CN115715320A - 一种通用型供临床多次回输异体dnt细胞的高效体外扩增方法 - Google Patents
一种通用型供临床多次回输异体dnt细胞的高效体外扩增方法 Download PDFInfo
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Abstract
本发明涉及一种通用型供临床多次回输异体DNT细胞的高效体外扩增方法。在本发明的方法中，在连续培养过程中分阶段递减T细胞活化剂的用量，而无需额外添加白细胞介素‑4或AB血清。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020103137321 | 2020-04-20 | ||
| CN202010313732.1A CN113528434A (zh) | 2020-04-20 | 2020-04-20 | 一种通用型供临床多次回输异体dnt细胞的高效体外扩增方法 |
| PCT/CN2021/087312 WO2021213236A1 (zh) | 2020-04-20 | 2021-04-14 | 一种通用型供临床多次回输异体dnt细胞的高效体外扩增方法 |
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|---|---|
| CN115715320A true CN115715320A (zh) | 2023-02-24 |
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| CN202010313732.1A Pending CN113528434A (zh) | 2020-04-20 | 2020-04-20 | 一种通用型供临床多次回输异体dnt细胞的高效体外扩增方法 |
| CN202180029637.1A Pending CN115715320A (zh) | 2020-04-20 | 2021-04-14 | 一种通用型供临床多次回输异体dnt细胞的高效体外扩增方法 |
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| CN202010313732.1A Pending CN113528434A (zh) | 2020-04-20 | 2020-04-20 | 一种通用型供临床多次回输异体dnt细胞的高效体外扩增方法 |
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| US (1) | US20230242875A1 (zh) |
| EP (1) | EP4141105A4 (zh) |
| JP (1) | JP7502813B2 (zh) |
| CN (2) | CN113528434A (zh) |
| WO (1) | WO2021213236A1 (zh) |
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| CN116083359A (zh) * | 2021-11-05 | 2023-05-09 | 瑞创生物技术有限公司 | 一种体外大规模扩增富含Tscm和Tcm的双阴性T细胞的方法 |
| CN116355846A (zh) * | 2021-12-28 | 2023-06-30 | 北京永泰生物制品有限公司 | 一种质量稳定可控的扩增活化淋巴细胞的方法及其用于防治神经科疾病中的用途 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101313061B (zh) * | 2005-11-18 | 2013-05-15 | 大学健康网络 | 扩增双阴性t细胞的方法 |
| CN104109653B (zh) * | 2014-06-12 | 2017-06-13 | 浙江瑞顺生物技术有限公司 | 利用无动物血清培养体系大规模扩增人外周血dnt细胞的方法 |
| EP3180011B1 (en) * | 2014-08-15 | 2021-03-17 | University Health Network | Immunotherapy for the treatment of cancer |
| CN107002018B (zh) | 2014-12-25 | 2019-12-03 | 东洋制罐集团控股株式会社 | 培养容器以及培养容器的制造方法 |
| CN104789595A (zh) * | 2015-04-20 | 2015-07-22 | 范国煌 | 嵌合抗原受体双阴性t细胞的构建方法 |
| CA2942214C (en) | 2015-09-15 | 2023-01-24 | University Health Network | Combination therapy with double negative t-cells |
| CN105483083B (zh) * | 2016-01-20 | 2018-10-23 | 北京医明佳和生物科技有限公司 | 双阴性t细胞的转化扩增方法 |
| US20200046768A1 (en) | 2018-08-09 | 2020-02-13 | University Health Network | Double negative t cells and pd-1 blockade for the treatment of cancer |
-
2020
- 2020-04-20 CN CN202010313732.1A patent/CN113528434A/zh active Pending
-
2021
- 2021-04-14 JP JP2022564067A patent/JP7502813B2/ja active Active
- 2021-04-14 US US17/920,373 patent/US20230242875A1/en active Pending
- 2021-04-14 CN CN202180029637.1A patent/CN115715320A/zh active Pending
- 2021-04-14 WO PCT/CN2021/087312 patent/WO2021213236A1/zh unknown
- 2021-04-14 EP EP21792497.6A patent/EP4141105A4/en active Pending
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| EP4141105A1 (en) | 2023-03-01 |
| US20230242875A1 (en) | 2023-08-03 |
| JP7502813B2 (ja) | 2024-06-19 |
| CN113528434A (zh) | 2021-10-22 |
| WO2021213236A1 (zh) | 2021-10-28 |
| JP2023522727A (ja) | 2023-05-31 |
| EP4141105A4 (en) | 2024-05-29 |
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