CN115624664A

CN115624664A - Miniaturized membrane oxygenator

Info

Publication number: CN115624664A
Application number: CN202211407527.7A
Authority: CN
Inventors: 刘鹏; 李晓坤; 王俊; 刘日东
Original assignee: Jiangsu Saiteng Medical Technology Co ltd
Current assignee: Jiangsu Saiteng Medical Technology Co ltd
Priority date: 2022-11-10
Filing date: 2022-11-10
Publication date: 2023-01-20
Anticipated expiration: 2042-11-10
Also published as: CN115624664B

Abstract

The invention discloses a miniaturized membrane oxygenator, which comprises a shell, a heating element, an oxygenation membrane, a first air port, a second air port, a first blood port and a second blood port, wherein the shell comprises a shell, a first end cover and a second end cover; the first blood port is arranged on the first end cover or the shell, the second blood port is arranged on the second end cover or the shell, and the first blood port and the second blood port are both communicated with the inside of the shell; the heating element is arranged on the outer wall of the shell and used for regulating and controlling the temperature of blood in the shell. The miniaturized membrane oxygenator provided by the invention can reduce the blood priming volume and meet the requirement of blood temperature regulation.

Description

Miniaturized membrane oxygenator

Technical Field

The invention relates to the technical field of extracorporeal circulation, in particular to a miniaturized membrane oxygenator.

Background

The oxygenator is also called an artificial lung, can replace the function of the lung in a medium-short time, and is an indispensable device in life support. In the related art, although the extracorporeal circulation membrane oxygenator for clinical operation has different specifications, the priming volume is too large and expensive when the oxygenator is used for infants or small animals (such as rats and rabbits).

The existing miniaturized membrane oxygenator for infants or small animals is generally a reduced version of an oxygenator for CPB adults, namely, oxygenating filaments are vertically distributed in the oxygenator, heat exchange water pipes are arranged at the periphery/inside of the oxygenating filaments, blood enters from a blood inlet of the oxygenator, is subjected to heat exchange through the heat exchange water pipes, then is contacted with the oxygenating filaments for blood oxygenation, and is discharged from a blood outlet after oxygenation is completed. In this method, the priming volume of blood is increased in order to maintain a certain heat exchange efficiency/contact area of blood with the heat exchange tubes. However, since the ECMO for infants and young children or the small animals only need to keep the blood warm, in a further improvement scheme, the blood priming volume is reduced by eliminating the design of the heat exchange water pipe, but the scheme cannot keep the blood temperature, partial functions are lost, and additional equipment/methods are needed to keep the blood/operation objects temperature during use. Therefore, the complex achievement of bedside management is increased when the infant is used, and the success rate of the experiment is reduced when the infant is used in the animal experiment.

Disclosure of Invention

In view of the disadvantages of the prior art, it is an object of the present invention to provide a miniaturized membrane oxygenator capable of reducing the blood priming volume without losing the oxygenator function and providing a certain temperature maintaining function.

A miniaturized membrane oxygenator comprises a shell, a heating element, an oxygenation membrane, a first air port, a second air port, a first blood port and a second blood port;

the shell comprises a shell body, a first end cover and a second end cover, the shell body is provided with a first port, a second port and a hollow cavity which penetrates through the first port and the second port, the first end cover is connected with the first port, and the second end cover is connected with the second port;

the oxygenation membrane is arranged in the hollow cavity chamber; the first air port is arranged on the first end cover, the second air port is arranged on the second end cover, and the first air port and the second air port are communicated through an oxygenating filament of the oxygenation membrane; the first blood port is arranged on the first end cover or the shell is close to the first end cover, the second blood port is arranged on the second end cover or the shell is close to the second end cover, and the first blood port and the second blood port are both communicated with the hollow cavity;

the heating member is arranged on the outer wall of the shell, and the heating member is used for regulating and controlling the temperature of blood in the hollow cavity.

Optionally, the heating member includes a heating element, a first electrode and a second electrode, the heating element is arranged on the outer wall of the casing, and the first electrode and the second electrode are electrically connected with the heating element.

Optionally, the heating element is a conductive coating coated on the outer wall of the shell or a conductive wire wound on the outer wall of the shell.

Optionally, the hollow chamber comprises an oxygenation space, a first isolation space and a second isolation space, the first isolation space is adjacent to the first port, the second isolation space is adjacent to the second port, and the oxygenation space is between the first isolation space and the second isolation space;

the oxygenation membrane is arranged in the oxygenation space, a first isolating piece is arranged in the first isolating space, and a second isolating piece is arranged in the second isolating space.

Optionally, the oxygenation membrane is formed by cross-weaving a plurality of the oxygenation filaments.

Optionally, the first air port is disposed at the top of the first end cover and opposite to the first port, and the second air port is disposed at the top of the second end cover and opposite to the second port; the first blood port is arranged on the shell and close to the first isolating piece, and the second blood port is arranged on the shell and close to the second isolating piece.

Optionally, a first buffer space is arranged between the oxygenation membrane and the inner wall of the housing near the first port, and the first blood port is communicated with the first buffer space; a second buffer space is arranged between the oxygenation membrane and the inner wall of the shell near the second port, and the second blood port is communicated with the second buffer space.

The miniaturized membrane oxygenator of claim wherein the first blood port is disposed on top of the first endcap and opposite the first port and the second blood port is disposed on top of the second endcap and opposite the second port; the first air port is formed in the side face of the first end cover, and the second air port is formed in the side face of the second end cover.

Optionally, be equipped with dispersion spare in the cavity, dispersion spare is including being located the first dispersed portion of first port department and being located the second dispersed portion of second port department, first dispersed portion includes first guiding gutter and first through-hole, first guiding gutter with first blood mouth is relative, first through-hole intercommunication first guiding gutter with oxygenation space, second dispersed portion includes second guiding gutter and second through-hole, the second guiding gutter with second blood mouth is relative, the second through-hole intercommunication the second guiding gutter with oxygenation space.

Optionally, the first dispersion portion further includes a first flow guiding body, and the first flow guiding body protrudes from a groove bottom of the first flow guiding groove to a groove opening of the first flow guiding groove; the second dispersion part further comprises a second flow guiding body, and the second flow guiding body protrudes from the groove bottom of the second flow guiding groove to the groove opening of the second flow guiding groove.

Optionally, an end of the first flow guiding body facing the first blood port is a curved surface structure; the end part of the second flow guiding body facing the second blood port is of a curved surface structure.

The implementation of the scheme has the following beneficial effects:

the miniaturized membrane oxygenator comprises a shell, a heating element, an oxygenation membrane, a first air port, a second air port, a first blood port and a second blood port, wherein the shell comprises a shell, a first end cover arranged at the first port of the shell and a second end cover arranged at the second port of the shell, the first air port is formed in the first end cover, the second air port is formed in the second end cover, the first blood port is formed in the first end cover or the shell, the second blood port is formed in the second end cover or the shell, the oxygenation membrane is arranged in a hollow cavity in the shell, and the heating element is arranged on the outer wall of the shell. The blood can enter the hollow cavity through either the first blood port or the second blood port to be oxygenated with the oxygenation membrane, and then is discharged through the other one of the first blood port and the second blood port; the oxygen can enter from the first gas inlet and be discharged from the second gas outlet, or enter from the second gas inlet and be discharged from the first gas outlet; the user does not need to strictly distinguish the blood inlet and the blood outlet, the air inlet and the air outlet, the operation is convenient, and the time can be saved for rescuing patients.

Blood enters the hollow chamber from the blood port to carry out oxygenation reaction with the oxygenation membrane, the blood is heated by the heating element arranged on the outer wall of the shell during the oxygenation reaction, and the blood does not need to be in contact with the heat exchange medium pipe, so that the blood prefilling amount of the oxygenator is greatly reduced, the contact between the blood and foreign matters is reduced, and the oxygenator has a temperature regulation function. It is worth noting that since the blood flow rate of the miniaturized membrane oxygenator is generally 20-1000 ml, the way of arranging the heating element on the outer wall of the shell to exchange heat with the blood in the shell can fully meet the requirement of blood temperature regulation.

Drawings

FIG. 1 is a schematic diagram of a miniaturized membrane oxygenator provided by an embodiment of the present invention;

FIG. 2 is a schematic cross-sectional view of a miniaturized membrane oxygenator provided by an embodiment of the present invention;

FIG. 3 is a schematic flow diagram of oxygen and blood in a miniaturized membrane oxygenator as provided by embodiments of the present invention;

FIG. 4 is a schematic flow diagram of oxygen and blood in a miniaturized membrane oxygenator as provided by embodiments of the present invention;

FIG. 5 is a schematic diagram of a miniaturized membrane oxygenator according to an embodiment of the present invention;

FIG. 6 is a schematic flow diagram of oxygen and blood in a miniaturized membrane oxygenator as provided by embodiments of the present invention;

FIG. 7 is a schematic flow diagram of oxygen and blood in a miniaturized membrane oxygenator according to an embodiment of the present invention.

In the figure:

100 housing, 101 first port, 102 second port, 104 oxygenation space, 105 first isolation space, 106 second isolation space, 107 first buffer space, 108 second buffer space,

200 heating element, 201 heating element, 202 first electrode, 203 second electrode, 204 wire,

300 a dispersion member, 302 a first flow guide channel, 303 a first through hole, 304 a first flow guide body, 306 a second flow guide channel, 307 a second through hole, 308 a second flow guide body,

the oxygen-containing film of 400 a is provided,

500 a first end cap, 501 a first blood port, 502 a first gas port,

600 second end cap, 601 second blood port, 602 second gas port,

700 the first spacer to be used for the first spacer,

800 second spacer.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present invention, it should be noted that the terms "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on orientations or positional relationships shown in the drawings or orientations or positional relationships that the product of the present invention is conventionally placed in use, and are only used for convenience of description and simplicity of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like are used solely to distinguish one from another and are not to be construed as indicating or implying relative importance. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

In the description of the present invention, it should also be noted that, unless otherwise explicitly stated or limited, the terms "disposed" and "connected" are to be interpreted broadly, e.g., as being fixed or detachable or integrally connected; either mechanically or electrically. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.

In the present invention, unless expressly stated or limited otherwise, the recitation of a first feature "on" or "under" a second feature may include the recitation of the first and second features being in direct contact, and may also include the recitation that the first and second features are not in direct contact, but are in contact via another feature between them. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. "beneath," "under" and "beneath" a first feature includes the first feature being directly beneath and obliquely beneath the second feature, or simply indicating that the first feature is at a lesser elevation than the second feature.

Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.

The present embodiment provides a miniaturized membrane oxygenator, which includes a housing, a heating element, an oxygenation membrane, a first air port, a second air port, a first blood port, and a second blood port. The shell comprises a shell body, a first end cover and a second end cover, the shell body is provided with a first port, a second port and a hollow cavity which is communicated with the first port and the second port, the first end cover is connected with the first port, and the second end cover is connected with the second port. The oxygenation membrane is arranged in the hollow cavity chamber; the first air port is arranged on the first end cover, the second air port is arranged on the second end cover, and the first air port and the second air port are communicated through an oxygenating filament of the oxygenation membrane; the first blood port is arranged on the first end cover or the shell is close to the first end cover, the second blood port is arranged on the second end cover or the shell is close to the second end cover, and the first blood port and the second blood port are communicated with the hollow cavity. The heating member is arranged on the outer wall of the shell, and the heating member is used for regulating and controlling the temperature of blood in the hollow cavity.

This example provides a miniaturized membrane oxygenator that may be used for infant treatment or for experiments on small animals such as rats and rabbits. Infants and small animals have less blood than adults, and oxygenators for adults require more blood to prime, and are therefore not suitable for infants and small animals. The present embodiment provides a miniaturized membrane oxygenator that can reduce blood priming and is convenient and fast to use.

Fig. 5-7 show a miniaturized membrane oxygenator configuration, please refer to fig. 5-7, the miniaturized membrane oxygenator includes a housing, a heating element 200, an oxygenation membrane 400, a first gas port 502, a second gas port 602, a first blood port 501, and a second blood port 601.

The housing comprises a shell 100, a first end cap 500 and a second end cap 600, wherein the shell 100 is provided with a first port 101, a second port 102 and a hollow cavity which penetrates through the first port 101 and the second port 102, the first end cap 500 is connected with the first port 101, and the second end cap 600 is connected with the second port 102.

The hollow chamber comprises an oxygenation space 104, a first isolation space 105 and a second isolation space 106, the first isolation space 105 being adjacent to the first port 101, the second isolation space 106 being adjacent to the second port 102, the oxygenation space 104 being between the first isolation space 105 and the second isolation space 106. The oxygenation membrane 400 is disposed in the oxygenation space 104, a first partition 700 is disposed in the first isolation space 105, and a second partition 800 is disposed in the second isolation space 106.

The first gas port 502 is located at the top of the first end cap 500 opposite the first port 101, and the second gas port 602 is located at the top of the second end cap 600 opposite the second port 102. The oxygenation membrane 400 is formed by interweaving a plurality of the oxygenation filaments. The first air port 502 is communicated with the second air port 602 through the oxygenating filaments of the oxygenation membrane 400, and oxygen can be injected into the oxygenating filaments from the first air port 502 and discharged from the second air port 602, or can enter the oxygenating filaments from the second air port 602 and then be discharged from the first air port 502.

The first blood port 501 is disposed on the housing 100 and is adjacent to the first spacer 700. The second blood port 601 is disposed on the housing 100 and near the second partition 800. The first blood port 501 and the second blood port 601 are both communicated with the hollow chamber.

Referring to fig. 5, a first buffer space 107 is disposed between the oxygenation membrane 400 and the inner wall of the housing 100 near the first port 101, and the first blood port 501 is communicated with the first buffer space 107. The first buffer space surrounds the oxygenation membrane. In the first buffer space, the distance between the outer wall of the oxidation film and the inner wall of the shell decreases progressively from the first separator to the second separator. When blood is injected from the first blood port 501, the blood is accumulated in the first buffer space to surround the oxygenation membrane and slowly permeates into the oxygenation membrane, and the first buffer space is favorable for dispersing the blood in the oxygenation membrane, expanding the contact area with the oxygenation membrane and reducing the flow velocity of the blood, so that the oxygenation effect is improved. In addition, the oxygenation membrane is formed by weaving the oxygenation filaments, so that the blood turbulence can be increased, the blood flow rate can be reduced, and the oxygenation effect can be further improved. Correspondingly, a second buffer space 108 is arranged between the oxygenation membrane 400 and the inner wall of the housing 100 near the second port 102, and the second blood port 601 is communicated with the second buffer space 108. The second buffer space surrounds the oxygenation membrane. In the second buffer space, the distance between the outer wall of the oxygen-containing membrane and the inner wall of the shell decreases progressively from the second separator to the first separator. The second buffer space is the same as the first buffer space, and also plays a role in uniformly dispersing blood and improving oxygenation effect in the process of injecting blood from the second blood port.

The heating member 200 is disposed on the outer wall of the housing 100, and the heating member 200 is used to regulate the temperature of blood in the hollow chamber. In one possible implementation manner, the heating member 200 may include a heating body, a first electrode, and a second electrode, the heating body is disposed on the outer wall of the housing, and the first electrode and the second electrode are electrically connected to the heating body. The heating element may be a conductive coating coated on the outer wall of the casing 100 or a conductive wire wound on the outer wall of the casing 100.

Figures 6 and 7 show the flow paths of oxygen and blood in the membrane oxygenator of the present embodiment, and since the membrane oxygenator of the present embodiment is provided with an approximately symmetrical configuration, blood can be injected from either of the first blood port 501 and the second blood port 601 and then discharged from the other of the first blood port 501 and the second blood port 601. Oxygen may be injected from either of the first gas port 502 and the second gas port 602 and then discharged from the other of the first gas port 502 and the second gas port 602. Wherein the flow direction of the blood and the oxygen in the oxygenation space may be the same or opposite. The design reduces the production and assembly requirements, can save the cost, does not need to distinguish blood separation, blood discharge, air intake and exhaust when in use, is convenient for a user to operate, and can save the operation time. And, first gas port and second gas port are established on the end cover, and first blood mouth and second blood mouth are established in the casing side, and the gas port is different with the direction of blood mouth, do benefit to the user and distinguish, reducible maloperation.

In the miniaturized membrane oxygenator provided by the embodiment, blood can enter the hollow chamber through either the first blood port or the second blood port to be oxygenated with the oxygenation membrane, and then is discharged through the other of the first blood port and the second blood port. The oxygen can enter from the first gas inlet and be discharged from the second gas outlet, or enter from the second gas inlet and be discharged from the first gas outlet. The user does not need to strictly distinguish the blood inlet, the blood outlet, the air inlet and the air outlet, the operation is convenient, and the time can be saved for rescuing patients. In addition, blood enters the hollow cavity from the blood port to carry out oxygenation reaction with the oxygenation membrane, the blood is heated by the heating element arranged on the outer wall of the shell during the oxygenation reaction, and the blood does not need to be in contact with the heat exchange medium pipe, so that the blood prefilling amount of the oxygenator is greatly reduced, the contact between the blood and foreign matters is reduced, and the oxygenator has a temperature regulation function. It should be noted that, since the blood flow of the miniaturized membrane oxygenator is generally 20 ml to 1000ml, the way of disposing the heating element on the outer wall of the housing to exchange heat with the blood in the housing can fully meet the requirement of blood temperature regulation.

Figures 1-4 show another configuration of a miniaturized membrane oxygenator. Referring to fig. 1 and 2, the miniaturized membrane oxygenator of the present embodiment includes a housing 100, a heating member 200, a dispersing member 300, an oxygenation membrane 400, a first end cap 500, and a second end cap 600. The housing 100 has a first port 101, a second port 102, and a hollow chamber that passes through the first port 101 and the second port 102. The heating member 200 is provided on the outer wall of the housing 100. The dispersion member 300 is disposed in the hollow cavity, an oxygenation chamber is formed between an outer wall of the dispersion member 300 and an inner wall of the housing 100, the dispersion member 300 includes a first dispersion portion located at the first port 101 and a second dispersion portion located at the second port 102, the first dispersion portion includes a first flow guide groove 302 and a first through hole 303, the first through hole 303 communicates the first flow guide groove 302 with the oxygenation chamber, the second dispersion portion includes a second flow guide groove 306 and a second through hole 307, and the second through hole 307 communicates the second flow guide groove 306 with the oxygenation chamber. The oxygenation membrane 400 is disposed within the oxygenation chamber and surrounds the dispersion member 300. The first end cap 500 is connected to the first port 101, the first end cap 500 includes a first blood port 501 and a first air port 502, the first blood port 501 faces the first flow guide groove 302 and is in fluid communication with the first flow guide groove 302, and the first air port 502 is in communication with the oxygenation chamber. The second end cap 600 is connected to the second port 102, the second end cap 600 includes a second blood port 601 and a second air port 602, the second blood port 601 faces the second guiding gutter 306 and is in fluid communication with the second guiding gutter 306, and the second air port 602 is in communication with the oxygenation chamber.

The miniaturized membrane oxygenator comprises a shell, a first end cover, a second end cover, a dispersing piece, an oxygenation membrane and a heating piece, wherein the heating piece is arranged on the outer wall of the shell, the dispersing piece is arranged inside the shell, the first end cover is arranged at a first port of the shell, the second end cover is arranged at a second port, opposite to the first port, of the shell, the oxygenation membrane is arranged in an oxygenation cavity between the outer wall of the dispersing piece and the inner wall of the shell, a first air inlet and a first blood port opposite to the first port are formed in the first end cover, and a second air inlet and a second blood port opposite to the second port are formed in the second end cover. The blood can enter the oxygenation chamber through the first blood port to be oxygenated with the oxygenation membrane and then discharged through the second blood port, or can enter the oxygenation chamber through the second blood port to be oxygenated with the oxygenation membrane and then discharged through the first blood port; oxygen can enter from the first gas inlet and be discharged from the second gas outlet, or enter from the second gas inlet and be discharged from the first gas outlet; the user does not need to distinguish the blood inlet and the blood outlet, the operation is convenient, and the time can be saved for rescuing patients.

Because the first blood port, the oxygenation chamber and the second blood port are almost linearly communicated, blood can rapidly enter the oxygenation chamber after entering from the blood ports, and the blood priming volume at the inlet is reduced. Because the blood only contacts with the oxygenation membrane after entering from the blood port and does not need to contact with the heat exchange water pipe, the blood priming volume of the oxygenator is greatly reduced, and the contact between the blood and foreign matters is reduced. In addition, the heating element is arranged on the outer wall of the shell to control the temperature of the blood flowing in the shell, so that the oxygenator has oxygenation and temperature regulation functions, and the blood flow of the miniaturized membrane oxygenator is generally 5-35 ml, and the mode that the heating element is arranged on the outer wall of the shell to exchange heat with the blood in the shell can meet the requirement of blood temperature regulation.

In one possible implementation, the oxygenation chamber comprises an oxygenation space 104, a first isolation space 105 and a second isolation space 106, the first isolation space 105 being adjacent to the first port 101, the second isolation space 106 being adjacent to the second port 102, the oxygenation space 104 being between the first isolation space 105 and the second isolation space 106. The oxygenation membrane 400 is disposed in the oxygenation space 104, the first partition 700 is disposed in the first partition space 105, and the second partition 800 is disposed in the second partition space. The first and

second spacers

700, 800 are used to seal off the oxygenation space 104, preventing blood in the oxygenation space 104 from flowing out of the first and

second ports

101, 102.

In one possible implementation, the oxygenation membrane 400 is formed by interweaving oxygenating filaments, wherein the openings at one end of the oxygenating filaments are communicated with the first air port 502 through the first partition member 700, and the openings at the other end of the oxygenating filaments are communicated with the second air port 602 through the second partition member 800. Most of the oxygenation filaments of the miniaturized membrane oxygenator on the market are arranged along the length direction of the oxygenator shell, and the oxygenation filaments are parallel to each other, so that the flow rate is very low when blood firstly contacts the oxygenation filaments when the blood enters the oxygenation cavity from the blood inlet, and the blood can quickly flow to the blood outlet along the oxygenation filaments once the blood enters the oxygenation filaments. In contrast, in the present embodiment, the oxygenation membrane 400 is formed by interlacing the oxygenation filaments, and the blood is in a turbulent state rather than flowing in the same direction in the oxygenation membrane 400, so that more blood cells can be in more uniform contact with the surface of the oxygenation filaments, and the oxygenation effect is improved.

In a possible implementation manner, the first dispersion part may include a first guiding gutter 302, a first through hole 303, and a first guiding body 304, the first guiding gutter 302 faces the first port 101 and the first blood port 501, the first guiding body 304 protrudes from the bottom of the first guiding gutter 302 to the opening of the first guiding gutter 302, the first guiding gutter 302 may be regarded as an annular groove surrounding the first guiding body 304, the first through hole 303 is disposed on a side of the annular groove near the bottom of the groove, and the first through hole 303 penetrates through a wall of the first guiding gutter 302 and an outer wall of the dispersion member 300, so that the first guiding gutter 302 communicates with the oxygenation space 104. The second dispersion part may include a second guiding gutter 306, a second through hole 307 and a second guiding body 308, the second guiding gutter 306 faces the second port 102 and the second blood port 601, the second guiding body 308 protrudes from the bottom of the second guiding gutter 306 to the opening of the second guiding gutter 306, the second guiding gutter 306 may be regarded as an annular groove surrounding the second guiding body 308, the second through hole 307 is provided at a side of the annular groove near the bottom of the groove, the second through hole 307 penetrates the wall of the second guiding gutter 306 and the outer wall of the dispersion member 300, so that the second guiding gutter 306 communicates with the oxygenation space 104.

The end of the first flow guiding body 304 facing the first blood port 501 and the end of the second flow guiding body 308 facing the second blood port 601 are both curved structures. The blood enters from the blood port and contacts the flow guiding body, is dispersed around under the blocking action of the flow guiding body, and then flows into the flow guiding groove, and then flows to the oxygenation membrane 400 from the through hole at the lower part of the flow guiding groove. The end part of the flow guide body facing the blood port is set to be a curved surface, so that the contact between the blood and the flow guide body is relatively mild, the blood is dispersed more uniformly, and the damage of the blood flow impact on blood cells can be reduced.

In one possible implementation manner, the heating member 200 includes a heating body 201, a first electrode 202 and a second electrode 203, the heating body 201 is disposed on an outer wall of the housing, and the first electrode 202 and the second electrode 203 are both electrically connected to the heating body 201. In practical applications, the heating element 201 may be a conductive coating layer coated on the outer wall of the casing or a conductive wire wound on the outer wall of the casing. The first electrode 202 and the second electrode 203 are respectively connected with the electric wire 204 and then connected with the power supply to form a conductive path, after the power is on, the heating body 201 generates heat to exchange heat with blood flowing in the shell, so that the temperature of the blood is regulated and controlled.

The flow paths of oxygen and blood in the membrane oxygenator of this embodiment are shown in FIGS. 3 and 4. Since the membrane oxygenator of this embodiment is provided with an approximately symmetrical configuration, blood can be injected from either of the first blood port 501 and the second blood port 601 and then discharged from the other of the first blood port 501 and the second blood port 601, and oxygen can be injected from either of the first gas port 502 and the second gas port 602 and then discharged from the other of the first gas port 502 and the second gas port 602. Wherein the flow direction of blood and oxygen in the oxygenation space may be the same or opposite, as shown in fig. 3, and the flow direction of blood and oxygen in the oxygenation space is the same, as shown in fig. 4, and the flow direction of blood and oxygen in the oxygenation space is opposite. The structural design reduces the production and assembly requirements, can save the cost, does not need to distinguish blood separation, blood discharge, air intake and exhaust when in use, is convenient for a user to operate, and can save the operation time. In addition, the first blood port 501 is arranged in the middle of the first end cap 500, the second blood port 601 is arranged in the middle of the second end cap 600, the first air port 502 is arranged on the side of the first end cap 500, the second air port 602 is arranged on the side of the second end cap 600, and the directions of the air ports and the blood ports are different, so that the blood port can be distinguished by a user, and misoperation can be reduced.

It is to be noted that the foregoing is only illustrative of the preferred embodiments of the present invention and the technical principles employed. It will be understood by those skilled in the art that the present invention is not limited to the particular embodiments described herein, but is capable of various obvious changes, rearrangements and substitutions as will now become apparent to those skilled in the art without departing from the scope of the invention. Therefore, although the present invention has been described in some detail by the above embodiments, the invention is not limited to the above embodiments, and may include other equivalent embodiments without departing from the spirit of the invention, and the scope of the invention is determined by the scope of the appended claims.

Claims

1. A miniaturized membrane oxygenator, comprising a housing, a heating element (200), an oxygenation membrane (400), a first air port (502), a second air port (602), a first blood port (501) and a second blood port (601);

the shell comprises a shell body (100), a first end cover (500) and a second end cover (600), the shell body (100) is provided with a first port (101), a second port (102) and a hollow cavity penetrating through the first port (101) and the second port (102), the first end cover (500) is connected with the first port (101), and the second end cover (600) is connected with the second port (102);

the oxygenation membrane (400) is arranged in the hollow cavity; the first air port (502) is arranged on the first end cover (500), the second air port (602) is arranged on the second end cover (600), and the first air port (502) is communicated with the second air port (602) through an oxygenated yarn of the oxygenation membrane (400); the first blood port (501) is arranged on the first end cover (500) or the shell (100) is close to the first end cover (500), the second blood port (601) is arranged on the second end cover (600) or the shell (100) is close to the second end cover (600), and the first blood port (501) and the second blood port (601) are both communicated with the hollow cavity;

the heating element (200) is arranged on the outer wall of the shell (100), and the heating element (200) is used for regulating and controlling the temperature of blood in the hollow cavity.

2. The miniaturized membrane oxygenator of claim 1, wherein the heating element (200) includes a heat generating body (201), a first electrode (202), and a second electrode (203), the heat generating body (201) is provided on an outer wall of the housing, and the first electrode (202) and the second electrode (203) are electrically connected to the heat generating body (201).

3. The miniaturized membrane oxygenator of claim 2, wherein the heat generating body (201) is a conductive coating coated on an outer wall of the housing (100) or a conductive wire wound on the outer wall of the housing (100);

the oxygen-containing film (400) is formed by interweaving a plurality of oxygen-containing filaments.

4. The miniaturized membrane oxygenator of claim 3 wherein the hollow chamber includes an oxygenation space (104), a first isolation space (105), and a second isolation space (106), the first isolation space (105) being proximate to the first port (101), the second isolation space (106) being proximate to the second port (102), the oxygenation space (104) being between the first isolation space (105) and the second isolation space (106);

the oxygenation membrane (400) is arranged in the oxygenation space (104), a first separator (700) is arranged in the first separation space (105), and a second separator (800) is arranged in the second separation space (106).

5. The miniaturized membrane oxygenator of claim 4,

the first air port (502) is arranged at the top of the first end cover (500) and is opposite to the first port (101), and the second air port (602) is arranged at the top of the second end cover (600) and is opposite to the second port (102); the first blood port (501) is arranged on the shell (100) and close to the first isolating piece (700), and the second blood port (601) is arranged on the shell (100) and close to the second isolating piece (800).

6. The miniaturized membrane oxygenator of claim 5 wherein a first buffer space (107) is provided between the oxygenation membrane (400) and the inner wall of the housing (100) near the first port (101), the first blood port (501) communicating with the first buffer space (107); a second buffer space (108) is arranged between the oxygenation membrane (400) and the inner wall of the shell (100) near the second port (102), and the second blood port (601) is communicated with the second buffer space (108).

7. The miniaturized membrane oxygenator of claim 4, wherein the first blood port (501) is disposed on top of the first end cap (500) opposite the first port (101), and the second blood port (601) is disposed on top of the second end cap (600) opposite the second port (102); the first air port (502) is arranged on the side surface of the first end cover (500), and the second air port (602) is arranged on the side surface of the second end cover (600).

8. The miniaturized membrane oxygenator of claim 7,

a dispersion member (300) is arranged in the hollow cavity, the dispersion member (300) comprises a first dispersion part located at the first port (101) and a second dispersion part located at the second port (102), the first dispersion part comprises a first flow guide groove (302) and a first through hole (303), the first flow guide groove (302) is opposite to the first blood port (501), the first through hole (303) is communicated with the first flow guide groove (302) and the oxygenation space (104), the second dispersion part comprises a second flow guide groove (306) and a second through hole (307), the second flow guide groove (306) is opposite to the second blood port (601), and the second through hole (307) is communicated with the second flow guide groove (306) and the oxygenation space (104).

9. The miniaturized membrane oxygenator of claim 1, wherein the first dispersion portion further includes a first flow conductor (304), the first flow conductor (304) protruding from a floor of the first flow channel (302) to a floor of the first flow channel (302); the second dispersion portion further includes a second flow conductor (308), the second flow conductor (308) protruding from a bottom of the second flow channel (306) to a mouth of the second flow channel (306).

10. The miniaturized membrane oxygenator of claim 9, wherein an end of the first flow conductor (304) facing the first blood port (501) is a curved structure; the end part of the second flow guiding body (308) facing the second blood port (601) is of a curved surface structure.