CN115569083A - High-water-content antibacterial sanitary wet tissue and preparation method thereof - Google Patents
High-water-content antibacterial sanitary wet tissue and preparation method thereof Download PDFInfo
- Publication number
- CN115569083A CN115569083A CN202211290401.6A CN202211290401A CN115569083A CN 115569083 A CN115569083 A CN 115569083A CN 202211290401 A CN202211290401 A CN 202211290401A CN 115569083 A CN115569083 A CN 115569083A
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- CN
- China
- Prior art keywords
- wet tissue
- sodium hyaluronate
- antibacterial
- water
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title description 24
- 239000000835 fiber Substances 0.000 claims abstract description 57
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 40
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 31
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 31
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 31
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000007788 liquid Substances 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 15
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 6
- 239000004311 natamycin Substances 0.000 claims description 29
- NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 claims description 29
- 229960003255 natamycin Drugs 0.000 claims description 29
- 235000010298 natamycin Nutrition 0.000 claims description 29
- 239000000243 solution Substances 0.000 claims description 27
- 238000001035 drying Methods 0.000 claims description 17
- 150000001875 compounds Chemical class 0.000 claims description 15
- 238000002791 soaking Methods 0.000 claims description 15
- 238000000034 method Methods 0.000 claims description 14
- -1 quaternary ammonium salt compound Chemical class 0.000 claims description 13
- 230000001954 sterilising effect Effects 0.000 claims description 13
- 239000003054 catalyst Substances 0.000 claims description 12
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 12
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 12
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 11
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 claims description 11
- 238000001914 filtration Methods 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims description 9
- 229920000858 Cyclodextrin Polymers 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 8
- GKQHIYSTBXDYNQ-UHFFFAOYSA-M 1-dodecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+]1=CC=CC=C1 GKQHIYSTBXDYNQ-UHFFFAOYSA-M 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 7
- 239000003513 alkali Substances 0.000 claims description 6
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 6
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000001116 FEMA 4028 Substances 0.000 claims description 4
- 229960004853 betadex Drugs 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 239000002253 acid Substances 0.000 claims description 3
- 230000003115 biocidal effect Effects 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000013329 compounding Methods 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- 230000007935 neutral effect Effects 0.000 claims description 3
- 238000010992 reflux Methods 0.000 claims description 3
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims description 3
- YZOUYRAONFXZSI-SBHWVFSVSA-N (1S,3R,5R,6R,8R,10R,11R,13R,15R,16R,18R,20R,21R,23R,25R,26R,28R,30R,31S,33R,35R,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-37,39,40,41,42,43,44,45,46,47,48,49-dodecamethoxy-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,38-diol Chemical compound O([C@@H]([C@H]([C@@H]1OC)OC)O[C@H]2[C@@H](O)[C@@H]([C@@H](O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3O)OC)O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3OC)OC)O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3OC)OC)O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3OC)OC)O3)O[C@@H]2CO)OC)[C@H](CO)[C@H]1O[C@@H]1[C@@H](OC)[C@H](OC)[C@H]3[C@@H](CO)O1 YZOUYRAONFXZSI-SBHWVFSVSA-N 0.000 claims description 2
- NMDQPQZRIKCRDU-UHFFFAOYSA-N 3-chloro-2-dodecylpyridine Chemical compound CCCCCCCCCCCCC1=NC=CC=C1Cl NMDQPQZRIKCRDU-UHFFFAOYSA-N 0.000 claims description 2
- 239000002841 Lewis acid Substances 0.000 claims description 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 2
- 238000009960 carding Methods 0.000 claims description 2
- 238000007598 dipping method Methods 0.000 claims description 2
- 150000007517 lewis acids Chemical class 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- 230000003014 reinforcing effect Effects 0.000 claims description 2
- 230000000845 anti-microbial effect Effects 0.000 claims 5
- 239000003242 anti bacterial agent Substances 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- 239000008213 purified water Substances 0.000 description 8
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 108010039918 Polylysine Proteins 0.000 description 4
- 229920000297 Rayon Polymers 0.000 description 4
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 239000000645 desinfectant Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000011056 performance test Methods 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 239000003906 humectant Substances 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 239000000022 bacteriostatic agent Substances 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000002657 fibrous material Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 229940049920 malate Drugs 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229920002972 Acrylic fiber Polymers 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000011964 heteropoly acid Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 229940071575 silver citrate Drugs 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- QUTYHQJYVDNJJA-UHFFFAOYSA-K trisilver;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Ag+].[Ag+].[Ag+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QUTYHQJYVDNJJA-UHFFFAOYSA-K 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/738—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/85—Polyesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to an antibacterial sanitary wet tissue with high water content, wherein a wet tissue solution comprises the following raw materials: the carrier is non-woven fabric comprising an upper layer, a middle layer and a lower layer, and the upper layer and the lower layer are made of the same fiber raw material and are made of sodium hyaluronate grafted PET fibers. The antibacterial agent with quick-acting bacteriostasis and slow-acting bacteriostasis is matched as the antibacterial component of the wet tissue liquid, and the wet tissue liquid is soaked or sprayed on a double-layer structure carrier prepared by grafting the sodium hyaluronate with the PET fiber on the upper layer, so that the prepared wet tissue has good water retention performance. It has also been found that the sodium hyaluronate grafted PET fibers have the synergistic effect of colloidal silver in improving the antibacterial and antibacterial stability of wet wipes, so that the wet wipes can maintain good stability when the total amount of all components except water in the wet wipes is not more than 0.1 wt%.
Description
Technical Field
The invention belongs to the technical field of wet tissues, and particularly relates to an antibacterial sanitary wet tissue with high water content and a preparation method thereof.
Background
The wet tissue is a sanitary product with the functions of cleaning, nursing, moisturizing and the like. With the improvement of the living standard of people, the requirements of people on cleanness and health are higher, and particularly since the outbreak of new coronary pneumonia, the sanitary wet tissue becomes an important member in the life of people as a convenient disinfection product.
The sanitary wet tissue is a product which takes non-woven fabrics, fabrics or dust-free paper as a carrier and takes water, humectant, bactericide, preservative and the like as auxiliary materials and has cleaning and sterilizing effects on the surface of a human body or an object, and the requirement on antibacterial performance is high, for example, patent CN202110387027.0 discloses a compound sterilizing disinfectant wet tissue and a preparation method thereof, wherein the disinfectant wet tissue is mainly prepared from compound non-woven fabrics, and the surface of the non-woven fabrics is soaked with disinfectant; the disinfectant comprises the following raw materials: 55-65 parts of purified water, 3-5 parts of ethanol, 4-7 parts of an active agent, 3-4 parts of a humectant, 2-4 parts of an aromatic, 1-3 parts of an aloe extract and 0.4-0.6 part of citric acid by weight; the active agent comprises, by weight, 1-2 parts of benzalkonium chloride, 2-3 parts of phosphomolybdic tungstic heteropoly acid and 1-2 parts of polyhexamethylene guanidine; the humectant comprises 1-1.5 parts of glycerol and 2-2.5 parts of butanediol by weight; the aromatic comprises, by weight, 1-2 parts of peppermint oil and 1-2 parts of essence. The wet tissue has good sterilization and disinfection effects by using the wet tissue liquid containing a large amount of antibacterial components, but the quaternary ammonium salt antibacterial agent has high content and high irritation. Patent CN202210353059.3 discloses a biological sterilization antiviral composition, a sanitary wet tissue and application thereof, wherein epsilon-polylysine is 0.01-0.1%, natamycin is 0-0.05%, citric acid radicals are used for adjusting pH, and the rest components are reverse osmosis pure water. The wet tissue liquid adopts epsilon-polylysine and natamycin as antibacterial components, has excellent antibacterial property, no stimulation to human bodies, environmental protection and no pollution, but has poor antibacterial stability because the epsilon-polylysine has degradability in water, the antibacterial effect is best when the molecular weight of the epsilon-polylysine is 3600 mu-4300 mu, and the antibacterial activity is lost when the molecular weight is lower than 1300 mu, so the wet tissue cannot be placed for a long time, otherwise the antibacterial property is attenuated, and the antibacterial effect is reduced.
Therefore, the development of the sanitary wet tissue with the antibacterial performance and less antibacterial agent consumption has important significance for further popularizing the application of the sanitary wet tissue in the fields of civilian use, catering, medical treatment and the like.
Disclosure of Invention
In order to solve the technical problems, the invention provides the high-water-content antibacterial sanitary wet tissue and the preparation method thereof.
In order to realize the purpose, the following technical scheme is adopted:
the high-water-content antibacterial sanitary wet tissue comprises a carrier and wet tissue liquid, wherein the wet tissue liquid comprises the following raw materials: the carrier is non-woven fabric comprising an upper layer, a middle layer and a lower layer, the fiber raw materials of the upper layer and the lower layer are the same, and the carrier is sodium hyaluronate grafted PET fibers.
Further, the insoluble silver salt such as silver citrate, silver malate, colloidal silver, preferably colloidal silver, and the wet tissue comprises the following raw materials in parts by weight: 0.01-0.08 part of quaternary ammonium salt compound, 0.01-0.08 part of colloidal silver, 0.01-0.08 part of natamycin inclusion compound and water to make up 100 parts, wherein the grafting ratio of the sodium hyaluronate grafted PET fiber is 3-7.5wt%.
Further, the inventors of the present invention unexpectedly found that, by properly selecting the combination of the antibacterial and bacteriostatic agents, the total usage amount of the antibacterial and bacteriostatic agent is not higher than 0.1wt% relative to 100 parts by weight of the wet towel liquid, and the bactericidal rate of more than 90% can still be achieved. The wet tissue liquid comprises the following raw materials in parts by weight: 0.03-0.06 part of quaternary ammonium salt compound, 0.01-0.05 part of colloidal silver and 0.01-0.05 part of natamycin clathrate compound, wherein the quaternary ammonium salt compound comprises one or more of benzalkonium chloride, cetylpyridinium chloride and dodecyl pyridinium chloride, and more preferably, the quaternary ammonium salt compound simultaneously comprises benzalkonium chloride, cetylpyridinium chloride and dodecyl pyridinium chloride; the total weight of the quaternary ammonium salt compound, the colloidal silver and the natamycin inclusion compound is 0.05 to 0.1 part, and the water is complemented to 100 parts.
The colloidal silver has low solubility in water, and the reaction of ionizing and visible light decomposing into silver is slow, so that the sterilizing effect of the sanitary wet tissue is safer, more slowly released and more durable.
The colloidal silver is a commercially available product.
The weight average molecular weight of the sodium hyaluronate is less than 10000.
The sodium hyaluronate grafted PET fiber is prepared by a method comprising the following steps:
s1, soaking PET fibers in alkali liquor, heating to a reflux state, stirring at a constant temperature for reaction, adding acid liquor to neutralize to be neutral after the reaction is finished, and filtering, washing and drying for later use;
s2, soaking the fiber obtained in the step S1 in an aqueous solution of a catalyst, filtering and drying; soaking the dried fiber in sodium hyaluronate water solution, filtering and drying; and washing and drying to obtain the grafted modified PET fiber.
The titer of the PET fiber in the step S1 is 1-2dtex, and the length is 30-40mm; the type of the alkali liquor is not particularly limited, and the alkali liquor is commonly used in the field, and includes but is not limited to sodium hydroxide solution and potassium hydroxide solution, the concentration of the alkali liquor is 10-15wt%, and the reaction time is 0.5-1h; the acid solution is not particularly limited, and is commonly used in the art, and includes but is not limited to one or a combination of two or more of hydrochloric acid solution, acetic acid solution and sulfuric acid solution; the washing is carried out for 1 to 5 times by using deionized water;
the catalyst in the step S2 is Lewis acid selected from FeCl 3 ·6H 2 O、AlCl 3 ·6H 2 O、SnCl 4 ·5H 2 O、ZnCl 2 One or a combination of two or more of the above, the concentration of the catalyst in the aqueous solution of the catalyst is 3-7wt%, the time for soaking the catalyst solution is 5-15min, the drying temperature is 50-80 ℃, and the time is 1-3h; the concentration of the sodium hyaluronate solution is 6-15wt%, the time for soaking in the sodium hyaluronate solution is 10-15min, the drying temperature after soaking is 100-150 ℃, and the time is 20-60min; the washing is to wash and remove the catalyst and the unreacted polyhydroxy polymer remained on the surface of the fiber by deionized water, the washing times are 1 to 5 times, the final drying temperature is 50 to 80 ℃, and the time is 6 to 12 hours.
Step S1 is that PET fiber is hydrolyzed in alkaline water solution to generate-COOH on the surface of the fiber, and step S2 is that-COOH on the surface of the fiber and-OH on sodium hyaluronate are subjected to esterification reaction to generate the sodium hyaluronate grafted PET fiber.
The natamycin inclusion compound adopts an inclusion agent which is a beta-cyclodextrin compound and is selected from one or the combination of two or more of hydroxypropyl-beta-cyclodextrin, methyl-beta-cyclodextrin and maltosyl-beta-cyclodextrin.
Preferably, the inclusion agent of the natamycin inclusion compound is hydroxypropyl-beta-cyclodextrin.
Natamycin is a polyene macrolide antifungal substance, and has high inhibitory capacity on various molds and yeasts. The natamycin is difficult to be absorbed by the digestive tracts of people and livestock, and has no harmful effects such as carcinogenesis, teratogenesis, sensitization and the like on the people and the livestock, but the bioavailability of the natamycin is low due to the extremely low and unstable water solubility of the natamycin, and the cyclodextrin has a special cavity and can be used for clathrating the natamycin, so that the water solubility of the natamycin is obviously improved. The technology of including natamycin by cyclodextrin for solubilization is well established, the preparation method of the natamycin inclusion compound is not limited in particular, and the natamycin inclusion compound can be prepared by referring to the preparation method of natamycin-hydroxypropyl-beta-cyclodextrin inclusion compound disclosed in patent CN 201210252599.9.
The quaternary ammonium salt compound comprises one or the combination of two or more of dodecyl pyridine chloride, benzalkonium chloride and cetylpyridinium chloride. More preferably, both benzalkonium chloride, cetylpyridinium chloride and dodecyl pyridinium chloride are included.
The fiber raw material of the middle layer is selected from one or the combination of two or more of PET fiber, viscose fiber, PA6 fiber and acrylic fiber.
The square gram weight of the upper layer and the lower layer of the carrier is 10-30, the square gram weight of the middle layer is 15-30, and the square gram weight of the carrier is 40-90.
The invention also provides a preparation method of the high-water-content antibacterial sanitary wet tissue, which comprises the following steps:
respectively opening, carding, forming a web, compounding, prewetting, compacting, spunlacing, reinforcing, drying, curling, sterilizing and slitting three layers of fiber raw materials to prepare a carrier; and (3) attaching the wet tissue liquid on a carrier through a dipping or spraying process, and packaging to obtain the sanitary wet tissue with the water content of the solution being more than 99.9%.
The package is formed by folding and packaging 1-100 wet tissues into a packaging bag or a packaging box.
Compared with the prior art, the invention has the beneficial effects that:
according to the invention, the antibacterial agent with quick-acting antibacterial activity and slow-acting antibacterial activity is matched as an antibacterial component of the wet tissue liquid, and the wet tissue prepared by spraying or soaking the antibacterial component on a three-layer structure carrier with the upper layer and the lower layer prepared by grafting the sodium hyaluronate with the PET fibers has good antibacterial effect and water retention performance.
The inventor also finds that the sodium hyaluronate grafted PET fibers have the effect of improving the antibacterial property and the antibacterial stability of the wet tissue by cooperating with the colloidal silver, so that the wet tissue can still keep good antibacterial property and antibacterial stability and cannot go moldy and go bad when the total amount of antibacterial components in a wet tissue liquid is not higher than 0.1wt%, the using amount of the antibacterial components is reduced, the stimulation of chemical raw materials to skin is reduced, the cost is also reduced, the safety of the wet tissue is improved, and the pollution to the environment is reduced.
Detailed Description
The present invention will be further described with reference to the following examples, but the present invention is not limited to the descriptions in the following. Unless otherwise specified, "parts" in the examples of the present invention are parts by weight. All reagents used are commercially available in the art.
Colloidal silver was purchased from Shanghai Dry chemical Co., ltd and had an average particle diameter of 50nm.
Sodium hyaluronate was purchased from Shanghai Shi Fan Biotech Co., ltd and had a weight average molecular weight of 8000Da.
The PET fiber is purchased from China petrochemical chemical fiber Limited, and has the fineness of 1.56dtex and the length of 38mm.
The viscose fiber is purchased from Dada chemical fiber company of Sanyou group in Tang mountain, and has fineness of 1.67dtex and length of 38mm.
Hydroxypropyl-beta-cyclodextrin was obtained from Zhiyuan Biotech, inc., shandong, having a number average molecular weight of 1548.
Preparation of Natamycin clathrate
Preparation example a1
The method comprises the following steps: dissolving 0.1mol of natamycin in 120g of potassium hydroxide solution with the concentration of 0.15 mol/L;
step two: adding 0.55mol of hydroxypropyl-beta-cyclodextrin into the mixed solution obtained in the step one, and carrying out ultrasonic inclusion reaction with natamycin for 40min at the temperature of 35 ℃, wherein the ultrasonic frequency is 75KHz, and the ultrasonic power is 30W/cm 2 ；
Step three: and (3) dropwise adding a hydrochloric acid solution with the concentration of 1mol/L into the reaction system in the second step for neutralization to neutrality, filtering by using a 0.45-micron microfilm, precooling the filtrate in a refrigerator at-20 ℃ for overnight, freeze-drying in a freeze-dryer at-44 ℃ under 1.3Pa for 24h the next day, taking out to obtain natamycin-hydroxypropyl-beta-cyclodextrin inclusion powder, and storing at the shading temperature of-20 ℃.
Preparation of sodium hyaluronate grafted PET fiber
Preparation b1
S1, soaking PET fibers in a sodium hydroxide solution with the concentration of 15wt%, heating to a reflux state, stirring at a constant temperature to react for 30min, dropwise adding 15wt% of dilute hydrochloric acid to neutralize to be neutral after the reaction is finished, filtering, washing with deionized water for 3 times, and drying at 60 ℃ for 6h to constant weight for later use;
s2, soaking the fibers obtained in the step 1) in AlCl serving as a catalyst 3 ·6H 2 Concentration of OIs prepared by dissolving 7wt% water solution in water for 10min, filtering, and oven drying at 60 deg.C for 3 hr; soaking the dried fiber in 15wt% sodium hyaluronate water solution for 15min, filtering, and drying at 150 deg.C for 60min; washing with deionized water for 3 times, and drying at 60 ℃ for 12h to obtain the sodium hyaluronate grafted PET fiber.
Preparation example b2
The same as in preparation example b1 was repeated, except that the concentration of the aqueous solution of sodium hyaluronate in step S2 was 10% by weight.
Preparation of high water content antibiotic sanitary wet tissue
Example 1
Adding 0.03 part of benzalkonium chloride, 0.01 part of cetylpyridinium chloride, 0.02 part of colloidal silver and 0.04 part of the natamycin inclusion compound prepared in preparation example a1 into 99.9 parts of purified water, and adding the purified water into the purified water one by one to stir and disperse for 30min to obtain wet tissue liquid;
the sodium hyaluronate grafted PET fiber prepared in preparation example b1 is loosened and crossly laid to form a carded web, and the square gram weight of the web is 15;
opening viscose fibers, and crossly laying to form a carded web, wherein the square gram weight of the web is 20;
compounding a sodium hyaluronate grafted PET fiber net, a viscose fiber net and a sodium hyaluronate grafted PET fiber net from top to bottom, prewetting and compacting the composite net by a prewetting device, carrying out four-pass front and back spunlace reinforcement in a spunlace machine, wherein the spunlace pressure is 75bar, 110bar and 75bar respectively, so that the upper layer fiber net, the middle layer fiber net and the lower layer fiber net are mutually entangled and compounded into a whole, drying at 120 ℃ to constant weight, naturally cooling to room temperature, curling, carrying out ultraviolet sterilization, and cutting into 130mm × 170mm to obtain a spunlace non-woven carrier;
spraying the wet towel solution onto the prepared carrier, folding 80 pieces of the carrier, sealing, and packaging in PE packaging bag.
Example 2
The procedure was as in example 1 except that cetylpyridinium chloride was replaced with dodecylpyridinium chloride.
Example 3
The process was the same as in example 1 except that silver malate was bis-silver.
Example 4
The same as example 1 except that the fiber material of the sodium hyaluronate-grafted PET fiber web was prepared as in preparation example b 2.
Example 5
The rest is the same as the example 1, except that the amount of the colloidal silver in the wet tissue solution is 0.01 part, and the purified water is added to make up 100 parts.
Example 6
The process was the same as in example 1 except that the wet wipe solution was 0.01 parts colloidal silver and 0.02 parts cetylpyridinium chloride.
Example 7
The process is the same as in example 1 except that the wet tissue solution contains benzalkonium chloride 0.01 parts and cetylpyridinium chloride 0.03 parts.
Example 8
The procedure of example 1 was repeated, except that the wet wipe was prepared by adding 99.9 parts of purified water to 0.02 part of benzalkonium chloride, 0.02 part of cetylpyridinium chloride, 0.02 part of dodecylpyridinium chloride, 0.02 part of colloidal silver, and 0.02 part of the natamycin clathrate prepared in preparation a1, and stirring and dispersing the resulting mixture.
Example 9
The process was the same as in example 1 except that the wet wipe solution contained 0.01 part of natamycin clathrate and 99.93 parts of purified water.
Comparative example 1
The rest was the same as example 1 except that the fiber material of the upper and lower layers of the support was PET.
Comparative example 2
The procedure of example 1 was repeated, except that the wet tissue solution was prepared by adding 0.02 part of benzalkonium chloride, 0.03 part of cetylpyridinium chloride, 0.02 part of dodecylpyridinium chloride, and 0.03 part of the natamycin clathrate prepared in preparation example a1 to 99.9 parts of purified water and mixing them by sonication.
Comparative example 3
The same as in example 1 except for 0.06 parts of colloidal silver and 0 parts of the natamycin clathrate prepared in preparation a 1.
The graft ratio was calculated with reference to the following formula for the sodium hyaluronate-grafted PET fibers prepared in preparation examples b1 and b 2:
grafting ratio: g = (m) 1 -m 0 )/m 0 ×100％
In the formula, m 1 Mass of sodium hyaluronate grafted PET fibers, m 0 Is the mass of PET fibers.
TABLE 1
| Item | Percent by weight of grafting |
| Preparation b1 | 6.0 |
| Preparation example b2 | 4.1 |
The high water content antibiotic sanitary wet tissues prepared in examples 1 to 9 and comparative examples 1 to 3 were subjected to the following performance tests, and the results are shown in Table 2:
average overflow volume: the multiple wet wipes prepared in examples 1 to 9 or comparative examples 1 to 3 were allowed to stand for one week, then the uppermost 20 wet wipes and the lowermost 20 wet wipes in the stack were taken out and weighed, the amount of overflow of each wet wipe pack was calculated as follows, 3 wet wipes were randomly taken from each batch of examples or comparative examples, the average of the calculated amounts of overflow was weighed as the average amount of overflow of the batch,
B i ＝(W i -W i0 )/W i0 ×100％
in the formula, B i The overflow amount of the ith wet tissue pack is i =1, 2 and 3; wi is the weight of 20 pieces of wet tissues at the lowest part of the ith wet tissue pack, g; w i0 Is the ith wet tissue packageG, the weight of the upper 20 wet tissues.
Sterilization property: the sterilization performance test in appendix C is carried out according to the hygienic standard GB/T15979-2002 of disposable sanitary products, the sterilization performance test is 20min, and the sterilization rate is more than 90 percent, so that the product has the sterilization effect.
And (3) antibacterial stability: the original packaged wet tissue prepared by the method is placed in a constant temperature box at 37 ℃ for 3 months, the relative humidity is kept at 75%, and a C3.2 sterilization performance test is carried out.
TABLE 2
The table 2 shows that the wet tissue prepared by the invention has good disinfection effect and water retention performance, and the inventor also finds that the sodium hyaluronate grafted PET fiber has the function of improving the antibacterial property and the antibacterial stability of the wet tissue by cooperating with the insoluble silver salt, so that the wet tissue can still keep good antibacterial property when the total antibacterial component content in the wet tissue liquid is not higher than 0.1wt%, and the wet tissue can not go moldy and go bad after being normally placed for 2 years, thereby not only reducing the use amount of the antibacterial component, reducing the stimulation of chemical raw materials to skin, but also reducing the cost, increasing the safety of the wet tissue and reducing the pollution to the environment.
The above detailed description is directed to one of the possible embodiments of the present invention, which is not intended to limit the scope of the invention, but rather the scope of the invention is intended to include all equivalent implementations or modifications without departing from the scope of the invention.
Claims (9)
1. The high-water-content antibacterial sanitary wet tissue comprises a carrier and wet tissue liquid, and is characterized in that the wet tissue liquid comprises the following raw materials: the carrier is non-woven fabric comprising an upper layer, a middle layer and a lower layer, and the upper layer and the lower layer are made of the same fiber raw material and are made of sodium hyaluronate grafted PET fibers.
2. The high water content antimicrobial sanitary wet wipe as set forth in claim 1, wherein the sparingly soluble silver salt is colloidal silver, and the wet wipe solution comprises the following raw materials in parts by weight: 0.01-0.08 part of quaternary ammonium salt compound, 0.01-0.08 part of colloidal silver, 0.01-0.08 part of natamycin clathrate compound and water for 100 parts, wherein the grafting ratio of the sodium hyaluronate grafted PET fiber is 3-7.5wt%.
3. The high moisture antimicrobial sanitary wet wipe of claim 2, wherein the quaternary ammonium salt compound comprises one or more of benzalkonium chloride, cetylpyridinium chloride and dodecyl pyridinium chloride in an amount of 0.03 to 0.06 parts, 0.01 to 0.05 parts of colloidal silver, and 0.01 to 0.05 parts of natamycin clathrate; the total weight of the quaternary ammonium salt compound, the colloidal silver and the natamycin inclusion compound is 0.05 to 0.1 part, and the water is complemented to 100 parts.
4. The high moisture antimicrobial sanitary wet wipe of claim 1 wherein the colloidal silver has an average particle size of 15 to 150nm.
5. The high water content antimicrobial sanitary wet wipe as set forth in claim 1 wherein the sodium hyaluronate has a weight average molecular weight of 10000 or less.
6. The high water content antimicrobial sanitary wet wipe of claim 1 wherein the sodium hyaluronate grafted PET fibers are prepared by a process comprising the steps of:
s1, soaking PET fibers in alkali liquor, heating to a reflux state, stirring at a constant temperature for reaction, adding acid liquor to neutralize to be neutral after the reaction is finished, and filtering, washing and drying for later use;
s2, soaking the fiber obtained in the step S1 in an aqueous solution of a catalyst, filtering and drying; soaking the dried fiber in sodium hyaluronate water solution, filtering and drying; and washing and drying to obtain the grafted modified PET fiber.
7. The high-water content antibacterial hygienic wet wipe as set forth in claim 6, wherein the PET fibers in the step S1 have a fineness of 1 to 2dtex,the length is 30-40mm; the concentration of the alkali liquor is 10-15wt%, and the reaction time is 0.5-1h; the catalyst in the step S2 is Lewis acid selected from FeCl 3 ·6H 2 O、AlCl 3 ·6H 2 O、SnCl 4 ·5H 2 O、ZnCl 2 One or a combination of two or more of the above, the concentration of the catalyst in the aqueous solution of the catalyst is 3-7wt%, and the time for soaking the catalyst solution is 5-15min; the concentration of the sodium hyaluronate solution is 6-15wt%, and the time for soaking the sodium hyaluronate solution is 10-15min.
8. The high-water-content antibacterial sanitary wet wipe as claimed in claim 1, characterized in that the natamycin inclusion compound is a beta-cyclodextrin compound selected from one or a combination of two or more of hydroxypropyl-beta-cyclodextrin, methyl-beta-cyclodextrin and maltosyl-beta-cyclodextrin; preferably, the inclusion agent of the natamycin inclusion compound is hydroxypropyl-beta-cyclodextrin; the quaternary ammonium salt compound comprises one or the combination of two or more of dodecyl pyridine chloride, benzalkonium chloride and cetylpyridinium chloride.
9. A method for preparing the high water content antibiotic sanitary wet wipe as set forth in any one of claims 1 to 8, comprising the steps of:
respectively opening, carding, forming a web, compounding, prewetting, compacting, spunlacing, reinforcing, drying, curling, sterilizing and slitting three layers of fiber raw materials to prepare a carrier; and (3) attaching the wet tissue liquid on a carrier through a dipping or spraying process, and packaging to obtain the sanitary wet tissue with the water content of the solution being more than 99.9%.
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