CN115698079A - 抗cd79b抗体药物偶联物、其制备方法及其医药用途 - Google Patents

抗cd79b抗体药物偶联物、其制备方法及其医药用途 Download PDF

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CN115698079A
CN115698079A CN202180042603.6A CN202180042603A CN115698079A CN 115698079 A CN115698079 A CN 115698079A CN 202180042603 A CN202180042603 A CN 202180042603A CN 115698079 A CN115698079 A CN 115698079A
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antibody
adc
cells
alkyl
drug
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任文明
梁金栋
许建烟
黄建
杨昌永
廖成
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Shanghai Tuojie Biomedical Technology Co ltd
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Shanghai Tuojie Biomedical Technology Co ltd
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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    • C07K2317/00—Immunoglobulins specific features
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CN202180042603.6A 2020-07-27 2021-07-27 抗cd79b抗体药物偶联物、其制备方法及其医药用途 Pending CN115698079A (zh)

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CN2020107308998 2020-07-27
CN202010730899 2020-07-27
CN202010735910 2020-07-28
CN202010735910X 2020-07-28
PCT/CN2021/108666 WO2022022508A1 (zh) 2020-07-27 2021-07-27 抗cd79b抗体药物偶联物、其制备方法及其医药用途

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US (1) US12642862B2 (enExample)
EP (1) EP4190812A4 (enExample)
JP (1) JP7817236B2 (enExample)
KR (1) KR20230044275A (enExample)
CN (1) CN115698079A (enExample)
AU (1) AU2021317378A1 (enExample)
BR (1) BR112023001359A2 (enExample)
CA (1) CA3184724A1 (enExample)
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CA3248952A1 (en) * 2022-01-26 2025-07-10 Shanghai Mabgen Biotech Ltd. PHARMACEUTICAL COMPOSITION COMPRISING AN ANTI-CD79B ANTIBODY-DRUG CONJUGATE AND ITS USE
EP4480499A1 (en) * 2022-02-16 2024-12-25 Medilink Therapeutics (Suzhou) Co., Ltd. Conjugate of antibody-eribulin or derivative thereof, intermediate thereof, preparation method therefor, pharmaceutical composition thereof and use thereof
KR20240150773A (ko) * 2022-02-24 2024-10-16 에보포인트 바이오사이언시스 컴퍼니 리미티드 항체 및 약물 접합체 및 이의 용도
CN119998325A (zh) * 2022-08-08 2025-05-13 Atb治疗公司 抗CD79b的人源化抗体
WO2024078612A1 (en) * 2022-10-14 2024-04-18 Genequantum Healthcare (Suzhou) Co., Ltd. Linker-payload compound, conjugates and applications thereof
CN117917248A (zh) * 2022-10-20 2024-04-23 英诺湖医药(杭州)有限公司 酶裂解连接子及包含其的配体-艾瑞布林偶联物
EP4623936A1 (en) * 2022-11-22 2025-10-01 Keymed Biosciences (Chengdu) Co., Ltd. Fused ring compound, conjugate thereof and use thereof
CN118271439B (zh) * 2022-12-29 2025-06-13 深圳泽安生物医药有限公司 抗CD79b抗体及其用途
KR20250143351A (ko) * 2023-04-12 2025-10-01 레메젠 코, 리미티드 모노메틸 아우리스타틴 e 화합물의 제조 및 정제 방법
CN122514386A (zh) * 2024-02-02 2026-08-04 江苏恒瑞医药股份有限公司 抗CD79b抗体药物偶联物联合免疫治疗剂、化疗剂治疗肿瘤
WO2025209279A1 (zh) * 2024-04-03 2025-10-09 英诺湖医药(杭州)有限公司 一种抗b7h3抗体-艾瑞布林偶联物及其应用
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