CN115715751B - Composition and slimming cream with effects of reducing subcutaneous fat content and moisturizing - Google Patents
Composition and slimming cream with effects of reducing subcutaneous fat content and moisturizing Download PDFInfo
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Abstract
The application relates to the technical field of cosmetics and discloses a composition and slimming cream with the effects of reducing subcutaneous fat content and moisturizing. A composition with effects of reducing subcutaneous fat content and supplementing water and tightening comprises penetration component, fat reducing component, protein supplementing component and adjuvant; the osmotic component comprises propylene glycol, cinnamoyl lysine ester; the lipid-lowering component comprises caffeine, chinese medicinal extract and L-malic acid; the protein supplement component includes soybean peptide, collagen peptide, bonito elastin peptide and sodium hyaluronate; the composition prepared by the application promotes the permeation of the lipid-reducing component and the protein component through the high-efficiency permeation of the permeation component, the lipid-reducing component plays a role in effectively reducing lipid by stimulating active enzymes and the like of an organism, and can effectively tighten skin, supplement skin moisture and have excellent beautifying and shaping effects while rapidly reducing lipid.
Description
Technical Field
The application relates to the technical field of cosmetics, in particular to a composition and slimming cream with the effects of reducing subcutaneous fat content and moisturizing and tightening.
Background
Subcutaneous fat refers to subcutaneous adipose tissue, and can store energy and preserve heat. However, the thickness of subcutaneous fat is not easily too high, and it is considered that obesity is a condition that the thickness of the abdominal skin wrinkles of adult women is more than 20mm, referring to the evaluation standard of national nutrition survey data of the Ministry of thick living in japan for the degree of fatness of children and adults in japan.
At present, along with gradual improvement of national income level, the number of obese people is increased due to bad living habits. Obesity not only has a great influence on the morphology of the human body, so that the figure is lost, the personal charm is reduced, and other diseases are easily caused.
Therefore, a large number of weight-reducing products are available on the market, and the weight-reducing products are generally oral products such as weight-reducing medicines and weight-reducing tea, and smearing products such as weight-reducing cream. Although the oral products can have a certain weight reduction effect in a short time, the following problems are also present: first, targeting is poor. After administration, blood diffuses to the whole body, and it is difficult to reduce blood fat in a certain part of the body. Secondly, the side effect is too large and rebound is easy. The action mechanism of the weight-losing medicine is generally to improve metabolism of the organism and increase decomposition and consumption of fat through hormone action, so that the weight is reduced. However, the dosage of the hormone is difficult to control, and the endocrine effect of the human body is greatly influenced by excessive hormone action, so that the human body is greatly harmed. And the hormone takes effect obviously, which is easy to cause a large amount of fat loss in a short time and skin relaxation.
In the fat-reducing products for application, active substances such as lipolytic enzyme are generally added into skin cream to decompose subcutaneous fat, so as to achieve the purpose of reducing fat, but when the lipolytic enzyme directly acts on human skin, the lipolytic enzyme is difficult to be absorbed by the skin and permeate into the skin, so that the fat-reducing effect is poor.
In view of the above-mentioned problems, there is a need in the industry to develop a skin care product that can significantly reduce the subcutaneous fat content, and at the same time, has a better tightening effect and reduces the possibility of wrinkling of the skin.
Disclosure of Invention
The application provides a composition and a slimming cream with the effects of reducing subcutaneous fat content and moisturizing and tightening, so that the smearing product can remarkably reduce the subcutaneous fat content, can also play a role in tightening skin and reduce the possibility of skin relaxation.
In a first aspect, the present application provides a composition having the effects of reducing subcutaneous fat content and moisturizing and tightening, which adopts the following technical scheme:
a composition with effects of reducing subcutaneous fat content and supplementing water and tightening comprises penetration component, fat reducing component, protein supplementing component and adjuvant; the weight ratio of the penetrating component, the fat reducing component, the protein supplementing component and the auxiliary agent is (10-20): 5-20): 10-30): 15-40;
each part of penetrating component consists of the following raw materials in parts by weight:
50-70 parts of propylene glycol and 10-20 parts of cinnamoyl lysine ester;
each part of the fat reducing component consists of the following raw materials in parts by weight:
5-18 parts of caffeine, 20-60 parts of traditional Chinese medicine extract and 2-5 parts of L-malic acid;
the traditional Chinese medicine extract comprises a red sage root extract, a ligusticum chuanxiong hort extract and a peach seed extract;
each protein supplementing component consists of the following raw materials in parts by weight:
10-30 parts of soybean peptide, 10-30 parts of collagen peptide, 10-30 parts of bonito elastin peptide and 20-50 parts of sodium hyaluronate;
the molecular weight of the soybean peptide, the collagen peptide and the bonito elastin peptide is 50-3000 daltons; the molecular weight of the sodium hyaluronate is 5 ten thousand to 2000 ten thousand daltons.
By adopting the technical scheme, the propylene glycol has fat-soluble property, strong permeability and large dissolving power; the cinnamoyl lysine ester is formed by connecting cinnamoyl chloride and lysine acetate through an amide bond, and contains ester groups, can act with propylene glycol, can be combined into a stratum corneum lipid barrier to damage the tight arrangement of membrane lipid while improving the solubility of protein supplement components, further changes the permeability of skin, plays a role in transdermal permeation promotion, and is beneficial to the protein supplement components to enter the dermis layer. The ester bond of the cinnamoyl lysine ester is degradable, has better biological safety, and can be discharged by human body along with waste.
The caffeine micromolecular substance in the lipid-reducing component is easy to permeate and diffuse between skin layers, activates adrenergic receptors, increases the concentration of cyclic adenosine monophosphate and carries out lipolysis; meanwhile, caffeine can activate phosphorylated hormone-sensitive triglyceride lipase in the lipolytic process, accelerate the lipolytic process and reduce fat accumulation.
Meanwhile, the traditional Chinese medicine extract used in the fat-reducing component can accelerate the circulation of local blood, promote the microcirculation of the local blood and accelerate the metabolism of human bodies, so that the residual products generated by lipolytic metabolism can be discharged rapidly. The Chinese medicinal extract is also rich in flavonoids, which can promote lipolysis. The Chinese medicinal extract is rich in p-hydroxy cinnamic acid derivatives such as ferulic acid, and can be used as antioxidant to reduce the possibility of oxidative denaturation of protein supplement components.
L-malic acid is used as a metabolic intermediate in the triphosphate circulation, and can be used for supplementing trace amount, so that the L-malic acid can play a role in maintaining metabolic stability in the rapid metabolic process of an organism, and further, the L-malic acid is used for assisting in reducing fat.
The protein supplementing component is rich in collagen and elastin, and under the action of the penetrating component, the soybean peptide, the collagen peptide and the bonito elastin peptide are controlled within a proper molecular weight range, so that the penetration amount of the collagen and the elastin is improved;
the collagen peptide is a small molecular polypeptide formed after collagen is treated by artificial protease, and can be effectively absorbed and utilized; can effectively supplement collagen components relative to other polypeptides; the collagen peptide has high activity, and can be efficiently targeted and absorbed by human body;
the bonito elastin peptide provides elastin, which works together with collagen to give skin tissue elasticity and tensile ability; elastin determines the elasticity and softness of skin, and has effects of preventing aging and promoting regeneration for physiological aging process of skin caused by physical factors such as light;
the soybean peptide can provide various amino acids and active peptides, can supplement nutrition components of dermis, can be used together with L-malic acid, can maintain the stable pH value of the composition, and can improve the absorption and utilization rate of the soybean peptide;
adjuvants include, but are not limited to, emulsifiers, emulsion stabilizers, preservatives, and water, the adjuvants being such that the penetrating component, the lipid-lowering component, the protein-supplementing component form a stable microemulsion system;
when the composition is used, the penetrating component opens a passage from the outside into the dermis layer, which helps the lipid-lowering component and the protein-supplementing component in the lipid-lowering component penetrate into the dermis layer. The active substances in the fat-reducing composition play a significant role in reducing fat by stimulating nerve fibers to accelerate fat degradation and blood circulation. The protein supplementing component is rich in collagen, elastin and sodium hyaluronate, is used as a filler and skin nutrient substances to replace partial fat cells, plays a good role in filling, is gradually absorbed and metabolized by skin in the later stage, and can reduce the possibility of skin relaxation while reducing fat rapidly.
After the composition is absorbed by skin, sodium hyaluronate in the protein supplementing component helps the skin to absorb a large amount of water, so that the composition has good moisturizing effect. At the same time, the macromolecular sodium hyaluronate can promote the repair of the horny layer, so that the barrier effect of the horny layer is recovered, the absorption and penetration of active ingredients in the composition are not hindered, and the possibility of skin sensitivity and water loss is reduced.
In summary, the interaction of the lipid-lowering component, the permeation component and the protein-supplementing component is used in the application, so that the skin elasticity can be maintained, the skin moisture can be supplemented, the skin barrier can be restored, and an excellent cosmetic effect can be achieved.
Optionally, the preparation method of the cinnamoyl lysine ester comprises the following steps:
respectively weighing and dissolving cinnamoyl chloride and lysine acetate according to the weight ratio of 1 (1.2-1.4); dropwise adding cinnamoyl chloride solution into lysine acetate salt solution at 0-5 ℃, reacting for 3-6 h at a temperature of 20-25 ℃, reacting for 4-8 h at a temperature of 20-25 ℃, separating liquid, and filtering to obtain cinnamoyl lysine ester.
Through adopting acyl chlorination reaction, the cinnamoyl chloride and lysine acetate react, and the prepared cinnamoyl lysine has better permeability, can obviously promote the penetration of protein supplementary components and lipid-reducing components, so that the skin is still full of elasticity while the human body is rapidly and effectively reduced in lipid.
Optionally, the traditional Chinese medicine extract also comprises a garcinia cambogia extract.
By adopting the technical scheme, the garcinia cambogia extract is rich in hydroxycitric acid, the hydroxycitric acid inhibits the activity of ATP-citrate lyase, the possibility of converting sugar into fat is reduced, the good fat reducing effect is further maintained, and the possibility of fat reducing rebound is reduced.
Preferably, the weight ratio of the red sage root extract, the ligusticum chuanxiong hort extract, the peach kernel extract and the garcinia cambogia extract in the traditional Chinese medicine extract is (20-25)/(15-25)/(25-40)/(10-12).
By adopting the technical scheme, the composition of the traditional Chinese medicine extract is optimized, the content of the peach kernel extract is increased, so that the content of unsaturated glyceride such as oleic acid glyceride and the like in the traditional Chinese medicine extract is increased, the stability of the traditional Chinese medicine extract in the composition can be improved, and the fat reducing effect is further optimized.
Optionally, the osmotic component also contains menthol, and the weight ratio of menthol to cinnamoyl lysine ester is (5-10) (10-20).
By adopting the technical scheme, menthol and cinnamoyl lysine ester have a synergistic effect in promoting the penetration of the composition, so that the fat reducing and tightening effects of the composition can be further enhanced. Meanwhile, the menthol can be used as a placebo and acts on nerve receptors of a human body to make the organism have cool feeling, thereby generating calm and soothing effect on sense organs and reducing the possibility of bad feeling such as irritation caused by hydroxycitric acid and malic acid in the composition.
Optionally, the molecular weight of the collagen peptide and the bonito elastin peptide is 180-1000 daltons.
By adopting the technical scheme, the molecular weight of the collagen peptide and the molecular weight of the bonito elastin peptide are controlled, so that the decomposition and absorption time of the protein supplementary component is in a moderate range, the lipid-reducing rate is matched with the absorption rate of the protein supplementary component, and the possibility of skin fine lines is further reduced.
Preferably, palmitoyl pentapeptide is also included in the protein supplement component.
By adopting the technical scheme, the palmitoyl pentapeptide has the functions of promoting the generation of collagen and elastic fibers and supplementing protein with components, has a synergistic effect in improving the skin tightening function, and further reduces the possibility of fine lines on the skin.
Preferably, the auxiliary agent comprises an emulsifying agent, wherein the emulsifying agent consists of sweet almond oil and polysorbate according to the weight ratio of (0.5-3) to (1-3).
By adopting the technical scheme, the palmitoyl pentapeptide and the protein supplementing component can exist in the emulsifier stably, and under the action of the emulsifier, the composition forms a microemulsion system, so that the absorption of the protein supplementing component and the palmitoyl pentapeptide can be effectively improved.
Optionally, the auxiliary agent further comprises a flavoring agent, and the flavoring agent comprises orange peel extract.
By adopting the technical scheme, the orange peel extract contains abundant active substances such as limonene, the limonene can endow the composition with the characteristic flavor of fruit fragrance, reduce the possibility of releasing hunger information by hypothalamus in brain, and can directly act on lipid of skin stratum corneum, so that micropores among cells are increased, and the permeability of the composition is further improved.
In a second aspect, the present application provides a slimming cream, which adopts the following technical scheme:
a slimming cream comprising the aforementioned composition having the effects of reducing subcutaneous fat content and moisturizing and tightening, wherein the content of the composition is not less than 70%.
By adopting the technical scheme, the composition prepared by the application overcomes the difficult problems of high efficiency of fat reduction and skin tightening. At the same time, the contradiction between high permeation efficiency and slight damage of the skin barrier layer is overcome. The composition has good effects of reducing fat, removing wrinkle and supplementing water at 70%.
In summary, the present application has the following beneficial effects:
1. the lipid-reducing component and the protein-supplementing component can permeate quickly under the action of the permeation component through the interaction among the permeation component, the lipid-reducing component and the protein-supplementing component, are absorbed by the body, and can effectively reduce the subcutaneous fat thickness through various physiological actions such as promoting lipolysis and accelerating blood circulation. Under the action of the protein supplementing component, nutrients and moisture in the dermis layer are supplemented, the skin is firmly blocked, the influence of the penetrating component on the skin is reduced, so that moisture is not easy to run off, and substances such as elastin, collagen, active peptide, sodium hyaluronate and the like in the protein supplementing component are absorbed by the dermis layer, so that the skin elasticity is maintained, the skin is compacted, and the possibility of occurrence of fine lines is reduced.
2. The application also uses the specific osmotic component cinnamoyl lysine ester, so that the osmotic absorption effect of the composition is remarkable, and the fat reducing effect of the composition is excellent.
3. The gamboge extract is used for inhibiting the activity of ATP-citrate lyase, so that a good lipid-reducing effect is further maintained, and the possibility of lipid-reducing rebound is reduced.
4. Menthol is used in the present application, and on the one hand menthol and cinnamoyl lysine ester have a synergistic effect in promoting the penetration of the composition, and can further enhance the fat reducing and tightening effects of the composition. On the other hand, menthol is used as placebo and acts on nerve receptors of human body to make organism cool, thereby producing tranquilization and relieving effect on sense organs and reducing possibility of bad feeling such as irritation caused by hydroxycitric acid and malic acid in the composition.
5. In the application, palmitoyl pentapeptide is also used, has the functions of promoting the generation of collagen and elastic fibers and supplementing protein, has a synergistic effect in improving the skin tightening function, and further reduces the possibility of fine lines on the skin.
Detailed Description
The weight-reducing products on the market at present mainly comprise oral products such as weight-reducing medicines, weight-reducing tea and the like, and smearing products such as weight-reducing cream and the like. The oral products generally take effect quickly, but have a plurality of side effects, are easy to rebound and cause skin to relax. The effective components in the smearing product are difficult to permeate into the lower part of the dermis layer through the cuticle and the dermis layer, so that the degradation efficiency of the effective components on subcutaneous fat is low, and even the subcutaneous fat cannot be degraded.
In order to solve the above problems, the present applicant conducted extensive studies on the composition of numerous skin care products, and as a result found that: small molecular substances such as caffeine can enter the body to activate phosphorylated hormone-sensitive triglyceride lipase, so that the degradation of fat is promoted; the extracts of the traditional Chinese medicines such as the red sage root, the ligusticum chuanxiong hort, the peach kernel and the like can promote blood circulation, accelerate metabolism of the organism and enable free fatty acid obtained by subcutaneous fat degradation to be discharged out of the body; l-malic acid is taken as a metabolic intermediate in the triphosphate circulation, and is micro-supplemented, so that the L-malic acid can be stable in the rapid metabolic process of an organism, thereby assisting in reducing fat; the caffeine, the salvia miltiorrhiza bunge and other traditional Chinese medicine extracts and the L-malic acid are used as lipid-lowering components, and the three components are compounded to have a synergistic effect in improving subcutaneous fat metabolism.
And the penetration enhancing component is selected from cinnamoyl lysine ester and propylene glycol. Propylene glycol has fat-soluble property, strong penetrability and high dissolving power; the cinnamoyl lysine ester is formed by connecting cinnamoyl chloride and lysine acetate through an amide bond, and contains ester groups, can act with propylene glycol, can be combined into a stratum corneum lipid barrier to damage the tight arrangement of membrane lipid while improving the solubility of protein supplement components, further changes the permeability of skin, plays a role in transdermal permeation promotion, and is beneficial to the protein supplement components to enter the dermis layer. Reducing the permeation difficulty of protein supplementing components.
The protein supplementing component is rich in elastin, collagen, sodium hyaluronate, and micromolecular active peptide and amino acid, and can effectively supplement nutrients in dermis, maintain skin elasticity, tighten skin and reduce the possibility of appearance of fine lines.
The three active ingredients in the composition interact, so that the difficult problems between high efficiency of reducing fat and skin tightening are successfully overcome.
Unless otherwise specified, the raw materials for the preparation examples and examples of the present application are as follows:
extract of red sage root: model FH-26474, food grade;
ligusticum chuanxiong Hort extract: extracting the dry rhizome of ligusticum chuanxiong hort and producing area western medicine;
peach kernel extract: extracting the source, peach kernel, dried rehmannia root, ningxia herb, 80-mesh powder and food grade;
garcinia cambogia extract: PB20211217, the main ingredient of which is hydroxycitric acid;
orange peel extract: extracting with water vapor, and extracting with oily substance as main components: limonene;
the soybean peptide, the collagen peptide and the bonito elastin peptide are customized, and the target molecular weight is obtained through the control of the enzymolysis process.
Preparation example of cinnamoyl lysine ester
Preparation example 1
Cinnamoyl lysine ester, prepared according to the following steps:
taking 1kg of cinnamoyl chloride and 1.2kg of lysine acetate salt for later use;
adding lysine acetate salt into 1.3L of triethylamine for preliminary dissolution, adding 6.5L of chloroform for stirring dissolution, and obtaining lysine acetate salt solution;
adding cinnamoyl chloride into the chloroform solution, and stirring and uniformly mixing to obtain a cinnamoyl chloride solution;
cooling the lysine acetate salt solution to 0 ℃ in an ice salt bath, dropwise adding the cinnamoyl chloride solution into the lysine acetate salt solution, carrying out heat preservation reaction for 3h, naturally heating to 20 ℃, and carrying out heat preservation reaction for 8h; after the reaction, separating the liquid by using a separating funnel, and drying the organic phase by using anhydrous magnesium sulfate for 8 hours; filtration, distillation under reduced pressure, and separation and purification using silica gel column chromatography (v ethyl acetate/v petroleum ether=9:1) gave cinnamoyl lysine ester.
PREPARATION EXAMPLES 2 to 5
Cinnamoyl lysine ester differs from preparation example 1 in that: the weight ratio of the cinnamoyl chloride to the lysine acetate is different, the reaction conditions are different, and the concrete steps are as follows:
TABLE 1 reaction conditions for cinnamoyl lysine esters
| Parameters (parameters) | Preparation example 1 | Preparation example 2 | Preparation example 3 | Preparation example 4 | Preparation example 5 |
| Weight ratio of cinnamoyl chloride to lysine acetate salt | 1:1.2 | 1:1.3 | 1:1.4 | 1:1.4 | 1:1.4 |
| Reaction temperature one (. Degree.C.), reaction time one (h) | 0，3 | 0，3 | 0，3 | 5,6 | 0，3 |
| Reaction temperature II (DEG C), reaction time II (h) | 20,8 | 20,8 | 20,8 | 20,8 | 25,4 |
Examples
Examples 1 to 20
A composition having the effects of reducing subcutaneous fat content and moisturizing and tightening, the formulation of which is shown in table 2 below:
TABLE 2 composition of the compositions
Wherein "/" indicates no addition;
cinnamoyl lysine ester was prepared from preparation 1;
the molecular weight of the soybean peptide is 50-180 daltons;
the molecular weight of the collagen peptide is 1000-2000 daltons;
the molecular weight of the bonito elastin peptide is 1500-3000 dalton;
the molecular weight of the sodium hyaluronate is 100-2000 ten thousand daltons;
glyceryl stearate, sweet almond oil and polysorbate are used as emulsifying agents;
a composition with effects of reducing subcutaneous fat content and moisturizing and tightening is prepared by the following steps:
weighing raw materials according to the formula of Table 2 for later use;
dividing the water and emulsifier into 4 equal parts;
mixing 1 equal part of water and an emulsifying agent with all raw materials in the osmotic component to obtain osmotic emulsion;
mixing 1 equal part of water and an emulsifying agent with all raw materials in the fat-reducing component to obtain a fat-reducing emulsion;
mixing 1 equal part of water and an emulsifying agent with each raw material in the protein supplementing component to obtain protein supplementing emulsion;
blending the osmotic emulsion, the fat-reducing emulsion, the protein-supplementing emulsion with the rest water, the emulsifying agent, the potassium sorbate and the flavoring agent, homogenizing at 3000rpm to obtain the composition with the effects of reducing subcutaneous fat content and supplementing water and tightening.
Examples 21 to 24
A composition having the effects of reducing subcutaneous fat content and moisturizing and tightening, which is different from example 20 in that cinnamoyl lysine ester is derived from the following sources:
the lauroyl lysine ester used in example 21 was derived from preparation 2;
the lauroyl lysine ester used in example 22 was derived from preparation 3;
the lauroyl lysine ester used in example 23 was derived from preparation 4;
the lauroyl lysine ester used in example 24 was derived from preparation 5;
example 25
A composition having the effects of reducing subcutaneous fat content and moisturizing and tightening is different from example 24 in the molecular weight of collagen peptide and bonito elastin peptide, and is specifically as follows:
the molecular weight of the collagen peptide is 180-500 daltons;
the molecular weight of the bonito elastin peptide is 300-1000 dalton.
Comparative example
Comparative example 1
A composition differs from example 1 in that 83g of glyceryl stearate and 0.5g of potassium sorbate and 41.5g of water are used instead of 125g of the osmotic component.
Comparative example 2
A composition differs from example 1 in that 20.8g of glycine methyl ester was used instead of 20.8g of cinnamoyl lysine ester.
Comparative example 3
A composition differs from example 11 in that 90.3g of glyceryl stearate and 0.5g of potassium sorbate and 45.2g of water are used in place of 136g of protein-supplementing component.
Comparative example 4
A composition was distinguished from example 11 in that 136g of palmitoyl pentapeptide was used as a mass substitute for soybean peptide, collagen peptide, bonito elastin peptide and sodium hyaluronate.
Comparative example 5
A composition is different from example 5 in that 65g of Garcinia cambogia extract is used instead of Saviae Miltiorrhizae radix extract, rhizoma Ligustici Chuanxiong extract, and semen Persicae extract.
Application examples and application comparative examples
Application examples 1 to 25, application comparative examples 1 to 5
A weight reducing cream comprises 70wt% of composition, and application examples 1-25 and application comparative examples 1-4 differ only in the sources of the compositions, and specifically comprises the following steps:
TABLE 3 sources of compositions
Application example 26
A weight reducing cream is formulated with 100% by weight of the composition of example 25.
Clinical use detection
Experimental group subjects: the 30-50 year old people, gender women, actual recruitment of volunteers 350 and effective data 341.
Test packets: 341 persons were randomly divided into 31 groups of 11 persons each.
Test period: 4-16 weeks.
Detection frequency: initial values, skin related values after 4 weeks, after 8 weeks and after 16 weeks.
The scheme is as follows: any other product (cosmetics or external medicines) cannot be used before the test of the test part of the subject, and water cannot be contacted 1-3 hours before the test; the subject was sitting still in the laboratory at 20±5 ℃ for at least 20min before testing, was unable to drink water and beverages, and had the forearms and face exposed and remained relaxed; subjects were coated twice daily with a weight reducing cream, each time 0.1g/10cm 2 The method comprises the steps of carrying out a first treatment on the surface of the Wherein each group member selects the weight-reducing cream prepared by the same application example or application comparative example.
And (3) particularly reminding:
the composition contains natural plant extracts, and partial sensitive personnel may have uncomfortable symptoms such as skin itch, redness and the like, and the use is stopped immediately when the uncomfortable symptoms are suggested to occur, so that the dosage is reduced or the use frequency is reduced.
Test 1: determination of lipid-lowering Effect
Test parameters:
measuring the subcutaneous fat thickness of the abdomen by adopting a conventional ultrasonic measurement method, respectively subtracting the initial subcutaneous fat thickness from the subcutaneous fat thickness after 4 weeks, 8 weeks and 16 weeks, namely subtracting the highest value and the lowest value of each group from the difference, and taking an average value;
similarly, after the weight reducing cream is used for 16 weeks, stopping the use for 4 weeks, subtracting the subcutaneous fat thickness after the use for 4 weeks from the subcutaneous fat thickness after the use for 16 weeks, wherein the difference is the rebound quantity of the subcutaneous fat thickness, removing the highest value and the lowest value of each group, and taking an average value;
TABLE 4 average subcutaneous fat thickness reduction (mm) for application examples 1-26, application comparative examples 1-5
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Annotation: "-" indicates that rebound occurred and subcutaneous fat thickness increased.
Test 2: skin moisture determination
Test parameters: the skin moisture meter is used for detecting the moisture content of the skin cuticle;
the subject fixation areas were examined for skin abdominal moisture after initial values, after 4 weeks, after 8 weeks, and after 16 weeks, respectively.
TABLE 5 Abdominal moisture values (%)
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Test 3: skin firmness measurement test parameters: collecting wrinkle images of a smearing area and a control area of a sample of a subject, and analyzing total wrinkle volume values at different positions by using analysis software. The tested area is smeared with the slimming cream; the control area is smeared with glycerol solution; collecting wrinkle images of a smearing area and a control area of a sample of a subject, analyzing total volume values of wrinkles at different positions by using analysis software, calculating difference values before and after testing, and calculating relative change rates of the wrinkles according to the formula;
relative rate of change of wrinkles= (average of total volume difference of wrinkles on smear side-average of total volume difference of wrinkles on control side)/average of total volume difference of wrinkles on control side x 100%;
wherein, the average value of the total volume difference value of the wrinkles at the smearing side = the average value of the initial value of the total volume of the wrinkles at the smearing side-after use, the average value of the total volume measurement value of the wrinkles at the smearing side at different measurement time points;
wherein, the average value of the total volume difference value of the control side wrinkles = the average value of the initial value of the total volume of the control side wrinkles-the average value of the total volume measurement value of the control side wrinkles at different measurement time points after use;
the relative rates of change of abdominal wrinkles after 4 weeks, after 8 weeks and after 16 weeks, respectively, were examined for the subject-immobilized areas. The higher the relative change rate of wrinkles, the better the tightening effect.
TABLE 6 relative rates of change (%)
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The data in tables 4-6 were analyzed:
it can be seen in combination with example 1 and comparative example 1 and with tables 4-6 that: the lack of the penetration component in comparative example 1 also makes it difficult to sufficiently penetrate the fat-reducing component and the protein-supplementing component only by the emulsion system, thereby making it difficult for the composition to exert an effective fat-reducing effect, and the reduced fat thickness by the experimenter is almost negligible in the use time range after 16 weeks. In comparative example 2, an amino acid ester salt was used, but the permeation effect was not good, unlike cinnamoyl lysine ester. In example 1, the penetration component is used, so that the penetration of the effective components of the composition can be obviously promoted in a microemulsion system, and the fat reducing effect is obvious.
It can be seen in combination with examples 11-12 and comparative examples 3-4 and with tables 4-6 that: the lack of the protein-supplementing component in comparative example 2 clearly shows that the skin of the experimenter has more fine wrinkles, whereas in comparative example 3, palmitoyl pentapeptide alone was used as the protein-supplementing component, and the improvement of fine wrinkles was not apparent. The reason for this may be that palmitoyl pentapeptide cannot directly supplement elastin and collagen required for skin, and it can only stimulate the body, producing elastin and collagen, resulting in poor improvement effect of fine wrinkles.
In example 1, the skin wrinkles can be significantly improved by directly supplementing the components required for the dermis layer such as elastin, collagen, active peptide, amino acid and sodium hyaluronate. In example 12, palmitoyl pentapeptide and elastin act together on the skin to maintain the long-term elasticity of the skin.
It can be seen in connection with examples 1-5 that: the ratio of the caffeine, the traditional Chinese medicine extract and the L-malic acid has a certain influence on the fat reducing effect, and the weight ratio of the caffeine, the traditional Chinese medicine extract and the L-malic acid is controlled to be 15:50:5 by optimizing the ratio of the caffeine, the traditional Chinese medicine extract and the L-malic acid, so that the fat reducing effect can be remarkably improved, and the average fat thickness is reduced by 2.67mm.
It can be seen in combination with examples 5-8 and comparative example 5 and with tables 4-6 that: in comparative example 5, the Garcinia cambogia extract was not used as a lipid-reducing component, and the lipid-reducing effect was weak in place of the extract of Salvia Miltiorrhiza and the like; the garcinia cambogia, the root of red-rooted salvia, the rhizome of chuanxiong and the peach kernel act together, so that the synergistic effect exists in the aspect of reducing fat.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (7)
1. A composition with the effects of reducing subcutaneous fat content and moisturizing and tightening, which is characterized by comprising a penetrating component, a fat-reducing component, a protein supplementing component and an auxiliary agent; the weight ratio of the penetrating component, the fat reducing component, the protein supplementing component and the auxiliary agent is (10-20): 5-20): 10-30): 15-40;
each part of penetrating component consists of the following raw materials in parts by weight:
50-70 parts of propylene glycol and 10-20 parts of cinnamoyl lysine ester;
each part of the fat reducing component consists of the following raw materials in parts by weight:
5-18 parts of caffeine, 20-60 parts of traditional Chinese medicine extract and 2-4 parts of L-malic acid;
the Chinese medicinal extract comprises Saviae Miltiorrhizae radix extract, rhizoma Ligustici Chuanxiong extract, semen Persicae extract, and Garcinia cambogia extract;
each protein supplementary component consists of the following raw materials in parts by weight:
10-30 parts of soybean peptide, 10-30 parts of collagen peptide, 10-30 parts of bonito elastin peptide and 20-50 parts of sodium hyaluronate;
the molecular weight of the soybean peptide, the collagen peptide and the bonito elastin peptide is 50-3000 daltons; the molecular weight of the sodium hyaluronate is 5 ten thousand to 2000 ten thousand daltons;
the preparation method of the cinnamoyl lysine ester comprises the following steps:
respectively weighing and dissolving cinnamoyl chloride and lysine acetate according to the weight ratio of 1 (1.2-1.4); dropwise adding cinnamoyl chloride solution into lysine acetate salt solution at 0-5 ℃, reacting for 3-6 h at a temperature of 20-25 ℃, reacting for 4-8 h at a temperature of 20-25 ℃, separating liquid, and filtering to obtain cinnamoyl lysine ester;
the weight ratio of the red sage root extract, the ligusticum chuanxiong hort extract, the peach kernel extract and the garcinia cambogia extract in the traditional Chinese medicine extract is (20-25)/(15-25)/(25-40)/(10-12).
2. A composition having the effects of reducing subcutaneous fat content and moisturizing as set forth in claim 1, wherein: the osmotic component also contains menthol, and the weight ratio of menthol to cinnamoyl lysine ester is (5-10) (10-20).
3. A composition having the effects of reducing subcutaneous fat content and moisturizing as set forth in claim 1, wherein: the molecular weight of the collagen peptide and the bonito elastin peptide is 180-1000 daltons.
4. A composition having the effects of reducing subcutaneous fat content and moisturizing as set forth in claim 1, wherein: the protein supplement component also comprises palmitoyl pentapeptide.
5. A composition having the effects of reducing subcutaneous fat content and moisturizing as set forth in claim 1, wherein: the auxiliary agent comprises an emulsifying agent, wherein the emulsifying agent consists of sweet almond oil and polysorbate according to the weight ratio of (0.5-3) to (1-3).
6. A composition having the effects of reducing subcutaneous fat content and moisturizing as set forth in claim 5, wherein: the auxiliary agent also comprises a flavoring agent, wherein the flavoring agent comprises an orange peel extract.
7. A weight reducing cream, characterized in that: a composition comprising the composition having the effects of reducing subcutaneous fat content and moisturizing as defined in any one of claims 1 to 6, said composition being contained in an amount of not less than 70%.
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| US20040146539A1 (en) * | 2003-01-24 | 2004-07-29 | Gupta Shyam K. | Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090126881A (en) * | 2008-06-05 | 2009-12-09 | (주)아모레퍼시픽 | Patch for slimming containing caffeine |
| CN105997611A (en) * | 2016-05-15 | 2016-10-12 | 佛山市芊茹化妆品有限公司 | Cosmetic composition with bodybuilding and slimmingfunctions |
| CN107488130A (en) * | 2017-08-22 | 2017-12-19 | 上海鲍林化工有限公司 | A kind of preparation method of lauroyl lysine |
| CN113260423A (en) * | 2018-10-26 | 2021-08-13 | 伊万·加拉宁 | Topical application composition and method for promoting optimal skin white adipose tissue composition in vivo |
| CN109481320A (en) * | 2018-12-12 | 2019-03-19 | 广州睿森生物科技有限公司 | A kind of fat reducing weight reducing microemulsion and preparation method thereof |
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