phenylethanol.
Still further, the gel matrix comprises a natural polysaccharide and/or protein; preferably, the natural polysaccharides include starch and chitin, and the proteins include soy protein isolate and whey protein; preferably, the gel matrix comprises at least one of starch, chitin, soy protein isolate and whey protein. The surfactant comprises a nonionic surfactant, preferably at least one of fatty acid polyoxyethylene ester, coconut monoethanolamide, and sorbitan sesquioleate.
The gel matrix and the surfactant are specifically selected to be matched with the oily substance in the embodiment of the invention, so that the performance of the formed emulsion gel is ensured.
The embodiment of the invention also provides a preparation method of the emulsion gel, which comprises the following steps:
adding gel matrix into distilled water, dispersing with high speed disperser at 15000-20000rpm for 1-5min to obtain gel matrix suspension;
adjusting the pH of the gel matrix suspension to 6.0-7.0, then mixing with the oil phase substance and the surfactant, and dispersing the mixed solution again for 1-3min at the rotating speed of 10000-15000rpm by using a high-speed disperser;
then carrying out freeze drying treatment, wherein the temperature is set to be-30 to-15 ℃, and the time is set to be 1-3h; and standing at 25 deg.C, i.e. room temperature for 45 min-1.5 hr to obtain emulsion gel with antioxidant property.
The emulsion gel can be used for protecting bioactive substances which are easily influenced by environment and are difficult to utilize. The embodiment of the invention also provides an emulsion gel compound which comprises an active ingredient and the emulsion gel, wherein the active ingredient can be one of natural products such as curcumin, beta-carotene and the like which are easily influenced by environment, easily deteriorate and easily decompose.
The preparation method of the emulsion gel compound comprises the following steps:
mixing the active substance with part of the oil phase substance to form active substance-oil phase system mixed liquid with the mass concentration of 5-10%; and then taking the mixed solution of the active substance and the oil phase system as an oil phase substance to prepare the emulsion gel compound. In particular, the amount of the solvent to be used,
adding gel matrix into distilled water, dispersing with high speed disperser at 15000-20000rpm for 1-5min to obtain gel matrix suspension;
adjusting the pH value of the gel matrix suspension to 6.0-7.0, then mixing with the active substance-oil phase system mixed solution, the residual oil phase substance and the surfactant, and dispersing the mixed solution again by using a high-speed disperser at the rotating speed of 10000-15000rpm for 1-3min; wherein the mass ratio of part of the oil phase substances to the rest of the oil phase substances is always 1;
then carrying out freeze drying treatment, wherein the temperature is set to be-30 to-15 ℃, and the time is set to be 1-3h; and standing for 45 minutes to 1.5 hours at the temperature of between 20 and 30 ℃ to finally obtain the emulsion gel with the antioxidant property.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
This example provides an emulsion gel, which comprises the following raw materials: 5 parts by weight of starch, 3 parts by weight of olive oil and 2 parts by weight of polyoxyethylene fatty acid ester.
This example provides a method for preparing an emulsion gel, comprising:
5 parts by weight of starch was added to 50 parts by weight of deionized water, and the dispersion was completed by dispersing for 2min at 15000rpm using a high speed disperser to obtain a gel matrix suspension.
The pH of the gel base suspension was adjusted to 7.0, and then 3 parts by weight of olive oil, 2 parts by weight of polyoxyethylene fatty acid were added, and the mixed solution was dispersed again for 3min at 10000rpm using a high speed disperser to form a mixture.
Freeze drying the emulsified and homogenized mixture at-15 deg.c for 1 hr; standing the mixture after freeze drying, and standing at 25 deg.C for 1h to obtain emulsion gel with antioxidant property.
The embodiment of the invention also provides a preparation method of the emulsion gel compound, which comprises the following steps:
weighing curcumin, adding 1.5 weight parts of oil phase substance, placing in an ultrasonic water bath device, and performing ultrasonic treatment for 1min to obtain bioactive substance-oil phase system mixed solution with content of 5%.
Adding 5 parts by weight of starch into 50 parts by weight of deionized water, and dispersing for 2min at the rotating speed of 15000rpm by using a high-speed disperser to finish dispersion to obtain the gel matrix suspension.
Mixing the gel matrix with water to form a gel matrix suspension, then mixing the gel matrix suspension with an active substance-oil phase system mixed solution, the rest oil phase substance and a surfactant, and then freeze-drying and standing; wherein the mass ratio of part of the oil-phase substances to the rest of the oil-phase substances is 1 。
Example 2
This example provides an emulsion gel, which comprises the following raw materials: 10 parts by weight of whey protein, 5 parts by weight of 3, 4-dihydroxyphenylethanol and 4 parts by weight of coconut monoethanolamide.
This example provides a method for preparing an emulsion gel, comprising:
10 parts by weight of whey protein was added to 100 parts by weight of deionized water, and dispersed for 4min at 18000rpm using a high speed disperser to complete the dispersion, resulting in a gel matrix suspension.
The pH of the gel base suspension was adjusted to 6.0, followed by adding 5 parts by weight of 3, 4-dihydroxybenzene ethanol and 4 parts by weight of coconut monoethanolamide, and dispersing the mixed solution again using a high speed disperser at 12000rpm for 3min to form a mixture.
Freeze-drying the emulsified and homogenized mixture at-30 deg.C for 2h; standing the mixture after freeze drying, and standing at 25 deg.C for 1h to obtain emulsion gel with antioxidant property.
The embodiment of the invention also provides a preparation method of the emulsion gel compound, which comprises the following steps:
weighing beta-carotene, adding 2.5 weight parts of oil phase substance, and placing in an ultrasonic water bath device for ultrasonic treatment for 1min to obtain 8% bioactive substance-oil phase system mixed solution.
10 parts by weight of whey protein was added to 100 parts by weight of deionized water, and dispersed for 4min at 18000rpm using a high speed disperser to complete the dispersion, to obtain a gel matrix suspension.
Mixing the gel matrix with water to form a gel matrix suspension, then mixing the gel matrix suspension with an active substance-oil phase system mixed solution, the rest oil phase substance and a surfactant, and then freeze-drying and standing; wherein the mass ratio of part of the oil phase substances to the rest of the oil phase substances is 1.
Example 3
This example provides an emulsion gel, which comprises the following raw materials: 15 parts by weight of chitin, 10 parts by weight of olive oil and 5 parts by weight of sorbitan sesquioleate.
This example provides a method for preparing an emulsion gel, comprising:
adding 15 parts by weight of chitin into 150 parts by weight of deionized water, and dispersing for 5min at the rotating speed of 20000rpm by using a high-speed disperser to complete dispersion, thereby obtaining the gel matrix suspension.
The pH of the resulting gel base suspension was adjusted to 6.0, followed by addition of 10 parts by weight of olive oil and 5 parts by weight of sorbitan sesquioleate, and dispersion of the mixed solution again for 3min at 15000rpm using a high-speed disperser to form a mixture.
Freeze drying the emulsified and homogenized mixture at-20 deg.c for 3 hr; standing the mixture after freeze drying, and standing at 25 deg.C for 1h to obtain antioxidant emulsion gel.
The embodiment of the invention also provides a preparation method of the emulsion gel compound, which comprises the following steps:
weighing curcumin, adding 5 parts by weight of oil phase substance, placing in an ultrasonic water bath device, and performing ultrasonic treatment for 1min to prepare a bioactive substance-oil phase system mixed solution with the content of 10%.
Adding 15 parts by weight of chitin into 150 parts by weight of deionized water, and dispersing for 5min at the rotating speed of 20000rpm by using a high-speed disperser to complete dispersion, thereby obtaining the gel matrix suspension.
Mixing the gel matrix with water to form a gel matrix suspension, then mixing the gel matrix suspension with an active substance-oil phase system mixed solution, the rest oil phase substance and a surfactant, and then freeze-drying and standing; wherein the mass ratio of part of the oil phase substances to the rest of the oil phase substances is 1.
Example 4
This example provides an emulsion gel, which comprises the following raw materials: 6 parts by weight of chitin and isolated soy protein compound (the mass ratio of the chitin to the isolated soy protein is 1.
This example provides a method for preparing an emulsion gel, comprising:
adding 6 parts by weight of chitin and isolated soybean protein compound into 60 parts by weight of deionized water, and dispersing for 3min at the rotating speed of 17000rpm by using a high-speed disperser to complete dispersion to obtain the gel matrix suspension.
The pH of the resulting gel base suspension was adjusted to 7.0, followed by addition of 1 part by weight of olive oil and 3 parts by weight of polyoxyethylene fatty acid, and dispersion of the mixed solution again for 2min at 13000rpm using a high-speed disperser to form a mixture.
Freeze-drying the emulsified and homogenized mixture at-15 deg.C for 1h; standing the mixture after freeze drying, and standing at 25 deg.C for 1h to obtain antioxidant emulsion gel.
The embodiment of the invention also provides a preparation method of the emulsion gel compound, which comprises the following steps:
weighing beta-carotene, adding 0.5 weight part of oil phase substance, placing in an ultrasonic water bath device, and performing ultrasonic treatment for 1min to obtain 7% bioactive substance-oil phase system mixed solution.
Adding 6 parts by weight of chitin and isolated soy protein compound into 60 parts by weight of deionized water, and dispersing for 3min at the rotating speed of 17000rpm by using a high-speed disperser to complete dispersion to obtain gel matrix suspension.
Mixing the gel matrix with water to form a gel matrix suspension, then mixing the gel matrix suspension with an active substance-oil phase system mixed solution, the rest oil phase substance and a surfactant, and then freeze-drying and standing; wherein the mass ratio of part of the oil phase substances to the rest of the oil phase substances is 1.
Example 5
This example provides an emulsion gel, which comprises the following raw materials: 5 parts by weight of starch and whey protein compound (the mass ratio of starch to whey protein is 3.
This example provides a method for preparing an emulsion gel, comprising:
adding 5 parts by weight of starch and whey protein compound into 50 parts by weight of deionized water, and dispersing for 2min at the rotating speed of 15000rpm by using a high-speed disperser to complete dispersion to obtain the gel matrix suspension.
The pH of the resulting gel matrix suspension was adjusted to 7.0, followed by addition of 1 part by weight of 3, 4-dihydroxyphenylethanol and 2 parts by weight of coconut monoethanolamide, and dispersion of the mixture again using a high speed disperser at 10000rpm for 1min to form a mixture.
Freeze drying the emulsified and homogenized mixture at-20 deg.c for 1 hr; standing the mixture after freeze drying, and standing at 25 deg.C for 1h to obtain antioxidant emulsion gel.
The embodiment of the invention also provides a preparation method of the emulsion gel compound, which comprises the following steps:
weighing curcumin, adding 0.5 weight part of oil phase substance, and placing in an ultrasonic water bath device for ultrasonic treatment for 1min to obtain a bioactive substance-oil phase system mixed solution with a content of 9%.
Adding 5 parts by weight of starch and whey protein compound into 50 parts by weight of deionized water, and dispersing for 2min at the rotating speed of 15000rpm by using a high-speed disperser to complete dispersion to obtain the gel matrix suspension.
Mixing the gel matrix with water to form a gel matrix suspension, then mixing the gel matrix suspension with an active substance-oil phase system mixed solution, the rest oil phase substance and a surfactant, and then freeze-drying and standing; wherein the mass ratio of part of the oil phase substances to the rest of the oil phase substances is 1.
Example 6: this example provides an emulsion gel, in which the formulation components, weight parts, preparation method and conditions of the raw materials except the bioactive substances are the same as those in example 5, and curcumin is changed to beta-carotene without changing the weight parts.
This example provides an emulsion gel complex, in which the formulation components, weight parts, and preparation methods and conditions of the raw materials except for the bioactive substances are the same as those in example 5, and curcumin is changed to beta-carotene without changing the weight parts.
Comparative example 1: the comparative example provides an emulsion gel, except the gel substrate, the other raw material formula components, the weight parts, the preparation method and the conditions are all consistent with those of the example 5, and the compound of the starch and the whey protein is changed into the compound of the soy protein isolate and the chitin, and the weight parts are not changed.
The comparative example provides an emulsion gel compound, except the gel matrix, the other raw material formula components, the weight parts, the preparation method and the conditions are all consistent with those of the example 5, and the compound of the starch and the whey protein is changed into the compound of the soy protein isolate and the chitin, and the weight parts are not changed.
Comparative example 2: this comparative example provides an emulsion gel, the formulation ingredients, weight parts, and preparation methods and conditions of the remaining raw materials, except for the oil phase species, were in accordance with example 5, and 3, 4-dihydroxyphenylethanol was changed to the conventional oil phase species in the art, triglyceride, weight parts, was unchanged.
This comparative example provides an emulsion gel composite, the formulation ingredients, weight parts, and preparation methods and conditions of the remaining raw materials, except for the oil phase species, were in accordance with example 5, and 3, 4-dihydroxybenzene ethanol was changed to the oil phase species, triglyceride, which is conventional in the art, with the weight parts being unchanged.
Comparative example 3: the comparative example provides an emulsion gel, except for the surfactant type, the other raw material formula components, the weight parts, the preparation method and the conditions are all consistent with those of the example 5, and the coconut monoethanolamide is changed into the anionic surfactant sodium dodecyl benzene sulfonate in the field, and the weight parts are not changed.
Except for the surfactant, other raw material formula components, parts by weight, preparation methods and conditions are consistent with those in example 5, and the coconut monoethanolamide is changed into the anionic surfactant sodium dodecyl benzene sulfonate in the field, so that the parts by weight are unchanged.
Experimental example 1
According to the experiment of "determination of DPPH free radical scavenging ability" in the research on the preparation of hydroxytyrosol in olive leaves and the antioxidant activity thereof (DOI: 10.27345/d.cnki. Gsnyu.2020.001087), the emulsion gels and emulsion gel composites of examples 1-6 and comparative examples 1-3 were respectively subjected to the measurement of antioxidant effect, the absorbance of the reaction solution was measured every 10min, 3 times were measured, and DPPH free radical scavenging rate was calculated, and the following results were obtained:
TABLE 1 results on DPPH radical scavenging ability
Comparing the DPPH radical scavenging ability results of the emulsion gel of example 2 and the emulsion gel of example 5, it can be seen that the gel matrix itself does not significantly affect the antioxidant properties of the emulsion gel product when the preferred amphiphilic oil phase substance, 3, 4-dihydroxybenzene ethanol, is used as the oil phase substance.
Comparing the DPPH radical scavenging ability results of the emulsion gel of example 5 and the emulsion gel of comparative example 1, it can be seen that the stability of 3, 4-dihydroxybenzene ethanol in the emulsion gel product is low due to the change of the gel matrix, thereby influencing the oxidation resistance of the product to some extent.
Comparing the DPPH radical scavenging ability results of the emulsion gel of example 5 and the emulsion gel of comparative example 2, it can be seen that the antioxidant property of the emulsion gel product is greatly reduced when amphiphilic substances such as 3, 4-dihydroxybenzene ethanol are not used as the oil phase substance.
Experimental example 2
According to the experiment of 'stability of active substances in emulsion gel' related to the research on construction and stability of glycosylated protein-polyphenol Pickering emulsion delivery system loaded with natural active substances (DOI: 10.27776/d.cnki. Gwhgy.2019.000074) in Chinese literature, the stability determination and calculation of bioactive substances are carried out on the emulsion gel complexes in examples 1-6 and comparative examples 1-3 by using an ultraviolet spectrophotometry method.
For the stability determination of curcumin, methanol is used for demulsification extraction and determination is carried out at the wavelength of 425nm, and meanwhile, the retention rate of products is calculated; for the stability determination of beta-carotene, chloroform was used for demulsification extraction and determination was performed at a wavelength of 450nm while calculating the product retention. The measuring time is 30d, meanwhile, a certain amount of products are taken at intervals of 10d for measurement, and the total retention rate of the products is calculated according to the proportion.
The final stability test results were as follows:
as is clear from comparison between example 5 and comparative example 2, when an amphiphilic substance such as 3, 4-dihydroxybenzene ethanol is not used as an oil phase substance, the protection capability of the prepared emulsion gel to a bioactive substance is poor.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The emulsion gel is characterized in that the raw materials comprise, by weight, 5-15 parts of a gel matrix, 1-10 parts of an oil phase substance and 1-5 parts of a surfactant, wherein the oil phase substance is selected from olive oil or an amphiphilic phenol hydroxyl alcohol compound.
2. The emulsion gel of claim 1, wherein the amphiphilic phenolic hydroxyl alcohol compound is selected from the group consisting of 3, 4-dihydroxybenzyl alcohol.
3. The emulsion gel of claim 1, wherein the raw materials of the emulsion gel comprise, in parts by weight, 5 to 15 parts of a gel matrix, 1 to 5 parts of a surfactant, and 1 to 10 parts of olive oil or 3, 4-dihydroxyphenylethanol.
4. An emulsion gel according to any of claims 1 to 3, wherein the gel matrix comprises natural polysaccharides and/or proteins;
preferably, the natural polysaccharides include starch and chitin, and the proteins include soy protein isolate and whey protein;
preferably, the gel matrix comprises at least one of starch, chitin, soy protein isolate, and whey protein;
preferably, the surfactant comprises a non-ionic surfactant, preferably at least one of fatty acid polyoxyethylene ester, coconut acid monoethanolamide, and sorbitan sesquioleate.
5. A method of preparing the emulsion gel of claim 1 comprising combining the gel matrix, the oil phase material, and the surfactant.
6. The method of claim 5, comprising: mixing the gel matrix with water to form a gel matrix suspension, then mixing with the oil phase substance and the surfactant, and then carrying out freeze-drying and standing.
7. The method of claim 6, comprising: mixing the gel matrix and the water, and dispersing for 1-5 minutes at the rotating speed of 15000-20000rpm to form a gel matrix suspension;
adjusting the pH of the gel matrix suspension to 6.0-7.0, then mixing with the oil phase substance and the surfactant and dispersing at 10000-15000rpm for 1-3 minutes to form a mixture;
then, the mixture is lyophilized for 1-3 hours at-30 to-15 ℃; then standing for 45 minutes to 1.5 hours at the temperature of 25 ℃.
8. An emulsion gel composite comprising an active ingredient and the emulsion gel of claim 1.
9. A method of preparing the emulsion gel composite of claim 8, comprising: mixing the active substance, gel matrix, oil phase substance and surfactant.
10. The method of claim 9, comprising: mixing the active substance with part of the oil phase substance to form active substance-oil phase system mixed liquid with the mass concentration of 5-10%;
mixing the gel matrix with water to form a gel matrix suspension, then mixing the gel matrix suspension with the active substance-oil phase system mixed solution, the rest oil phase substance and the surfactant, and then freeze-drying and standing; wherein the mass ratio of part of the oil phase substances to the rest of the oil phase substances is always 1.
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