CN115624603B - Traditional Chinese medicine composition for treating migraine and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating migraine and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating migraine and a preparation method thereof, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 20 parts of glabrous greenbrier rhizome, 10 to 20 parts of south dodder seed, 10 to 20 parts of tall gastrodia tuber, 10 to 20 parts of thinleaf milkwort root-bark, 10 to 20 parts of prepared tuber fleeceflower root, 10 to 15 parts of dried rehmannia root, 10 to 15 parts of Chinese angelica, 10 to 15 parts of divaricate saposhnikovia root, 10 to 15 parts of danshen root, 10 to 15 parts of szechuan lovage rhizome, 10 to 20 parts of tangerine peel, 10 to 15 parts of immature bitter orange, 10 to 15 parts of grassleaf sweelflag rhizome, 10 to 15 parts of common burreed rhizome, 10 to 15 parts of dahurian angelica root, 5 to 10 parts of common fenugreek seed and 5 to 10 parts of turmeric root tuber. The prescription has the effects of nourishing liver and kidney, nourishing heart and tranquillizing, promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, nourishing and repairing cerebral nerves, has the characteristics of quick response and good curative effect, and has the effective rate of about 98 percent in clinical application.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine composition for treating migraine and a preparation method thereof.
Background
Migraine (migrine) is a clinically common chronic, recurrent primary headache with extensive clinical and genetic heterogeneity, manifested as episodic unilateral or/and bilateral pulsatile headache, often accompanied by symptoms such as nausea, vomiting, photophobia, aversion to sound, reluctant to exercise, etc. Currently, western medicine therapies generally employ vasoconstrictors, magnesium preparations, analgesics, anxiolytics, sedatives and other drugs: if the medicines such as tiapride, compound red sage root tablet, indomethacin and the like are taken, the pain symptoms can be changed temporarily, the migraine can not be treated fundamentally, the recurrence rate is high, and serious side effects can be produced when the medicines are taken for a long time. The traditional Chinese medicine for treating migraine has the characteristics of small toxic and side effects, reliable curative effect and the like, has been proved by a large number of clinical practices and experimental researches, and has been widely applied to the clinical treatment of migraine.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for treating migraine, which has quick response and good curative effect, and a preparation method thereof.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a traditional Chinese medicine composition for treating migraine is prepared from the following raw materials in parts by weight:
10 to 20 parts of glabrous greenbrier rhizome, 10 to 20 parts of south dodder seed, 10 to 20 parts of tall gastrodia tuber, 10 to 20 parts of thinleaf milkwort root-bark, 10 to 20 parts of prepared tuber fleeceflower root, 10 to 15 parts of dried rehmannia root, 10 to 15 parts of Chinese angelica, 10 to 15 parts of divaricate saposhnikovia root, 10 to 15 parts of danshen root, 10 to 15 parts of szechuan lovage rhizome, 10 to 20 parts of tangerine peel, 10 to 15 parts of immature bitter orange, 10 to 15 parts of grassleaf sweelflag rhizome, 10 to 15 parts of common burreed rhizome, 10 to 15 parts of dahurian angelica root, 5 to 10 parts of common fenugreek seed and 5 to 10 parts of turmeric root tuber.
Preferably, the preparation method comprises the following steps of:
10 parts of glabrous greenbrier rhizome, 10 parts of semen cuscutae, 10 parts of tall gastrodia tuber, 10 parts of polygala root, 10 parts of prepared tuber fleeceflower root, 10 parts of dried rehmannia root, 10 parts of Chinese angelica, 10 parts of divaricate saposhnikovia root, 10 parts of red sage root, 10 parts of szechuan lovage rhizome, 10 parts of dried orange peel, 10 parts of immature bitter orange, 10 parts of grassleaf sweelflag rhizome, 10 parts of common burreed rhizome, 10 parts of dahurian angelica root, 5 parts of common fenugreek seed and 5 parts of turmeric root-tuber.
Preferably, the preparation method comprises the following steps of:
20 parts of glabrous greenbrier rhizome, 20 parts of semen cuscutae, 20 parts of tall gastrodia tuber, 20 parts of polygala root, 20 parts of prepared tuber fleeceflower root, 15 parts of dried rehmannia root, 15 parts of Chinese angelica, 15 parts of divaricate saposhnikovia root, 15 parts of red sage root, 15 parts of szechuan lovage rhizome, 20 parts of dried orange peel, 15 parts of immature bitter orange, 15 parts of grassleaf sweelflag rhizome, 15 parts of common burreed rhizome, 15 parts of dahurian angelica root, 10 parts of common fenugreek seed and 10 parts of turmeric root-tuber.
Preferably, the preparation method comprises the following steps of:
15 parts of glabrous greenbrier rhizome, 15 parts of semen cuscutae, 15 parts of tall gastrodia tuber, 15 parts of polygala root, 15 parts of prepared tuber fleeceflower root, 12.5 parts of dried rehmannia root, 12.5 parts of Chinese angelica, 12.5 parts of divaricate saposhnikovia root, 12.5 parts of red sage root, 12.5 parts of szechuan lovage rhizome, 15 parts of dried orange peel, 12.5 parts of immature bitter orange, 12.5 parts of grassleaf sweetflag rhizome, 12.5 parts of common burreed rhizome, 12.5 parts of dahurian angelica root, 7.5 parts of fenugreek seed and 7.5 parts of turmeric root tuber.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating migraine, which comprises the following steps:
s1, weighing the components according to the weight portion;
s2, crushing the weighed glabrous greenbrier rhizome, the Chinese dodder seed, the tall gastrodia tuber, the thinleaf milkwort root-bark, the prepared fleeceflower root, the dried rehmannia root, the Chinese angelica, the divaricate saposhnikovia root, the red sage root, the szechuan lovage rhizome, the dried orange peel, the immature bitter orange, the grassleaf sweetflag rhizome, the common burreed rhizome, the dahurian angelica root, the fenugreek seed and the turmeric root-tuber into 100 meshes, adding 6 times of water, leaching for 6 hours under the gradient temperature change condition of room temperature to 100 ℃, and filtering to obtain water extract and dregs;
s3, mixing the residues with 40% ethanol according to the proportion of 1:10 Mixing the materials according to the ratio of (m/v), carrying out high-pressure homogenization treatment once by an ultrahigh-pressure homogenizer at a flow rate of 4-6L/h, regulating the temperature of the dreg liquid to 45-60 ℃, regulating the concentration of ethanol to 60%, carrying out high-pressure homogenization treatment once at a flow rate of 4-6L/h, regulating the temperature of the dreg liquid to 45-60 ℃, regulating the concentration of ethanol to 75%, carrying out high-pressure homogenization treatment once at a flow rate of 4-6L/h, recovering an alcohol solvent after the dreg liquid temperature is 45-60 ℃, and taking an alcohol extract;
s4, mixing the obtained water extract and the alcohol extract, concentrating and drying to obtain the extract.
As a further design of the scheme, in the step S2, water leaching is carried out at room temperature for 1h, water leaching is carried out at 50 ℃ for 2h, water leaching is carried out at 70 ℃ for 1h, and water leaching is carried out at 100 ℃ for 1h.
As a further design of the present embodiment, in the step S3, the pressure is adjusted to 150 to 200MPa during the instantaneous high-pressure treatment.
The invention has the following beneficial effects:
the formula has the effects of nourishing liver and kidney, nourishing heart and tranquillizing, promoting blood circulation and removing blood stasis, dredging collaterals and relieving pain, nourishing and repairing brain nerves, and can effectively treat migraine, tension headache with phlegm and blood stasis obstruction syndrome, wherein the syndrome is as follows: the pain is severe, or the pain is caused by attack and punching, or the pain is like cone thorn, or is associated with eyes and teeth, with dizziness and photophobia, chest distress and epigastric distention, nausea and vomiting, irritability and repeated attacks.
The medicine has the characteristics of quick response and good curative effect, and the effective rate of clinical application reaches about 98 percent.
The gradient temperature-variable water extraction and ethanol gradient concentration high-pressure homogeneous extraction mode are adopted, so that the full precipitation of the effective components loaded in the traditional Chinese medicine can be promoted, and the effective rate of the medicine is improved.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the present invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications could be made by those skilled in the art without departing from the inventive concept. These are all within the scope of the present invention.
Example 1
S1, weighing according to the weight portion: 10 parts of glabrous greenbrier rhizome, 10 parts of semen cuscutae, 10 parts of tall gastrodia tuber, 10 parts of polygala root, 10 parts of prepared tuber fleeceflower root, 10 parts of dried rehmannia root, 10 parts of Chinese angelica, 10 parts of divaricate saposhnikovia root, 10 parts of red sage root, 10 parts of szechuan lovage rhizome, 10 parts of dried orange peel, 10 parts of immature bitter orange, 10 parts of grassleaf sweelflag rhizome, 10 parts of common burreed rhizome, 10 parts of dahurian angelica root, 5 parts of common fenugreek seed and 5 parts of turmeric root-tuber;
s2, crushing the weighed glabrous greenbrier rhizome, the south dodder seed, the tall gastrodia tuber, the thinleaf milkwort root-bark, the prepared fleeceflower root, the dried rehmannia root, the Chinese angelica, the divaricate saposhnikovia root, the red sage root, the szechuan lovage rhizome, the dried orange peel, the immature bitter orange, the grassleaf sweetflag rhizome, the common burreed rhizome, the dahurian angelica root, the fenugreek seed and the turmeric root tuber into 100 meshes, adding 6 times of water, leaching for 1h at room temperature, leaching for 2h at 50 ℃, leaching for 1h at 70 ℃, leaching for 1h at 100 ℃, and filtering to obtain water extract and dregs;
s3, mixing the residues with 40% ethanol according to the proportion of 1:10 Mixing the materials according to the ratio of (m/v), placing the mixture in an ultrahigh pressure homogenizer, regulating the pressure to 175MPa, carrying out high-pressure homogenization treatment once at a flow rate of 5L/h, regulating the temperature of the residue liquid to 45 ℃, regulating the concentration of ethanol to 60%, carrying out high-pressure homogenization treatment once at a flow rate of 5L/h, regulating the temperature of the residue liquid to 55 ℃, regulating the concentration of ethanol to 75%, carrying out high-pressure homogenization treatment once at a flow rate of 5L/h, regulating the temperature of the residue liquid to 60 ℃, recovering an alcohol solvent after the treatment is finished, and taking an alcohol extract;
s4, mixing the obtained water extract and the alcohol extract, concentrating and drying to obtain the extract.
Example 2
S1, weighing according to the weight portion: 20 parts of glabrous greenbrier rhizome, 20 parts of semen cuscutae, 20 parts of tall gastrodia tuber, 20 parts of polygala root, 20 parts of prepared tuber fleeceflower root, 15 parts of dried rehmannia root, 15 parts of Chinese angelica, 15 parts of divaricate saposhnikovia root, 15 parts of red sage root, 15 parts of szechuan lovage rhizome, 20 parts of dried orange peel, 15 parts of immature bitter orange, 15 parts of grassleaf sweelflag rhizome, 15 parts of common burreed rhizome, 15 parts of dahurian angelica root, 10 parts of common fenugreek seed and 10 parts of turmeric root-tuber;
s2, crushing the weighed glabrous greenbrier rhizome, the south dodder seed, the tall gastrodia tuber, the thinleaf milkwort root-bark, the prepared fleeceflower root, the dried rehmannia root, the Chinese angelica, the divaricate saposhnikovia root, the red sage root, the szechuan lovage rhizome, the dried orange peel, the immature bitter orange, the grassleaf sweetflag rhizome, the common burreed rhizome, the dahurian angelica root, the fenugreek seed and the turmeric root tuber into 100 meshes, adding 6 times of water, leaching for 1h at room temperature, leaching for 2h at 50 ℃, leaching for 1h at 70 ℃, leaching for 1h at 100 ℃, and filtering to obtain water extract and dregs;
s3, mixing the residues with 40% ethanol according to the proportion of 1:10 Mixing the materials according to the ratio of (m/v), placing the mixture in an ultrahigh pressure homogenizer, regulating the pressure to 175MPa, carrying out high-pressure homogenization treatment once at a flow rate of 5L/h, regulating the temperature of the residue liquid to 45 ℃, regulating the concentration of ethanol to 60%, carrying out high-pressure homogenization treatment once at a flow rate of 5L/h, regulating the temperature of the residue liquid to 55 ℃, regulating the concentration of ethanol to 75%, carrying out high-pressure homogenization treatment once at a flow rate of 5L/h, regulating the temperature of the residue liquid to 60 ℃, recovering an alcohol solvent after the treatment is finished, and taking an alcohol extract;
s4, mixing the obtained water extract and the alcohol extract, concentrating and drying to obtain the extract.
Example 3
S1, weighing according to the weight portion: 15 parts of glabrous greenbrier rhizome, 15 parts of semen cuscutae, 15 parts of tall gastrodia tuber, 15 parts of polygala root, 15 parts of prepared tuber fleeceflower root, 12.5 parts of dried rehmannia root, 12.5 parts of Chinese angelica, 12.5 parts of divaricate saposhnikovia root, 12.5 parts of red sage root, 12.5 parts of szechuan lovage rhizome, 15 parts of dried orange peel, 12.5 parts of immature bitter orange, 12.5 parts of grassleaf sweetflag rhizome, 12.5 parts of common burreed rhizome, 12.5 parts of dahurian angelica root, 7.5 parts of fenugreek seed and 7.5 parts of turmeric root tuber;
s2, crushing the weighed glabrous greenbrier rhizome, the south dodder seed, the tall gastrodia tuber, the thinleaf milkwort root-bark, the prepared fleeceflower root, the dried rehmannia root, the Chinese angelica, the divaricate saposhnikovia root, the red sage root, the szechuan lovage rhizome, the dried orange peel, the immature bitter orange, the grassleaf sweetflag rhizome, the common burreed rhizome, the dahurian angelica root, the fenugreek seed and the turmeric root tuber into 100 meshes, adding 6 times of water, leaching for 1h at room temperature, leaching for 2h at 50 ℃, leaching for 1h at 70 ℃, leaching for 1h at 100 ℃, and filtering to obtain water extract and dregs;
s3, mixing the residues with 40% ethanol according to the proportion of 1:10 Mixing the materials according to the ratio of (m/v), placing the mixture in an ultrahigh pressure homogenizer, regulating the pressure to 175MPa, carrying out high-pressure homogenization treatment once at a flow rate of 5L/h, regulating the temperature of the residue liquid to 45 ℃, regulating the concentration of ethanol to 60%, carrying out high-pressure homogenization treatment once at a flow rate of 5L/h, regulating the temperature of the residue liquid to 55 ℃, regulating the concentration of ethanol to 75%, carrying out high-pressure homogenization treatment once at a flow rate of 5L/h, regulating the temperature of the residue liquid to 60 ℃, recovering an alcohol solvent after the treatment is finished, and taking an alcohol extract;
s4, mixing the obtained water extract and the alcohol extract, concentrating and drying to obtain the extract.
Test data
Test grouping: selecting 60 healthy male SD rats with the weight of 200-220 g, adaptively feeding for 7d under the conditions of indoor temperature of 22-25 ℃ and relative humidity of 40-60%, free intake of sufficient water and food and the like, weighing (the weight is between 250-310 g), and randomly dividing into 6 groups according to the weight: blank (blank), model, example 1, example 2, example 3, aspirin positive control.
The test method comprises the following steps: the test group was continuously administered for 15 days at a dose of 30mL/60kg body weight, and the blank group and the model group were fed with equal volumes of distilled water via gavage. After the last administration, the test group and the model group duplicate migraine animal models by injecting nitroglycerin injection subcutaneously at 10mg/kg, and the blank group is injected with an equivalent amount of physiological saline. 3-5 min after molding, the phenomena of double ears reddening, back paw face beating, frequent front limb deflection, cage climbing and the like occur in the rat, the period lasts for about 3 hours, and the phenomenon of curling and lying occurs when the activity is reduced, so that the model is successfully copied. After the successful molding, 4 hours, 10% chloral hydrate was anesthetized, 3ml and 2ml of jugular blood of the rat were respectively taken and injected into a centrifuge tube containing 30. Mu.l of 10% EDTA-Na2 and 10. Mu.l of aprotinin (containing 100U/ml), and the mixture was gently shaken to mix the mixture, and the mixture was centrifuged at 3000rpm at 4℃for 10 minutes to separate plasma. Storing in a refrigerator with ultralow temperature of-80 ℃ for standby. Before measurement, putting the sample into ice water for re-melting, after mixing uniformly, centrifuging at 4 ℃ for 5min at 3000rpm again, taking supernatant, and respectively measuring the contents of CGRP and ET in the blood plasma according to the specification of the kit, wherein the results are shown in Table 1:
| group of | GCRP(pg/ml) | ET(pg/ml) |
| Blank group | 109.54±24.85* | 79.46±13.98** |
| Model group | 140.34±20.38 | 115.63±15.32 |
| Aspirin group | 80.65±16.97* | 75.23±1.06** |
| Example 1 test group | 92.35±21.69* | 71.17±9.36** |
| Example 2 test group | 83.35±21.87* | 69.89±8.35** |
| Example 3 test group | 88.35±22.57* | 70.39±9.45** |
Remarks: p <0.05, p <0.01 compared to model group.
Taking migraine diagnosis criteria formulated by the International headache Association (IHS) as diagnosis criteria, collecting 50 patients with migraine, wherein 35 patients with migraine and 15 patients without migraine are treated by taking the traditional Chinese medicine obtained in example 2, 30mg/60kg body weight, one treatment course is 7 days, and after 4 treatment courses, the number of days and times of headache attacks are counted and halved, and the result is that: the number of headache attacks and the halving rate of the number of attacks reach 98.43 percent, and no adverse event occurs.
The foregoing describes specific embodiments of the present invention. It is to be understood that the invention is not limited to the particular embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the claims without affecting the spirit of the invention.
Claims (7)
1. A traditional Chinese medicine composition for treating migraine is characterized in that: the material is prepared from the following raw materials in parts by weight:
10 to 20 parts of glabrous greenbrier rhizome, 10 to 20 parts of south dodder seed, 10 to 20 parts of tall gastrodia tuber, 10 to 20 parts of thinleaf milkwort root-bark, 10 to 20 parts of prepared tuber fleeceflower root, 10 to 15 parts of dried rehmannia root, 10 to 15 parts of Chinese angelica, 10 to 15 parts of divaricate saposhnikovia root, 10 to 15 parts of danshen root, 10 to 15 parts of szechuan lovage rhizome, 10 to 20 parts of tangerine peel, 10 to 15 parts of immature bitter orange, 10 to 15 parts of grassleaf sweelflag rhizome, 10 to 15 parts of common burreed rhizome, 10 to 15 parts of dahurian angelica root, 5 to 10 parts of common fenugreek seed and 5 to 10 parts of turmeric root tuber.
2. The traditional Chinese medicine composition for treating migraine according to claim 1, wherein: the material is prepared from the following raw materials in parts by weight:
10 parts of glabrous greenbrier rhizome, 10 parts of semen cuscutae, 10 parts of tall gastrodia tuber, 10 parts of polygala root, 10 parts of prepared tuber fleeceflower root, 10 parts of dried rehmannia root, 10 parts of Chinese angelica, 10 parts of divaricate saposhnikovia root, 10 parts of red sage root, 10 parts of szechuan lovage rhizome, 10 parts of dried orange peel, 10 parts of immature bitter orange, 10 parts of grassleaf sweelflag rhizome, 10 parts of common burreed rhizome, 10 parts of dahurian angelica root, 5 parts of common fenugreek seed and 5 parts of turmeric root-tuber.
3. The traditional Chinese medicine composition for treating migraine according to claim 1, wherein: the material is prepared from the following raw materials in parts by weight:
20 parts of glabrous greenbrier rhizome, 20 parts of semen cuscutae, 20 parts of tall gastrodia tuber, 20 parts of polygala root, 20 parts of prepared tuber fleeceflower root, 15 parts of dried rehmannia root, 15 parts of Chinese angelica, 15 parts of divaricate saposhnikovia root, 15 parts of red sage root, 15 parts of szechuan lovage rhizome, 20 parts of dried orange peel, 15 parts of immature bitter orange, 15 parts of grassleaf sweelflag rhizome, 15 parts of common burreed rhizome, 15 parts of dahurian angelica root, 10 parts of common fenugreek seed and 10 parts of turmeric root-tuber.
4. The traditional Chinese medicine composition for treating migraine according to claim 1, wherein: the material is prepared from the following raw materials in parts by weight:
15 parts of glabrous greenbrier rhizome, 15 parts of semen cuscutae, 15 parts of tall gastrodia tuber, 15 parts of polygala root, 15 parts of prepared tuber fleeceflower root, 12.5 parts of dried rehmannia root, 12.5 parts of Chinese angelica, 12.5 parts of divaricate saposhnikovia root, 12.5 parts of red sage root, 12.5 parts of szechuan lovage rhizome, 15 parts of dried orange peel, 12.5 parts of immature bitter orange, 12.5 parts of grassleaf sweetflag rhizome, 12.5 parts of common burreed rhizome, 12.5 parts of dahurian angelica root, 7.5 parts of fenugreek seed and 7.5 parts of turmeric root tuber.
5. The method for preparing a traditional Chinese medicine composition for treating migraine according to any one of claims 1 to 4, which is characterized in that: the method comprises the following steps:
s1, weighing the components according to the weight portion;
s2, crushing the weighed glabrous greenbrier rhizome, the Chinese dodder seed, the tall gastrodia tuber, the thinleaf milkwort root-bark, the prepared fleeceflower root, the dried rehmannia root, the Chinese angelica, the divaricate saposhnikovia root, the red sage root, the szechuan lovage rhizome, the dried orange peel, the immature bitter orange, the grassleaf sweetflag rhizome, the common burreed rhizome, the dahurian angelica root, the fenugreek seed and the turmeric root-tuber into 100 meshes, adding 6 times of water, leaching for 6 hours under the gradient temperature change condition of room temperature to 100 ℃, and filtering to obtain water extract and dregs;
s3, mixing the residues with 40% ethanol according to the proportion of 1:10 Mixing the materials according to the ratio of (m/v), carrying out high-pressure homogenization treatment once by an ultrahigh-pressure homogenizer at a flow rate of 4-6L/h, regulating the temperature of the dreg liquid to 45-60 ℃, regulating the concentration of ethanol to 60%, carrying out high-pressure homogenization treatment once at a flow rate of 4-6L/h, regulating the temperature of the dreg liquid to 45-60 ℃, regulating the concentration of ethanol to 75%, carrying out high-pressure homogenization treatment once at a flow rate of 4-6L/h, recovering an alcohol solvent after the dreg liquid temperature is 45-60 ℃, and taking an alcohol extract;
s4, mixing the obtained water extract and the alcohol extract, concentrating and drying to obtain the extract.
6. The method according to claim 5, wherein in the step S2, the water is extracted for 1h at room temperature, 2h at 50 ℃, 1h at 70 ℃ and 1h at 100 ℃.
7. The method according to claim 5, wherein in the step S3, the pressure is adjusted to 150 to 200MPa during the instantaneous high-pressure treatment.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19958427A1 (en) * | 1998-12-03 | 2000-06-21 | Sichuan Taiji Pharmaceutical C | Drug for curing migraine and the preparation method |
| CN102614430A (en) * | 2012-03-27 | 2012-08-01 | 安徽华佗国药股份有限公司 | Medicine for treating headache disease and preparation method of medicine |
| CN103239691A (en) * | 2013-05-30 | 2013-08-14 | 通化金马药业集团股份有限公司 | Application of medicine composition in preparation of medicaments for treating headache |
| CN103550496A (en) * | 2013-11-14 | 2014-02-05 | 高晓燕 | Traditional Chinese medicine for treating migraine |
| CN104547628A (en) * | 2013-10-16 | 2015-04-29 | 栾晓明 | Traditional Chinese medicine for treating migraine |
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| KR102123972B1 (en) * | 2012-12-21 | 2020-06-18 | 타슬리 파마슈티컬 그룹 컴퍼니 리미티드 | Pharmaceutical composition for treating headache, and preparation method thereof |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19958427A1 (en) * | 1998-12-03 | 2000-06-21 | Sichuan Taiji Pharmaceutical C | Drug for curing migraine and the preparation method |
| CN102614430A (en) * | 2012-03-27 | 2012-08-01 | 安徽华佗国药股份有限公司 | Medicine for treating headache disease and preparation method of medicine |
| CN103239691A (en) * | 2013-05-30 | 2013-08-14 | 通化金马药业集团股份有限公司 | Application of medicine composition in preparation of medicaments for treating headache |
| CN104547628A (en) * | 2013-10-16 | 2015-04-29 | 栾晓明 | Traditional Chinese medicine for treating migraine |
| CN103550496A (en) * | 2013-11-14 | 2014-02-05 | 高晓燕 | Traditional Chinese medicine for treating migraine |
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