CN115667283A - Rna指导的千碱基规模基因组重组工程 - Google Patents

Rna指导的千碱基规模基因组重组工程 Download PDF

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CN115667283A
CN115667283A CN202180033011.8A CN202180033011A CN115667283A CN 115667283 A CN115667283 A CN 115667283A CN 202180033011 A CN202180033011 A CN 202180033011A CN 115667283 A CN115667283 A CN 115667283A
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ala
glu
sequence
leu
protein
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丛乐
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Leland Stanford Junior University
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Leland Stanford Junior University
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CN202180033011.8A 2020-03-03 2021-03-02 Rna指导的千碱基规模基因组重组工程 Pending CN115667283A (zh)

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US202062984618P 2020-03-03 2020-03-03
US62/984,618 2020-03-03
US202163146447P 2021-02-05 2021-02-05
US63/146,447 2021-02-05
PCT/US2021/020513 WO2021178432A1 (en) 2020-03-03 2021-03-02 Rna-guided genome recombineering at kilobase scale

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US (1) US20230091242A1 (https=)
EP (1) EP4114845A4 (https=)
JP (1) JP2023515670A (https=)
KR (1) KR20220151175A (https=)
CN (1) CN115667283A (https=)
AU (1) AU2021231769A1 (https=)
BR (1) BR112022017196A2 (https=)
CA (1) CA3173526A1 (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120555441A (zh) * 2025-05-29 2025-08-29 西北农林科技大学 基于CtIP蛋白提高CRISPR/Cas9介导的外源基因整合效率的DNA适配体及其应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4396340A4 (en) * 2021-09-01 2025-09-24 Univ Leland Stanford Junior RNA-GUIDED GENOME RECOMBINATION AT THE KILOBASE SCALE
JP2025505732A (ja) * 2022-02-10 2025-02-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー キロ塩基スケールでのｒｎａガイドゲノムリコンビニアリング
WO2023154892A1 (en) * 2022-02-10 2023-08-17 Possible Medicines Llc Rna-guided genome recombineering at kilobase scale
WO2024168265A1 (en) * 2023-02-10 2024-08-15 Possible Medicines Llc Aav delivery of rna guided recombination system
WO2024168253A1 (en) * 2023-02-10 2024-08-15 Possible Medicines Llc Delivery of an rna guided recombination system

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AU752105B2 (en) * 1997-12-05 2002-09-05 Europaisches Laboratorium Fur Molekularbiologie (Embl) Novel dna cloning method
US9388430B2 (en) * 2013-09-06 2016-07-12 President And Fellows Of Harvard College Cas9-recombinase fusion proteins and uses thereof
WO2016022363A2 (en) * 2014-07-30 2016-02-11 President And Fellows Of Harvard College Cas9 proteins including ligand-dependent inteins
EP3265559B1 (en) * 2015-03-03 2021-01-06 The General Hospital Corporation Engineered crispr-cas9 nucleases with altered pam specificity
WO2016205759A1 (en) * 2015-06-18 2016-12-22 The Broad Institute Inc. Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
US11479793B2 (en) * 2015-07-15 2022-10-25 Rutgers, The State University Of New Jersey Nuclease-independent targeted gene editing platform and uses thereof
WO2019089910A1 (en) * 2017-11-01 2019-05-09 Ohio State Innovation Foundation Highly compact cas9-based transcriptional regulators for in vivo gene regulation
KR20210152597A (ko) * 2017-12-22 2021-12-15 (주)지플러스생명과학 키메라 게놈 조작 분자 및 방법
EP4396340A4 (en) * 2021-09-01 2025-09-24 Univ Leland Stanford Junior RNA-GUIDED GENOME RECOMBINATION AT THE KILOBASE SCALE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120555441A (zh) * 2025-05-29 2025-08-29 西北农林科技大学 基于CtIP蛋白提高CRISPR/Cas9介导的外源基因整合效率的DNA适配体及其应用

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IL296057A (en) 2022-10-01
EP4114845A1 (en) 2023-01-11
JP2023515670A (ja) 2023-04-13
MX2022010835A (es) 2022-09-29
AU2021231769A1 (en) 2022-09-29
WO2021178432A1 (en) 2021-09-10
KR20220151175A (ko) 2022-11-14
EP4114845A4 (en) 2024-03-06
US20230091242A1 (en) 2023-03-23
WO2021178432A9 (en) 2021-10-28
BR112022017196A2 (pt) 2022-10-25
CA3173526A1 (en) 2021-09-10

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