CN115715298A - 靶向bcma和cd19的嵌合抗原受体car或car构建体及其应用 - Google Patents

靶向bcma和cd19的嵌合抗原受体car或car构建体及其应用 Download PDF

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CN115715298A
CN115715298A CN202180040445.0A CN202180040445A CN115715298A CN 115715298 A CN115715298 A CN 115715298A CN 202180040445 A CN202180040445 A CN 202180040445A CN 115715298 A CN115715298 A CN 115715298A
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amino acid
car
sequence
domain
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常建辉
朱雁林
荆光军
王晶翼
王江漫
蔡珍珍
侯攀燕
肖亮
薛彤彤
王潇东
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Chengdu Kelun Precision Biotechnology Co ltd
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Sichuan Kelun Biotech Biopharmaceutical Co Ltd
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Abstract

提供了一种包含抗BCMA和CD19的抗体的嵌合抗原受体(CAR)或CAR构建体，以及编码该CAR或CAR构建体的核酸分子、经改造的免疫细胞以及制备该免疫细胞的方法。该CAR或CAR构建体和经改造的免疫细胞用于预防和/或治疗B细胞相关病况(例如B细胞及浆细胞相关的恶性肿瘤或自身免疫疾病(如系统性红斑狼疮)等)，能有效避免靶点逃逸，防止多发性骨髓瘤的复发。

Description

PCT国内申请，说明书已公开。

Claims (31)

  1. PCT国内申请，权利要求书已公开。
CN202180040445.0A 2020-07-06 2021-06-25 靶向bcma和cd19的嵌合抗原受体car或car构建体及其应用 Pending CN115715298A (zh)

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CN202010644219 2020-07-06
CN2020106442190 2020-07-06
PCT/CN2021/102417 WO2022007650A1 (zh) 2020-07-06 2021-06-25 靶向bcma和cd19的嵌合抗原受体car或car构建体及其应用

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116478929A (zh) * 2023-04-07 2023-07-25 上海科棋药业科技有限公司 靶向bcma和cd19的双特异性car-t细胞
CN116751310A (zh) * 2023-06-13 2023-09-15 广东省第二人民医院（广东省卫生应急医院） 靶向cd19和gprc5d配体的嵌合抗原受体及其应用
CN116987192A (zh) * 2023-09-26 2023-11-03 旭和（天津）医药科技有限公司 抗人b淋巴细胞刺激因子受体baffr的抗原结合多肽及其用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117143248A (zh) * 2022-05-24 2023-12-01 合源康华医药科技(北京)有限公司 靶向bcma-cd19的双特异性嵌合抗原受体及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3088095A1 (en) * 2017-11-15 2019-05-23 Novartis Ag Bcma-targeting chimeric antigen receptor, cd19-targeting chimeric antigen receptor, and combination therapies
CN110923255B (zh) * 2018-09-19 2023-08-29 上海恒润达生生物科技股份有限公司 靶向bcma和cd19嵌合抗原受体及其用途
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CN109485734B (zh) * 2018-12-30 2020-05-12 广州百暨基因科技有限公司 一种靶向bcma和cd19的双特异性嵌合抗原受体及其应用

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CN116751310A (zh) * 2023-06-13 2023-09-15 广东省第二人民医院（广东省卫生应急医院） 靶向cd19和gprc5d配体的嵌合抗原受体及其应用
CN116751310B (zh) * 2023-06-13 2024-02-13 广东省第二人民医院（广东省卫生应急医院） 靶向cd19和gprc5d配体的嵌合抗原受体及其应用
CN116987192A (zh) * 2023-09-26 2023-11-03 旭和（天津）医药科技有限公司 抗人b淋巴细胞刺激因子受体baffr的抗原结合多肽及其用途
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