CN115737468A - Mild multi-effect repair composition containing propagum germanium and application thereof - Google Patents
Mild multi-effect repair composition containing propagum germanium and application thereof Download PDFInfo
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- CN115737468A CN115737468A CN202211500762.9A CN202211500762A CN115737468A CN 115737468 A CN115737468 A CN 115737468A CN 202211500762 A CN202211500762 A CN 202211500762A CN 115737468 A CN115737468 A CN 115737468A
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Cosmetics (AREA)
Abstract
The invention discloses a mild multi-effect repairing composition containing propafenone, which comprises the following components in parts by weight: 1 to 9 parts of propagum germanium, 200 to 650 parts of rice fermentation product filtrate, 10 to 40 parts of rye seed extract, 0.1 to 0.5 part of hydrolyzed gardenia extract, 0.05 to 0.4 part of atractylodes macrocephala extract, 10 to 50 parts of arbutin leaf extract and 5 to 20 parts of snow lotus herb extract; the repairing composition is mild and non-irritating, has effects of keeping moisture, resisting aging and resisting inflammation, and can be used as cosmetic additive to be added into cosmetic such as cosmetic lotion, makeup removing cream, lotion, essence, facial cream, gel, facial mask, etc. The mild multi-effect repairing composition disclosed by the invention starts from the skin, mildly conditions the skin, stimulates the skin repairing function and further enhances the repairing effect.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a mild multi-effect repairing composition containing propagum germanium, and further relates to an application of the mild multi-effect repairing composition.
Background
The propafenone has the main effect of being a skin conditioner in cosmetics and skin care products, has the risk coefficient of 1, generally has no influence on pregnant women and infants, and has no pox-causing property. Propagum germanium belongs to metal organic matters, is widely used as a medicament, has no antiviral effect in vitro, but has antiviral effect in vivo. The experimental results show that 0.1mg/kg of propagum can inhibit the hepatic damage (GOT increase) of the hepatic damage model caused by galactosamine and carbon tetrachloride. The propagum germanium 10mg/kg can inhibit liver injury caused by tea isothio \27677acid salt, and has direct protection effect on liver. After oral administration of propafenone to rats and dogs, the plasma textile concentration peaked at 2-3 hours and then rapidly extinguished, but the extinction constant was smaller in rats than in dogs. Healthy volunteers take the medicine orally for 3 times 1 day, and the concentration in plasma does not change between the 7 th day and the 1 st day after continuous taking, which shows the safety and effectiveness of propafenib as a medicine, so the effect and the application of propafenib should be considered in the field of cosmetics.
At present, most of cosmetics on the market play a corresponding role by adding various substances with obvious effects, but the cosmetics using the propafenone substance are few, and the use of the substances is not very common in China. Moreover, most cosmetics are too pursuing their efficacy and do not consider the protection of the skin itself. For the skin with thin and sensitive skin barrier, the development of a skin care product which has no pressure on the skin and is suitable for people with sensitive skin and tender skin is also indispensable.
Disclosure of Invention
The object of the present invention is to provide mild multi-effect restorative compositions containing propafenone, which are mild and non-irritating and have moisturizing, anti-inflammatory and anti-ageing effects.
Another object of the present invention is to provide the use of the mild multi-effect repairing composition in skin care additives.
The technical scheme adopted by the invention is that the mild multi-effect repairing composition containing propafenone comprises the following components in parts by weight: 1 to 9 parts of propagum germanium, 200 to 650 parts of rice fermentation product filtrate, 10 to 40 parts of rye seed extract and 0.1 to 0.5 part of hydrolyzed gardenia extract.
The present invention is also characterized in that,
preferably, the composition also comprises 0.05 to 0.4 part of white atractylodes rhizome extract and 10 to 50 parts of bearberry leaf extract.
Preferably, the composition also comprises 5 to 20 parts of snow lotus herb extract.
Preferably, the composition comprises the following components in parts by weight: 2 to 8 portions of propagum germanium, 300 to 600 portions of rice fermentation product filtrate, 15 to 35 portions of rye seed extract and 0.15 to 0.45 portion of hydrolyzed gardenia extract.
Preferably, the composition comprises the following components in parts by weight: 3 to 7 parts of propagum germanium, 350 to 550 parts of rice fermentation product filtrate, 17 to 30 parts of rye seed extract, 0.2 to 0.5 part of hydrolyzed gardenia extract, 0.05 to 0.4 part of white atractylodes rhizome extract and 10 to 50 parts of bearberry leaf extract.
Preferably, the composition comprises the following components in parts by weight: 3 to 7 parts of propagum germanium, 350 to 550 parts of rice fermentation product filtrate, 17 to 30 parts of rye seed extract, 0.2 to 0.5 part of hydrolyzed gardenia extract, 0.07 to 0.38 part of bighead atractylodes rhizome extract, 15 to 45 parts of bearberry leaf extract and 8 to 15 parts of snow lotus herb extract.
The invention has the beneficial effects that:
(1) Under the condition of taking propagum as a base, a mild and non-irritant environment is provided for the whole composition, the mechanical and biological properties of a dermis layer and an epidermis layer are activated and strengthened through a rye seed extract in a rye seed extracting solution, so that the natural stretching capacity of the skin is recovered, the fiber cell contraction capacity of the skin is enhanced, the epidermal cells are activated to renew and recover the elasticity and the tonicity of the skin, and the composition has the effects of brightening, firming and resisting wrinkles;
(2) The snow lotus herb extract in the snow lotus herb extracting solution helps the skin to lock moisture, repair the skin and remove free radical, and because the snow lotus herb contains abundant vitamin c, the anti-oxidation effect is enhanced, and the mild repair and anti-aging performance is provided on the basis of mildness and moisture retention;
(3) The bearberry leaf extract, the hydrolyzed gardenia extract and the bighead atractylodes rhizome extract have the skin conditioning effect, are all active substances, have the skin conditioning effect, and further have the specific effects of resisting bacteria, inflammation, allergy and the like on the basis, so that the whole composition has the effects of mildness and repair.
(4) The rice fermentation product filtrate is a natural rice bran fermentation product, and the natural fermentation filtrate has the functions of balance and repair, which is not in line with the efficacy of propagage and provides strong and effective basic repair function. The mild multi-effect repairing composition disclosed by the invention starts from the skin, mildly conditions the skin, stimulates the skin repairing function and further enhances the repairing effect.
Detailed Description
The present invention will be described in detail with reference to the following embodiments.
The mild multi-effect repairing composition containing propafenone can be used as an additive of cosmetics to be added into cosmetics such as lotion, makeup removing cream, emulsion, essence, cream, jelly, facial mask and the like.
The propagum in the composition belongs to metal organic matters, is an oral chronic hepatitis therapeutic drug researched and developed by Japan three and chemical research institute, activates cytotoxic cells (T cells) and natural killer cells (NK cells), and destroys cells infected by viruses. Propaggermanium also increases antibody production, facilitating exclusion of virus-associated antigens. In addition, propaggrium enhances the production of interferon-alpha/beta, thereby inhibiting viral replication. Propagum germanium has no teratogenic, apoplastic and carcinogenic effects. 249 cases of HBeAg positive chronic hepatitis B patients are subjected to double-blind control clinical tests, and the administration group orally takes 10mg of propaggermanium and idt for 6 months, so that the negative conversion rate of the e antigen is 32.9 percent, the titer of the e antigen of 62.2 percent of patients is reduced, the clinical symptoms are improved, and the adverse reactions are few. The propafenone has the main effects of being a skin conditioner in cosmetics and skin care products, has the risk coefficient of 1, is safe, can be used at ease, generally has no influence on pregnant women, and has no pox-causing property. In addition to being safe and mild, propagyl can regulate the function of skin cells, and can enable the cells to generate a biological dehydrogenation process, like a biological oxidation-reduction process, so as to prevent the peroxidation of the cells, and the function can prevent the rough process of the skin and generate the effect of smoothing the skin. In addition, free electrons are present, which deprives the diseased cells of potential (H abstraction) + Procedure) The electric potential is enabled to be normal, so that the skin inflammation is eliminated, and the skin is restored to a normal healthy state. And the Ge-O bond in the structure can be combined with sugar, fat and lactic acid in blood vessels and discharged out of the body, thereby cleaning blood, regulating blood concentration, promoting skin metabolism and enhancing the elasticity and freshness of skin.
The rice fermentation product filtrate in the composition is purchased from Wuhan Haishan science and technology limited company, and mainly comprises the following components: 98.2% of rice fermentation product filtrate, 0.6% of butanediol, 0.5% of 1, 2-hexanediol and 0.6% of p-hydroxyacetophenone are colorless to light yellow transparent liquid, and the functional substance is rice fermentation product filtrate, so that the rice fermentation product filtrate has the effects of moisturizing, relieving, resisting wrinkles and the like, is suitable for people who are easy to be allergic and hormone faces, can balance skin micro-ecology, and can even replace water in an anhydrous formula. In addition, the product has skin whitening effect, and can inhibit melanin growth and tyrosinase activity. The skin care product has a promoting effect on the generation of cholesterol and brain amide which are important components of sebum, and the increase of the content of the cholesterol and the brain amide is helpful for improving the skin softness, so that the skin care product has a conditioning effect; has effects of activating glutathione reductase, improving skin function by combining with its oxidation resistance, and resisting aging. The effects of the composition and the propafenib are mutually fused, and the skin care foundation is formed.
The rye seed extract is purchased from Ganxiang Huahan biotechnology Limited company, consists of water, a rye seed extract and phenoxyethanol, has the functional components of the rye seed extract, is an active substance consisting of arabinoxylan extracted from rye seeds, is called Fuguyin, and is called anti-aging functional substance together with vitreous factor, and the functional principle of the extract is to restore the natural stretching capability of the skin, enhance the fiber cell contraction capability of the skin and activate the renewal of epidermal cells to restore the elasticity and the tonicity of the skin by activating and strengthening the mechanical and biological properties of a dermis layer and an epidermis layer. The rye seed extract reserves rich proteins, amino acids, vitamins, glucose and other components of rye, contains ferulic acid and natural resorcinol, is used for comprehensively conditioning skin, activates various abilities of the skin during conditioning, and plays a role in cooperation with other compositions.
The hydrolyzed gardenia extract is purchased from EPC Natural Products Co., ltd, consists of 36 percent of hydrolyzed gardenia and 64 percent of maltodextrin, has the functions of protecting liver, benefiting gallbladder, reducing blood pressure, calming, stopping bleeding, reducing swelling and the like, can diminish inflammation, sterilize, protect skin, resist allergy and improve cell activity, and experiments prove that the gardenia extract can obviously inhibit the ear shell swelling of mice and the foot sole swelling caused by formaldehyde caused by dimethylbenzene and has obvious treatment effect on the soft tissue injury of the mice and rabbits. The skin-care lotion also assists the repair function of other compositions, provides anti-inflammatory efficacy for sensitive skin and the like, has an inhibiting effect on staphylococcus aureus, diplococcus meningitides, catacoccus and the like, has an inhibiting effect on various skin fungi in vitro, and provides a sterile, anti-inflammatory and mild repair environment for the whole conditioning process of skin.
The rhizoma atractylodis macrocephalae extract in the composition is purchased from Yunnan England biotechnology limited and consists of rhizoma atractylodis macrocephalae extract, butanediol, water, phenoxyethanol and ethylhexylglycerin, and the components of the rhizoma atractylodis macrocephalae extract comprise atractylone (Atractylylon), atractylenolide A (Bu-tenolide A), atractylenolide B (Butenolide B), 3-beta-acetoxyatractylone (acetoxy-lon), 3-beta-hydroxy atractylone (Hydroxyatractylenon), apine dienone (Selina-4 (14), 7 (11) -dien-8-one) and sesquiterpene (C-C) 15 H 22 O), and the like. The Atractylodis rhizoma extract has effects of promoting proliferation of laminin-5 and collagen heart type formation, enhancing skin cell metabolism, resisting aging, and can be used as humectant. Animal experiments show that the rhizoma atractylodis macrocephalae has obvious antioxidation, can effectively reduce lipid peroxidation, reduce the content of LPO, avoid the destructive effect of harmful substances on the structure and the function of a tissue thin chemical book cell, improve the activity trend of SOD, enhance the scavenging capacity of organisms on free radicals and reduce the damage of the free radicals to the organisms. The Atractylodis rhizoma extract provides the composition with effects of promoting skin cell metabolism and resisting aging.
Arctostaphylos uva-ursi extract, purchased from Ganxiang Huahan Biotech Co., ltd, contains hydroquinone derivatives (content 7% -9%, mainly arbutin), polyphenol tannins (up to 15%, mainly gallotannins, digallic tannins, catechols and anthocyanidin derivatives), phenolic acids (about 0.25%), flavones (1.3%), triterpenes, small amounts of volatile oils and waxes as main components. Arbutin can effectively inhibit biological tyrosinase activity in skin, block melanin formation, and accelerate the decomposition and excretion of melanin by directly combining with tyrosinase, thereby reducing skin pigmentation, and removing stains, freckles and the like; the folium Vaccinii Vitis-idaeae extract can also enhance cell activity, eliminate free radicals, and resist aging; it also has antibacterial effect, and can be used as antibacterial agent and antiinflammatory agent; the composition of the invention and the snow lotus herb extract liquid are cooperated to play the effects of enhancing the skin activity and the like in the later period.
The saussurea involucrata extract is purchased from Ganxiang Huahan Biotechnology limited company, consists of water, saussurea involucrata extract and phenoxyethanol, is a light yellow transparent liquid, and can quickly diminish inflammation; the snow lotus herb extract is a pure natural product extracted from snow lotus herb, can clear free radicals in vivo, effectively delay skin aging, and simultaneously can help skin to absorb and lock water, keep moisture for a long time and avoid dry and rough skin.
Most of the existing repair products pay attention to the adoption of skin care products with strong efficacy for repair, but do not pay attention to the fact that the repair effect can be dependent on the products after reaching the repair effect, and the repair is not truly 'repair', but effective repair is to stimulate the repair function of the skin while mildly protecting the skin, so that the skin tends to be in a healthy and automatic repair state, and further other specific efficacies are exerted.
Example 1
The mild and multi-effect repairing composition containing propagum germanium comprises the following components: 0.5g of propagum germanium, 40g of rice fermentation product filtrate, 1g of rye seed extract and 0.01g of hydrolyzed gardenia extract.
Example 2
The mild and multi-effect repairing composition containing propagum germanium comprises the following components: 0.7g of propaferan germanium, 50g of rice fermentation product filtrate, 2g of rye seed extract and 0.03g of hydrolyzed gardenia extract.
Example 3
The mild and multi-effect repairing composition containing propagum germanium comprises the following components: 0.9g of propagum germanium, 65g of rice fermentation product filtrate, 4g of rye seed extract and 0.05g of hydrolyzed gardenia jasminoides ellis extract.
Example 4
The mild and multi-effect repairing composition containing propagum germanium comprises the following components: 0.6g of propagum germanium, 45g of rice fermentation product filtrate, 1.5g of rye seed extract, 0.02g of hydrolyzed gardenia extract, 0.04g of white atractylodes rhizome extract and 5g of bearberry leaf extract.
Example 5
The mild multi-effect conditioning composition containing propagum of the embodiment comprises the following components: 0.8g of propagum germanium, 55g of rice fermentation product filtrate, 3g of rye seed extract, 0.04g of hydrolyzed gardenia extract and 2g of snow lotus herb extract.
Example 6
The mild multi-effect conditioning composition containing propagum of the embodiment comprises the following components: 0.7g of propagum germanium, 45g of rice fermentation product filtrate, 1.5g of rye seed extract, 0.02g of hydrolyzed gardenia extract, 0.02g of bighead atractylodes rhizome extract, 3g of bearberry leaf extract and 1g of snow lotus herb extract.
Example 7
The mild multi-effect conditioning composition containing propagum of the embodiment comprises the following components: 0.9g of propagum germanium, 65g of rice fermentation product filtrate, 4g of rye seed extract, 0.05g of hydrolyzed gardenia extract, 0.04g of bighead atractylodes rhizome extract, 5g of bearberry leaf extract and 2g of snow lotus herb extract.
The preparation method of the compositions of the above examples 1 to 7 comprises the following steps: weighing the components, and stirring and mixing the components uniformly at normal temperature to obtain the product.
The application method of any one of the compositions in the embodiments 1 to 7 is to add any one of the compositions into the cosmetics, wherein the composition accounts for 0.5 to 8 percent of the total weight of the cosmetics, and the skin care cosmetics such as lotion, makeup removing cream, emulsion, essence, cream, gel, facial mask and the like can be prepared according to the conventional process and auxiliary materials for preparing the cosmetics. The selection of the other ingredients in the cosmetic and the preparation process may be carried out according to the conventional procedures in the art at the time of production.
To better illustrate the advantages of the present invention, the efficacy tests of the mild pleiotropic repairing compositions of the present invention containing propagum germanium are given below:
comparative example on efficacy test to demonstrate the effect of the present invention, comparative examples of the present invention are given below:
comparative example 1
The composition only contains 0.02g of rhizoma Atractylodis Macrocephalae extract and 3g of bearberry leaf extract.
Comparative example 2
The composition only contains 0.04g of rhizoma Atractylodis Macrocephalae extract and 5g of folium Vaccinii Vitis-idaeae extract.
Comparative example 3
Only cream texture.
Comparative example 4
One commercially available non-irritating multi-effect repair cream is purchased.
In order to better illustrate the advantages of the present invention, the experimental results of the technical solution provided by the present invention are given below:
1. chick embryo chorioallantoic Membrane (CAMVA) experiments
Test samples: the compositions of examples 1 to 7 and comparative examples 1 to 4 were respectively added to a common emulsion external base to prepare test samples, wherein the composition accounted for 5% of the total mass of the emulsion.
The test method comprises the following steps: the chick embryo is placed in a microcomputer full-automatic incubator for incubation, a small hole is drilled at the narrow end of the chick embryo on the 4 th day, and about 4mL of egg white is extracted. A window of about 2cm was opened above the chicken ring and covered with preservative film. Then put into a constant temperature and humidity box for continuous incubation. On the 10 th day, the chick embryos are taken out, eggshells around the window are stripped, 226 chick embryos with good growth are selected and randomly divided into 24 groups, the groups are respectively 3 negative control groups (blank), 3 positive control groups (common emulsion external matrix), test samples (10 each) prepared by the compositions of examples 1-7 and comparative examples 1-4, chorion blood vessels are exposed, a Teflon ring is placed at the dense part of each blood vessel, a Teflon ring is placed in each chick embryo, 40 mu L of each group of samples are added in each ring, then the chick embryos are placed in a constant temperature and humidity box for incubation for 30 minutes, the Teflon rings are taken down and washed by PBS until no obvious residue exists in the test sample. The area outside the teflon ring was used as a control, and the vascular injury in the teflon ring was observed under a stereoscopic microscope, and the vascular stimulatory effect was scored according to table 1. The results are shown in Table 2.
TABLE 1CAMVA test Scoring standards
TABLE 2CAMVA test score Table
| Sample (I) | Score of |
| Negative control group | Are all 0 grade |
| Positive control group | Are all 0 grade |
| Example 1 | Are all 0 grade |
| Example 2 | Are all 0 grade |
| Example 3 | Are all 0 grade |
| Example 4 | Are all 0 grade |
| Example 5 | Are all 0 grade |
| Example 6 | Are all 0 grade |
| Example 7 | Are all 0 grade |
| Comparative example 1 | Are all 0 grade |
| Comparative example 2 | Are all 0 grade |
| Comparative example 3 | Are all 0 grade |
| Comparative example 4 | Are all 0 grade |
As can be seen from the CAMVA test results in Table 2, the compositions of examples 1-7 achieved the desired effect, all on a 0 scale. The compositions of comparative examples 1 to 4 were also of grade 0. Indicating that the composition is non-irritating to blood vessels.
2. Human body safety inspection method
Human safety test methods skin closed patch tests were tested with reference to the cosmetic safety technical Specification (2015 edition), chapter 2, section seven, human skin patch test method.
(1) Test samples: the compositions of examples 1 to 7 and comparative examples 1 to 4 were respectively added to a common emulsion external base to prepare test samples, wherein the composition accounted for 5% of the total mass of the emulsion. Meanwhile, 2% hydroquinone ointment was used as a control.
(2) The tester selects: volunteers who are 18-60 years old and meet the requirements of the test are selected as the subjects. The following conditions were not included as subjects: those who use antihistamines for nearly one week or immunosuppressants for nearly one month; in the last two months, any anti-inflammatory drug is applied to the tested part; the subject has a clinically unvulcanized inflammatory skin condition; insulin-dependent diabetic patients; patients suffering from asthma or other chronic respiratory diseases undergoing therapy; those receiving anti-cancer chemotherapy within approximately 6 months; patients with immunodeficiency or autoimmune disease; lactating or pregnant women; bilateral mastectomy and bilateral underarm lymph node resection; the judgment of the test result is influenced by scars, pigments, atrophy, port wine stains or other flaws on the skin to be tested; participation in other clinical trial investigators; those with high constitutional sensitivity; non-volunteer participants or those who cannot complete the prescribed content as required by the trial.
(3) The test method comprises the following steps: suitable subjects were selected as 50, 30 women and 20 men. The selected area is not more than 50mm 2 And qualified spot test equipment with the depth of about 1 mm. The test sample is put into a small chamber of a spot tester, and the dosage is about 0.020-0.025 g. The patch test device with the test sample applied thereto was applied to the curved side of the forearm of the subject with a hypoallergenic tape and applied evenly to the skin with a gentle pressure of the palm for 24 hours. The skin reactions were observed according to the standard of table 3 30 minutes (after the indentation disappears), 24 hours, and 48 hours after the test sample patch was removed, and the observation results were recorded, the skin reaction grading standard of the skin-enclosed patch test is shown in table 3,
the test results are shown in table 4.
TABLE 3 skin response grading Standard for skin Enclosed Patch test
TABLE 4 Patch test score
| Sample (I) | 30 minutes | 24 hours | 48 hours |
| Control group | Are all 0 grade | Are all 0 grade | Are all 0 grade |
| Example 1 | Are all 0 grade | Are all 0 grade | Are all 0 grade |
| Example 2 | Are all 0 grade | Are all 0 grade | Are all 0 grade |
| Example 3 | Are all 0Stage | Are all 0 grade | Are all 0 grade |
| Example 4 | Are all 0 grade | Are all 0 grade | Are all 0 grade |
| Example 5 | Are all 0 grade | Are all 0 grade | Are all 0 grade |
| Example 6 | Are all 0 grade | Are all 0 grade | Are all 0 grade |
| Example 7 | Are all 0 grade | Are all 0 grade | Are all 0 grade |
| Comparative example 1 | Are all 0 grade | Are all 0 grade | Are all 0 grade |
| Comparative example 2 | Are all 0 grade | Are all 0 grade | Are all 0 grade |
| Comparative example 3 | Are all made ofLevel 0 | Are all 0 grade | Are all 0 grade |
| Comparative example 4 | Are all 0 grade | Are all 0 grade | Are all 0 grade |
As can be seen from the patch results of Table 4, the compositions of examples 1 to 7 and the compositions of comparative examples 1 to 4 both achieved the expected effects and were negative reactions. Does not generate very strong positive reaction and has no hidden danger to the safety of human body. The combination of the components in the composition is safe, and the mild and non-irritant characteristics of the composition are not destroyed when the composition is used with propafel.
3. Moisture retention efficacy testing
Testing in a QB/T4256-2011 mode.
(1) Test samples: the compositions of examples 1 to 7 and comparative examples 1 to 4 were respectively added to a common emulsion external base to prepare test samples, wherein the composition accounted for 5% of the total mass of the emulsion.
(2) Subject selection
The number of subjects: effective subjects were 220, 10 per group.
Subject conditions: the age is between 18 and 65 years (except pregnant or lactating women); the base value of a capacitance method skin moisture tester in a forearm test area is between 15 and 45 (Corneometer Unit, C.U.); patients without severe systemic disease, immune deficiency or autoimmune disease, the test site has not received skin treatment, cosmetic and other tests that may affect outcome; those with inactive allergic disease; those without constitutional hypersensitivity; hormone drugs and immunosuppressants have not been used in the last month; the test sites were not enrolled in other clinical trials now or in the last three months.
(3) Measurement procedure
Preparation before testing: any product (cosmetics or external medicines) cannot be used 2-3 days before the test of the tested part, and water cannot be contacted for 1-3 hours. Before the test, the test subject needs to uniformly clean the skin of the test site and wipe the skin clean with dry facial tissue. The test site should be exposed and relaxed in a standard room for at least 20 minutes without drinking water or beverages prior to official testing.
Testing an instrument: skin moisture test probe Corneometer CM825.
The determination method comprises the following steps: the sample application and control areas should be randomly distributed over the left and right arm calibration areas to ensure that all sample and control area positions are statistically balanced. The test sample is (2.0 +/-0.1) mg/cm 2 The amount of the sample is smeared for a single time, the sample is evenly smeared in the test area by using the latex finger cot, and the actual sample smearing amount is recorded. According to the use instruction of a skin moisture tester, the sample area and the control area are measured after the tester is adjusted, and each area is measured at least 3 times in parallel; the initial values for each area were measured (before using the sample) and then the skin moisture content of the test and control areas was measured after a set time. The set times were 2 hours, 3 hours and 8 hours. The test of the same subject is performed by the same measuring person, and the measuring probe should be cleaned before each test. During the use of the sample, if adverse reactions occurred on the skin of the subject, the test should be immediately discontinued, and the subject is appropriately treated and the adverse reactions recorded.
(4) Calculation results
Descriptive statistics: descriptive statistics are performed on the measured values of each test area, including quantity, mean, standard deviation, minimum, median, maximum.
And (3) differential analysis: calculating the difference between the initial value of each test area and the measured value at other time points, and then using the difference to statistically analyze the difference between the sample area and the control area at different time points. If the test data is normal distribution, performing statistical analysis by adopting a t test method; if the test data is in non-normal distribution, statistical analysis is carried out by a rank and test method. The statistical methods all adopt a two-tail test, and the test level is alpha =0.05.
(5) Determination of results
Positive results: before and after the sample is used, the significance level P of the moisture content of the horny layer of the skin is less than 0.05, which shows that the tested product has the moisturizing effect.
Negative results: before and after the sample is used, the significance level P of the water content of the horny layer of the skin is more than or equal to 0.05, which shows that the tested product has no moisturizing effect. The test results are shown in Table 5.
TABLE 5 moisture content of stratum corneum of skin at various times for test samples
Statistical analysis is carried out on the experimental results of the table 5, after 2 hours of use, the moisture content of the skin stratum corneum of the examples 6 and 7 has a significant difference compared with a control group, and P is less than 0.002; after 3 hours of use, the moisture content of the skin horny layer of the examples 6 and 7 has a significant difference compared with a control group, and P is less than 0.001; after 8 hours of use, the moisture content of the horny layer of the skin of the examples 6 and 7 has a significant difference compared with a control group, and P is less than 0.001; showing that the formulations of examples 6 and 7 have a stimulating effect on the moisture content of the stratum corneum of the skin, when the emulsion is prepared by continuously using the composition of the present invention. The moisture content of the stratum corneum of comparative example 3 is lower than that of all the examples, which shows that the moisture content of the stratum corneum is reduced, and the moisture content of the stratum corneum of the common cream is lower than that of all the components.
4. Barrier repair efficacy testing
The effect of the T/ZHCA 003-2018 cosmetic is tested by the epidermal water loss test method.
(1) Test samples: the examples 1 to 7 and the comparative examples 1 to 4 were added to a general emulsion external base to prepare test samples in which the composition accounted for 5% of the total mass of the emulsion.
(2) Subject selection
The number of subjects: effective subjects were 220, 10 per group.
Subject conditions: volunteers aged 18-60 years who meet the requirements of the test. The following could not be selected as subjects: those who use antihistamines for nearly one week or immunosuppressants for nearly one month; in the last two months, any anti-inflammatory drug is applied to the tested part; a subject having a clinical incurability of inflammatory skin diseases; insulin dependent diabetes mellitus patients; patients suffering from asthma or other chronic respiratory diseases undergoing treatment; those who receive anti-cancer therapy within approximately six months; patients with immunodeficiency or autoimmune disease; lactating or pregnant women; bilateral mastectomy and bilateral underarm lymph node resection; the judgment of the test result is influenced by scars, pigments, atrophy, port wine stains or other blemishes on the skin to be tested; participation in other clinical trial investigators; those with high constitutional sensitivity; non-volunteer participants or those who cannot complete the prescribed content as required by the trial.
(3) Measurement procedure
Testing an instrument: through epidermis water loss tester Tewameter
The measuring method comprises the following steps: the left and right forearm curvature of the subjects were randomly divided into the smear and control sides to ensure that the smear and control sides were statistically balanced. Before each measurement, the test site was cleaned with clear water and blotted with a dry, non-dusting, absorbent paper towel. Sit still for at least 20min in a standard test environment without drinking water or drink, with the forearms exposed, remaining relaxed, avoiding touching the test area. The test was carried out according to the instructions of the tester for water loss through the epidermis. When measuring the TEWL value, the instrument probe must be placed at the center of the test area. When measuring, the average value of 10 continuous points of the TEWL value curve is taken [ the standard deviation should be less than 0.2 g/(h.m) 2 )]As a measured value; initial values for each zone were measured (before using the sample) and then TEWL values were determined for the test and control zones after a set time. The set time was 7 days and 8 days. Testing of the same subject must be done by the same tester using the same instrument. Adverse reactions such as the skin of the subject during the use of the sample should be immediateThe test was discontinued and the subject was treated appropriately. Adverse reactions were recorded.
(4) Calculation results
Descriptive statistics: descriptive statistics are performed on the measured values of each test area, including quantity, mean, standard deviation, minimum, median, maximum.
And (3) differential analysis: the change rates of the TEWL average values on the sample application side and the control side were calculated, respectively, and then the difference between the sample application area and the control area at different measurement time points was statistically analyzed using the change rates. If the test data is in normal distribution, performing statistical analysis by adopting a t test method; if the test data is in non-normal distribution, statistical analysis is carried out by a rank and test method. The statistical methods all adopt a two-tail test, and the test level alpha =0.05.
(5) Determination of results
And (4) positive result: compared with the comparative example 2, the change rate of the TEWL value of the sample smearing side is remarkably different, P is less than 0.05, and the tested sample has the effect of promoting the recovery of the transepidermal water loss of the skin with damaged barrier.
Negative results: compared with the comparative example 2, the change rate of the TEWL value on the sample application side has no significant difference P which is more than or equal to 0.05, and the change rate shows that the tested sample has no promotion effect on the recovery of the transepidermal water loss of the skin with damaged barrier. The test results are shown in Table 6.
TABLE 6 TEWL values of the test samples at different times
Note: under the test condition, the higher the TEWL value obtained, the more the transepidermal water diversion loss of unit time and unit cross-sectional area; the lower the TEWL value, the less the amount of transepidermal water loss per unit time and per unit cross-sectional area.
Statistical analysis of the test results in table 6 shows that the change rates of the TEWL values in examples 1 to 7 in the transdermal water loss after 7 days and 14 days of use are significantly different from those in comparative example 3 (cream texture only), and P is less than 0.001, which indicates that the compositions in examples 1 to 7 have an effect of promoting the recovery of the transdermal water loss in the barrier-damaged skin. The change rate of the TEWL value of the comparative examples 1-4 is far higher than that of the examples, which shows that the change rate of the TEWL value is extremely weak to the skin barrier repair effect. The results of the repair efficacy test further prove the repair ability of the synergistic effect of the components and contents of the formula on the skin.
5. DPPH free radical scavenging experiment
The test was carried out according to T/SHRH 006-2018 Experimental methods for the scavenging of cosmetic-free radicals (DPPH).
(1) Test samples: examples 1 to 7 and comparative examples 1 to 4.
(2) Reagents and materials: except for other indications, all the reagents are analytically pure, and the water is first-grade water meeting the GB/T6682 specification. DPPH (1, 1-diphenyl-2-trinitrophenylhydrazine), content 99%; the purity of the vitamin C standard substance is more than or equal to 98 percent; 95% ethanol AR.0.04mg/ml PPH solution: weighing 2mgDPPH, dissolving with 95% ethanol, diluting to a constant volume in a 50mL brown volumetric flask, and storing in dark place.
Preparing a Vc standard solution: accurately weighing a certain amount of vitamin standard substance, preparing into solution with concentration of 0.08, 0.04, 0.02, 0.01mg/mL with 95% ethanol, and preparing at present.
(3) Analytical procedure
Sample treatment: the water soluble sample was diluted with water and the oil soluble sample was diluted with 95% ethanol.
TABLE 7 solution addition reagent
| Sample tube | Background of sample | Blank tube | Positive control tube | |
| Sample solution (mL) | 2 | 2 | - | - |
| Positive control solution (mL) | - | - | - | 2 |
| Water or 95% ethanol solvent (mL) | - | 2 | 2 | - |
| DPPH solution (mL) | 2 | - | 2 | 2 |
| Total volume (mL) | 4 | 4 | 4 | 4 |
The reagents were added to the solutions in the volume shown in Table 7, mixed, shaken, reacted at 37 ℃ for 30min in the dark, and the absorbance was measured at 517nm using 2mL of distilled water and 2mL of 95% ethanol as a blank.
(4) Calculation of results
Calculation of DPPH-radical clearance: DPPH clearance% = (1-a) i- A j /A 0 )×100
A 0 -absorbance of blank; a. The i -absorbance of the sample after reaction with DPPH; a. The j -absorbance of the sample background; 100-scaling factor.
(5) Test validity verification
Each batch of experiment requires the test of adding a positive control, IC of vitamin C 50 The test system is considered to be effective if the concentration of the sample to be tested (corresponding to the concentration of the sample to be tested when 50% of the clearing effect is achieved) is 0.02-0.06 mg/mL.
And (3) calculating the clearance rate of free radicals of the sample under each tested concentration according to a formula, and counting the Standard Deviation (SD) between the clearance rates of the parallel tubes of each group, wherein the SD value is less than or equal to 3 percent, and the test parallelism is considered to be effective.
TABLE 8 radical scavenging ratio (%)
| Sample (I) | Free radical scavenging rate |
| Positive control group | 0 |
| Example 1 | 15 |
| Example 2 | 18 |
| Example 3 | 19 |
| Example 4 | 32 |
| Example 5 | 31 |
| Example 6 | 30 |
| Example 7 | 35 |
| Comparative example 1 | 28 |
| Comparative example 2 | 29 |
| Comparative example 3 | 5 |
| Comparative example 4 | 18 |
Analysis of the results in table 8 shows that the mild multi-effect skin care composition also has the ability to scavenge DPPH radicals under synergistic action, and example 7 has the strongest ability to scavenge radicals and is significantly different from comparative example 3.
In conclusion, the mild multi-effect skin care composition containing propafenone ensures that the moisture content of the skin stratum corneum can reach 47.36 on the basis of ensuring the safety of a human body without stimulation and stimulation to blood vessels, has obvious repairing effect on the aspect of barrier repair, proves that the mild propafenone is non-irritant and is suitable for people with sensitive and tender skin, and simultaneously proves that the original effect of the propafenone is damaged under the mutual matching of the propafenone and other components in the composition, the synergistic effect provides certain effects on the aspects of moisture preservation and repair, and the respective anti-inflammatory and anti-aging characteristics of the propafenone are exerted.
Claims (7)
1. The mild multi-effect repairing composition containing propagum germanium is characterized by comprising the following components in parts by weight: 1 to 9 parts of propagum germanium, 200 to 650 parts of rice fermentation product filtrate, 10 to 40 parts of rye seed extract and 0.1 to 0.5 part of hydrolyzed gardenia extract.
2. The mild multi-effect conditioning composition containing propagum according to claim 1, further comprising 0.05 to 0.4 parts of atractylodes macrocephala koidz extract and 10 to 50 parts of bearberry leaf extract.
3. The mild multi-effect repairing composition containing propafenone germanium according to claim 1, further comprising 5-20 parts of snow lotus herb extract.
4. The mild multipurpose conditioning composition containing propafenone according to claim 1, characterized by comprising the following components in parts by weight: 2 to 8 portions of propagum germanium, 300 to 600 portions of rice fermentation product filtrate, 15 to 35 portions of rye seed extract and 0.15 to 0.45 portion of hydrolyzed gardenia extract.
5. The mild multipurpose conditioning composition containing propafenone according to claim 2, characterized by comprising the following components in parts by weight: 3 to 7 parts of propagum germanium, 350 to 550 parts of rice fermentation product filtrate, 17 to 30 parts of rye seed extract, 0.2 to 0.5 part of hydrolyzed gardenia extract, 0.05 to 0.4 part of white atractylodes rhizome extract and 10 to 50 parts of bearberry leaf extract.
6. The mild multipurpose conditioning composition containing propafenone according to claim 3, characterized by comprising the following components in parts by weight: 3 to 7 parts of propagum germanium, 350 to 550 parts of rice fermentation product filtrate, 17 to 30 parts of rye seed extract, 0.2 to 0.5 part of hydrolyzed gardenia extract, 0.07 to 0.38 part of bighead atractylodes rhizome extract, 15 to 45 parts of bearberry leaf extract and 8 to 15 parts of snow lotus herb extract.
7. Use of a mild multipurpose conditioning composition containing propafenone according to any one of claims 1 to 6 as an additive in skin care products.
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| CN107737272A (en) * | 2017-12-03 | 2018-02-27 | 同济大学 | A kind of Chinese medicine composition and its methods for making and using same with freckle removing and whitening effect |
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| CN107737272A (en) * | 2017-12-03 | 2018-02-27 | 同济大学 | A kind of Chinese medicine composition and its methods for making and using same with freckle removing and whitening effect |
| KR102347109B1 (en) * | 2021-08-24 | 2022-01-05 | 주식회사 코씨드바이오팜 | Cosmetic composition for improvement of moisturizing with hydrolyzed plant extract |
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