CN115670960A - Mosquito-repelling spray liquid - Google Patents
Mosquito-repelling spray liquid Download PDFInfo
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- CN115670960A CN115670960A CN202211371870.0A CN202211371870A CN115670960A CN 115670960 A CN115670960 A CN 115670960A CN 202211371870 A CN202211371870 A CN 202211371870A CN 115670960 A CN115670960 A CN 115670960A
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- estragole
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention discloses mosquito-repellent spray liquid which comprises the following components in parts by weight: 1-3 parts of karanal, 2-4 parts of elemene, 2-5 parts of estragole, 1-3 parts of acetic acid leaf alcohol ester, 80-120 parts of ethanol, 5-7 parts of solubilizer and 0.01-0.03 part of preservative, and also discloses a preparation method and a mosquito repellent effect thereof.
Description
Technical Field
The invention relates to the technical field of daily chemicals, in particular to a mosquito-repellent spray liquid, a preparation method and application thereof, and a mosquito-repellent itching-relieving article.
Background
A plurality of mosquito repellent products are available on the market, and the burning or heating type products generally use pyrethroid chemical insecticides and easily cause lung discomfort; floral water and other products generally use chemosynthetic repellent DEET or anophelifuge, have irritation and toxicity, are not suitable for long-term use, or are used under the condition that infants are present, and have limited mosquito repellent effect on citronella oil, eucalyptus oil, lemon tea tree oil and the like in the market. The principle of common mosquito repelling products for repelling mosquitoes is to hide or shield human odor by using chemical substances.
Chinese invention patent application (CN 110251435B) discloses an essential oil spray with mosquito-repelling and itching-relieving effects and a preparation method thereof, and relates to an essential oil spray and a preparation method thereof. The essential oil spray with mosquito repelling and itching relieving effects comprises syringa amurensis schneid and jasmine distillate, ledum palustre essential oil, lemon grass essential oil, camphor tree leaf extract, wormwood extract, menthol, an emulsifier, hydrogenated castor oil, glycerol, propylene glycol, hyaluronic acid, ascorbic acid, lutein and the balance of deionized water; the method comprises the following steps: 1. preparing a distillate of syringa amurensis flowers and jasmine flowers; 2. preparing Ledum minutissima essential oil; 3. preparing lemongrass essential oil; 4. preparing camphor tree leaf extract; 5. preparing a wormwood extract; 6. weighing; 7. preparing a phase A with stable state; 8. preparing a light brown transparent liquid phase B; 9. mixing; 10. and (6) canning. The invention has more medicinal flavors and more complex preparation process, and in the evaluation of the effect, the effect is not exact only by testing the times that mosquitoes stop and attack the back of the hand of a tested person.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to solve the problem of providing the mosquito repellent spray liquid with definite curative effect.
The invention aims to provide a mosquito-repellent spray liquid which comprises the following components in parts by weight: 1-3 parts of karanal, 2-4 parts of elemi-none, 2-5 parts of estragole and 1-3 parts of leaf alcohol acetate.
The mosquito-repellent spray liquid comprises the following components in parts by weight: 1 part of karanal, 4 parts of eleusinone, 2 parts of estragole and 3 parts of folic alcohol acetate.
The mosquito-repellent spray liquid comprises the following components in parts by weight: 3 parts of karanal, 2 parts of eleutherone, 5 parts of estragole and 1 part of acetic acid leaf alcohol ester.
The mosquito-repellent spray liquid comprises the following components in parts by weight: 2 parts of karanal, 3 parts of eleusine, 4 parts of estragole and 2 parts of acetic acid leaf alcohol ester
The mosquito-repellent spray liquid also comprises 80-120 parts of ethanol, 5-7 parts of solubilizer and 0.01-0.03 part of preservative.
The solubilizer is one or more of PEG-40 hydrogenated castor oil, dimethyl phthalate and polyoxyethylene stearate.
The preservative of the mosquito-repellent spray liquid is one or more of nipagin ester, gemma BP, methylisothiazolinone, PHMB, PHMG, benzalkonium chloride, benzalkonium bromide, hexadecyl trimethyl ammonium bromide and bisdecyl dimethyl ammonium chloride.
The invention also aims to provide a preparation method of the mosquito-repellent spray liquid, which comprises the following steps:
s1, adding a solubilizer into a reaction kettle, sequentially adding karanal, elenoline, estragole and folic alcohol acetate, stirring and dissolving in the solubilizer;
and S2, adding ethanol into the reaction kettle, adding a preservative, stirring to dissolve the preservative into the ethanol, slowly adding the solution obtained in the step S1, continuously stirring for 10-40 min, then increasing the rotating speed, controlling the temperature to be below 60 ℃, and continuously stirring to be uniform.
The mosquito-repellent spray liquid is applied to preparing mosquito-repellent products.
A mosquito repellent and itching relieving product is prepared by adding adjuvants into the mosquito repellent spray liquid to prepare into one of sachet, sustained release tablet, spray, aerosol, cream and nanometer emulsion.
Wherein karanal is a chemical also known as 2- (2, 4-dimethyl-3-cyclohexyl) -5-methyl-5- (1-methylpropyl) -1, 3-dioxan. CAS:117933-89-8; elenolinone, chemical name 5-methyl-3-heptanone oxime, CAS No.:22457-23-4; estragole of formula C 10 H 12 O, molecular weight of 148.22, colorless to light yellow liquid, and has anise-like fragrance. The boiling point is 216 ℃. Soluble in ethanol and chloroform, and somewhat insoluble in water. Folic acetate, CAS No.3681-71-8, the Chinese alias: cis-3-hexenyl acetate.
Compared with the prior art, the invention has the beneficial effects that: the plant essential oil composition is safe and non-irritant to skin, can shorten the coma starting time of female aedes albopictus and prolong the awakening time, and is different from common mosquito repelling products, wherein the mosquito repelling principle of the common mosquito repelling products is to hide or shield human odor by using chemical substances; but also can wet the legs of the mosquito, which makes the flying difficult.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by one skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the invention defined by the appended claims.
Example 1: spray agent
Taking 1 part of karanal, 4 parts of elemi-none, 2 parts of estragole, 3 parts of acetic acid leaf alcohol ester, 80 parts of ethanol, 7 parts of PEG-40 hydrogenated castor oil and 0.03 part of nipagin ester, and the preparation method comprises the following steps:
s1, adding PEG-40 hydrogenated castor oil into a reaction kettle, sequentially adding karanal, elemi ketone, estragole and acetic acid leaf alcohol ester, stirring and dissolving in a solubilizer;
and S2, adding ethanol into the reaction kettle, adding the nipagin ester, stirring to dissolve the preservative into the ethanol, slowly adding the solution obtained in the step S1, continuously stirring for 40min, then increasing the rotating speed, controlling the temperature to be below 60 ℃, continuously stirring to be uniform, and canning by adopting a light-resistant glass bottle and an ultramicro atomization spray pump head to obtain the nano-emulsion.
Example 2: sachet with fragrance
Taking 3 parts of karanal, 2 parts of elemi-none, 5 parts of estragole, 1 part of acetic acid leaf alcohol ester, 120 parts of ethanol, 5 parts of dimethyl phthalate and 0.01 part of benzalkonium bromide, and the preparation method comprises the following steps:
s1, adding dimethyl phthalate into a reaction kettle, sequentially adding karanal, elenoline, estragole and folic alcohol acetate, stirring and dissolving in a solubilizer;
s2, adding ethanol into the reaction kettle, adding benzalkonium bromide, stirring to dissolve the preservative into the ethanol, slowly adding the solution obtained in the step S1, continuously stirring for 40min, increasing the rotating speed, controlling the temperature to be below 60 ℃, continuously stirring to be uniform, stirring cotton, and filling into a non-woven fabric bag to obtain the anti-bacterial cotton.
Example 3: cream formulation
Taking 2 parts of karanal, 3 parts of elemi-none, 4 parts of estragole, 2 parts of acetic acid leaf alcohol ester, 100 parts of ethanol, 6 parts of polyoxyethylene stearate and 0.02 part of benzalkonium chloride, and the preparation method comprises the following steps:
s1, adding polyoxyethylene stearate into a reaction kettle, sequentially adding karanal, elemi ketone, estragole and leaf alcohol acetate, stirring and dissolving in a solubilizer;
s2, adding ethanol into the reaction kettle, adding benzalkonium chloride, stirring to dissolve the preservative into the ethanol, slowly adding the solution obtained in the step S1, continuously stirring for 40min, increasing the rotating speed, controlling the temperature to be below 60 ℃, continuously stirring to be uniform, and adding the cream matrix to obtain the cream.
Example 4: comparing the amount of Aedes albopictus coma and revival at specific time points
The test object is a mosquito, and 100 aedes albopictus mosquitoes captured in a common house are taken; the test method comprises the following steps: preparing two cube glass containers with the side length of 40cm, wherein one is used as an observation group, the other is used as a comparison group, and the glass containers are provided with openable covers; the spray of example 1 of the present invention and 180ml of Liushen toilet water of a control group were sprayed around and on the bottom of the glass, respectively, to wet the glass, aedes albopictus was put in the glass, the glass was covered with a cover, and the numbers of Aedes albopictus in coma and awakening state were observed for a specific time, as shown in tables 1-2.
TABLE 1 Aedes albopictus coma quantity (number)
| 1 minute (1 minute) | 2 minutes | 5 minutes | 10 minutes | |
| The invention | 25 | 56 | 78 | 100 |
| Liushen toilet water | 3 | 8 | 10 | 12 |
TABLE 2 awakening number of Aedes albopictus
| 20 minutes | 30 minutes | 40 minutes | 50 minutes | |
| The invention | 5 | 12 | 34 | 54 |
| Liushen toilet water | 78 | 84 | 88 | 98 |
As can be seen from the table above, the mosquito killer can cause coma of half mosquitoes in 2 minutes and all mosquitoes in 10 minutes, and the effect is better than that of a control group; at 50 minutes, only about half of mosquitoes revived, and the control group revived almost completely; also, it was observed that the legs of aedes albopictus were difficult to fly in contact with the present invention, probably because the legs of aedes albopictus have high water repellency and once wetted with an oily solution, weight gain resulted in immobility.
Example 5: mosquito repellent test: reference GB/T13917.9-2009 evasion agent evaluation standard
Selecting testers and test insects: 300 test insects are put into the mosquito cage, the back of the hand of a tester is exposed to the skin of 40mm multiplied by 40mm, and the rest part is tightly shielded. The hands are put into the mosquito cage and stay for 2min, close observation shows that the mosquitoes are stopped, and the hands shake the arms to expel the mosquitoes before the mouth of the mosquito is penetrated into the skin, and the record is that 1 test insect is stopped. More than 30 test persons who stop falling from the beginning and test insects are qualified for attack, and the persons and mosquitoes in the cage can be subjected to repellent tests.
Avoidance test: 12 testers (half of men and women, no wine, tea or coffee should be drunk before and during the test, and no essence-containing products should be used) with qualified offensive power are selected and divided into 3 groups, namely a group 1 of the invention and a group 3 of the sprays of the invention, the control group adopts a 180ml Liushen toilet water group, 4 persons in each group draw skin areas of 50mm multiplied by 50mm on the backs of the hands of the two hands, wherein one hand is uniformly coated with the sprays of the invention or Liushen toilet water according to the dosage of 1.5 muL/cm < 2 >, the skin of 40mm multiplied by 40mm is exposed, the rest parts are strictly shielded, and the other hand is blank control. After the spray or Liushen toilet water is smeared for 2 hours, the hands are put into a mosquito cage with qualified attacking power for 2 minutes, and whether mosquitoes come forward or come back and fall to suck blood is observed. And then testing once every 1h, judging that the repellent fails as long as one mosquito sucks blood in front of the mosquito, and recording the effective protection time (h) of the repellent. The contrast test is firstly carried out by the contrast hand each time, the test insects with qualified attack force can be continuously tested, and the test insects with unqualified attack force are replaced by the qualified test insects for testing. The test results are shown in table 3.
The effective protection time is the average of the effective protection times of 4 subjects per group (1 decimal left).
TABLE 3 mosquito repellent test results
| Item | Effective guard time (h) |
| Inventive example 1 | 8.2 |
| Inventive example 3 | 8.9 |
| Liushen toilet water | 4.3 |
As can be seen from table 3, the spray of examples 1 and 3 had a mosquito repelling time of more than 8 hours, while the spray of comparative example had a mosquito repelling time of less than 5 hours, because the present invention had a good mosquito repelling effect.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (10)
1. The mosquito-repellent spray is characterized by comprising the following components in parts by weight: 1-3 parts of karanal, 2-4 parts of elemi-none, 2-5 parts of estragole and 1-3 parts of leaf alcohol acetate.
2. The mosquito-repellent spray liquid of claim 1, which is characterized by comprising the following components in parts by weight: 1 part of karanal, 4 parts of eleusinone, 2 parts of estragole and 3 parts of folic alcohol acetate.
3. The mosquito-repellent spray liquid of claim 1, which is characterized by comprising the following components in parts by weight: 3 parts of karanal, 2 parts of eleutherone, 5 parts of estragole and 1 part of acetic acid leaf alcohol ester.
4. The mosquito-repellent spray liquid of claim 1, which is characterized by comprising the following components in parts by weight: 2 parts of karanal, 3 parts of eleutherone, 4 parts of estragole and 2 parts of acetic acid leaf alcohol ester.
5. The mosquito repellent spray according to claim 1, further comprising 80-120 parts of ethanol, 5-7 parts of solubilizer and 0.01-0.03 part of preservative.
6. The mosquito repellent spray according to claim 5, wherein the solubilizer is one or more of PEG-40 hydrogenated castor oil, dimethyl phthalate and polyoxyethylene stearate.
7. The mosquito-repellent spray according to claim 5, wherein the preservative is one or more of nipagin ester, gemma BP, methylisothiazolinone, PHMB, PHMG, benzalkonium chloride, benzalkonium bromide, cetyltrimethylammonium bromide, and bisdecyl dimethyl ammonium chloride.
8. The mosquito-repellent spray liquid of claim 5, wherein the preparation method comprises the following steps:
s1, adding a solubilizer into a reaction kettle, sequentially adding karanal, elenoline, estragole and folic alcohol acetate, stirring and dissolving in the solubilizer;
s2, adding ethanol into the reaction kettle, adding a preservative, stirring to dissolve the preservative into the ethanol, slowly adding the solution obtained in the step S1, continuously stirring for 10-40 min, then increasing the rotating speed, controlling the temperature to be below 60 ℃, and continuously stirring to be uniform.
9. Use of the mosquito repellent spray of claim 5 in the preparation of a mosquito repellent product.
10. A mosquito repellent and itching relieving product is characterized in that the mosquito repellent spray liquid prepared according to claim 5 is added with auxiliary materials to prepare one of sachets, sustained-release hanging tablets, sprays, aerosols, creams and nano-emulsions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211371870.0A CN115670960A (en) | 2022-11-03 | 2022-11-03 | Mosquito-repelling spray liquid |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202211371870.0A CN115670960A (en) | 2022-11-03 | 2022-11-03 | Mosquito-repelling spray liquid |
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| Publication Number | Publication Date |
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| CN115670960A true CN115670960A (en) | 2023-02-03 |
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| CN202211371870.0A Pending CN115670960A (en) | 2022-11-03 | 2022-11-03 | Mosquito-repelling spray liquid |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020005393A (en) * | 2000-07-05 | 2002-01-17 | 안용준, 김영수 | Pesticide composition |
| CN102432588A (en) * | 2011-11-25 | 2012-05-02 | 河南科技大学 | Method for synthesizing karanal |
| CN105152877A (en) * | 2015-09-08 | 2015-12-16 | 广西中烟工业有限责任公司 | Preparation method for estragole and application of estragole |
| CN113767935A (en) * | 2021-08-17 | 2021-12-10 | 淄博市北园府食品有限公司 | Preparation method of mosquito-repellent spray and mosquito-repellent spray |
-
2022
- 2022-11-03 CN CN202211371870.0A patent/CN115670960A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020005393A (en) * | 2000-07-05 | 2002-01-17 | 안용준, 김영수 | Pesticide composition |
| CN102432588A (en) * | 2011-11-25 | 2012-05-02 | 河南科技大学 | Method for synthesizing karanal |
| CN105152877A (en) * | 2015-09-08 | 2015-12-16 | 广西中烟工业有限责任公司 | Preparation method for estragole and application of estragole |
| CN113767935A (en) * | 2021-08-17 | 2021-12-10 | 淄博市北园府食品有限公司 | Preparation method of mosquito-repellent spray and mosquito-repellent spray |
Non-Patent Citations (1)
| Title |
|---|
| 黄致喜 等编著: "《中国现代化学史略》", 中国轻工业出版社, pages: 157 * |
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Effective date of registration: 20230919 Address after: No. 99 Laoya Road, Yaxi Street, Gaochun District, Nanjing City, Jiangsu Province, 211300 Applicant after: Nanjing Zhongchun Traditional Chinese Medicine Technology Co.,Ltd. Address before: Room 1501, 3 #, Shengrong Plaza, No. 1110 Dongpu Road, Tongyuan Community, Chengdong Street, Fengze District, Quanzhou City, Fujian Province, 362011 Applicant before: Fujian Weichen Biotechnology Co.,Ltd. |