CN115721696B - Liver soothing tablet and preparation process thereof - Google Patents
Liver soothing tablet and preparation process thereof Download PDFInfo
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a liver soothing tablet and a preparation process thereof, wherein the liver soothing tablet comprises fructus amomi: 50-100 parts; cardamom: 30-70 parts; vinegar rhizoma corydalis: 70-110 parts; dried orange peel: 120-160 parts; poria cocos: 180-220 parts; fructus Toosendan: 280-320 parts; agilawood: 160-200 parts; white peony root: 260-300 parts; rhizoma Wenyujin Concisa: 180-220 parts; fructus Aurantii: 160-200 parts; cortex Magnoliae officinalis: 80-120 parts; radix aucklandiae: 120-160 parts; dextrin: 230-270 parts; pregelatinized starch: 230-270 parts; sucrose: 112.5 parts; magnesium stearate: 8 parts; beta-cyclodextrin: 2 parts. The invention improves the production efficiency and reduces the fuel consumption, thereby reducing the production cost; the effective components in the thick paste are improved by 5%, the quality and performance of the product are stable, the qualification rate is improved, the effective period of the product is prolonged, and the problems of unstable curative effect, unsafe and difficult storage are solved.
Description
Technical Field
The invention relates to the technical field of pharmacy, in particular to a liver soothing tablet and a preparation process thereof.
Background
The traditional Chinese patent medicine is national treasure in China, develops for thousands of years, forms a medical science system which supplements Western medicine, at present, the traditional Chinese patent medicine becomes a modern economic industry which is few in China and has an independent intellectual property advantage system, a complete economic industry chain is formed by traditional Chinese medicine planting, traditional Chinese patent medicine manufacturing industry and traditional Chinese medicine circulation industry, the current society is along with the increasing of medical source and medicine source diseases and the change of health concepts and the conversion of medical modes, compared with the relatively larger toxic and side effects of chemical medicines, the traditional Chinese patent medicine has the characteristics and advantages of natural sources, small side effects, definite curative effect and relatively low price, the traditional Chinese patent medicine is increasingly focused by people, the traditional Chinese medicine has the advantages of remarkable development of traditional Chinese medicine services, the traditional Chinese medicine advantages are gradually recognized and accepted in the world, the sales volume is continuously increased to 130 more countries, and the market pattern of the large development of the traditional Chinese patent medicine enterprises is cast along with the good development environment. Along with the progress of science and technology, the modernization and internationalization of traditional Chinese medicine are strategic positioning and emerging connotations of the national development traditional Chinese medicine industry. The traditional Chinese medicine can treat difficult and complicated diseases which are difficult to cure by western medicines, which is already known worldwide and creates a plurality of wonder. In the period of ' SARS ', the Chinese patent medicine has the prevention function of ' SARS ' and the prominent expression of clinical SARS cases, so that the Chinese patent medicine is valued in China, and the world health organization's good-looking future Chinese medicine and large health industry has a wider development prospect.
The Shuganpian is a good medicine for treating stomach diseases, has small side effect and definite curative effect, and is prepared by respectively crushing fructus amomi, cardamom and rhizoma corydalis into fine powder and sieving; the pericarpium citri reticulatae is used for extracting volatile oil, the volatile oil is dissolved by a proper amount of ethanol, the most obvious medicinal effect of the pericarpium citri reticulatae is one of the precious raw materials with homology of medicine and food, such as phlegm reduction and cough relieving, heart and cerebral vessels dredging, blood pressure lowering and the like, has the functions of regulating qi and lowering adverse qi, regulating middle warmer and stimulating appetite, eliminating dampness and reducing phlegm, and is mainly used for treating qi stagnation and dampness obstruction of spleen and stomach, chest fullness and distention and pain, anorexia, vomiting and adverse flow of qi, difficult urination, lung qi obstruction, cough and excessive phlegm, and also for treating acute mastitis; decocting the residue in water for 1 hr, and filtering; poria and fructus Toosendan are added to promote digestion, promote appetite, remove food retention, relieve pain and relieve restlessness. Can be used for treating stagnation of liver-qi, pricking pain of two ribs, inappetence, dyspepsia, emesis, and pain of whole body.
The agilawood is a very precious medicinal material, has mild nature, is pungent and bitter in taste, and enters spleen channel, stomach channel and kidney channel. Has the effects of promoting qi circulation, relieving pain, warming middle-jiao, relieving vomiting and relieving asthma, and the agilawood and the dried orange peel in the variety have important roles in 12 traditional Chinese medicines, so that the whole product has definite curative effect, low toxic and side effects, easy carrying and large demand. The domestic market demand is huge, the annual demand is 1-5 hundred million, the growth potential is immeasurable, and the development prospect is wide.
Disclosure of Invention
The invention aims to provide a liver soothing tablet and a preparation process thereof, which are used for solving the technical problems of low product yield, unstable product quality and performance, high fuel consumption and unstable curative effect of products prepared by the prior art.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the invention provides a liver soothing tablet which is prepared from the following raw materials in parts by weight:
fructus Amomi: 50-100 parts; cardamom: 30-70 parts; vinegar rhizoma corydalis: 70-110 parts; dried orange peel: 120-160 parts; poria cocos: 180-220 parts; fructus Toosendan: 280-320 parts; agilawood: 160-200 parts; white peony root: 260-300 parts; rhizoma Wenyujin Concisa: 180-220 parts; fructus Aurantii: 160-200 parts; cortex Magnoliae officinalis: 80-120 parts; radix aucklandiae: 120-160 parts; dextrin: 230-270 parts; pregelatinized starch: 230-270 parts; sucrose: 112.5 parts; magnesium stearate: 8 parts; beta-cyclodextrin: 2 parts.
Further, the preparation method comprises the following raw materials in parts by weight:
fructus Amomi: 60-90 parts; cardamom: 40-60 parts; vinegar rhizoma corydalis: 80-100 parts; dried orange peel: 130-150 parts; poria cocos: 190-210 parts; fructus Toosendan: 290-310 parts; agilawood: 170-190 parts; white peony root: 270-290 parts; rhizoma Wenyujin Concisa: 190-210 parts; fructus Aurantii: 170-190 parts; cortex Magnoliae officinalis: 90-110 parts; radix aucklandiae: 130-150 parts; dextrin: 240-260 parts; pregelatinized starch: 240-260 parts; sucrose: 112.5 parts; magnesium stearate: 8 parts; beta-cyclodextrin: 2 parts.
Further, the preparation method comprises the following raw materials in parts by weight:
fructus Amomi: 70 parts; cardamom: 50 parts; vinegar rhizoma corydalis: 90 parts; dried orange peel: 140 parts; poria cocos: 200 parts; fructus Toosendan: 300 parts; agilawood: 180 parts; white peony root: 280 parts; rhizoma Wenyujin Concisa: 200 parts; fructus Aurantii: 180 parts; cortex Magnoliae officinalis: 100 parts; radix aucklandiae: 140 parts; dextrin: 250 parts; pregelatinized starch: 250 parts; sucrose: 112.5 parts; magnesium stearate: 8 parts; beta-cyclodextrin: 2 parts.
The invention provides a preparation process of a liver soothing tablet, which comprises the following steps:
s1, preparing agilawood percolate;
s2, preparing extract liquid;
s3, preparing particles.
Further, the step S1 includes the following substeps:
s11, weighing raw materials and crushing: placing the agilawood Chinese medicinal decoction pieces into a Chinese medicinal pulverizer, and crushing the Chinese medicinal decoction pieces with a pore diameter of 2-3 cm for later use;
s12, extracting: placing the coarsely crushed agilawood into an extraction tank, adding 60% -80% ethanol to soak for 20-30 min, controlling the steam pressure at 0.3MPa, opening a cooling tower and a cooling water valve, carrying out reflux extraction for 3 times, each time for 2 hours, and merging the liquid medicine into a liquid storage tank for standby after 100 meshes;
s13, taking the coarsely crushed costustoot, fructus aurantii, magnolia officinalis, white paeony root and curcuma longa, filling the coarsely crushed costustoot, fructus aurantii, magnolia officinalis, white paeony root and curcuma longa into an extraction tank, adding 60% ethanol while adding the medicinal materials for soaking for 2-3 hours, controlling the percolating flow rate to be 162-270L/h, starting percolating, and collecting a percolate for later use, wherein the percolating liquid amount is 5750-6250L;
s14, concentrating: recovering ethanol under reduced pressure to obtain clear paste without alcohol smell, and concentrating at 75-85deg.C to obtain clear paste with relative density of 1.20-1.25.
Further, the step S2 includes the following substeps:
s21, preparing dried orange peel volatile oil: decocting pericarpium Citri Tangerinae to obtain volatile oil, adding ethanol to 1000ml, and storing; 1400L of drinking water is added for the second time, and the collected liquid medicine amount is 1400-1540L;
s22, decocting poria cocos and szechwan chinaberry fruit in water for 2 times, and collecting 7200L-7740L of total liquid medicine;
s23, concentrating: pumping the extracting solution into an external circulation double-effect concentrator or a water double-effect vacuum concentrator, and concentrating at 75-85 ℃ to obtain clear paste with the relative density of 1.20-1.25 for later use;
s24, paste collection: stirring the clear paste for 30 minutes, and then collecting the clear paste, wherein the yield of the clear paste is 36.0-44.2%, and the amount of the clear paste is 620-760 kg.
Further, the step S3 includes the following substeps:
s31, preparing syrup: weighing purified water, boiling in a jacketed kettle, adding sucrose, and continuously stirring until the purified water is completely dissolved for later use;
s32, mixing: placing pregelatinized starch, dextrin and vinegar rhizoma corydalis fine powder into a mixer, premixing for 8-10S, adding liver soothing tablet extract, and mixing for 15-20S;
s33, drying: sucking the mixture obtained in the step S2 into a boiling drying granulator, and setting a drying temperature;
s34, mixing and sieving: placing the dry particles in a mixer, adding syrup, starting a quick button of the mixer, mixing for 15-20S, uniformly mixing, transferring into a swing type granulator to prepare wet particles, sucking the wet particles into a boiling drying granulator, drying, loading the dry wet particles in a stainless steel container, and crushing;
s35, preparing a soft material: placing one part of cardamon fine powder, amomum villosum fine powder and crushed fine powder into a mixer, starting a mixer quick button, premixing for 8-10S, starting the mixer quick button, and uniformly mixing for 15-20S;
s36, spray granulating and drying: sucking the mixed soft material into a boiling dryer, starting a peristaltic pump, setting the rotating speed of the peristaltic pump to be 80-200 rpm, spraying all agilawood percolate into the boiling dryer granulator, setting room temperature for drying for 35-50 min, and charging by a stainless steel material container after drying; when the moisture is 3 to 5 percent, stopping the machine for discharging;
s37, finishing: adding the dried granules into a swinging granulator for granulating;
s38, total mixing: magnesium stearate and granulated particles were mixed according to a 1:1, premixing for 5-10 min in a stainless steel container, wrapping pericarpium citri reticulatae volatile oil, and putting the rest particles and the premixed particles into a two-dimensional motion mixer for mixing; finally tabletting and split charging are carried out to obtain the liver soothing tablets.
Further, in the step S33, the drying temperature is 70.+ -. 10 ℃ and the drying time is 20-35 minutes.
Further, in the step S34, the mesh size of the sieving sheet used for sieving is 1.0 to 2.0mm.
Further, in the step S38, the rotating speed of the tablet press is 8-12 revolutions per minute, the pressure is 80-100 KN, and the quality of the prepared liver-soothing tablet is 0.6g.
Based on the technical scheme, the embodiment of the invention at least has the following technical effects:
(1) The liver soothing tablet and the preparation process thereof provided by the invention prolong the effective period of the effective components of the traditional Chinese medicine in the product, ensure the safety in the production process of the product and enable the effective components in the product to exert the effect of rose; the product yield is improved to 95% from the original less than 85%; the original safety of the product is improved to 70% by less than 55%; the production efficiency is improved, and the fuel consumption is reduced, so that the production cost is reduced; the effective components in the thick paste are improved by 5%, the quality and performance of the product are stable, the qualification rate is improved, the effective period of the product is prolonged, and the problems of unstable curative effect, unsafe and difficult storage are solved.
(2) According to the liver soothing tablet and the preparation process thereof, the agilawood is directly added into low-temperature spray, so that the volatility of active ingredients in agilawood is solved, and the curative effect and the safety in the production process of the medicine are ensured; the beta cyclodextrin of the volatile oil of the dried orange peel is wrapped and then added in a total way, so that the problem that the product quality is difficult to guarantee in the effective period due to poor medicine stability caused by the phenomenon that the volatile oil component is volatilized and lost easily in the production process in the prior art is solved.
(3) The liver soothing tablet and the preparation process thereof provided by the invention have important significance for energy conservation and emission reduction, and the liver soothing tablet can save energy, reduce consumption by 50 ten thousand yuan each year, reduce waste water COD by 100 tons and has 50% lower power consumption, gas consumption, water consumption and labor than the existing process.
Detailed Description
The following description of the technical solutions in the embodiments of the present invention will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the technical solutions should be considered that the combination does not exist and is not within the scope of protection claimed by the present invention.
The aim of the invention is realized by the following technical scheme:
1. preparing agilawood percolate:
s1: weighing 180.0kg of raw materials, namely agilawood decoction pieces;
s2, crushing, namely placing the weighed agilawood traditional Chinese medicine decoction pieces into a traditional Chinese medicine crusher, and crushing the traditional Chinese medicine decoction pieces with a 3cm aperture for later use; the main purpose of crushing is to maximize the efficacy;
s3, extracting, namely, using ethanol percolation methods with different concentrations to enable the active ingredients to be exerted to the maximum.
The agilawood extraction process adopts an optimal method selected by an orthogonal experiment method, the optimal extraction process of agilawood obtained by experiments is that the feed-liquid ratio is 70%, the extraction is carried out for 3 times, each time for 2.5 hours, and the optimal extraction process is stable and reliable.
2. Preparing extract liquid
S1, steaming the dried orange peel to obtain volatile oil: decocting dried orange peel with water twice, extracting volatile oil between 200-300 ml for the first time, adding ethanol to 1000ml of total amount, warehousing for standby, adding 1400L of drinking water for the second time, and collecting 1400-1540L of liquid medicine;
s2, decocting poria cocos and szechwan chinaberry fruit in water for 2 times, and collecting 7200L-7740L of total liquid medicine;
s3, concentrating: pumping the extracting solution into an external circulation double-effect concentrator or a water double-effect vacuum concentrator, and concentrating to obtain clear paste with the relative density of 1.20-1.25 (75-85 ℃);
s4, paste collection: stirring the clear paste for 30 minutes, and collecting the paste. Yield of the clear paste: 36.0 And (3) the concentration of the ointment is between 44.2 percent (the amount of the ointment is between 620 and 760 Kg).
3. Preparation of granules
1. Raw materials:
70 parts of fructus amomi, 50 parts of cardamom, 90 parts of rhizoma corydalis (processed with vinegar), 140 parts of dried orange peel, 200 parts of poria cocos, 300 parts of szechwan chinaberry fruit, 180 parts of agilawood, 280 parts of white paeony root, 200 parts of curcuma longa, 180 parts of fructus aurantii, 100 parts of magnolia officinalis, 140 parts of elecampane, 250 parts of dextrin, 250 parts of pregelatinized starch, 112.5 parts of sucrose and 8 parts of magnesium stearate; every 50-100 kg of dried orange peel, the following components are used in the following amounts: 0.216L of pericarpium citri reticulatae volatile oil, 50-100 kg of agilawood each time, and the following components are used in the amounts: agilawood percolate 810L.
2. The preparation method comprises the following steps:
example 1: preparation of granules
S1, preparing syrup: weighing 140.0kg of purified water, boiling in a jacketed kettle, adding 112.5kg of sucrose, and continuously stirring until the purified water is completely dissolved for later use;
s2, mixing: placing the prepared pregelatinized starch, dextrin and vinegar rhizoma corydalis fine powder in a mixer, premixing for 8S, adding the liver-soothing tablet extract, mixing for 15S, and drying;
s3, drying: sucking the soft material into a boiling drying granulator, setting the drying temperature to 70 ℃, and controlling the material temperature to 70+/-10 ℃ for drying for 20-35 minutes for later use;
s4, mixing and sieving: placing one part of dry particles in a mixer, adding one part of syrup, starting a quick button of the mixer, mixing for 15S, uniformly mixing, transferring into a swing type granulator to prepare wet particles, and drying;
s5, drying: sucking the wet granules into a boiling drying granulator, and setting the drying temperature to be 70 ℃; drying the materials at 70+/-10 ℃ for 35-50 minutes, and charging the materials in a stainless steel material container after drying;
s6, crushing: pulverizing the above granule;
s7, preparing a soft material: placing one part of fructus Amomi rotundus fine powder, fructus Amomi fine powder and pulverized fine powder into a mixer, starting a mixer quick button, premixing 8S, starting the mixer quick button, and mixing 15S uniformly;
s8, spray granulation and drying: sucking the mixed soft material into a boiling dryer, starting a peristaltic pump, setting the rotating speed of the peristaltic pump to 150rpm, spraying all the agilawood percolate into the boiling dryer granulator, and setting the room temperature for drying; drying for 40 minutes, charging by using a stainless steel material container after drying, and stopping discharging when the water content is 4%;
s9, finishing: adding the dried granules into a swinging granulator for granulating;
s10, total mixing: mixing the magnesium stearate and the granulated particles according to the proportion of 1:1, premixing for 8 minutes in a stainless steel container, wrapping pericarpium citri reticulatae volatile oil, and putting the rest particles and the premixed particles into a two-dimensional motion mixer for mixing;
s11, tabletting: the weight of the tablet is 0.6g, the rotating speed of the tablet press is 10 revolutions per minute, the pressure is 90KN, and the tablet is prepared after split charging.
Example 2: preparation of granules
S1, preparing syrup: weighing 140.0kg of purified water, boiling in a jacketed kettle, adding 112.5kg of sucrose, and continuously stirring until the purified water is completely dissolved for later use;
s2, mixing: placing the prepared pregelatinized starch, dextrin and vinegar rhizoma corydalis fine powder in a mixer, premixing for 8S, adding the liver-soothing tablet extract, mixing for 15S, and drying;
s3, drying: sucking the soft material into a boiling drying granulator, setting the drying temperature to 70 ℃, and controlling the material temperature to 70+/-10 ℃ for drying for 20 minutes for later use;
s4, mixing and sieving: placing one part of dry particles in a mixer, adding one part of syrup, starting a quick button of the mixer, mixing for 15S, uniformly mixing, transferring into a swing type granulator to prepare wet particles, and drying;
s5, drying: sucking the wet granules into a boiling drying granulator, and setting the drying temperature to be 70 ℃; drying the materials at 70+/-10 ℃ for 35 minutes, and charging the materials in a stainless steel material container after drying;
s6, crushing: pulverizing the above granule;
s7, preparing a soft material: placing one part of fructus Amomi rotundus fine powder, fructus Amomi fine powder and pulverized fine powder into a mixer, starting a mixer quick button, premixing for 8S, adding lignum Aquilariae Resinatum percolate, starting the mixer quick button, mixing for 15S, and drying;
s8, when the water content is 3% by drying at room temperature, stopping the machine for discharging;
s9, finishing: adding the dried granules into a swinging granulator for granulating;
s10, total mixing: mixing the magnesium stearate and the granulated particles according to the proportion of 1:1, premixing for 5 minutes in a stainless steel container, spraying an ethanol solution of pericarpium citri reticulatae volatile oil, and putting the rest particles and the premixed particles into a two-dimensional motion mixer for mixing;
s11, tabletting: the weight of the tablet is 0.6g, the rotating speed of the tablet press is 8 revolutions per minute, the pressure is 80KN, and the tablet is prepared after split charging.
In the embodiment 2, the method of adding the percolate and then drying is adopted, so that volatile components in agilawood are easy to lose, explosion of the volatile oil of the dried orange peel is easy to occur in the production, and the volatile oil of the dried orange peel is easy to soak spots without wrapping the tablet.
Example 3: preparation of granules
S1, preparing syrup: weighing 140.0kg of purified water, boiling in a jacketed kettle, adding 112.5kg of sucrose, and continuously stirring until the purified water is completely dissolved for later use;
s2, mixing: placing the prepared pregelatinized starch, dextrin and vinegar rhizoma corydalis fine powder in a mixer, premixing for 8S, adding the liver-soothing tablet extract, mixing for 15S, and drying;
s3, drying: sucking the soft material into a boiling drying granulator, setting the drying temperature to 70 ℃, and drying the soft material at 70+/-10 ℃ for 35 minutes for later use;
s4, mixing and sieving: placing one part of dry particles in a mixer, adding one part of syrup, starting a quick button of the mixer, mixing for 15S, uniformly mixing, transferring into a swing type granulator to prepare wet particles, and drying;
s5, drying: sucking the wet granules into a boiling drying granulator, and setting the drying temperature to be 70 ℃; drying the materials at 70+/-10 ℃ for 50 minutes, and charging the materials in a stainless steel material container after drying;
s6, crushing: pulverizing the above granule;
s7, preparing a soft material: placing one part of the cardamon fine powder, the amomum villosum fine powder and the crushed fine powder into a mixer, starting a mixer quick button, premixing 8S, adding 20kg of agilawood percolate, starting the mixer quick button, mixing 15S, and uniformly mixing and drying;
s8, spray granulation and drying: sucking the mixed soft material into a boiling dryer, starting a peristaltic pump, setting the rotation speed of the peristaltic pump to 200rpm, spraying the rest lignum aquilariae resinatum percolate into the boiling dryer granulator, drying at room temperature until the water content is 5%, and stopping discharging.
S9, finishing: adding the dried granules into a swinging granulator for granulating;
s10, total mixing: the magnesium stearate with the ingredients and the granules after finishing are mixed according to the proportion of 1:1 premixing for 10 minutes in a stainless steel container and spraying the ethanol solution of the pericarpium citri reticulatae volatile oil. Adding the rest particles and the pre-mixed particles into a two-dimensional motion mixer for mixing
S11, tabletting: the weight of the tablet is 0.6g, the rotating speed of the tablet press is 12 revolutions per minute, the pressure is 100KN, and the tablet is prepared after split charging.
In the embodiment 3, the method of adding the percolate and then drying is adopted, so that volatile components in agilawood are easy to lose, explosion of the volatile oil of the dried orange peel is easy to occur in the production, and the volatile oil of the dried orange peel is easy to soak spots without wrapping tablets.
The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (7)
1. The liver soothing tablet is characterized by being prepared from the following raw materials in parts by weight:
fructus Amomi: 50-100 parts; cardamom: 30-70 parts; vinegar rhizoma corydalis: 70-110 parts; dried orange peel: 120-160 parts; poria cocos: 180-220 parts; fructus Toosendan: 280-320 parts; agilawood: 160-200 parts; white peony root: 260-300 parts; rhizoma Wenyujin Concisa: 180-220 parts; fructus Aurantii: 160-200 parts; cortex Magnoliae officinalis: 80-120 parts; radix aucklandiae: 120-160 parts; dextrin: 230-270 parts; pregelatinized starch: 230-270 parts; sucrose: 112.5 parts; magnesium stearate: 8 parts; beta-cyclodextrin: 2 parts;
the liver soothing tablet is prepared by the following steps: s1, preparing percolate; the step S1 comprises the following substeps:
s11, weighing raw materials and crushing: placing the agilawood Chinese medicinal decoction pieces into a Chinese medicinal pulverizer, and crushing the Chinese medicinal decoction pieces with a pore diameter of 2-3 cm for later use;
s12, extracting: placing the coarsely crushed agilawood into an extraction tank, adding 60% -80% ethanol to soak for 20-30 min, controlling the steam pressure at 0.3MPa, opening a cooling tower and a cooling water valve, carrying out reflux extraction for 3 times, each time for 2 hours, and merging the liquid medicine into a liquid storage tank for standby after 100 meshes;
s13, taking the coarsely crushed costustoot, fructus aurantii, magnolia officinalis, white paeony root and curcuma longa, filling the coarsely crushed costustoot, fructus aurantii, magnolia officinalis, white paeony root and curcuma longa into an extraction tank, adding 60% ethanol while adding the medicinal materials for soaking for 2-3 hours, controlling the percolating flow rate to be 162-270L/h, starting percolating, and collecting a percolate for later use, wherein the percolating liquid amount is 5750-6250L;
s14, concentrating: recovering ethanol under reduced pressure until the alcohol smell is absent, concentrating at 75-85 ℃ to obtain fluid extract with the relative density of 1.20-1.25;
s2, preparing extract liquid; the step S2 includes the following substeps:
s21, preparing dried orange peel volatile oil: decocting pericarpium Citri Tangerinae to obtain volatile oil, adding ethanol to 1000ml, and storing; 1400L of drinking water is added for the second time, and the collected liquid medicine amount is 1400-1540L;
s22, decocting poria cocos and szechwan chinaberry fruit in water for 2 times, and collecting 7200L-7740L of total liquid medicine;
s23, concentrating: pumping the extracting solution into an external circulation double-effect concentrator or a water double-effect vacuum concentrator, and concentrating at 75-85 ℃ to obtain clear paste with the relative density of 1.20-1.25 for later use;
s24, paste collection: stirring the clear paste for 30 minutes, and then collecting the paste, wherein the yield of the clear paste is 36.0-44.2%, and the amount of the clear paste is 620-760 kg;
s3, preparing particles; the step S3 includes the following substeps:
s31, preparing syrup: weighing purified water, boiling in a jacketed kettle, adding sucrose, and continuously stirring until the purified water is completely dissolved for later use;
s32, mixing: placing pregelatinized starch, dextrin and vinegar rhizoma corydalis fine powder into a mixer, premixing for 8-10S, adding extract, and mixing for 15-20S;
s33, drying: sucking the mixture of the step S32 into a boiling drying granulator, and setting a drying temperature;
s34, mixing and sieving: placing the dry particles in a mixer, adding syrup, starting a quick button of the mixer, mixing for 15-20S, uniformly mixing, transferring into a swing type granulator to prepare wet particles, sucking the wet particles into a boiling drying granulator, drying, loading the dry wet particles in a stainless steel container, and crushing;
s35, preparing a soft material: placing one part of the cardamon fine powder and one part of the amomum villosum fine powder into a mixer, starting a mixer quick button, premixing for 8-10S, starting the mixer quick button again, and uniformly mixing for 15-20S;
s36, spray granulating and drying: sucking the mixed soft material into a boiling dryer, starting a peristaltic pump, setting the rotating speed of the peristaltic pump to be 80-200 rpm, spraying all percolate into the boiling dryer granulator, setting room temperature for drying for 35-50 min, and charging by a stainless steel material container after drying; when the moisture is 3 to 5 percent, stopping the machine for discharging;
s37, finishing: adding the dried granules into a swinging granulator for granulating;
s38, total mixing: magnesium stearate and granulated particles were mixed according to a 1:1, premixing for 5-10 min in a stainless steel container, wrapping pericarpium citri reticulatae volatile oil, and finally tabletting and subpackaging to obtain the liver-soothing tablets.
2. The liver soothing tablet according to claim 1 is characterized by being prepared from the following raw materials in parts by weight:
fructus Amomi: 60-90 parts; cardamom: 40-60 parts; vinegar rhizoma corydalis: 80-100 parts; dried orange peel: 130-150 parts; poria cocos: 190-210 parts; fructus Toosendan: 290-310 parts; agilawood: 170-190 parts; white peony root: 270-290 parts; rhizoma Wenyujin Concisa: 190-210 parts; fructus Aurantii: 170-190 parts; cortex Magnoliae officinalis: 90-110 parts; radix aucklandiae: 130-150 parts; dextrin: 240-260 parts; pregelatinized starch: 240-260 parts; sucrose: 112.5 parts; magnesium stearate: 8 parts; beta-cyclodextrin: 2 parts.
3. The liver soothing tablet according to claim 2 is characterized by being prepared from the following raw materials in parts by weight:
fructus Amomi: 70 parts; cardamom: 50 parts; vinegar rhizoma corydalis: 90 parts; dried orange peel: 140 parts; poria cocos: 200 parts; fructus Toosendan: 300 parts; agilawood: 180 parts; white peony root: 280 parts; rhizoma Wenyujin Concisa: 200 parts; fructus Aurantii: 180 parts; cortex Magnoliae officinalis: 100 parts; radix aucklandiae: 140 parts; dextrin: 250 parts; pregelatinized starch: 250 parts; sucrose: 112.5 parts; magnesium stearate: 8 parts; beta-cyclodextrin: 2 parts.
4. A process for preparing a liver-soothing tablet, which is applied to the liver-soothing tablet as claimed in claims 1 to 3, and is characterized by comprising the following steps:
s1, preparing percolate; the step S1 comprises the following substeps:
s11, weighing raw materials and crushing: placing the agilawood Chinese medicinal decoction pieces into a Chinese medicinal pulverizer, and crushing the Chinese medicinal decoction pieces with a pore diameter of 2-3 cm for later use;
s12, extracting: placing the coarsely crushed agilawood into an extraction tank, adding 60% -80% ethanol to soak for 20-30 min, controlling the steam pressure at 0.3MPa, opening a cooling tower and a cooling water valve, carrying out reflux extraction for 3 times, each time for 2 hours, and merging the liquid medicine into a liquid storage tank for standby after 100 meshes;
s13, taking the coarsely crushed costustoot, fructus aurantii, magnolia officinalis, white paeony root and curcuma longa, filling the coarsely crushed costustoot, fructus aurantii, magnolia officinalis, white paeony root and curcuma longa into an extraction tank, adding 60% ethanol while adding the medicinal materials for soaking for 2-3 hours, controlling the percolating flow rate to be 162-270L/h, starting percolating, and collecting a percolate for later use, wherein the percolating liquid amount is 5750-6250L;
s14, concentrating: recovering ethanol under reduced pressure until the alcohol smell is absent, concentrating at 75-85 ℃ to obtain fluid extract with the relative density of 1.20-1.25;
s2, preparing extract liquid; the step S2 includes the following substeps:
s21, preparing dried orange peel volatile oil: decocting pericarpium Citri Tangerinae to obtain volatile oil, adding ethanol to 1000ml, and storing; 1400L of drinking water is added for the second time, and the collected liquid medicine amount is 1400-1540L;
s22, decocting poria cocos and szechwan chinaberry fruit in water for 2 times, and collecting 7200L-7740L of total liquid medicine;
s23, concentrating: pumping the extracting solution into an external circulation double-effect concentrator or a water double-effect vacuum concentrator, and concentrating at 75-85 ℃ to obtain clear paste with the relative density of 1.20-1.25 for later use;
s24, paste collection: stirring the clear paste for 30 minutes, and then collecting the paste, wherein the yield of the clear paste is 36.0-44.2%, and the amount of the clear paste is 620-760 kg;
s3, preparing particles; the step S3 includes the following substeps:
s31, preparing syrup: weighing purified water, boiling in a jacketed kettle, adding sucrose, and continuously stirring until the purified water is completely dissolved for later use;
s32, mixing: placing pregelatinized starch, dextrin and vinegar rhizoma corydalis fine powder into a mixer, premixing for 8-10S, adding extract, and mixing for 15-20S;
s33, drying: sucking the mixture of the step S32 into a boiling drying granulator, and setting a drying temperature;
s34, mixing and sieving: placing the dry particles in a mixer, adding syrup, starting a quick button of the mixer, mixing for 15-20S, uniformly mixing, transferring into a swing type granulator to prepare wet particles, sucking the wet particles into a boiling drying granulator, drying, loading the dry wet particles in a stainless steel container, and crushing;
s35, preparing a soft material: placing one part of the cardamon fine powder and one part of the amomum villosum fine powder into a mixer, starting a mixer quick button, premixing for 8-10S, starting the mixer quick button again, and uniformly mixing for 15-20S;
s36, spray granulating and drying: sucking the mixed soft material into a boiling dryer, starting a peristaltic pump, setting the rotating speed of the peristaltic pump to be 80-200 rpm, spraying all percolate into the boiling dryer granulator, setting room temperature for drying for 35-50 min, and charging by a stainless steel material container after drying; when the moisture is 3 to 5 percent, stopping the machine for discharging;
s37, finishing: adding the dried granules into a swinging granulator for granulating;
s38, total mixing: magnesium stearate and granulated particles were mixed according to a 1:1, premixing for 5-10 min in a stainless steel container, wrapping pericarpium citri reticulatae volatile oil, and finally tabletting and subpackaging to obtain the liver-soothing tablets.
5. The process for preparing the liver soothing tablet according to claim 4, wherein the liver soothing tablet comprises the following steps: in the step S33, the drying temperature is 70+/-10 ℃ and the drying time is 20-35 minutes.
6. The process for preparing the liver soothing tablet according to claim 4, wherein the liver soothing tablet comprises the following steps: in the step S34, the aperture of the sieve sheet used for sieving is 1.0-2.0 mm.
7. The process for preparing the liver soothing tablet according to claim 4, wherein the liver soothing tablet comprises the following steps: in the step S38, the rotating speed of the tablet press is 8-12 revolutions per minute, the pressure is 80-100 KN, and the quality of the prepared liver-soothing tablet is 0.6g.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579364A (en) * | 2008-05-14 | 2009-11-18 | 北京和润创新医药科技发展有限公司 | Pharmaceutical composition and preparation method thereof |
| CN113181126A (en) * | 2021-05-07 | 2021-07-30 | 北京葆年堂(菏泽)药业有限公司 | Liver soothing pill and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101579364A (en) * | 2008-05-14 | 2009-11-18 | 北京和润创新医药科技发展有限公司 | Pharmaceutical composition and preparation method thereof |
| CN113181126A (en) * | 2021-05-07 | 2021-07-30 | 北京葆年堂(菏泽)药业有限公司 | Liver soothing pill and preparation method thereof |
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| Title |
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| 孙世发主编.《新编中成药大全》.河南科学技术出版社,2019,第559页. * |
| 路长岭 ; .舒肝片治疗功能性消化不良的观察.中国中医基础医学杂志.-,2011,第-卷(第08期),第929、931页. * |
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